RÉSUMÉ
The arsenic (As) content of coal relating with mineralization of gold in Southwest Guizhou Province, China is up to 35,000 ppm. The coal is burned indoors in open pits for daily cooking and crop drying. As a result, arsenic is precipitated and concentrated in corn (5-20 ppm), chili (100-800 ppm) and other foods. Arsenic concentrations in the drinking water of high-As coal areas are lower than 50 ppb. The estimated main sources of As exposure in this area are from polluted food. Approximately, 3000 arsenosis patients were found by 1998, and more than 100,000 people from six counties were under the threat in China. This paper presents the major ingestion pathway of this type arsenosis and relative geochemistry of high-As coal.
Sujet(s)
Pollution de l'air intérieur/analyse , Intoxication par l'arsenic/épidémiologie , Arsenic/analyse , Charbon/analyse , Surveillance de l'environnement/statistiques et données numériques , Analyse d'aliment/statistiques et données numériques , Exposition par inhalation/analyse , Arsenic/urine , Intoxication par l'arsenic/étiologie , Capsicum/composition chimique , Chine/épidémiologie , Surveillance épidémiologique , Eau douce/analyse , Poils/composition chimique , Humains , Analyse par activation neutronique , Sol/analyse , Zea mays/composition chimiqueRÉSUMÉ
Objectives To observe the frequencies of mutations at glycophorin A(GPA)of erythro-cytes in patients with high arsenic coal poisoning(HACP)in comparison with normal controls.Methods The peripheral erythrocytes were isolated and immunolabelled,and were detected by flow cytometry in40patients and18normal adults.Results The mutation frequencies(MF)were(21.23?13.97)?10 -6 for type NN,(33.13?25.72)?10 -6 for type NO,(110.90?63.58)?10 -6 for type MM,and(20.35?21.26)?10 -6 for type MO of erythrocytes in patients with HACP,which were significantly higher than those in normal controls.The mutation frequencies were(31.50?16.13)?10 -6 for type NN,(54.50?38.13)?10 -6 for type NO,(159.33?66.22)?10 -6 for type MM,and(45.16?12.69)?10 -6 for type MO of erythrocytes in tumor group of HACP patients,which were significantly higher than those of non-tumor group of the patients.Conclusions Arsenic poisoning may induce the mutation at the glycophorin-A locus of erythrocytes,sug-gesting that arsenic may be one of potential mutagens.GPA-MF may serve as a parameter for the detection of patients with HACP.
RÉSUMÉ
0.05). Conclusions MSI and LOH may play a certain role in the carcinogenesis and progression of arsenic-induced skin lesions.