RÉSUMÉ
Jacaranda oxyphylla Cham. is popularly known as 'caroba-de-São-Paulo' and it is used in traditional medicine for microbial infections. A new phytoquinoid (α/ß-glucoside-4-phenylacetate-6-(1-hydroxy-4-oxo-2,5-cyclohexadiene-1-acetate) (1) was isolated from J. oxyphylla leaves, together with three known compounds: quercetin-3-O-ß-d-galactoside (2), verbascoside (3) and polystyrene (4). Their chemical structures were elucidated using spectroscopic techniques and by comparison with the related known compounds. In addition, it was found a pronounced acetylcholinesterase inhibitory activity for the quinoid 1 (100.0 ± 0.8%) and phenolic compounds 2 and 3 (99.9 ± 0.7 and 99.3 ± 0.5%, respectively), if compared to the standard eserine (92.7 ± 0.4%), that was analysed by a microplate spectrophotometer.
Sujet(s)
Benzoquinones/isolement et purification , Bignoniaceae/composition chimique , Glucosides/isolement et purification , Anti-infectieux/pharmacologie , Benzoquinones/composition chimique , Benzoquinones/pharmacologie , Anticholinestérasiques/pharmacologie , Glucosides/composition chimique , Glucosides/pharmacologie , Feuilles de plante/composition chimiqueRÉSUMÉ
Jacaranda oxyphylla Cham. (Bignoniaceae) is a shrub found in the Brazilian cerrado and used in folk medicine to treat microbial infections. The aim of this study was to carry out a phytochemical screening and evaluate antioedematogenic, antimicrobial and antiacetylcholinesterase properties of J. oxyphylla crude extracts. All extracts analysed showed presence of terpenoids, which are potentially active chemical substances. A high AChE inhibitory activity for hexane extract from leaves and for the extracts from twigs was found. Ethanol extract from leaves of J. oxyphylla showed activity against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli) bacteria. This extract was also effective in inhibiting the stages of inflammation evaluated. Biological investigation and phytochemical screening of J. oxyphylla extracts provided additional evidence of its traditional medicinal value.
Sujet(s)
Antibactériens/pharmacologie , Bignoniaceae/composition chimique , Anticholinestérasiques/pharmacologie , Oedème/traitement médicamenteux , Antibactériens/isolement et purification , Bacillus cereus/effets des médicaments et des substances chimiques , Brésil , Anticholinestérasiques/isolement et purification , Escherichia coli/effets des médicaments et des substances chimiques , Inflammation/traitement médicamenteux , Médecine traditionnelle , Composés phytochimiques/isolement et purification , Composés phytochimiques/pharmacologie , Extraits de plantes/composition chimique , Extraits de plantes/pharmacologie , Feuilles de plante/composition chimique , Staphylococcus aureus/effets des médicaments et des substances chimiques , Terpènes/isolement et purification , Terpènes/pharmacologieRÉSUMÉ
The species of the Byrsonima genus (Malpighiaceae) have been used in folk medicine to treat gastrointestinal disorders, asthma and skin infections. In this study, the total phenolic content, antioxidant activity and phytochemical screening were carried out in polar extracts of Byrsonima coccolobifolia, Byrsonima verbascifolia and Byrsonima intermedia. The presence of tannins and flavonoids in the samples and high phenols content was observed. B. coccolobifolia and B. intermedia species showed the best results of antioxidant action. It was analysed the correlation between the methods, and there was a great correlation between phenolic content and antioxidant assay, showing that the phenolic substances contribute to the antioxidant activities of these plants.
Sujet(s)
Antioxydants/composition chimique , Flavonoïdes/composition chimique , Malpighiaceae/composition chimique , Phénols/composition chimique , Tanins/composition chimique , Extraits de plantes/composition chimique , Feuilles de plante/composition chimiqueRÉSUMÉ
Os autores relatam um caso de pseudo tumor renal determinado por hipertrofia nodular compensatoria em virtude de trombose da arteria renal. A hipotese de lesao expansiva solida foi sugerida tanto pela ultrasonografia como pela nefrotomografia. Na internacao o paciente apresentava quadro de hipertensao arterial severa, e poliglobulia importante. Manifestacoes estas que desapareceram apos a nefrectomia