Carcinoma in situ within the bladder trigone with an isolated metastasis to the prostate without involvement of prostatic urethra: a unique case report.

BACKGROUND: Carcinoma in situ of the bladder is a high-grade cancer that originates in the superficial layer of the bladder. It has the potential to invade nearby organs, and it can spread through blood and lymphatic circulation to distant parts of the body. CASE PRESENTATION: A 58-year-old non-smoker male presented with gross and microscopic hematuria. His family history included his father's recent bladder cancer. Initial investigations showed hematuria, inflammation, negative urine culture, digital rectal examination revealed an enlarged right lobe of the prostate, and an elevated Prostate-Specific Antigen level. Histopathological examination of samples taken from the bladder mucosa and the prostate confirmed urothelial carcinoma in situ in the bladder and prostate. Further evaluation revealed no other metastasis. The tumor was classified as T4aN0M0. The patient underwent radical cystoprostatectomy and histopathological examination showed that the tumor invading the muscularis propria of the bladder as well as the prostatic glands, but no malignancy was found in prostatic urethra and other areas. The patient was discharged three weeks post-operation and completed on adjuvant chemotherapy consisting of Gemcitabine, and Cisplatin to prevent of relapse. The patient is currently in a good healthy. CONCLUSION: The occurrence of bladder cancer metastasizing to the prostate without involving the prostatic urethra is uncommon and requires precise diagnostic techniques for accurate tumor classification. Early management is advised to enhance the prognosis for the patient.

A rare case of thyroid-like follicular carcinoma of the kidney in a 75-year-old male: Case report and review of the literature.

INTRODUCTION AND SIGNIFICANCE: The presence of thyroid-like follicular carcinoma in the kidney is very rare, There have been few documented cases of this tumor's formation, and there are no specific signs for this tumor's presence and it is often discovered incidentally by chance, and the diagnosis depends mainly on histological examination and the negative results of thyroid marker tests. CASE PRESENTATION: We describe the case of an adult male who had prostate adenocarcinoma and later suffered from pain in the flank, so radiographic examination showed a mass in the right kidney, which was removed, and the result of histopathologic examination was thyroid-like follicular carcinoma of the kidney. CLINICAL DISCUSSION: Although this tumor is rare, we need to keep it in mind as a potential diagnosis for renal lesions in our clinical practice. CONCLUSION: The presence of a low-grade malignancy and metastasis in this tumor is a good sign, and this is what motivates us to obtain more reports to better understand the nature of this tumor formation, which is important for human health.