[Exploratory study of the socio-demographic and psychopathological features of persons reported as perpetrators of violence in Cordoba City]. / Estudio exploratorio de las características socio-demográficas y psicopatológicas de personas denunciadas como agresores de violencia doméstica en la Ciudad de Córdoba.

Background: Nowadays, domestic violence is a public health problem due to its magnitude and socio-sanitary effects. Aim: Examine the epidemiological, sociodemographic and psychopathological characteristics of people denounced as aggressors in the city of Córdoba. Material and Methods: exploratory, retrospective and cross-sectional study of people denounced as alleged intrafamiliar violence aggressors at the Family Violence Prosecution Unit of the Córdoba Province Court of Law throughout the period from June 2011 to May 2012. Results: 86% were men and 14% women of an age ±35. Couple violence was the most predominant in 69%. The denounced people had an educational level in 60.7%. The most frequent aggression was threat in 45.6%.Then, serious injuries in 35.3%. Most of the cases did not have a diagnosis of mental disorder (64.3%). The most common disorder was substance abuse (28.3%). Conclusion: The most frequently denounced form of violence was the intimate partner violence and it affects people at an early and productive age, showing a gender behavior and social risk factors.

Introducción: La violencia doméstica es actualmente un problema de salud pública debido a su magnitud y repercusiones sociosanitarias. Objetivo: explorar las características epidemiológicas sociodemográficas y psicopatológicas de personas denunciadas como agresores en la ciudad de Córdoba. Material y Métodos: estudio exploratorio, retrospectivo y transversal de los registros de personas denunciadas como presuntos agresores de violencia intrafamiliar en la fiscalía de violencia familiar de los tribunales Judiciales Provinciales de Córdoba Capital en el período junio 2011 a mayo 2012. Resultados: el (86%) fueron varones y el (14%) mujeres con una edad de ±35 años. La violencia de pareja fue la más prevalente en el (69%). El grupo etario más comprometido fue el de 20 a 39 años El tipo de lesión más frecuente fue la amenaza (45,6%), seguida de lesiones graves (35,3%). La mayor parte de los casos no presentó diagnóstico de trastorno mental (64,3%). El trastorno mental más frecuente fue el consumo de sustancia (28,3%). Conclusión: el tipo de violencia denunciada con mayor frecuencia fue la violencia intrafamiliar de pareja y afectó a la gente de edad joven y productiva mostrando un comportamiento de género y factores de riesgo social.

Localization of plasminogen in the extracellular matrix of hamster eggs: exogenous activation by streptokinase.

The plasminogen activator (PA)/plasminogen/plasmin proteolytic system has begun to be taken into account in the fertilization process. In this study, we demonstrated the presence of plasminogen in the extracellular matrix (ECM) of hamster oocytes by indirect immunofluorescence and immunoperoxidase assays using human anti-plasminogen. Plasminogen appeared first on the zona pellucida (ZP) of ovarian oocytes and later on the plasma membrane (PM) of oviducal eggs. This would suggest that oviducal oocytes modulate the expression of plasminogen binding sites on the PM. Human plasminogen as well as that of other species, known to be activated by streptokinase (SK), is rapidly converted to a plasmin-SK complex. We demonstrated the rapid formation of a SK-plasminogen complex that yields plasmin in the blood plasma of hamsters. Both the in vivo and in vitro SK treatment of eggs from superovulated female hamsters caused a decreased in the ZP dissolution time (ZPdt), probably either due to the proteolytic effect of plasmin or due to the SK-Plasminogen. Extracellular proteolysis assays carried out on agar-casein plates confirmed the proteolytic activity of SK-incubated eggs; the controls, on the contrary, failed to display a halo. These studies show that (1) superovulated hamster eggs contain plasminogen in their ECM, (2) oviducal eggs exhibit plasminogen on their PMs, indicating the presence of their corresponding binding sites, (3) in hamsters, SK, a non-enzymatic exogenous protein would be capable of activating ECM plasminogen to plasmin, and (4) the complex SK-plasminogen and/or the plasmin are capable of changing the ZPdt with alpha-chymotrypsin.