Material removal and surface damage in high-speed grinding of enamel.

Although high-speed grinding of the enamel surface is often required in restorative dentistry, the knowledge of grinding mechanics, material removal, and fracture damage mechanism related to this process is still relatively limited; therefore, it is important to perform relevant scientific and theoretical research. As per the occlusal surface and the buccal/lingual surface of the teeth, the experimental scheme of high-speed grinding of the enamel surface using a diamond grinding bur was designed, and the grinding force, force ratio, grinding temperature, chips, surface morphology, surface damage, and other important characteristics were tested and analyzed. Furthermore, the grinding geometry model, grinding mechanics, material fracture, and removal mechanism associated with the high-speed grinding of an enamel surface were considered. The results show that the grinding force, friction coefficient, grinding temperature, and surface damage achieved through buccal/lingual surface grinding are considerably greater, and the grinding quality is worse than that obtained via occlusal surface grinding under the same grinding conditions. With the increase in the feed rate, grinding force, friction coefficient, grinding temperature, and surface damage obviously increase, and the surface quality decreases. The embrittlement effect and the ironing mechanism are present during the process of high-speed grinding of enamel. Regardless of the feed rate, the three types of material fracture modes of the buccal/lingual surface are more serious than those of the occlusal surface (making it more likely to produce unstable large chips or tearing chips); moreover, the brittle fracture and damage of the final machined surface are more obvious. The cutting mechanics and cutting mechanism identified in this study will provide scientific guidance for dental grinding operations.

The prognostic value of long non-coding RNA H19 in various cancers: A meta-analysis based on 15 studies with 1584 patients and the Cancer Genome Atlas data.

BACKGROUND: Recent studies have shown that long noncoding RNA (lncRNA) H19 is aberrantly expressed in various cancers. However, the prognostic significance of H19 in cancer patients remains to be elucidated. Here, we designed and conducted a meta-analysis to evaluate the prognostic value of this lncRNA for malignant solid neoplasms. METHODS: Relevant publications were collected from PubMed, Cochrane Library, Web of Science, and Embase databases. The relevant survival data of patients with H19-associated cancers were downloaded from The Cancer Genome Atlas (TCGA) project. Statistically significant relationships between H19 expression levels and overall survival were analyzed by hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). RESULTS: A total of 15 studies with 1584 patients were ultimately included for this literature meta-analysis. An elevated level of H19 expression was found to be negatively correlated with the overall survival (OS) (HR = 1.62, 95% CI = 1.36-1.93, P < .001) in various cancers. Abnormal H19 expression was also positively correlated with poor tumor differentiation (P < .0001), more advanced clinical stage (P < .0001), earlier lymph node metastasis (P < .0001), and earlier distant metastasis (P < .05). The relationship between elevated H19 expression and overall survival was further validated by a TCGA dataset consisting of 7462 cancer patients (HR = 1.12, 95% CI = 1.03-1.22, P < .05). CONCLUSION: Our study indicates that H19 expression is closely relevant to clinical outcome and suggests that lncRNA H19 could be a crucial prognostic biomarker for certain carcinoma types.

Machinability of high-speed enamel cutting with carbide bur.

The cutting of tooth enamel using a high-speed air-turbine handpiece and carbide bur is a key procedure in oral surgeries, such as the minimally invasive extraction. However, presently little is known about the cutting mechanics and material removal mechanism related to tooth enamel machinability. In this study, the machinability of high-speed enamel cutting with carbide bur is studied by a computer-aided numerical control system. The dynamic cutting forces of enamel of the occlusal, buccal/lingual, and proximal surfaces were measured by the force measuring system. The force ratio, cutting torque, rotating speed, specific cutting energy, and bur wear were analyzed. The microstructure of enamel and carbide burs was observed by the scanning electron microscope, and the relationship between enamel microstructures and machinability was further analyzed. The results show that during the high-speed enamel cutting with carbide bur, the chip thickness is on the nano-scale, and the plastic deformation of the machined surface is obvious. With increased material removal rate, the cutting force, torque, specific cutting energy, and bur wear increases accordingly, whereas the rotating speed decelerates (p < 0.05). The different angles between the cutting direction and the axial direction of the enamel rods give rise to the large differences in the cutting mechanics and mechanism of the proximal, buccal/lingual, and occlusal surfaces of the teeth. When the cutting direction is parallel, vertical, and oblique 45° to the axial direction of the enamel rods, the force required for material fracture and crack propagation increases, and the cutting force increases as a consequence. Parallel and oblique 45° cutting are the main modes of tooth segmentation in the minimally invasive extraction. In comparison with the parallel cutting mode, the cutting force, torque, and cutting ratio of the oblique 45° cutting mode can be significantly increased, and the tool wear is obviously accelerated. This is the lowest priority in segmentation surgery, hence the problems of overload and temperature rise need to be considered. The cutting mechanics and cutting mechanism obtained in this study will provide scientific process guidance for dental cutting operations with the air-turbine handpiece driving bur.