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Nat Prod Res ; 36(17): 4435-4438, 2022 Sep.
Article de Anglais | MEDLINE | ID: mdl-34544288

RÉSUMÉ

Chenopodin is an 11S-type globulin purified from Chenopodium quinoa seeds, which can bind carbohydrates and hemagglutinating human erythrocytes. The present study aimed to evaluate the N-terminal structure of the heterodimeric Chenopodin and its effects in models of inflammation. Chenopodin presented two subunits on its structure and has N-terminal homology with other Chenopodin in 92%. Chenopodin decreased paw edema and neutrophil recruitment induced by carrageenan in mice. Concluding, we demonstrated that Chenopodin exhibits in vivo anti-inflammatory activity.


Sujet(s)
Anti-inflammatoires , Oedème , Animaux , Anti-inflammatoires/pharmacologie , Anti-inflammatoires/usage thérapeutique , Carragénane/effets indésirables , Oedème/induit chimiquement , Oedème/traitement médicamenteux , Humains , Inflammation/induit chimiquement , Inflammation/traitement médicamenteux , Souris
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