RÉSUMÉ
Abatacept es el primer agente biológico aprobado para el tratamiento de la Artritis Reumatoidea (AR) que actúa inhibiendo la co-estimulación de linfocitos T. Si bien se ha reportado su eficacia en psoriasis y artritis psoriásica, existen casos de psoriasis inducida por el fármaco como así también reactivación de las lesiones en pacientes previamente enfermos. Una mujer con antecedentes de AR en tratamiento con Abatacept endovenoso presentó máculas eritemato-escamosas y pruriginosas en toda la superficie corporal, clínica e histológicamente compatibles con psoriasis. La suspensión del tratamiento con Abatacept, ocasionó la desaparición de las lesiones cutáneas. Mas de 4 años después se encuentra en tratamiento con Rituximab sin haber vuelto a presentar compromiso cutáneo.
Abatacept is the first biological agent approved for the treatment of Rheumatoid Arthritis (RA) that acts blocking interaction of T lymphocytes. Although its efficacy in psoriasis and psoriatic arthritis has been reported, there are reports of drug induced psoriasis as well as reactivation of cutaneous lesions. A woman with a history of RA under treatment with Abatacept IV presented erythematous-scaly and pruritic macules on the entire body surface, clinically and histologically compatible with psoriasis. The suspension of treatment with Abatacept caused the disappearance of the cutaneous lesions. More than 4 years later he is in treatment with Rituximab without presenting cutaneous lesions.
Sujet(s)
Polyarthrite rhumatoïde , Psoriasis , AbataceptRÉSUMÉ
Se reporta el caso de una paciente con cistitis en donde se aisló Gardnerella vaginalis. Se trata de paciente femenino de 71 años de edad que presentó disuria, poliaquiuria, micción imperiosa y dolor suprapúbico, sin otra sintomatología. Refirió orina turbia a simple vista, además de mal olor de la misma. Al examen físico no se evidenció ningún signo sugestivo, por ejemplo de vaginosis bacteriana, según los criterios clínicos. Una hematología reveló leve linfopenia. Al examen de orina ésta fue aspecto turbio, con signos sugestivos de infección urinaria. Al realizar el urocultivo, en este creció y se identificó Gardnerella vaginalis. Se indicó Metronizadol. Se evidenció adecuada respuesta al tratamiento y resolución del cuadro clínico. El papel de G. vaginalis en las infecciones urinarias se discute, ya que es raro encontrale en infecciones extra-vaginales
Sujet(s)
Humains , Femelle , Cystite , Gardnerella vaginalis , Maladies du vaginRÉSUMÉ
The well-known neural mass model described by Lopes da Silva et al. (1976) and Zetterberg et al. (1978) is fitted to actual EEG data. This is achieved by reformulating the original set of integral equations as a continuous-discrete state space model. The local linearization approach is then used to discretize the state equation and to construct a nonlinear Kalman filter. On this basis, a maximum likelihood procedure is used for estimating the model parameters for several EEG recordings. The analysis of the noise-free differential equations of the estimated models suggests that there are two different types of alpha rhythms: those with a point attractor and others with a limit cycle attractor. These attractors are also found by means of a nonlinear time series analysis of the EEG recordings. We conclude that the Hopf bifurcation described by Zetterberg et al. (1978) is present in actual brain dynamics.
Sujet(s)
Cybernétique , Électroencéphalographie , Modèles neurologiques , Humains , Fonctions de vraisemblance , Neurones/physiologie , Dynamique non linéaireRÉSUMÉ
A new method is presented for computing the electric lead field of a realistic head shape model which has piecewise homogeneous conductivity. The basic formulae are derived using the well-known reciprocity theorem. Previously described methods are also based upon this theorem, but these first calculate the electric potential inside the head by a scalar boundary element method (BEM), and then approximate the ohmic current density by some sort of gradient. In contrast, this paper proposes the direct evaluation of the ohmic current density by discretizing the vector Green's second identity which leads to a vector version of BEM. This approach also allows the derivation of the same equations for the three concentric spheres model as obtained by Rush and Driscoll [8]. The results of simulations on a spherical head model indicate that the use of a vector BEM leads to an improvement of accuracy in the computation of the ohmic current density with respect to those reported previously, in term of different measures of error.