RÉSUMÉ
INTRODUCTION: Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) have demonstrated promising results in the treatment of peritoneal carcinomatosis (PC). The purpose of this study was to assess the impact of this combined procedure on quality of life (QoL). MATERIALS AND METHODS: A prospective single centre study of 216 consecutive patients treated with CRS and HIPEC was conducted using the Gastro-Intestinal Quality of Life Index questionnaire (GIQLI), completed preoperatively and at 1, 3, 6 and 12 months. RESULTS: Questionnaire compliance was 81%, 90%, 89%, 89% and 74% at baseline, 1, 3, 6 and 12 months respectively. QoL was significantly decreased up to 6 months and returned to baseline at 12 months. In multivariate analysis, factors decreasing QoL were origin of PC at 3 months, presence of stoma at 6 months and length of surgery over 270 min and disease recurrence at 12 months. CONCLUSIONS: Despite morbidity associated with CRS and HIPEC, QoL returned to baseline at one year after surgery. This treatment strategy should be considered for the treatment of peritoneal carcinomatosis.
Sujet(s)
Protocoles de polychimiothérapie antinéoplasique/usage thérapeutique , Carcinomes/thérapie , Tumeurs colorectales/thérapie , Hyperthermie provoquée , Tumeurs primitives multiples/thérapie , Tumeurs de l'ovaire/thérapie , Tumeurs du péritoine/thérapie , Péritoine/chirurgie , Pseudomyxome péritonéal/thérapie , Qualité de vie , Sujet âgé , Camptothécine/administration et posologie , Camptothécine/analogues et dérivés , Carcinomes/secondaire , Cisplatine/administration et posologie , Études de cohortes , Tumeurs colorectales/anatomopathologie , Association thérapeutique , Femelle , Humains , Irinotécan , Mâle , Mésothéliome/thérapie , Adulte d'âge moyen , Mitomycine/administration et posologie , Composés organiques du platine/administration et posologie , Tumeurs de l'ovaire/anatomopathologie , Oxaliplatine , Tumeurs du péritoine/secondaire , Études prospectives , Tumeurs de l'estomac/anatomopathologie , Tumeurs de l'estomac/thérapie , Résultat thérapeutiqueRÉSUMÉ
OBJECTIVE: To assess the safety and efficiency of steam vein sclerosis (SVS) of the great saphenous vein (GSV) in a multicentre open prospective cohort study. DESIGN: 75 consecutive adult patients with GSV reflux, CEAP C2-C5 and vein diameter 4-13 mm. METHODS: Patients treated using an SVS™ generator delivering homogenous pulses of superheated steam were followed up at 8 days and 1, 3, 6 and 12 months (clinical, duplex ultrasound, quality of life [QoL] with SF12). RESULTS: 88 veins were treated in 75 patients. At 6 months, 72/75 (96%) veins were obliterated (95% CI: 89-99) and Kaplan-Meier analysis found an obliteration rate of 96.1% at 12 months. QoL increased at 6 months for both the physical and mental components (p = 0.049 and p < 0.001 respectively). SVS was well tolerated: no major complications were reported. Adverse events occurred mainly at day 8 and incidents amounted to ecchymosis (n = 60) and pain (n = 7). CONCLUSIONS: SVS achieved an obliteration rate similar to that of other thermal ablation techniques. It was well tolerated with minimal post-operative pain.
