Sujet(s)
Dysplasie ventriculaire droite arythmogène/diagnostic , Tronc brachiocéphalique/malformations , Anomalies congénitales des vaisseaux coronaires/diagnostic , Syncope/étiologie , Adulte , Biopsie , Coronarographie , Vaisseaux coronaires/anatomopathologie , Diagnostic différentiel , Humains , Imagerie par résonance magnétique , Mâle , Myocarde/anatomopathologieRÉSUMÉ
A 33-year-old woman with congenital heart disease and atrial and ventricular arrhythmias, managed over the long term with an implantable cardioverter defibrillator, epicardial pacing system, and amiodarone, experienced an increase in palpitations and a shock from her defibrillator. Evaluation revealed decreases in amiodarone and desethylamiodarone serum concentrations from previous levels. Rifampin had been added to her therapy 5 weeks earlier. Increases in amiodarone and desethylamiodarone concentrations were observed after an increase in the amiodarone dosage and discontinuation of rifampin. The time course suggested that the addition of rifampin led to reductions in serum concentrations of both the drug and metabolite.
Sujet(s)
Amiodarone/sang , Antibiotiques antituberculeux/effets indésirables , Troubles du rythme cardiaque/sang , Cardiopathies congénitales/sang , Rifampicine/effets indésirables , Adulte , Antibiotiques antituberculeux/usage thérapeutique , Troubles du rythme cardiaque/traitement médicamenteux , Troubles du rythme cardiaque/thérapie , Défibrillateurs implantables , Femelle , Cardiopathies congénitales/complications , Cardiopathies congénitales/thérapie , Humains , Rifampicine/usage thérapeutiqueRÉSUMÉ
Previous reports have described the occurrence of ventricular output failure in a permanent DDD pacemaker system related to an increase in the atrial output in the presence of low atrial lead impedance (Medtronic Synergyst/Synergyst II). This phenomenon is seen exclusively following atrial paced events and may potentially lead to significant bradyarrhythmia or ventricular asystole in a pacemaker dependent patient. We describe the occurrence of analogous behavior in a Medtronic Symbios 7006 generator.
Sujet(s)
Arrêt cardiaque/étiologie , Atrium du coeur/physiopathologie , Bloc cardiaque/thérapie , Pacemaker/effets indésirables , Tachycardie auriculaire ectopique/complications , Dysfonction ventriculaire gauche/complications , Sujet âgé , Électrocardiographie , Panne d'appareillage , Arrêt cardiaque/physiopathologie , Bloc cardiaque/physiopathologie , Humains , Mâle , Tachycardie auriculaire ectopique/physiopathologie , Dysfonction ventriculaire gauche/physiopathologieRÉSUMÉ
Previous reports have described the occurrence of ventricular output failure in a permanent DDD pacemaker system related to an increase in the atrial output in the presence of low atrial lead impedance (Medtronic Synergyst/Synergyst II). This phenomenon is seen exclusively following atrial paced events, and may potentially lead to significant bradyarrhythmia or ventricular asystole in a pacemaker dependent patient. We describe the occurrence of analogous behavior in a Medtronic Symbios 7006 generator.