Fully Organic Sensors for Continuous Real-Time Digestion Monitoring.

Monitoring the gastric digestive function is important for the diagnosis of gastric disorders and drug development. However, there is no report on the in situ and real-time monitoring of digestive functions. Herein, we report a flexible fully organic sensor to effectively monitor protein digestion in situ in a simulated gastric environment for the first time. The sensors are made of a blend of gluten that is a protein and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) that is a conducting polymer. During the protein digestion, the breakdown of the polypeptides increases the level of separation among the PEDOT chains, thereby increasing the resistance. The resistance variation is sensitive to various conditions, including the concentration of pepsin that is the enzyme for protein digestion, temperature, pH value, and digestive drugs. Hence, these sensors can provide real-time information about the digestion and efficacy of digestive drugs. In addition, the signals can be collected via a convenient wireless communication manner.

Soft Ionic Pressure Sensor with Aloe Vera Gel for Low-Pressure Applications.

Ionic pressure sensors are made of ionic compounds suspended in a suitable solvent mixture. When external pressure is exerted on them, it is reflected as a change in electrical parameters due to physical deformation and a redistribution of ions within the sensing medium. Variations in the composition and material of the sensing medium result in different pressure sensors with varying operating ranges and sensitivity. This work presents the design and fabrication procedure of a novel soft-pressure sensor for a very low-pressure range (<20 mm Hg) using Aloe vera gel and Glycerin as the solvent for the ionic sensing medium. We also provide a comparative study on the performance of sensor prototypes with varying solvent concentrations and geometric parameters based on a series of characterization experiments. Maximum sensitivity (7.498×10-4 Ω/mmHg) was observed when using 40% glycerin in the sensing medium, filled in a toroidal geometry with outer and inner channel diameters of 8 mm and 7 mm, respectively. The proposed sensor is entirely soft and can be designed to conform to any desired geometry.

Stretchable Capacitive Pressure Sensing Sleeve Deployable onto Catheter Balloons towards Continuous Intra-Abdominal Pressure Monitoring.

Intra-abdominal pressure (IAP) is closely correlated with intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) diagnoses, indicating the need for continuous monitoring. Early intervention for IAH and ACS has been proven to reduce the rate of morbidity. However, the current IAP monitoring method is a tedious process with a long calibration time for a single time point measurement. Thus, there is the need for an efficient and continuous way of measuring IAP. Herein, a stretchable capacitive pressure sensor with controlled microstructures embedded into a cylindrical elastomeric mold, fabricated as a pressure sensing sleeve, is presented. The sensing sleeve can be readily deployed onto intrabody catheter balloons for pressure measurement at the site. The thin and highly conformable nature of the pressure sensing sleeve captures the pressure change without hindering the functionality of the foley catheter balloon.