RÉSUMÉ
Lack of investment for magnetic resonance (MR) fusion systems is an obstacle to deliver targeted prostate biopsies within the prostate cancer diagnostic pathway. We developed a coordinate-based method to support cognitive targeted prostate biopsies and then performed an audit on cancer detection and the location of lesions. In each patient, the prostate is considered as two separate hemiprostates, and each hemiprostate is divided into 4 × 4 × 4 units. Each unit is therefore defined by a three-dimensional coordinate. We prospectively applied our coordinates approach to target 106 prostatic lesions in 93 men. Among 45 (of 106; 42.5%) lesions positive for cancer, 27 lesions (60.0%) harbored clinically significant disease. PSA density was significantly higher in patients with proven cancer (median: 0.264 ng ml-2) when compared to the noncancer group (median: 0.145 ng ml-2; P = 0.003, Wilcoxon rank-sum test). Lesions with Prostate Imaging-Reporting and Data System (PIRADS) score of 5 were found to have a cancer incidence of 65.2%, while PIRADS 4 and 3 lesions have a lower risk of cancer detection, as expected, at 37.3% and 31.3%, respectively. The probability of a lesion being cancerous in our series significantly decreases as we go from the "apex-to-base" dimension (odds ratio [OR]: 2.62, 95% confidence interval [CI]: 1.55-4.44, P = 0.00034). Our analysis also indicates that the probability of cancer decreases as the prostate volume increases (OR: 1.03, 95% CI: 1.01-1.05, P = 0.00327). Based on this feasibility study, the use of coordinates to guide cognitive targeted prostate biopsies warrants future validation study in additional centers.
Sujet(s)
Biopsie/instrumentation , Prostate/anatomopathologie , Enregistrements/normes , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Biopsie/méthodes , Biopsie/statistiques et données numériques , Comportement coopératif , Humains , Imagerie par résonance magnétique/méthodes , Mâle , Adulte d'âge moyen , Enregistrements/statistiques et données numériques , Royaume-UniRÉSUMÉ
This article was migrated. The article was marked as recommended. Background. This article uses a case study approach to describe and analyse how a peer-led committee was used to develop leadership skills among junior doctors. Junior doctors are a potentially powerful group of leaders within the healthcare sector, yet more senior staff members may encounter difficulty engaging with this group. Leadership and engagement are essential for optimal functioning of an organisation. Alternatives. Typical methods used to develop leadership skills and promote engagement with leadership activities include higher degrees, short courses, coaching, and experiential learning activities. One alternative can be to use experiential learning that has be informed by situated learning theory and the concept of communities of practice. Solution. A peer-led committee of junior doctors was established using to develop leadership skills and promote engagement with leadership activities. The committee was designed to address five features of a community of practice: mutual engagement, joint enterprise, shared repertoire, learning, and community. This peer-led committee included elected roles and met regularly out of hours over two sites within the Southern District Health Board, New Zealand. Recommendations. This intervention was well-received by junior doctors and has been sustained in the Southern District Health Board. A peer-led committee structured with the features of a community of practice may be useful method for others to use when they seek to promote and support the development leadership skills of junior doctors.
RÉSUMÉ
Introduction Pediatric circumcision is a commonly performed operation, yet outcomes related to procedures performed for medical indications remain underreported. Aim The aim of this study was to report outcomes of therapeutic circumcision from our center. Methods Prospective registry of elective circumcisions was maintained and analyzed at a single institution in the United Kingdom. Data collected included information on complications (early and late), emergency presentations, and referrals back from primary care services. Results Between August 2015 and June 2019, 300 patients (mean age: 9 years; range: 3-16 years) underwent therapeutic circumcision. The average length of follow-up data available was 2.1 years (range: 6 months to 4 years). The overall complication rate was 4.7% ( n = 16). There were no unplanned admissions and no cases returned to the operating room as emergency. Only 1% ( n = 3) of patients presented with an early complication (minor bleeding, pain, urinary retention), and 3.7% ( n = 11) suffered a late complication (meatal stenosis [2.7%]). All cases of meatal stenosis had lichen sclerosus confirmed on histology. Cosmetic satisfaction was 99%. Conclusion Therapeutic circumcision is an effective procedure in the pediatric population, which carries a low risk of early and late complications. Our study found that meatal stenosis only occurred in those patients with confirmed lichen sclerosus histology.