[Current situation and development trend of digital traditional Chinese medicine pharmacy].

The 21st century is a highly information-driven era, and traditional Chinese medicine(TCM) pharmacy is also moving towards digitization and informatization. New technologies such as artificial intelligence and big data with information technology as the core are being integrated into various aspects of drug research, manufacturing, evaluation, and application, promoting interaction between these stages and improving the quality and efficiency of TCM preparations. This, in turn, provides better healthcare services to the general population. The deep integration of emerging technologies such as artificial intelligence, big data, and cloud computing with the TCM pharmaceutical industry will innovate TCM pharmaceutical technology, accelerate the research and industrialization process of TCM pharmacy, provide cutting-edge technological support to the global scientific community, boost the efficiency of the TCM industry, and promote economic and social development. Drawing from recent developments in TCM pharmacy in China, this paper discussed the current research status and future trends in digital TCM pharmacy, aiming to provide a reference for future research in this field.

[Research and application of model fruit fly in prevention and treatment of neuropsychiatric disorders by traditional Chinese medicine and natural compounds: a review].

As an important model animal, fruit fly is characterized by outstanding genetic characteristics, relatively perfect nervous system, rapid reproduction, and low cost. Thus, it has been applied in the research on neuropsychiatric disorders in recent years, showing great potential in life science. The incidence of neuropsychiatric disorders has been on the rise, and the disorders have high disability rate and low case fatality rate. The global drug demand for such diseases is second only to cardiovascular and cerebrovascular diseases. At the moment, the demand of the drugs for the diseases have been rising, and it is an urgent task to develop related drugs. However, the research and development of the drugs are time-intensive and have a high failure rate. A suitable animal model can help shorten the time for drug screening and development, thereby reducing the cost and failure rate. This study reviews the application of fruit flies in several common neuropsychiatric disorders, which is expected to provide new ideas for the research and application of the model animals in traditional Chinese medicine.

[Two new compounds from Smilax glaucochina].

A new sesquiterpenes named glaucochinarol A (1) and a new phenylpropane glycoside named glcacochinaside A (2), together with six known ones, including trichothecolone (3), ß-D-(6-O-trans-feruloyl)fructofuranosyl-α-D-O-glucopyranoisde (4), 3,4,5-trimethoxyphenyl-ß-D-glucopyranoside (5), (4R)-p-menth-1-ene-7,8-diol-7-O-ß-D-glucopyranoside (6), naringenin (7), and emodin-8-O-ß-glucoside (8) were isolated from smilax glaucochina warb. Their structures were elucidated on the basis of NMR, MS and published data. Compounds 3-8 were isolated from the species for this first time.

Six new furostanol glycosides from Smilax glauco-china and their cytotoxic activity.

Six new steroidal saponins, namely glauco-chinaosides A-F, and one known compound were isolated from the tubers of Smilax glauco-china. Their structures were elucidated by a combination of spectroscopic analysis and hydrolysis followed by spectral and chromatographic analysis. Compounds 1-7 were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, and Lovo). Compounds 1, 2, and 5 exhibited cytotoxic activity against SGC-7901, with IC50 values of 2.7, 11.5, and 6.8 µM, respectively.

[Phenylpropanoid Constituents of Smilax trinervula].

Objective: To study the phenylpropanoid constituents of Smilax trinervula. Methods: The chemical constituents were isolated and purified by macroporous adsorption resin chromatography, gel chromatography and high performance liquid chromatography. Their structures were identified by spectroscopic analysis and comparison with literatures. Results: Nine phenylpropanoid compounds were isolated and their structures were identified as( +)-lyoniresin-4-yl ß-D-glucopyranoside( 1),(-)-8'-epilyoniresin-4-yl ß-glucopyranoside( 2),( +)-lyoniresin-4'-yl ß-glucopyranoside( 3),(-)-lyoniresinol-2α-O-ß-D-glucopyranoside( 4),( +)-lyoniresinol( 5),icariol A2( 6),icariol A2-4-O-ß-D-glucopyranoside( 7),7S,7'S,8R,8'R-icariol A2-9-O-ß-D-glucopyranoside( 8) and( +)-syringaresinol-4'-O-ß-D-glucopyranoside( 9). Conclusion: All the compounds are isolated from Smilax genus for the first time.

[Studies on chemical constituents of rhizomes of Smilax trinervula].

The chemical constituents were separated and purified from the 70% ethanol extract of Smilax trinervulaby various chromatographic methods including silica gel, Sephadex LH-20, MCI and preparative HPLC. Their structures were obtained and identified by analysis of the spectroscopic data. Compounds 1-11 were separated from this genus for the first time. Compound 12 was obtained from S. trinervula for the first time.

["Total amount" release kinetics evaluation of traditional Chinese medicine sustained-release preparations based on material rough set theory].

The release kinetics research of sustained-release formulations of traditional Chinese medicines (TCM) is an inalienable part of the chain of TCM modernization, which plays an important role in the development of modern compound TCM preparation. However, the research method or pattern in line with the specific characteristics of TCM, i.e., multi-component and multi-target, is still lacking. On the basis of material rough set theory, this paper reviewed the advantages and disadvantages of the existing evaluation patterns and methods, a tentative idea about the "total amount" release characteristics evaluation on TCM compound sustained-release preparation has suggested so as to evaluate the release kinetics and to promote the development of evaluation methodology on TCM sustained-release preparations.

[Comparison of microwave-assisted and conventional extraction of Corydalis yanhusuo].

OBJECTIVE: To compare the extraction yield and economic cost in the microwave-assisted extraction and conventional extraction of Corydalis yanhusuo. METHODS: Both of the extractions of Corydalis yanhusuo were optimized by orthogonal design. The contents of tetrahydropalmatine and total alkaloids were determined by HPLC and ultraviolet spectrophotometer, respectively. Meanwhile, the electricity consumption was determined in the extraction process. RESULTS: Comparing with conventional extraction, the microwave-assisted extraction saved time and money, and provided higher extraction yield of tetrahydropalmatine and total alkaloids. CONCLUSION: The microwave-assisted extraction has advantages in high efficiency and low cost.