RÉSUMÉ
Tumor tissue repositories (TTRs) play a pivotal role in both basic and translational research by acting as a conduit to facilitate innovative research, thereby providing solutions to treat the incurable disease--'Cancer'. One of the fundamental requirements to achieve this goal would be the acquisition of high quality tumor tissue specimens that are stored in such a manner that its integrity is preserved. Further, a quality system should be in place that assures the compliance of procedures that are the key to a smooth functioning of all the inter-related departments that play a key role in the entire operations. To address this, we have initiated an effort to build a tumor tissue repository of brain tumor tissues in the Southern part of the Indian sub-continent. One of the cardinal features of brain tumors is the heterogeneity, both phenotypically and genotypically. Moreover, significant gaps exist in current understanding of the molecular pathways involved in the genesis, progression, and biological and clinical behavior of brain tumors. We hope that our initiative will provide researchers accessibility to a reserve of high quality tissues in this part of the globe. We have created and validated a complete histology service including tissue processing, embedding, sectioning and H&E staining for fixed tissues, in addition to creating and staining frozen sections. To our knowledge, such a structured initiative to store brain tumor samples is the first of its kind in the India.
Sujet(s)
Recherche biomédicale/organisation et administration , Tumeurs du cerveau/anatomopathologie , Contrôle de qualité , Banques de tissus/organisation et administration , Banques de tissus/normes , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Marqueurs biologiques tumoraux/génétique , Marqueurs biologiques tumoraux/métabolisme , Recherche biomédicale/éthique , Tumeurs du cerveau/génétique , Tumeurs du cerveau/métabolisme , Enfant , Cryoconservation , Femelle , Humains , Techniques immunoenzymatiques , Mâle , Adulte d'âge moyen , ARN messager/génétique , ARN tumoral/génétique , RT-PCR , Manipulation d'échantillons , Donneurs de tissus , Jeune adulteSujet(s)
Protocoles de polychimiothérapie antinéoplasique/effets indésirables , Infections à cytomégalovirus/étiologie , Gastrite/étiologie , Lymphome à grandes cellules anaplasiques/complications , Strongyloïdose/étiologie , Adulte , Albendazole/usage thérapeutique , Anthelminthiques/usage thérapeutique , Protocoles de polychimiothérapie antinéoplasique/administration et posologie , Protocoles de polychimiothérapie antinéoplasique/usage thérapeutique , Antiviraux/usage thérapeutique , Bléomycine/administration et posologie , Bléomycine/effets indésirables , Cyclophosphamide/administration et posologie , Cyclophosphamide/effets indésirables , Infections à cytomégalovirus/traitement médicamenteux , Doxorubicine/administration et posologie , Doxorubicine/effets indésirables , Maladies endémiques , Ganciclovir/usage thérapeutique , Gastrite/traitement médicamenteux , Gastrite/parasitologie , Gastrite/virologie , Humains , Sujet immunodéprimé , Immunosuppresseurs/effets indésirables , Leucovorine/administration et posologie , Leucovorine/effets indésirables , Lymphome à grandes cellules anaplasiques/traitement médicamenteux , Mâle , Méthotrexate/administration et posologie , Méthotrexate/effets indésirables , Oman , Prednisolone/administration et posologie , Prednisolone/effets indésirables , Prednisone/administration et posologie , Prednisone/effets indésirables , Induction de rémission , Strongyloïdose/traitement médicamenteux , Vincristine/administration et posologie , Vincristine/effets indésirablesRÉSUMÉ
A 45-year-old diabetic man presented with an episodic history of painless gross hematuria. He had had no previous urinary symptoms or any other medical problems. His physical examination, urine cytology, and computed tomography scan findings were normal. Cystoscopy demonstrated two nodular masses in the urinary bladder with a hemorrhagic mucosal surface. Biopsies revealed amyloidosis, and immunohistochemical staining of the specimens defined the process as amyloid AA (mostly seen in secondary amyloidosis). The workup for systemic conditions associated with amyloid AA was negative. This represents an unusual case of primary localized AA-type amyloidosis of the bladder.
