[DIEP flap reconstruction after palliative curettage mastectomy in locally advanced breast cancer]. / Colgajo DIEP de cobertura tras mastectomía de limpieza paliativa en cáncer de mama localmente avanzado.

BACKGROUND: Curettage mastectomy is indicated as a palliative treatment in locally advanced breast cancer. We present our experience with the use of a DIEP flap reconstruction following extensive mastectomy. METHODS: We report the case of a patient with very advanced local breast cancer that was subsidiary to aggressive palliative surgery after chemotherapy. RESULTS: It was considered that the closure that could be performed with the latissimus dorsi muscle was unsuitable, therefore a DIEP flap was performed. The patient was discharged uneventfully. CONCLUSION: The DIEP reconstruction offers great cutaneous extension. It can be a resource in highly selected cases of locally advanced breast cancer in which surgery becomes the main treatment.

Colgajo DIEP de cobertura tras mastectomía de limpieza paliativa en cáncer de mama localmente avanzado / DIEP flap reconstruction after palliative curettage mastectomy in locally advanced breast cancer

Fundamento. La mastectomía de limpieza está indicada con carácter paliativo en el cáncer de mama localmente avanzado. Para cerrar el defecto cutáneo puede ser necesario el empleo de un injerto. Mostramos nuestra experiencia con el uso de un colgajo DIEP (Deep Inferior Epigastric artery Perforators) de cobertura tras la realización de una mastectomía de gran extensión. Material y métodos. Se muestra el caso de una paciente con un tumor de mama muy avanzado localmente, que era subsidiaria de un tratamiento quirúrgico agresivo tras la administración de quimioterapia. Resultados. Se consideró que el cierre que puede ofrecer un colgajo realizado con el músculo dorsal ancho esta insuficiente, por lo que se realizó un DIEP. La paciente presentó una evolución postoperatoria satisfactoria. Conclusiones. El colgajo DIEP de cobertura ofrece una gran extensión cutánea. Puede ser un recurso en casos muy seleccionados de tumores de mama localmente avanzados, en los que la cirugía se convierte en la principal arma terapéutica (AU)

Background. Curettage mastectomy is indicated as a palliative treatment in locally advanced breast cancer. We present our experience with the use of a DIEP flap reconstruction following extensive mastectomy. Methods. We report the case of a patient with very advanced local breast cancer that was subsidiary to aggressive palliative surgery after chemotherapy. Results. It was considered that the closure that could be performed with the latissimus dorsi muscle was unsuitable, therefore a DIEP flap was performed. The patient was discharged uneventfully. Conclusion. The DIEP reconstruction offers great cutaneous extension. It can be a resource in highly selected cases of locally advanced breast cancer in which surgery becomes the main treatment (AU)

La estadificación con resonancia magnética puede cambiar el manejo terapéutico en el cáncer de mama / Using magnetic resonance imaging for staging can change the therapeutic management in patients with breast cancer

Objetivo. Comparar 2 series de pacientes con cáncer de mama, una estadificadas mediante resonancia magnética (RM) preoperatoria y la otra con técnicas convencionales, y estudiar los cambios de tratamiento y el número de mastectomías y de reintervenciones por afectación de los bordes. Material y métodos. Se revisaron 600 pacientes divididas en 300 con RM preoperatoria (serie 1) y 300 sin RM (serie 2). Se valoraron: la edad, el estado menopáusico, el tamaño tumoral anatomopatológico, la multiplicidad y bilateralidad, el tratamiento quirúrgico y tipo de tratamiento, la administración de quimioterapia neoadyuvante y las reintervenciones por márgenes afectos. Las variables fueron comparadas con las pruebas t de Student y la Chi-cuadrado. Resultados. La edad media fue similar (51,5 y 51,8 años, p=0,71). El tamaño tumoral medio fue menor (p<0,001) en la serie 1 (16,9 vs 22,3mm). Se detectaron más tumores múltiples (p<0,001) en la serie 1 (28,7 vs 15,7%). La tasa de mastectomías en la serie 1 (25%) fue menor (p<0,001) que en la 2 (48%). Las técnicas de cirugía oncoplástica y bilaterales solo fueron realizadas en la serie 1. La quimioterapia neoadyuvante fue administrada más frecuentemente (p<0,001) en la serie 1 (30,7 vs 9,3%). La diferencia no fue significativa (p=0,095) en el número de reintervenciones por márgenes afectos (7,2% serie 1; 3,2% serie 2). Conclusión. Las mastectomías disminuyen al emplear la RM, con disponibilidad de técnicas de cirugía oncoplástica y quimioterapia neoadyuvante. Pese al aumento de cirugías conservadoras en la serie con RM, no observamos un aumento significativo del número de reintervenciones por márgenes afectos, aunque existe una tendencia (AU)

Objective. To compare two series of patients with breast cancer, one staged using preoperative MRI and the other staged using conventional techniques, analyzing the changes to treatment, the number of mastectomies, and the number of reinterventions due to involvement of the margins. Material and methods. We reviewed 600 patients divided into 300 patients with preoperative MRI (series 1) and 300 without preoperative MRI (series 2). We recorded the following variables: age, menopausal status, tumor size on pathological examination, multiplicity and bilaterality, surgical treatment and type of treatment, the administration of neoadjuvant chemotherapy, and reintervention for involved margins. We used Student's t-test and the chi-square test to compare the variables between the two series. Results. The mean age of patients in the two series was similar (51.5 and 51.8 years, P=0.71). The mean size of the tumor was smaller in series 1 (16.9mm vs 22.3mm) (P<.001). More multiple tumors were detected in series 1 (28.7 vs 15.7%) (P<.001). The rate of mastectomies was lower in series 1 (25 vs 48%) (P<.001). Oncoplastic and bilateral surgeries were performed only in series 1. Neoadjuvant chemotherapy was administered more often in series 1 (30.7 vs 9.3%) (P<.001). The difference in the number of reinterventions for involved margins did not reach significance (7.2% in series 1 vs 3.2% in series 2) (P=.095). Conclusion. When MRI was used for staging, neoadjuvant chemotherapy and oncoplastic surgery were used more often and the mastectomy rate decreased. Despite the increase in conservative surgery in patients staged with MRI, the number of reinterventions for involved margins did not increase, although there was a trend towards significance (AU)

[Using magnetic resonance imaging for staging can change the therapeutic management in patients with breast cancer]. / La estadificación con resonancia magnética puede cambiar el manejo terapéutico en el cáncer de mama.

OBJECTIVE: To compare two series of patients with breast cancer, one staged using preoperative MRI and the other staged using conventional techniques, analyzing the changes to treatment, the number of mastectomies, and the number of reinterventions due to involvement of the margins. MATERIAL AND METHODS: We reviewed 600 patients divided into 300 patients with preoperative MRI (series 1) and 300 without preoperative MRI (series 2). We recorded the following variables: age, menopausal status, tumor size on pathological examination, multiplicity and bilaterality, surgical treatment and type of treatment, the administration of neoadjuvant chemotherapy, and reintervention for involved margins. We used Student's t-test and the chi-square test to compare the variables between the two series. RESULTS: The mean age of patients in the two series was similar (51.5 and 51.8 years, P=0.71). The mean size of the tumor was smaller in series 1 (16.9 mm vs 22.3 mm) (P<.001). More multiple tumors were detected in series 1 (28.7 vs 15.7%) (P<.001). The rate of mastectomies was lower in series 1 (25 vs 48%) (P<.001). Oncoplastic and bilateral surgeries were performed only in series 1. Neoadjuvant chemotherapy was administered more often in series 1 (30.7 vs 9.3%) (P<.001). The difference in the number of reinterventions for involved margins did not reach significance (7.2% in series 1 vs 3.2% in series 2) (P=.095). CONCLUSION: When MRI was used for staging, neoadjuvant chemotherapy and oncoplastic surgery were used more often and the mastectomy rate decreased. Despite the increase in conservative surgery in patients staged with MRI, the number of reinterventions for involved margins did not increase, although there was a trend towards significance.

Association between [18F]fluorodeoxyglucose uptake and prognostic parameters in breast cancer.

BACKGROUND: This study analysed the correlation between [(18)F]fluorodeoxyglucose (FDG) uptake assessed by positron emission tomography (PET) in breast tumours, and histopathological and inmunohistochemical prognostic factors. METHODS: FDG-PET was performed before surgery in 275 women with primary breast cancer. The standarized uptake value (SUV) was compared with histopathological findings after surgery. RESULTS: A positive relationship was found between the SUV and tumour size (r = 0.46, P < 0.001), axillary lymph node status (P < 0.001), histological type (P < 0.001), histological grade (P < 0.001), oestrogen receptor status (P < 0.001), p53 (P < 0.001) and Ki-67 (P < 0.001) expression. Multivariable linear regression showed that tumour size, histological grade, Ki-67 expression, oestrogen receptor status and histological type were significantly related to the SUV. CONCLUSION: The SUV is a preoperative and non-invasive metabolic factor that relates to some prognostic factors in breast cancer.

[New developments in the surgical treatment of breast cancer]. / Novedades en el tratamiento quirúrgico del cáncer de mama.

Adecuate surgical treatment is mandatory in order to achieve cure in patients with breast cancer. Breast surgeons have to choice the best surgical technique over the breast and over the axillary nodes. Two new surgical aproaches have been implemented in the last decade: oncoplastic conservative surgery and sentinel lymph node biopsy. Oncoplastic surgery provides oncologic safety results and good cosmetic outcome. In this paper the technical steps and indications of different oncoplastic techniques in conservative breast surgery are review. Concerning to axillary surgery sentinel lymph node biopsy is the gold standard. However there are several controversial points in sentinel node biopsy referring to indications, identification and histological findings.

Novedades en el tratamiento quirúrgico del cáncer de mama / No disponible

Un tratamiento quirúrgico correcto es imprescindible para conseguir lacuración de las pacientes con cáncer de mama. El cirujano debe elegirla mejor cirugía tanto en la mama como en los ganglios axilares. Enla última década se han incorporado dos nuevas técnicas quirúrgicas:la cirugía oncoplástica conservadora y la biopsia de ganglio centinela.La cirugía oncoplástica aporta seguridad oncológica y buen resultadoestético. En este trabajo se revisan los pasos técnicos y las indicacionesde las diferentes técnicas oncoplásticas que se emplean en cirugía conservadorade mama. Respecto a la cirugía axilar, la biopsia de gangliocentinela es la técnica de elección actual. Sin embargo existen aspectoscontrovertidos en la biopsia del ganglio centinela respecto a indicaciones,técnicas de identifi cación y hallazgos histológicos(AU)

Adecuate surgical treatment is mandatory in order to achieve cure inpatients with breast cancer. Breast surgeons have to choice the bestsurgical technique over the breast and over the axillary nodes. Two newsurgical aproaches have been implemented in the last decade: oncoplasticconservative surgery and sentinel lymph node biopsy. Oncoplasticsurgery provides oncologic safety results and good cosmetic outcome.In this paper the technical steps and indications of different oncoplastictechniques in conservative breast surgery are review. Concerning to axillarysurgery sentinel lymph node biopsy is the gold standard. Howeverthere are several controversial points in sentinel node biopsy referringto indications, identifi cation and histological fi ndings(AU)

Novedades en el tratamiento quirúrgicodel cáncer de mama / New developments in the Surgical Treatment of Breast Cancer

Un tratamiento quirúrgico correcto es imprescindible para conseguir lacuración de las pacientes con cáncer de mama. El cirujano debe elegirla mejor cirugía tanto en la mama como en los ganglios axilares. Enla última década se han incorporado dos nuevas técnicas quirúrgicas:la cirugía oncoplástica conservadora y la biopsia de ganglio centinela.La cirugía oncoplástica aporta seguridad oncológica y buen resultadoestético. En este trabajo se revisan los pasos técnicos y las indicacionesde las diferentes técnicas oncoplásticas que se emplean en cirugía conservadorade mama. Respecto a la cirugía axilar, la biopsia de gangliocentinela es la técnica de elección actual. Sin embargo existen aspectoscontrovertidos en la biopsia del ganglio centinela respecto a indicaciones,técnicas de identifi cación y hallazgos histológicos (AU)

Adecuate surgical treatment is mandatory in order to achieve cure inpatients with breast cancer. Breast surgeons have to choice the bestsurgical technique over the breast and over the axillary nodes. Two newsurgical aproaches have been implemented in the last decade: oncoplasticconservative surgery and sentinel lymph node biopsy. Oncoplasticsurgery provides oncologic safety results and good cosmetic outcome.In this paper the technical steps and indications of different oncoplastictechniques in conservative breast surgery are review. Concerning to axillarysurgery sentinel lymph node biopsy is the gold standard. Howeverthere are several controversial points in sentinel node biopsy referringto indications, identifi cation and histological fi ndings (AU)

[Medium and long-term results of the use of videothorascopy in surgery of pulmonary metastasis resection]. / Resultados a medio y largo plazo de la utilización de videotoracoscopia en la cirugía de resección de las metástasis pulmonares.

The surgical resection of pulmonary metastases is a method of treatment accepted as habitual in thoracic surgery. However, it continues to be a source of controversy if this resection must be realised by thoracotomy or by modern video-assisted techniques. With the aim of finding a response to this controversy in our work milieu, a review was made of the surgical interventions carried out in order to resect pulmonary metastases. Between January 1997 and December 2001, 56 patients were found whose pulmonary metastases had been resected by videothorascopy out of a total of 252 metastasectomies (22.2%). The primary tumours were classified in 4 groups: sarcoma (n=11); colorectal (n=25); renal (n=5); and others (n=15). Videothorascopy was carried out on the right hemithorax (n=28), left hemithorax (n=22) or on both at once (n=6). Operational mortality was nil and the only morbidity attributable to the technique was a defect of re-expansion following the removal of the thoracic drainage in one patient. Using the Kaplan-Meier method, the probability of survival in this series of patients was 60.4% after 5 years, with an average survival time of 48 months. All of this data supports the use of videothorascopy in our milieu on patients with pulmonary metastases. However, in the light of the results, it is important in using this technique to place special emphasis on obtaining good margins of resection, due to the real risk of local recurrence on these margins in the medium term.

Resultados a medio y largo plazo de la utilización de videotoracoscopia en la cirugía de resección de las metástasis pulmonares / Medium and long-term results of the use of videothorascopy in surgery of pulmonary metastasis resection

La resección quirúrgica de las metástasis pulmonares es un método de tratamiento aceptado como habitual en la cirugía torácica. Sin embargo, continúa siendo un motivo de controversia si esta resección se debe realizar por toracotomía, o por las modernas técnicas vídeo asistidas. Con la finalidad de buscar una respuesta a dicha controversia en nuestro medio de trabajo, se efectuó una revisión de las intervenciones quirúrgicas realizadas con el objetivo de resecar metástasis pulmonares. Entre enero de 1997 y diciembre de 2001, se encontraron 56 pacientes a quienes se había resecado metástasis pulmonares por videotoracoscopia de entre un total de 252 metastasectomías (22,2%). Se clasificaron los tumores primarios en 4 grupos: sarcoma (n=11); colorrectal (n=25); renales (n=5); y otros (n=15). La videotoracoscopia se realizó en el hemitórax derecho (n=28), hemitórax izquierdo (n=22) o en ambos a la vez (n=6). La mortalidad operatoria fue nula y la única morbilidad atribuible a la técnica fue un defecto de reexpansión tras la retirada del drenaje torácico en un paciente. Utilizando el método de Kaplan-Meier, la probabilidad de supervivencia de esta serie de pacientes fue del 60,4% a los 5 años, con tiempo de supervivencia medio de 48 meses. Todos estos datos apoyan en nuestro medio el empleo de videotoracoscopia en pacientes con metástasis pulmonares. Sin embargo, y a la vista de los resultados, es importante al efectuar esta técnica poner un cuidado especial en conseguir buenos márgenes de resección, debido al riesgo real de recurrencia local sobre dichos márgenes a medio plazo

The surgical resection of pulmonary metastases is a method of treatment accepted as habitual in thoracic surgery. However, it continues to be a source of controversy if this resection must be realised by thoracotomy or by modern video-assisted techniques. With the aim of finding a response to this controversy in our work milieu, a review was made of the surgical interventions carried out in order to resect pulmonary metastases. Between January 1997 and December 2001, 56 patients were found whose pulmonary metastases had been resected by videothorascopy out of a total of 252 metastasectomies (22.2%). The primary tumours were classified in 4 groups: sarcoma (n=11); colorectal (n=25); renal (n=5); and others (n=15). Videothoroscopy was carried out on the right hemithorax (n=28), left hemithorax (n=22) or on both at once (n=6). Operational mortality was nil and the only morbidity attributable to the technique was a defect of re-expansion following the removal of the thoracic drainage in one patient. Using the Kaplan-Meier method, the probability of survival in this series of patients was 60.4% after 5 years, with an average survival time of 48 months. All of this data supports the use of videothorascopy in our milieu on patients with pulmonary metastases. However, in the light of the results, it is important in using this technique to place special emphasis on obtaining good margins of resection, due to the real risk of local recurrence on these margins in the medium term

Localized fibrous tumors of the pleura: experience with 7 recent cases.

OBJECTIVE: Localized fibrous tumors of the pleura are rare. We report 7 cases and review the literature in order to define the range of clinical characteristics of these tumors, treatment options, and prognosis. METHODS: A retrospective review of 7 cases treated between 1997 and 2003, focusing on clinical presentation, diagnostic tests, and treatment. The tumor was removed surgically in all cases, by thoracotomy in 6 cases and by video-assisted thoracoscopic surgery in 1 patient. RESULTS: All patients recovered fully after surgery, with no postoperative complications. One patient experienced recurrence twice, 33 and 67 months after the initial resection. All are alive at the time of writing, after a mean follow up period of 19 months (range 1 month to 5 years and 10 months). CONCLUSIONS: The treatment of choice for a fibrous tumor of the pleura is full resection and follow-up to detect possible late recurrence.

Current role for resection of thoracic metastases in children and young adults--do we need different strategies for this population?

UNLABELLED: A retrospective review of surgical interventions for pulmonary metastases found 44 surgical metastasectomies in patients 20 years old or younger. OBJECTIVE: Indications for pulmonary metastasectomy are well established in adults, but are not so clear when we are dealing with a younger population. PATIENTS AND METHODS: A retrospective review of surgical interventions for pulmonary metastases (from December 1996 to October 2001) found 44 surgical metastasectomies in patients considered pediatric or young adults (20 years old or younger). Initial primary tumor, disease-free interval (DFI), previous thoracotomies, tumor histology, number of metastases, surgery performed, postoperative complications, other treatments received, and outcomes were recorded. RESULTS: Median age was 16.3 years (range 5 to 20 years) with 27 male and 17 female patients. Primary tumors were sarcoma (n = 31), Ewing's tumor (n = 8), Wilms' tumor (n = 3), and testicular carcinoma (n = 2). 27 patients had undergone previous resection of pulmonary metastases. Approaches were posterolateral thoracotomy (n = 18), clamshell incision (n = 8), VATS (n = 7), axillary thoracotomy (n = 9), and others (n = 2). Wedge resections were the procedure of choice (n = 35). In very select cases 1 pneumonectomy, 3 lobectomies, 2 chest wall resections, and 1 spinal surgery (vertebrectomy) were performed. Intra-operative radiotherapy (IORT) was employed in 2 patients. Cardiopulmonary bypass was necessary in 1 patient in order to resect an intra-atrial tumor thrombus. There was no operative mortality. Morbidity was related to prolonged air leaks (3 patients), hemothorax (2 patients), cerebrospinal fluid leak (1 patient), atelectasia (1 patient), peritoneal pain (1 patient), and postoperative fever syndrome (1 patient). Patterns of failure were thoracic (lung-pleura-chest wall) (n = 20), distant (n = 3) and thoracic + distant (n = 6). CONCLUSION: A close collaboration between oncologists, radiotherapists, and surgeons is mandatory in order to obtain good results. IORT is an interesting option. Better results are obtained if there is a long DFI and probably justifies a more aggressive approach in these specific cases.

Lesiones mamarias no palpables: experiencia inicial con la biopsia estereotáxica automatizada / Non-palpable breast lesions: initial experience with the automated stereotaxic biopsy

Analizamos retrospectivamente en nuestra experiencia la eficacia de los sistemas MIBB (minimally invased breast biopsy) y ABBI (advanced breast biopsy instrumentation) en el diagnóstico de las lesiones mamograficas sospechosas no palpables. Se realizaron 70 biopsias: 36 con el MIBB y 34 con el ABBI. Mediante el MIBB se obtuvieron varios cilindros por un único punto de punción, con la biopsia ABBI se obtuvo un único cilindro de 1-2 cm de diámetro. La biopsia se indicó por microcalcificaciones (n = 40) y nódulos (n = 30). Analizamos las complicaciones técnicas, postbiopsia y los resultados histológicos. La lesión sospechosa fue correctamente localizada y biopsiada en el 98,5 per cent (36 de 36 MIBB y 33 de 34 ABBI) comprobada por la radiografía de la pieza, las imágenes estereotáxicas y el análisis histológico. En 4 casos (5,7 per cent) se observaron complicaciones técnicas que no impidieron completar la biopsia. En 3 casos (4,3 per cent) se presentaron complicaciones postbiopsia: 2 hematomas post ABBI y un sincope vagal post MIBB. 27 lesiones fueron malignas (38,5 per cent); 10 biopsiadas por MIBB y 13 por ABBI. No se observó tumor residual en la tumorectomía posterior en 5 de los 10 ABBI malignos reintervenidos. Tres pacientes con carcinomas de mama con márgenes de resección negativos se extirparon con la cánula ABBI sin practicar una intervención posterior. Los sistemas MIBB y ABBI fueron métodos de biopsia mamaria seguros y precisos y evitaron la cirugía posterior en el 71,2 per cent de casos. La localización, tamaño y grado de sospecha de la lesión son muy importantes para decidir el tipo de biopsia. Las lesiones sospechosas de más de 1 cm o las multifocales deben biopsiarse con el sistema MIBB. Las lesiones únicas de menos de 1cm deben biopsiarse con el sistema ABBI. Tumores de mama de pequeño tamaño en casos seleccionados podrían extirparse por completo con el ABBI sin necesitar una posterior tumorectomía (AU)

Papel de la cirugía en el tratamiento del linfomagástrico primario / Surgery´s role in management of primary gastric lymphoma

El Linfoma Gástrico Primario es una entidad patológica cuyo manejo óptimo está en discusión. Se estudian retrospectivamente 23 pacientes tratados en nuestro Centro por Linfoma Gástrico entre 1976 y 1998 con resección quirúrgica como terapia principal. En diez pacientes la cirugía fue el único tratamiento realizado, en el resto se asoció quimio y/o radioterapia según criterio del oncólogo-hematólogo responsable. No hubo diferencias en cuanto a morbimortalidad entre los diferentes tratamientos. Se analizan las características clínicas e histológicas y la evolución de los pacientes. Ninguno de los pacientes ha fallecido a consecuencia del linfoma, no habiéndose presentado tampoco ningún caso de recurrencia local ni a distancia. Opinamos que la cirugía es una opción válida en el tratamiento del Linfoma Gástrico Primario. La asociación de tratamientos complementarios dependerá del estadio definitivo, las características histológicas del tumor y la posibilidad de realizar o no una resección radical (AU)

[Role of surgery in the treatment of primary gastric lymphoma]. / Papel de la cirugía en el tratamiento del linfoma gástrico primario.

Primary gastric lymphoma's optimum management remains controversial. We reviewed our series of 23 patients with primary gastric lymphoma treated in our hospital between 1976 and 1998 with surgery as main therapy. Ten patients underwent surgical resection alone, whereas 13 also received postoperative adjuvant therapy, depending on the oncologist-haematologist's recommendations. No differences were found between treatments regarding mortality and morbidity. Clinical-histological features and patients, follow-up are analyzed. No patient died because of lymphoma and there wasn't either local or distant recurrence. We consider that surgery remains a valid option for the primary gastric lymphoma treatment. The introduction of combined modalities of radiation therapy and chemotherapy will depend on the final stage, the tumor histological features, and the feasibility of getting a radical resection.