RÉSUMÉ
This report summarizes closed, family, and open studies conducted sequentially over a 10 month period with the Cendehill rubella virus vaccine in more than 16,000 children and adolescents. This strain of rubella was attenuated by serial propogation on primary rabbit kidney cell cultures. Inoculation of the Cendehill vaccine produced seroconversion in 97 percent of the 3589 susceptible (seronegative) vaccinated persons. There was no spread of the virus to susceptible controls living in close contact with those vaccinated. The vaccine was well tolerated. No arthritis or arthralgia occured in 860 female subjects 13-18 years of age who were included in the study. The Cendehill vaccine would appear to meet the requirements of an acceptable vaccine (Summary)
Sujet(s)
Humains , Enfant d'âge préscolaire , Enfant , Adolescent , Adulte , Mâle , Femelle , Virus de la rubéole/immunologie , Vaccins antiviraux , Production d'anticorps , Études de suivi , Tests d'inhibition de l'hémagglutination , Placebo , Rubéole/prévention et contrôle , Vaccin antirubéoleux , VaccinationSujet(s)
Humains , Nourrisson , Enfant , Adolescent , Adulte , 21003 , Mâle , Femelle , Rubéole , Vaccin antirubéoleux/administration et posologie , Facteurs âges , Sérums immuns/analyse , Immunité innée , Macaca mulatta/immunologie , SuisseRÉSUMÉ
This paper presents our findings from a closed study involving 54 children, a family study involving 100 families and an open study involving more than 16,000 children, ages five years to 15 years, in an urban area in Jamaica. The vaccine produced good immunogenic response and did not spread the disease to susceptible controls in contact with the vaccinees. Our experience with the Cendehill rubella vaccine has shown that it has all the requirements of an acceptable vaccine. It produced sero-conversion in a large percentage of sero-negative vaccinees; it did not spread the disease to sero negative controls living in close contact; it produced only mild side effects in childern, and there was no evidence of arthralgia or arthritiis in vaccinees(AU)