RÉSUMÉ
Monopolar spindle 1, also known as threonine and tyrosine kinase (TTK), is a key component of spindle assembly checkpoint (SAC). It is considered to be a monitoring mechanism to ensure mitotic fidelity and genomic stability. TTK is overexpressed in a variety of malignant tumors, and patients with low expression of TTK tend to have a longer survival time, suggesting that it may be used as a biomarker for diagnosis and prognosis. Abnormal expression of TTK often impairs the function of SAC, resulting in irregular mitosis, increased aneuploidy and mitotic disaster, thus promoting the occurrence of tumors. Current studies have shown that TTK inhibitors can inhibit the proliferation of tumor cells and increase the sensitivity of tumor cells to therapy in combination with chemotherapy or radiotherapy to achieve sensitization and attenuated effects. This article will review the research and application of TTK and its inhibitors in malignant tumors.
RÉSUMÉ
Hyaluronidase is a type of glycosidase that can specifically degrade hyaluronic acid (HA). There are mainly 6 types, among which hyaluronidase-1 ( HYAL-1) and hyaluronidase-2 ( HYAL-2) has a more in-depth study and has different roles in different tumors. HYAL-1 and HYAL-2 have the potential to be used as biomarkers for the diagnosis of malignant tumors, especially in common malignant tumors such as colorectal cancer, pancreatic cancer, bladder cancer, and prostate cancer. Compared with traditional biomarkers, they have higher specificity and sensitivity. Other studies have shown that Hyaluronidase can assist chemotherapy drugs to enhance the efficacy of drugs. hyaluronidase plays both a role in promoting cancer and a role in suppressing cancer in malignant tumors. This article reviews the mechanism of Hyaluronidase in malignant tumors, which is expected to provide a new method for early diagnosis, early treatment and prognosis of malignant tumors.
RÉSUMÉ
<p><b>OBJECTIVE</b>With the purpose of selecting adequate quality and high production of Schizonepeta tenuifolia, the comparative experiments were carried out on different strain of S. tenuifolia in 2007.</p><p><b>METHOD</b>The test fields were divided into blocks randomly, and the agronomy characters were investigated in harvest time; the content of volatile oil was measured by steam distillation and the pulegone were determined by HPLC.</p><p><b>RESULT</b>The yield of S4 was 18.63% and 29.99% higher than that of CK1 and CK2, respectively. The contents of volatile oil and pulegone were also higher than those of CK and other strains in this test.</p><p><b>CONCLUSION</b>S4 shows the advantages of high production, strong disease resistance and high active components. S4 would be extended as the good breed in production.</p>