RÉSUMÉ
Coagulase-negative staphylococci (CNS) represent one of the most prevalent microorganisms in nosocomial infections worldwide, nevertheless little is known about their pathogenicity features. Thus, our aim was to characterize virulence aspects of CNS isolated from patients with bloodstream infections assisted in hospitals of Belo Horizonte, MG, Brazil. Strains were identified using bioMérieuxVitek® and for biofilm production evaluation, Congo Red Agar (CRA) and polystyrene plates were used. PCR was applied to detect icaA, icaB, icaC, atlE, sea, sec, sed, tsst-1 and agr. For statistical analyses were used hierarchical cluster, chi-square test and correspondence. 59 strains were analyzed, being S. haemolyticus the most prevalent. On CRA, 96.5% were biofilm producer, whereas on polystyrene plate, 100% showed adhesion at different times evaluated. Regarding genotypic analyses, 15.2%, 38.9%, 8.4%, 49.1%, 76.2%, 23.7%, 1.6%, 30.5% and 38.9% were positive for icaA, icaB, icaC, atlE, sea, sec, sed, tsst-1 and agr, respectively. Six clusters were formed and frequency distributions of agr, atlE, icaA, icaB, sea, sec, tsst-1 differed (P < 0.001). In conclusion, all strains were biofilm producer, with high prevalence of atlE, and had potential of toxin production, with high prevalence of sea. According to the group-analyses, icaB showed relationship with the strong adherence in samples.
Sujet(s)
Toxines bactériennes/analyse , Biofilms/croissance et développement , Sepsie/microbiologie , Infections à staphylocoques/microbiologie , Staphylococcus/physiologie , Adhérence bactérienne , Toxines bactériennes/génétique , Techniques de typage bactérien , Brésil , Analyse de regroupements , Infection croisée/microbiologie , Génotype , Hôpitaux , Humains , Réaction de polymérisation en chaîne , Staphylococcus/classification , Staphylococcus/isolement et purification , Staphylococcus/métabolisme , Facteurs de virulence/analyse , Facteurs de virulence/génétiqueRÉSUMÉ
Intra-abdominal infections (IAIs) represent one of the most common clinical problems in hospital practice, especially in surgical areas and centers of intensive care. The treatment of IAIs generally involves the draining of abscesses and empirical antimicrobial therapy. In this study, among 150 patients suffering from IAI, 106 (70.7%) yielded samples that presented microbial growth. Polyinfection was detected in 51.9% of the cases and varied from 2 to 9 distinct microbes per specimen. The overall mean number of micro-organisms isolated per patient was 2.17. Aerobic bacteria (as strict aerobes and facultative anaerobes), strict anaerobic bacteria, and fungi of the genus Candida represented 93.4%, 30.2%, and 13.2% of the cases positive for micro-organisms, respectively. The most common aerobic bacteria were those of the genera Staphylococcus, Escherichia, Proteus, and Streptococcus. Despite the frequent prior use (52%) with antimicrobials of recognized action against strict anaerobes, these micro-organisms constituted 30.9% of the total isolates, and the most frequently found were of the Bacteroides fragilis group and Prevotella species. The high prevalence of anaerobes in the specimens obtained from IAI demonstrates the need to give greater importance to these micro-organisms by making available material and human resources to carry out culture of the anaerobes as part of routine hospital procedures.
Sujet(s)
Abcès abdominal/microbiologie , Infections bactériennes/microbiologie , Péritonite/microbiologie , Abcès abdominal/épidémiologie , Appendicite/épidémiologie , Appendicite/microbiologie , Infections bactériennes/épidémiologie , Maladie des voies biliaires/épidémiologie , Maladie des voies biliaires/microbiologie , Brésil/épidémiologie , Loi du khi-deux , Diverticulite/épidémiologie , Diverticulite/microbiologie , Humains , Pancréatite/épidémiologie , Pancréatite/microbiologie , Péritonite/épidémiologieRÉSUMÉ
Schistosoma mansoni infection is likely to be responsible for a significant proportion of cases of myelopathy occurring in areas where schistosomiasis is endemic. The aim of this study is to describe the clinical, laboratory and therapeutic data of 23 patients with schistosomal myeloradiculopathy. The medical records of 23 patients with schistosomal myelopathy admitted to two general hospitals of Belo Horizonte (MG), in Brazil, from 1995 to 1999, were reviewed retrospectively. Seventeen patients were male (74%). The mean age for the whole group was 27 years. Lower limb weakness and associated lumbar and/or lower limb pain were reported by 20 patients (87%), and 16 (70%) were unable to walk. All individuals presented urinary retention and 19 (83%) complained of intestinal dysfunction. The treatment was based on the association of antischistosomal drugs and corticosteroids. Five patients (22%) presented a full response to treatment, 13 (57%) partial response without functional limitations and 4 (17%) partial improvement with limitations or no response. Three out of the 4 patients who stopped steroids before 45 days of treatment developed recurrence of the symptoms and signs of myelopathy. Our cases demonstrate the severe presentation of the disease and the data disclosed here suggest that treatment with steroids should be kept for months after clinical improvement.
Sujet(s)
Schistosomiase du système nerveux central/parasitologie , Schistosomiase à Schistosoma mansoni/complications , Maladies de la moelle épinière/parasitologie , Adolescent , Hormones corticosurrénaliennes/usage thérapeutique , Adulte , Animaux , Enfant , Enfant d'âge préscolaire , Femelle , Humains , Mâle , Adulte d'âge moyen , Schistosomiase du système nerveux central/diagnostic , Schistosomiase du système nerveux central/traitement médicamenteux , Études rétrospectives , Schistosomiase à Schistosoma mansoni/diagnostic , Schistosomiase à Schistosoma mansoni/traitement médicamenteux , Schistosomicides/usage thérapeutique , Maladies de la moelle épinière/diagnostic , Maladies de la moelle épinière/traitement médicamenteux , Stéroïdes/usage thérapeutique , Résultat thérapeutiqueRÉSUMÉ
The association between pyogenic liver abscesses and schistosomiasis has been confirmed by clinical and experimental studies. In this retrospective study of 78 patients with pyogenic liver abscesses the association with schistosomiasis has been investigated. Pyodermitis, a known focus of bacteremia, was observed in 19 patients (24%). Blood eosinophilia was observed in 30 patients (39%). Staphylococcus aureus was cultured from abscesses in 17 out of 38 patients (45%). Forty-one out of 57 patients (53%) had stool examination. Schistosoma mansoni was the main parasite identified. Eggs of S. mansoni were also identified in liver biopsies in 7 out of 19 patients who did the exam. The large number of young patients with liver abscesses described here is different from what has been observed in developed countries. This clinical study provide support for the concept that granulomas of S. mansoni in the liver are foci for colonization with S. aureus, which in presence of staphylococcal bacteremia can form liver abscesses.
Sujet(s)
Abcès du foie/parasitologie , Schistosomiase à Schistosoma mansoni/complications , Adolescent , Adulte , Sujet âgé , Animaux , Brésil , Enfant , Enfant d'âge préscolaire , Femelle , Humains , Abcès du foie/diagnostic , Abcès du foie/microbiologie , Mâle , Adulte d'âge moyen , Études rétrospectives , Schistosomiase à Schistosoma mansoni/diagnostic , Infections à staphylocoques/complications , Staphylococcus aureus/isolement et purification , Suppuration/microbiologie , Suppuration/parasitologieRÉSUMÉ
A combined clinical and sonographic classification of hepatosplenic schistosomiasis mansoni to be used in field-based studies is proposed herein. Seven hundred forty one individuals out of 892 (83%), living in an area endemic for schistosomiasis in Brazil, have been submitted to clinical and ultrasound examinations. Based on two stool examinations the overall prevalence for schistosomiasis in this area was 73%. Abdominal palpation was performed with patients in dorsal decubit, during deep breath, by two experienced physicians and a portable ultrasound was used for the evaluation of liver fibrosis, portal collaterals and spleen size. Four groups of individuals were identified using data obtained by abdominal palpation and ultrasound examination: (1) palpable spleen and intense periportal thickening in 9 individuals (1.2%); (2) spleen not palpable and intense periportal thickening in 15 (2%); (3) palpable spleen with light to moderate periportal thickening in 32 (4.3%), and (4) palpable spleen with a normal liver on ultrasound in 30 (4%). The definition of hepatosplenic schistosomiasis in field-based studies as the finding of Schistosoma mansoni eggs in the stools in an individual with splenomegaly is not acceptable anymore. Abdominal ultrasound should be combined with clinical examination to accurately identify hepatosplenics in endemic areas for schistosomiasis.
Sujet(s)
Parasitoses hépatiques/diagnostic , Schistosomiase à Schistosoma mansoni/diagnostic , Maladies de la rate/diagnostic , Adolescent , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Brésil/épidémiologie , Enfant , Enfant d'âge préscolaire , Femelle , Humains , Parasitoses hépatiques/imagerie diagnostique , Parasitoses hépatiques/épidémiologie , Mâle , Adulte d'âge moyen , Palpation , Prévalence , Schistosomiase à Schistosoma mansoni/imagerie diagnostique , Schistosomiase à Schistosoma mansoni/épidémiologie , Maladies de la rate/imagerie diagnostique , Maladies de la rate/épidémiologie , ÉchographieRÉSUMÉ
Schistosoma mansoni infection is likely to be responsible for a significant proportion of cases of myelopathy occurring in areas where schistosomiasis is endemic. The aim of this study is to describe the clinical, laboratory and therapeutic data of 23 patients with schistosomal myeloradiculopathy. The medical records of 23 patients with schistosomal myelopathy admitted to two general hospitals of Belo Horizonte (MG), in Brazil, from 1995 to 1999, were reviewed retrospectively. Seventeen patients were male (74 percent). The mean age for the whole group was 27 years. Lower limb weakness and associated lumbar and/or lower limb pain were reported by 20 patients (87 percent), and 16 (70 percent) were unable to walk. All individuals presented urinary retention and 19 (83 percent) complained of intestinal dysfunction. The treatment was based on the association of antischistosomal drugs and corticosteroids. Five patients (22 percent) presented a full response to treatment, 13 (57 percent) partial response without functional limitations and 4 (17 percent) partial improvement with limitations or no response. Three out of the 4 patients who stopped steroids before 45 days of treatment developed recurrence of the symptoms and signs of myelopathy. Our cases demonstrate the severe presentation of the disease and the data disclosed here suggest that treatment with steroids should be kept for months after clinical improvement
Sujet(s)
Humains , Animaux , Mâle , Femelle , Enfant d'âge préscolaire , Enfant , Adolescent , Adulte , Adulte d'âge moyen , Schistosomiase du système nerveux central/parasitologie , Radiculopathie/parasitologie , Schistosoma mansoni/isolement et purification , Hormones corticosurrénaliennes/usage thérapeutique , Schistosomiase du système nerveux central/diagnostic , Schistosomiase du système nerveux central/traitement médicamenteux , Radiculopathie/diagnostic , Radiculopathie/traitement médicamenteux , Études rétrospectives , Schistosomicides/usage thérapeutique , Stéroïdes/usage thérapeutique , Résultat thérapeutiqueRÉSUMÉ
Schistosomiasis mansoni infection that occurs concurrently with Staphylococcus aureus bacteremia favors the formation of pyogenic liver abscess. The present experimental study in mice evaluated the following aspects of the relationship between infection with Schistosoma mansoni and liver abscess caused by S. aureus: a) the role of the eggs of S. mansoni in the genesis of the abscesses; b) the influence of different phases of schistosomiasis in the development of liver abscesses; and c) the effect of the treatment of schistosomiasis on the development of the abscesses. Macroscopic and histopathological study showed multiple liver abscesses around granulomas of S. mansoni in the acute and chronic phases of schistosomiasis. Treatment of acute schistosomiasis before experimentally-induced bacteremia did not prevent the formation of liver abscess. The study findings indicate that granulomas around S. mansoni eggs and worms lodged in the liver provide a focus and substrate for pyogenic abscesses caused by S. aureus.
Sujet(s)
Abcès du foie/anatomopathologie , Schistosomiase/anatomopathologie , Maladie aigüe , Animaux , Maladie chronique , Abcès du foie/complications , Abcès du foie/traitement médicamenteux , Mâle , Souris , Oxamniquine/usage thérapeutique , Schistosomiase/complications , Schistosomiase/traitement médicamenteux , Schistosomicides/usage thérapeutique , Infections à staphylocoques/complicationsRÉSUMÉ
Parasitic diseases which during their course in the host switch the immune system from a T helper 1 to a T helper 2 response may be detrimental to the host, contributing to granuloma formation, eosinophilia, hyper-IgE, and increased susceptibility to bacterial and fungal infections. Patients and animals with acute schistosomiasis and hyper-IgE in their serum develop pyogenic liver abscess in the presence of bacteremia caused by Staphylococcus aureus. The Salmonella-S. mansoni association has also been well documented. The association of tropical pyomyositis (pyogenic muscle abscess) and pyogenic liver abscess with Toxocara infection has recently been described in the same context. In tropical countries that may be an interesting explanation for the great morbidity of bacterial diseases. If the association of parasitic infections and pyogenic abscesses and/or fungal diseases are confirmed, there will be a strong case in favor of universal treatment for parasitic diseases to prevent or decrease the morbidity of superinfection with bacteria and fungi.
Sujet(s)
Abcès du foie/immunologie , Maladies parasitaires/immunologie , Adolescent , Animaux , Enfant , Femelle , Humains , Immunité cellulaire , Larve/immunologie , Abcès du foie/microbiologie , Abcès du foie/anatomopathologie , Mâle , Souris , Maladies parasitaires/complications , Maladies parasitaires/anatomopathologie , Études prospectives , Schistosomiase/complications , Lymphocytes auxiliaires Th1 , Lymphocytes auxiliaires Th2 , Toxocarose/complicationsRÉSUMÉ
OBJECTIVES: To study the role of human toxocariasis in the pathogenesis of pyogenic liver abscess. METHODS: We compared the serology for toxocariasis and serum levels of IgE in 16 patients with pyogenic liver abscess to those in 32 matched (age and gender) controls to define the possible association between these two entities. RESULTS: The serology for toxocariasis was positive in 10 of 16 patients compared with 4 of 32 controls. The relative odds and 95% confidence interval (conditional logistic regression), comparing cases and matched controls, was significant (1.4; 95% confidence interval, 1.1-1.7) for Toxocara serology. Regarding IgE serum levels, there was no difference between cases and controls. CONCLUSIONS: Human toxocariasis can be one of the predisposing causes of pyogenic liver abscess, especially in tropical countries in which this parasitic disease is common. Treatment of human toxocariasis may prevent morbid complications like hepatic abscess and should be considered in patients with clinical and/or serological evidence of Toxocara infection.
Sujet(s)
Abcès du foie/parasitologie , Toxocarose/complications , Adolescent , Adulte , Brésil/épidémiologie , Enfant , Enfant d'âge préscolaire , Femelle , Humains , Immunoglobuline E/sang , Abcès du foie/épidémiologie , Mâle , Adulte d'âge moyen , Études prospectives , Toxocarose/sang , Toxocarose/épidémiologieRÉSUMÉ
Previous definition of classic dengue, with or without bleeding, and of dengue hemorrhagic fever (DHF) that may evolve without bleeding and with or without dengue shock syndrome (DSS) are reviewed here. The classical approach to the diagnosis and treatment of dengue, although useful in the past, nowadays breeds confusion and adds a burden to the physician's task of decision-making regarding the treatment of patients with severe forms of the disease. The classification of dengue proposed in this paper, and summarized in a diagram, incorporates new concepts about sepsis, systemic inflammatory response syndrome (SIRS), and acute respiratory distress syndrome (ARDS). This new approach, in our view, is a useful guide to initial evaluation and treatment of the disease. It also approximates the dengue syndrome to other protocols and medical procedures routinely used in intensive care units, making it easier to be followed by the health personnel working in areas subject to epidemic bursts.
Sujet(s)
Dengue , Dengue/complications , Dengue/diagnostic , Dengue/étiologie , Dengue/physiopathologie , Dengue/thérapie , HumainsSujet(s)
Abcès/diagnostic , Abcès/microbiologie , Myosite/diagnostic , Myosite/microbiologie , Staphylococcus aureus , Toxocara canis , Toxocarose/parasitologie , Abcès/parasitologie , Abcès/anatomopathologie , Adolescent , Adulte , Animaux , Enfant , Femelle , Humains , Mâle , Souris , Myosite/parasitologie , Myosite/anatomopathologie , Climat tropicalRÉSUMÉ
The literature on the assessment of morbidity due to Schistosoma mansoni infection is updated. Imaging techniques such as ultrasonography, echodoppler cardiography, computerized tomography (CT scan) and magnetic resonance imaging (MRI) introduced a new perspective, and expanded our knowledge on morbidity. Three well-defined syndromes caused by schistosomiasis mansoni have been described: the stage of invasion, acute schistosomiasis (Katayama fever), and chronic schistosomiasis. Complications of the acute and chronic syndromes have also been reported: pulmonary hypertension, neuroschistosomiasis, association with Salmonella, association with Staphylococci, viral hepatitis B, glomerulonephritis. In most individuals with hepatosplenic schistosomiasis the spleen is increased in size. Hepatosplenic schistosomiasis can, however, occur without splenomegaly. The definition of hepatosplenic schistosomiasis in endemic areas as the finding of S. mansoni eggs in the stools in an individual with hepatosplenomegaly is not satisfactory anymore. Many aspects of morbidity are expected to change after schistosomiasis control. Some are expected to change quickly (worm burden, Salmonella bacteremia, hepatosplenic schistosomiasis in children) whereas others shall remain for years (pulmonary hypertension, glomerulonephritis, neuroschistosomiasis). Intestinal schistosomiasis in individuals with low worm burdens is very difficult to diagnose and therefore laborious to control.
Sujet(s)
Contrôle des maladies transmissibles , Schistosomiase à Schistosoma mansoni/épidémiologie , Brésil/épidémiologie , Maladies du système nerveux central/diagnostic , Maladies du système nerveux central/parasitologie , Glomérulonéphrite/complications , Hépatite B/complications , Humains , Hypertension pulmonaire/complications , Hypertension pulmonaire/diagnostic , Maladies intestinales/diagnostic , Maladies intestinales/parasitologie , Maladies du foie/diagnostic , Maladies du foie/parasitologie , Imagerie par résonance magnétique , Morbidité , Salmonelloses/complications , Schistosomiase à Schistosoma mansoni/complications , Schistosomiase à Schistosoma mansoni/diagnostic , Maladies de la rate/diagnostic , Maladies de la rate/parasitologie , Infections à staphylocoques/complications , Tomographie , ÉchographieRÉSUMÉ
We describe a case of visceral larva migrans syndrome complicated by liver abscess, pericardial effusion and ascites. To our knowledge, these findings have not been reported previously. The structural and immunological alterations caused by visceral larva migrans are thought to lead to the development of visceral abscesses.
Sujet(s)
Larva migrans viscérale/complications , Abcès du foie/complications , Toxocara canis , Animaux , Ascites/complications , Enfant d'âge préscolaire , Humains , Larva migrans viscérale/diagnostic , Abcès du foie/parasitologie , Mâle , Épanchement péricardique/complicationsRÉSUMÉ
In hospital-based series viral hepatitis B has been frequently described in association with schistosomiasis whilst in field-based studies the association has not been confirmed. The association between schistosomiasis and Salmonella bacteraemia has been well documented. More recently, acute schistosomiasis has been shown to be a facilitating factor in the genesis of pyogenic liver abscesses caused by Staphylococcus aureus. New evidences indicate an interaction between the acquired immunodeficiency syndrome (AIDS) and schistosomiasis. In this paper, data on the association of schistosomiasis with other infections are updated.
Sujet(s)
Syndrome d'immunodéficience acquise/complications , Hépatite B/complications , Abcès du foie/complications , Salmonelloses/complications , Schistosomiase/complications , Infections à staphylocoques/complications , Animaux , HumainsSujet(s)
Schistosomiase à Schistosoma mansoni/diagnostic , Schistosomiase à Schistosoma mansoni/épidémiologie , Adolescent , Adulte , Sujet âgé , Brésil/épidémiologie , Enfant , Enfant d'âge préscolaire , Maladies endémiques , Fèces/parasitologie , Humains , Nourrisson , Nouveau-né , Adulte d'âge moyen , Morbidité , Numération des oeufs de parasites , Prévalence , Population rurale , Schistosomiase à Schistosoma mansoni/imagerie diagnostique , ÉchographieRÉSUMÉ
This study was undertaken to determine the accuracy of splenic palpation for the diagnosis of splenomegaly, and to determine whether the frequency of individuals with a palpable spleen in an endemic area can be considered as an index of morbidity of schistosomiasis. For the clinical diagnosis of splenomegaly, two criteria have been tested: (A) presence of a palpable spleen and (B) presence of a palpable spleen whose border could be felt more than 4 cm below the costal margin. In an area of high prevalence of the disease (66.3%) 285 individuals aged 18 years or more have been submitted to abdominal ultrasonography and physical examination. Splenomegaly was defined as a splenic length greater than 120 mm by ultrasound and the sensitivity, specificity, positive and negative predictive values of criterion A were 72.2%, 90.5%, 35.1% and 97.8%. The values for criterion B were 27.8%, 98%, 50% and 95%, respectively. In an non endemic area, 517 individuals were submitted to the same protocol and 22 individuals had a palpable spleen, but no patient fulfilled criterion B for splenomegaly, and only one met the ultrasonographic criterion for splenomegaly. The authors concluded that abdominal palpation is a poor method for the diagnosis of splenomegaly.
Sujet(s)
Palpation/méthodes , Schistosomiase à Schistosoma mansoni/épidémiologie , Splénomégalie/diagnostic , Adolescent , Adulte , Sujet âgé , Brésil/épidémiologie , Enfant , Enfant d'âge préscolaire , Maladies endémiques , Humains , Nourrisson , Nouveau-né , Adulte d'âge moyen , Morbidité , Valeur prédictive des tests , Prévalence , Schistosomiase à Schistosoma mansoni/complications , Sensibilité et spécificité , Splénomégalie/épidémiologie , Splénomégalie/étiologieRÉSUMÉ
Data on the association of schistosomiasis and hepatitis B in field-based studies are scarce. Two areas have been selected for this study: i) Queixadinha, endemic for schistosomiasis, with a population of 693 individuals, and ii) Capão, a control non-endemic area, with 515 inhabitants. Sera of all individuals in both areas were tested for hepatitis B infection, yearly, from 1994 to 1997. In the first area hepatitis B was found in 32.1% of children up to one year old and reached a peak of 68.7% in the age range of 15 to 19 years. In the control area the prevalence of hepatitis B was under 5% up to 19 years of age and the highest prevalence was observed in adults over 45. HBsAg was detected in 9.4% of the individuals living in the endemic area for schistosomiasis and in 1.4% of the controls (OR = 4.98; 95% CI = 3.7-6.7). The index of chronicity of HBsAg was not statistically different in the studied areas (8.1% x 7.3%; OR = 1.09; 95% CI = 0.42-3.03), nor was it different for people with and without schistosomiasis in Queixadinha (8.7% x 7.0%). We conclude that the Schistosoma mansoni infection has not altered the course of hepatitis B in the studied area.
Sujet(s)
Antigènes de surface du virus de l'hépatite B/sang , Hépatite B chronique/complications , Schistosomiase à Schistosoma mansoni/complications , Adolescent , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Analyse de variance , Marqueurs biologiques , Brésil/épidémiologie , État de porteur sain/sang , Loi du khi-deux , Enfant , Enfant d'âge préscolaire , Maladies endémiques , Femelle , Humains , Nourrisson , Nouveau-né , Mâle , Adulte d'âge moyen , Prévalence , Population rurale , Schistosomiase à Schistosoma mansoni/épidémiologieRÉSUMÉ
We report a case of tropical pyomyositis in a boy who presented with a severe febrile illness associated with diffuse erythema, and swelling in many areas of the body which revealed on operation extensive necrotic areas of various muscles that required repeated débridement. The patient gave a history of contact with dogs, and an ELISA test for Toxocara canis was positive. He also presented eosinophilia and high serum IgE levels. Staphylococcus aureus was the sole bacteria isolated from the muscles affected. We suggest that tropical pyomyositis may be caused by the presence of migrating larvae of this or other parasites in the muscles. The immunologic and structural alterations caused by the larvae, in the presence of concomitant bacteremia, would favour seeding of the bacteria and the development of pyomyositis.
Sujet(s)
Larva migrans viscérale/complications , Myosite/complications , Infections à staphylocoques/complications , Toxocara canis , Adolescent , Animaux , Études de suivi , Humains , Larva migrans viscérale/diagnostic , Larva migrans viscérale/traitement médicamenteux , Mâle , Myosite/diagnostic , Myosite/traitement médicamenteux , Infections à staphylocoques/diagnostic , Infections à staphylocoques/traitement médicamenteux , Staphylococcus aureus/isolement et purificationRÉSUMÉ
Os principais estudos sobre a associação esquistossomose e hepatite pelos vírus B, C e D são apresentados e discutidos. As limitações de cada estudo são apontadas e os autores sugerem novos caminhos na investigação desta provável interação.
The papers published on the association of schistosomiasis with viral hepatitis (B, C and D) are reviewed. The shortcomings of each work are pointed out and suggestions are forwarded to try and direct the investigations on this probable interaction.