Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 5 de 5
Filtrer
Plus de filtres











Base de données
Gamme d'année
1.
PLoS One ; 16(5): e0252061, 2021.
Article de Anglais | MEDLINE | ID: mdl-34038435

RÉSUMÉ

Bacterial panicle blight (BPB) caused by Burkholderia glumae is one of the main concerns for rice production in the Americas since bacterial infection can interfere with the grain-filling process and under severe conditions can result in high sterility. B. glumae has been detected in several rice-growing areas of Colombia and other countries of Central and Andean regions in Latin America, although evidence of its involvement in decreasing yield under these conditions is lacking. Analysis of different parameters in trials established in three rice-growing areas showed that, despite BPB presence, severity did not explain the sterility observed in fields. PCR tests for B. glumae confirmed low infection in all sites and genotypes, only 21.4% of the analyzed samples were positive for B. glumae. Climate parameters showed that Montería and Saldaña registered maximum temperature above 34°C, minimum temperature above 23°C, and Relative Humidity above 80%, conditions that favor the invasion model described for this pathogen in Asia. Our study found that in Colombia, minimum temperature above 23°C during 10 days after flowering is the condition that correlates with disease incidence. Therefore, this correlation, and the fact that Montería and Saldaña had a higher level of infected samples according to PCR tests, high minimum temperature, but not maximum temperature, seems to be determinant for B. glumae colonization under studied field conditions. This knowledge is a solid base line to design strategies for disease control, and is also a key element for breeders to develop strategies aimed to decrease the effect of B. glumae and high night-temperature on rice yield under tropical conditions.


Sujet(s)
Burkholderia/génétique , Oryza/croissance et développement , Maladies des plantes/microbiologie , Climat tropical , Burkholderia/classification , Colombie , Oryza/microbiologie , Maladies des plantes/génétique , Virulence/génétique
2.
Sensors (Basel) ; 20(18)2020 Sep 07.
Article de Anglais | MEDLINE | ID: mdl-32906731

RÉSUMÉ

Affecting computing is an artificial intelligence area of study that recognizes, interprets, processes, and simulates human affects. The user's emotional states can be sensed through electroencephalography (EEG)-based Brain Computer Interfaces (BCI) devices. Research in emotion recognition using these tools is a rapidly growing field with multiple inter-disciplinary applications. This article performs a survey of the pertinent scientific literature from 2015 to 2020. It presents trends and a comparative analysis of algorithm applications in new implementations from a computer science perspective. Our survey gives an overview of datasets, emotion elicitation methods, feature extraction and selection, classification algorithms, and performance evaluation. Lastly, we provide insights for future developments.


Sujet(s)
Interfaces cerveau-ordinateur , Électroencéphalographie , Émotions , Algorithmes , Intelligence artificielle , Encéphale , Humains , Traitement du signal assisté par ordinateur
3.
Front Pediatr ; 6: 426, 2018.
Article de Anglais | MEDLINE | ID: mdl-30719430

RÉSUMÉ

DNA repair defects are inborn errors of immunity that result in increased apoptosis and oncogenesis. DNA Ligase 4-deficient patients suffer from a wide range of clinical manifestations since early in life, including: microcephaly, dysmorphic facial features, growth failure, developmental delay, mental retardation; hip dysplasia, and other skeletal malformations; as well as a severe combined immunodeficiency, radiosensitivity, and progressive bone marrow failure; or, they may present later in life with hematological neoplasias that respond catastrophically to chemo- and radiotherapy; or, they could be asymptomatic. We describe the clinical, laboratory, and genetic features of five Mexican patients with LIG4 deficiency, together with a review of 36 other patients available in PubMed Medline. Four out of five of our patients are dead from lymphoma or bone marrow failure, with severe infection and massive bleeding; the fifth patient is asymptomatic despite a persistent CD4+ lymphopenia. Most patients reported in the literature are microcephalic females with growth failure, sinopulmonary infections, hypogammaglobulinemia, very low B-cells, and radiosensitivity; while bone marrow failure and malignancy may develop at a later age. Dysmorphic facial features, congenital hip dysplasia, chronic liver disease, gradual pancytopenia, lymphoma or leukemia, thrombocytopenia, and gastrointestinal bleeding have been reported as well. Most mutations are compound heterozygous, and all of them are hypomorphic, with two common truncating mutations accounting for the majority of patients. Stem-cell transplantation after reduced intensity conditioning regimes may be curative.

4.
Rev Alerg Mex ; 64(2): 228-234, 2017.
Article de Espagnol | MEDLINE | ID: mdl-28658731

RÉSUMÉ

Common variable immunodeficiency is characterized by hypogammaglobulinemia and the inability to respond to vaccines. Patients mostly manifest infections, however only less than 5 % have pathological conditions as autoimmunity, granulomatous inflammation, and splenomegaly or lymphoproliferative disease among others, without showing infections. We report the case of a woman who debuted with localized cutaneous affection, facial angioedema, without other early symptoms. After diagnosis splenomegaly and bronchiectasis were documented. Angioedema and bronchiectasis responded with IVIG replacement. We also review the dermatological manifestations associated with CVID.


La inmunodeficiencia común variable se caracteriza por hipogammaglobulinemia e incapacidad para responder a las vacunas. Los pacientes en su mayoría manifiestan infecciones, sin embargo, menos de 5 % solo presenta patologías como autoinmunidad, inflamación granulomatosa, esplenomegalia o enfermedad linfoproliferativa, entre otras, sin infecciones. Se describe el caso de una mujer que debutó con afección cutánea localizada, angioedema facial, sin otros síntomas iniciales. Después del diagnóstico se documentó esplenomegalia y bronquiectasias. El angioedema y las bronquiectasias respondieron con la sustitución de la gammaglobulina intravenosa. En este artículo, además de la descripción del caso, se revisan las manifestaciones dermatológicas asociadas con inmunodeficiencia común variable.


Sujet(s)
Angioedème/étiologie , Déficit immunitaire commun variable/diagnostic , Adulte , Dilatation des bronches/étiologie , Déficit immunitaire commun variable/complications , Femelle , Humains , Infections de l'appareil respiratoire/étiologie , Splénomégalie/étiologie
5.
J Clin Immunol ; 36(1): 56-65, 2016 Jan.
Article de Anglais | MEDLINE | ID: mdl-26707787

RÉSUMÉ

PURPOSE: The hallmark of Primary immunodeficiencies (PID) is unusual infection, although other immunological non-infectious manifestations such as autoimmunity, allergy and cancer are often present. Most published reports focus on one disease or defect groups, so that a global prevalence of non-infectious manifestations of PID is hard to find. We aimed to describe the clinical features of our pediatric patients with PID, as well as the frequency and evolution of allergy, cancer and autoimmunity. METHODS: We reviewed all the available charts of patients being followed for PID from 1991 to the spring of 2012 at the National Institute of Pediatrics, Mexico City, to describe their demographic, clinical and laboratory features. Their diagnoses were established by pediatric immunologists in accordance to ESID criteria, including routine immunological workup and specialized diagnostic assays. We divided patients by decade of diagnosis to analyze their survival curves. RESULTS: There were 168 charts available, from which we excluded one duplicate and six equivocal diagnoses. We studied the charts of 161 PID patients (68% male, 86% alive), mostly from the center of the country, with a positive family history in 27% and known consanguinity in 11%. Eighty percent of the patients were diagnosed during the last decade. Current median age was 124 months; median age at onset of infections, 12 months; median age at diagnosis, 52 months; median age at death, 67.5 months. Severe infection and bleeding were the cause of 22 deaths. Eighty-six percent of all patients had at least one infection, while non-infectious manifestations had a global prevalence of 36%, namely: autoimmunity 19%, allergies 17%, and cancer 2.4%. Survival curves were not significantly different when compared by decade of diagnosis. CONCLUSIONS: Compared to other registry reports, we found a lower prevalence of antibody defects, and of associated allergy and cancer. We could only locate two isolated IgA deficiencies and four cases of cancer among our PID patients. Although antibody defects are the most prevalent group (30%), the distribution we found is similar to that reported in Iran, Kuwait, Egypt and Taiwan, with a close 27% share for phagocyte defects, and 26% for the formerly called "well-defined" syndromes. Of note, autoimmune and inflammatory complications are high among our patients with chronic granulomatous disease, as has been reported in both the United States and Japan, but not in Europe.


Sujet(s)
Maladies auto-immunes/épidémiologie , Hypersensibilité/épidémiologie , Déficits immunitaires/épidémiologie , Infections/épidémiologie , Tumeurs/épidémiologie , Maladies auto-immunes/diagnostic , Maladies auto-immunes/mortalité , Enfant , Consanguinité , Femelle , Humains , Hypersensibilité/diagnostic , Hypersensibilité/mortalité , Déficits immunitaires/diagnostic , Déficits immunitaires/mortalité , Infections/diagnostic , Infections/mortalité , Mâle , Mexique , Tumeurs/diagnostic , Tumeurs/mortalité , Phénotype , Prévalence , Analyse de survie
SÉLECTION CITATIONS
DÉTAIL DE RECHERCHE