Severe COVID-19 complicated with mild encephalitis/encephalopathy with reversible splenial lesion of the corpus callosum: a case report / 中华神经科杂志

Since the global COVID-19 pandemic, SARS-CoV-2 infection, which causes COVID-19, has been associated with a range of diseases whose atypical manifestations have been increasingly reported. The mild encephalitis or encephalopathy associated with reversible corpus callosum lesions or mild encephalitis/encephalopathy with reversible splenial lesion (MERS) is a rare clinical and radiographic syndrome. At present, the pathogenesis of MERS caused by COVID-19 is still unclear, and its pathogenesis may include hypoxic damage, inflammatory response, immune disorders, changes in osmotic pressure, excitatory amino acid toxicity, oxidative stress and functional abnormalities of renin-angiotensin system. This paper reports a case of severe COVID-19 complicated with MERS, and discusses the pathogenesis from a pathophysiological point of view.

The application of mr dti in cerebra infarction of optic radiation / 实用放射学杂志

Objective To evaluate the fiber altering and clinical relationship in patients with occipital and temporal lobe cerebral infarction with DTI.Methods Fifty patients suffering from cerebral stroke were analyzed with conventional MRI,DWI and DTI. The fibers of visual pathway were depicted ,and their fractional anisotropy (FA),apparent diffusion coefficient (ADC),isotropic im-age (Iso)and T2-weighted trace were measured and analyzed.Results Regions of interest (ROIs)were placed in infarction and nor-mal contralateral tissue for tracking the visual pathways.The different parameters were measured.FA is useful to differentiate hy-per-acute stroke from acute and sub-acute stroke.FA values increased slightly in hyper-acute and decreased in acute,sub-acute and chronic phase.The values of ADC in infarction regions in hyper-acute,acute and sub-acute phases were lower than those of the con-tralateral tissue.Iso and T2-weighted trace increased in acute phase and decreased in chronic phase.DTT was used to show the way and chang of visual pathway.Conclusion DTI could track the fiber of visual pathway,and depict the fiber of infarction zone.DTT could be used in evaluating the prognosis of patients.