Real World Data of Penile Cancer Treatment at a High-Volume Center in South America: Insights and Survival Trends.

OBJECTIVE: To report survival trends and oncological outcomes of penile cancer surgically treated patients, at a high-volume center, treating more than 25 patients each year, in a high incidence country. METHODS: Clinical charts of all patients that underwent surgical management for penile cancer were reviewed. The primary end points were cancer specific survival (CSS), progression-free survival, and local recurrence free survival. Kaplan-Meier plots were used for survival analyses. Multivariate analysis was performed using cox proportional hazard age-adjusted models to determine the effect of pN, pT, lymphovascular invasion for CSS. RESULTS: A total of 209 patients were identified, with a median follow up of 96 months (IQR 49-133). Organ-sparing surgerywas performed in 72.7%, 56.9% underwent dynamic sentinel lymph node biopsy, 110 patients underwent inguinal lymph node dissection, and 45 (21.5%) pelvic lymph node dissection. A total of 75 (35.8%) of patients relapsed, median time to relapse of 12 months (IQR 6-25). Overall estimates of CSS showed an 8-year CSS of 68.9%. Eight-year CSS was 90.5% for N0, and 32.8% in pN3 (P <.001). The Cox proportional hazard model showed that pN1-3, pT2-4, lymphovascular invasion and positive dynamic sentinel lymph node biopsy were the variables associated with worse 8-year CSS. CONCLUSION: To the best of our knowledge, we report one of the largest cohorts on the survival outcomes of penile cancer surgical treatment, in a single institution, over a long period of time, were most patients are referred with high-risk, locally advanced or nodal disease.

Tromboflebitis superficial del pene: primer reporte de caso en el Hospital Universitario Nacional de Colombia y recomendaciones actuales de manejo / Superficial Vein Thrombosis of the Penis: A Case Report and Current Recommendations for Diagnosis and Management

La enfermedad de Mondor es una condición caracterizada por la presencia de tromboflebitis en varios segmentos corporales, fue descrita inicialmente por Henri Mondor en 1939 con descripciones de casos que afectaban la circulación venosa de la reja costal y las glándulas mamarias. Se alude a Braun-Falco en 1955 la primera mención de la trombosis superficial del pene, sin embargo, fue hasta 1958 cuando Helm y Hodge describieron el primer caso con compromiso urogenital masculine. Actualmente se cuenta con información limitada sobre la tromboflebitis superficial del pene (enfermedad peniana de Mondor), por lo tanto, el presente artículo describe el primer caso de tromboflebitis de la vena superficial del pene registrado en el Hospital Universitario Nacional de Colombia y expone una propuesta de abordaje terapéutico actual, basada en una revisión reciente de la literatura.

Superficial vein thrombosis was described by Henri Mondor in 1939. At the start of the experience, the disease affected the venous circulation of the thoracic wall and breasts; Helm and Hodge publicated the first report of penile Mondor's disease in 1958. Currently, there is very little clinical information about penile Mondor's disease. This article shown the first case report of penile Mondor's disease in Colombia and proposes a novel, as well as, current algortihm for management of this disease