1.
Kidney Int
; 105(6): 1325, 2024 Jun.
Article
de Anglais
| MEDLINE
| ID: mdl-38777407
2.
Intern Med
; 2024 Feb 26.
Article
de Anglais
| MEDLINE
| ID: mdl-38403763
RÉSUMÉ
Atypical hemolytic uremic syndrome (aHUS) is a type of HUS. We herein report a case of aHUS triggered by pancreatitis in a patient with a heterozygous variant of membrane cofactor protein (MCP; P165S), a complement-related gene. Plasma exchange therapy and hemodialysis improved thrombocytopenia and anemia without leading to end-stage kidney disease. This MCP heterozygous variant was insufficient to cause aHUS on its own. Pancreatitis, in addition to a genetic background with a MCP heterozygous variant, led to the manifestation of aHUS. This case supports the "multiple hit theory" that several factors are required for the manifestation of aHUS.