RÉSUMÉ
Tissue damage in various diseases, hypoxic conditions, and some pathologies are associated with production of endogenous factors such as the soluble form of the surface receptor CD100, malonic dialdehyde, and arginase and their release into circulation. These factors modulate functional state of lymphocytes in the immune system: potentiate activation of B lymphocytes, activate synthesis and secretion of IL-25 and IL-17 cytokines, and suppress proliferative activity of T lymphocytes, thus modulating immunological reactivity of the organism. Reactions of innate and adaptive immunity develop against the background of changed immunological reactivity, which should be taken into account in the development of pathogenetically substantiated therapy.
Sujet(s)
Antigènes CD/métabolisme , Arginase/métabolisme , Sémaphorines/métabolisme , Animaux , Antigènes CD/génétique , Arginase/génétique , Lymphocytes B/immunologie , Lymphocytes B/métabolisme , Humains , Interleukine-17/métabolisme , Sémaphorines/génétique , Lymphocytes T/métabolismeRÉSUMÉ
Taban-Arshan extract decreased expression of T-lymphocyte activation markers, normalized T-cell-mediated immunity, and suppressed increased activity of natural killer receptors during culturing with lymphocytes of patients with atopic bronchial asthma. Taban-Arshan extract normalized activation processes in the B-cell immunity and stimulated expression of receptors of activation-induced apoptosis.