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Chem Commun (Camb)
; 59(71): 10660-10663, 2023 Aug 31.
Article
de Anglais
| MEDLINE
| ID: mdl-37581279
RÉSUMÉ
Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.