Remote RF excitation for small-bore MR imager at 15.2 T.

We report a method for remote excitation of the RF signal for preclinical-equivalent ultra high field Magnetic Resonance Imaging (MRI). A parallel-plate waveguide together with a bio-inspired surface coil were used to perform remote excitation experiments to acquire images with a small-bore MR imager at 15.2 T. The imager bore size limits the RF coil transmitter dimensions, so the Gielis super-formula was used to design an RF coil with small dimensions. Electromagnetic simulations of the principal mode were run to study the waveguide filled with air and loaded with a saline solution-filled tube. Radiation patterns were also computed in a semi-anechoic chamber for the same scenarios as above. A saline solution-filled spherical phantom and a formaldehyde-fixed mouse phantom were used to acquire images. Radiation patterns showed an omnidirectional distribution with no side lobes, and a very smooth behaviour with almost no loss of information in the saline solution-filled tube and without. The theoretical wave impedance was calculated and compared with simulated results showing an excellent correspondence. Spherical phantom image data and simulation results of B1 were contrasted and showed an important correlation. Ex vivo mouse images were of high quality and exhibited clear delineation of anatomical structures. These imaging results are in very good agreement with the simulations. Numerical, theoretical and experimental results validate this approach, using a bio-inspired surface coil with a simple waveguide for preclinical small-bore MRI at ultra high field.

A Data-Driven Multi-scale Technique for fMRI Mapping of the Human Somatosensory Cortex.

A previously introduced Bayesian non-parametric multi-scale technique, called iterated Multigrid Priors (iMGP) method, is used to map the topographic organization of human primary somatosensory cortex (S1). We analyze high spatial resolution fMRI data acquired at ultra-high field (UHF, 7T) in individual subjects during vibrotactile stimulation applied to each distal phalange of the left hand digits using both a travelling-wave (TW) and event-related (ER) paradigm design. We compare the somatotopic digit representations generated in S1 using the iMGP method with those obtained using established fMRI paradigms and analysis techniques: Fourier-based analysis of travelling-wave data and General Linear Model (GLM) analysis of event-related data. Maps derived with the iMGP method are similar to those derived with the standard analysis, but in contrast to the Fourier-based analysis, the iMGP method reveals overlap of activity from adjacent digit representations in S1. These findings validate the use of the iMGP method as an alternative to study digit representations in S1, particularly with the TW design as an attractive means to study cortical reorganization in patient populations such dystonia and carpal tunnel syndrome, where the degree of spatial overlap of cortical finger representations is of interest.