Prevalence and risk factors of thyroid nodules in breast cancer women with different clinicopathological characteristics: a cross-sectional study.

BACKGROUND: Association between breast cancer (BC) and thyroid nodules (TNs) is still unclear. This research was to estimate the prevalence and risk factors of TN in Chinese BC women at initial diagnosis. METHODS: 1731 Chinese early-stage BC women at initial diagnosis underwent thyroid ultrasound and 1:1 age-matched Chinese healthy women underwent health examination in corresponding period were enrolled for analysis. RESULTS: Prevalence of TN and TI-RADS ≥ 4 TN in BC patients (56.27% and 9.76%) were higher than healthy people (46.04% and 5.49%), respectively, P < 0.001. Among BC patients, prevalence of TN and TI-RADS ≥ 4 TN in hormone receptor (HR)-positive patients (59.57% and 11.81%) were higher than HR-negative patients (48.77% and 5.10%), respectively, P < 0.001, while without difference between HR-negative patients and healthy people. After adjusting for age and BMI, HR-positive patients had higher risk of TN (OR = 1.546, 95%CI 1.251-1.910, P < 0.001) and TI-RADS ≥ 4 TN (OR = 3.024, 95%CI 1.943-4.708, P < 0.001) than HR-negative patients. Furthermore, the risk of TI-RADS ≥ 4 TN was higher in patients with estrogen receptor (ER) positive (OR = 2.933, 95%CI 1.902-4.524), progesterone receptor (PR) positive (OR = 1.973, 95%CI 1.378-2.826), Ki-67 < 20% (OR = 1.797, 95%CI 1.280-2.522), and tumor size < 2 cm (OR = 1.804, 95%CI 1.276-2.552), respectively, P < 0.001. CONCLUSIONS: Prevalence of TN, especially TI-RADS ≥ 4 TN, in Chinese early-stage BC women was higher than healthy people. HR-positive patients had higher prevalence and risk of TN, while without difference between HR-negative patients and healthy people. The increased risk of TN was correlated with ER-positive, PR-positive, lower Ki-67 expression, and smaller tumor size.

Características clínico-patológicas de los pacientes asistidos en el Centro Docente Asociado de Oncología Médica en el Hospital Departamental de Soriano durante su primer año de funcionamiento / Clinical-pathological characteristics of patients assisted at the Associated Teaching Center of Medical Oncology at Soriano Departmental Hospital during its first year of operation / Características clínico-patológicas dos pacientes atendidos no Centro Docente Associado de Oncologia Médica no Hospital Departamental de Soriano durante seu primeiro ano de funcionamento

Introducción: Según el Ministerio de Salud las muertes por cáncer constituyen un cuarto del total de las defunciones registradas en Uruguay cada año. Objetivo: Conocer el perfíl epidemiológico de los pacientes diagnosticados de cáncer asistidos en el Hospital Departamental de Soriano. Material y métodos: Estudio observacional, retrospectivo y descriptivo que incluyó a los pacientes diagnosticados de cáncer asistidos en el Hospital Departamental de Soriano durante el 2022. Se mantuvo el anonimato de los pacientes en el análisis estadístico y se contó con la aprobación del Comité de Ética del Hospital de Clínicas. Resultados: Se incluyeron 113 pacientes nuevos; 53.1% fueron hombres, siendo la mediana de edad al diagnóstico de 69 años. Los 4 tumores más frecuentes para ambos sexos reunidos fueron: mama, próstata, pulmón y colo-recto; la distribución por estadio fue la siguiente: E IV 48.6% pacientes; EIII 22.5%; EII 26.5%; y EI 2.6%. En el 79.6% de las pacientes se contaba con la confirmación del diagnóstico mediante anatomía patológica. El tiempo entre el diagnóstico y el primer tratamiento oncológico fue ≤ 3 meses para el 88.2% de los pacientes. El total de los pacientes con EIV fueron contactados con la Unidad de Cuidados Paliativos. Únicamente el 15% de los casos fueron discutidos en Comité de Tumores. Conclusiones: Los datos analizados permitieron caracterizar el perfil epidemiológico del cáncer de los pacientes procedente de Soriano asistidos en el ámbito público y pueden contribuir a la implementación de políticas públicas orientadas a la prevención y por ende a la mejora en la asistencia pacientes asistidos.

Introduction: According to the Ministry of Health, cancer deaths constitute a quarter of the total deaths registered in Uruguay each year. Objective: To identify the epidemiological profile of patients diagnosed with cancer treated at the Departmental Hospital of Soriano. Materials and Methods: An observational, retrospective and descriptive study that included patients diagnosed with cancer attended at the Departmental Hospital of Soriano during 2022. The anonymity of the patients was maintained in the statistical analysis and approval was obtained from the Ethics Committee of the Hospital de Clínicas. Results: A total of 113 new patients were included; 53.1% were men, with a median age at diagnosis of 69 years old. The four most frequent tumors for both sexes were: breast, prostate, lung and colorectal; the distribution by stage was as follows: Stage IV 48.6% patients; Stage III 22.5%; Stage II 26.5%; and Stage I 2.6%. In 79.6% of the patients the diagnosis was confirmed by pathological anatomy. The time between diagnosis and first oncological treatment was ≤ 3 months for 88.2% of patients. The total number of patients with Stage IV were contacted by the Palliative Care Unit. Only 15% of the cases were discussed in the Tumor Committee. Conclusions: The data analyzed made it possible to characterize the epidemiological profile of cancer in patients from Soriano assisted in the public sector and may contribute to the implementation of public policies aimed at prevention and, therefore, at improving patient care.

Introdução: Segundo o Ministério da Saúde, as mortes por câncer constituem um quarto de todas as mortes registradas no Uruguai a cada ano. Objetivos: Conhecer o perfil epidemiológico dos pacientes diagnosticados com câncer atendidos no Hospital Departamental de Soriano. Material e Métodos: Estudo observacional, retrospectivo e descritivo que incluiu pacientes diagnosticados com câncer atendidos no Hospital Departamental de Soriano durante o ano de 2022. O anonimato dos pacientes foi mantido na análise estatística e foi aprovado pelo Comitê de Ética do Hospital de Clínicas. Resultados: foram incluídos 113 novos pacientes; 53,1% eram homens, com mediana de idade ao diagnóstico de 69 anos. Os 4 tumores mais frequentes para ambos os sexos combinados foram: mama, próstata, pulmão e colorretal; a distribuição por estágio foi a seguinte: E IV 48,6% pacientes; EIII 22,5%; EII 26,5%; EI 2,6%. Em 79,6% dos pacientes houve confirmação do diagnóstico pela patologia. O tempo entre o diagnóstico e o primeiro tratamento oncológico foi ≤ 3 meses para 88,2% dos pacientes. Todos os doentes com DIV foram contactados com a Unidade de Cuidados Paliativos. Apenas 15% dos casos foram discutidos no Comitê de Tumores. Conclusões: Os dados analisados ​​permitiram caracterizar o perfil epidemiológico do câncer em pacientes de Soriano atendidos na esfera pública e podem contribuir para a implementação de políticas públicas voltadas para a prevenção e, consequentemente, para a melhoria na assistência aos pacientes atendidos.

Prevalencia de los subtipos de cáncer de mama según la clasificación inmunohistoquímica y su relación con las características clínico-patológicas en una clínica privada de la ciudad de Córdoba / Prevalence of breast cancer subtypes according to the immunohistochemical classification and its relationship with clinicalpathological characteristics in a private clinic in the city of Córdoba

Introducción El cáncer de mama (cm) es una enfermedad heterogénea. La clasificación histopatológica ha tenido una limitada utilidad clínica debido a su pobre e insuficiente valor pronóstico y predictivo. Un esquema de clasificación basado en la caracterización inmunohistoquímica mediante la expresión de receptores hormonales, sobreexpresión del her2 neu y la amplificación de factor de proliferación Ki67 se correlaciona mucho más con los resultados clínicos, por su alto valor predictivo y pronóstico. Objetivo El objetivo del presente estudio es conocer la prevalencia de los distintos subtipos inmunohistoquímicos de cm y su relación con las características clínicopatológicas en pacientes de una clínica privada de la ciudad de Córdoba. Material y método Se trata de un estudio observacional descriptivo y analítico retrospectivo de corte transversal. Cumplieron con los criterios de inclusión 174 pacientes con cáncer de mama invasor que acudieron al Servicio de Oncología entre 2010 y 2015. Los 5 subtipos analizados fueron definidos sobre la base de la expresión de los distintos marcadores: Luminal A: re+ y/o rp+ her2- Ki67<14%; Luminal B: re+ y/o rp+ o - her2- Ki>14%; Luminal B Her2: re+ rp+ o- her2+ y Ki >14%; her2: re y rp- her2+; y Triple Negativo: re y rp- her2-. Las variables que se relacionaron fueron: edad, compromiso ganglionar, estadio al momento del diagnóstico, grado histológico y nuclear. Resultados Los subtipos luminales se correlacionaron con estadios iniciales al momento del diagnóstico, bajo grado nuclear e histológico (p<0,01), aunque el subtipo B se presenta con mayor afectación axilar. Los subtipos no luminales se relacionaron con un mayor grado histológico y nuclear (p<0,01), estadios más avanzados y mayor compromiso axilar, con afectación de pacientes más jóvenes en el caso de los Triple Negativos en comparación con los luminales.

Introduction Breast cancer is a heterogeneous disease. Histopathological classification has had limited clinical utility due to its poor and insufficient prognostic and predictive value. A classification scheme based on immunohistochemical characterization through expression of hormone receptors, overexpression of her2 neu and amplification of proliferation factor Ki67 correlates much more with clinical results, due to its high predictive and prognostic value. Objective To know the prevalence of the different immunohistochemical subtypes of breast cancer and its relation with the clinicopathological characteristics of a private clinic in the city of Córdoba. Materials and method It is a descriptive observational study and retrospective analytical crosssectional study. The inclusion criteria included 174 patients with invasive breast cancer who attended the Oncology Service between 2010 and 2015. The 5 subtypes analyzed were defined based on the expression of the different markers: Luminal A: re+ and/or rp+ her2- Ki67<14%; Luminal B: re+ and/or rp+ or - her2- Ki>14%; Luminal B Her2: re+ rp+ or- her2+ y Ki >14%; her2: re and rpher2+; and Triple negative: re and rp- her2-. The variables that were related were: age, ganglionic commitment, stage at the time of diagnosis, histological and nuclear grade. Results The luminal subtypes correlated with initial stages at the time of diagnosis, under nuclear and histological grade (p<0,01), although subtype B with greater axillary involvement. The non-luminal subtypes were associated with a higher histological and nuclear grade (p<0,01), more advanced stages and greater axillary involvement, with involvement of younger patients in the case of Triple Negative compared with luminal.