[Efficiency of polyoxidonium in combined therapy in patients with generalized peritonitis].

Emergency abdominal surgery for peritonitis is a topical problem awaiting solution. Disturbed immune status of patients with peritonitis dictates the necessity to supplement postoperative intensive therapy by medical preparation normalizing immune functions. We have studied 36 patients with generalized peritonitis of different etiology of whom 20 (controls) were treated by traditional methods and 16 received standard therapy plus polyoxidomium. The frequency of abdominal and other complications in the latter group decreased to 19.2% and lethality to 13.8% while duration of the hospital stay was reduced by 3.6 patient days.

[Experience in clinical use of primalan (mequitazine) in allergology]. / Opyt klinicheskogo primeneniia primalana (mekvitazina) v allergologii.

AIM: To study efficacy of primalan (mequitasine) in the treatment of allergic rhinoconjunctivitis and chronic recurrent urticaria. MATERIAL AND METHODS: The study included 140 patients. Of them, 60 patients had allergic rhinitis, 80 patients had chronic recurrent urticaria. All the patients received primalan (mequitasin) in a dose 10 mg/day (5 mg twice daily or a single dose 10 mg). The disease symptoms and side effects of primalan were assessed for 28 days of the treatment. RESULTS: Primalan (mequitasin) proved to be highly effective against allergic rhinitis (good and very good response--76%, satisfactory--20%) and chronic recurrent urticaria (the response in 90% patients). Good primalan tolerance was reported. Side effects were moderate and did not require the drug withdrawal (sleepiness in 6.6%, dryness of the mucosa in 5%). CONCLUSION: Primalan (mequitasin) can be recommended for wide application in therapy of allergic rhinitis and chronic recurrent urticaria.

[Common variable immunodeficiency in adults and problems of its immunotherapy]. / Obshchaia variabel'naia immunnaia nedostatochnost' u vzroslykh i problemy ee immunoterapii.

AIM: Clinicoimmunological study of adult patients with prevailing defect of humoral immunity, development of diagnostic criteria and treatment of this disease. MATERIALS AND METHODS: Clinical, immunological and microbiological examinations were made in 68 patients with defects of antibody formation. RESULTS: Total variable immunodeficiency (TVID), selective deficiency of IgA, congenital agammaglobulinemia, hyper-IgM-syndrome were detected in 74, 13, 10 and 3% of patients, respectively. TVID was frequently associated with respiratory, chronic ENT and gastrointestinal diseases, low CD4+ and high CD8+ levels. The response was achieved with combined therapy: antibacterial treatment + immunocorrection + differentiated replacement with plasma or immunoglobulins. CONCLUSION: In choice of immunotherapy of TVID patients it is necessary to consider parameters of immunogram. Intravenous administration of immunoglobulin preparations provided the highest effect in good safety.