RÉSUMÉ
INTRODUCTION AND IMPORTANCE: Lung adenocarcinoma may resemble the clinical presentation of an infectious or inflammatory lung disease. The coexistence of lung cancer, and polyserous effusions is uncommon, which may cause a diagnostic challenge. However, any polyserous effusions at a young age must always be suspicious for malignancy. CASE PRESENTATION: We report a case of 38-year-old male patient with polyserous effusions and pneumonia who was treated accordingly and showed clinical improvement with a significant reduction of pericardial and pleural effusions. Subsequent testing and a biopsy resulted in the histopathological diagnosis of an adenocarcinoma of the lung. CLINICAL DISCUSSION: Nonrecurrent polyserous effusions in lung adenocarcinoma are uncommon, and negative cytology results may not exclude malignancy due to the moderate sensitivity of pleural and pericardial fluid cytology. Clinicians should remain vigilant for false-negative results, especially in younger patients. Malignancy should not be ruled out because pleural and pericardial fluid cytology have a sensitivity of 60% and 92%, respectively. CONCLUSION: Our case highlights the diagnostic challenges posed by atypical presentations of lung adenocarcinoma and emphasizes the importance of considering malignancy in the differential diagnosis of polyserous effusions, even when initial cytology results are negative. Clarifying the rationale for this study enhances its relevance and impact.
Sujet(s)
Adénocarcinome pulmonaire , Tumeurs du poumon , Pneumopathie infectieuse , Humains , Mâle , Adulte , Diagnostic différentiel , Tumeurs du poumon/diagnostic , Tumeurs du poumon/anatomopathologie , Tumeurs du poumon/complications , Adénocarcinome pulmonaire/diagnostic , Adénocarcinome pulmonaire/anatomopathologie , Pneumopathie infectieuse/diagnostic , Épanchement péricardique/étiologie , Épanchement péricardique/diagnostic , Épanchement péricardique/anatomopathologie , Épanchement pleural/diagnostic , Épanchement pleural/étiologie , Adénocarcinome/diagnostic , Adénocarcinome/anatomopathologie , Épanchement pleural malin/anatomopathologie , Épanchement pleural malin/diagnostic , Épanchement pleural malin/étiologie , CytologieRÉSUMÉ
Objective: To investigate the importance of cell block and immunohistochemistry in the accurate diagnosis of serous effusion. Methods: A retrospective study was conducted on 3 124 cases of serous effusion from the Department of Pathology, Beijing Hospital from 2018 to 2022, include 2 213 cases of pleural effusion, 768 cases of peritoneal effusion, 143 cases of pericardial effusion. There were 1 699 males (54.4%) and 1 425 females (45.6%), average age 69 years old. Of which 1 292 cases were prepared with cell blocks and examined with immunohistochemical stain. Results: The percentage of malignant diagnosis increased from 64.9% (839/1 292) to 84.0% (1 086/1 292) after cell block preparation, and 1 086 cases were accurately diagnosed with histological type and/or origin of primary tumor. The undetermined diagnosis of suspected malignancy decreased from 13.3% (172/1 292) to 0.1% (1/1 292) and that of atypical hyperplasia from 18.8% (243/1 292) to 0.4% (5/1 292). The negative result for malignancy rate increased from 3.0% (38/1 292) to 15.5% (200/1 292). The differences highlighted above were statistically significant (Pearson's chi-squared test=12.739, P<0.01). Conclusion: Application of immunohistochemistry based on cell block can significantly improve malignant diagnosis in serous effusion, identify tumor origin and histological type as well as decrease the uncertain diagnosis.
Sujet(s)
Immunohistochimie , Épanchement péricardique , Épanchement pleural , Humains , Mâle , Femelle , Études rétrospectives , Sujet âgé , Épanchement péricardique/anatomopathologie , Épanchement pleural/anatomopathologie , Épanchement pleural/diagnostic , Liquide d'ascite/anatomopathologie , Cytodiagnostic/méthodes , Adulte d'âge moyen , Épanchement pleural malin/diagnostic , Épanchement pleural malin/anatomopathologie , AdulteRÉSUMÉ
BACKGROUND: Fiberglass has a larger aerodynamic diameter and is less likely to be inhaled into the lungs. Further, it will be cleared even if it is mechanically broken into smaller pieces and inhaled into the lungs. Fiberglass lung disease has been well documented if long term exposure but was thought reversible and would not cause severe diseases. The diagnosis of fiberglass lung disease depends on exposure history and histopathological findings. However, the exact occupational exposure history is often difficult to identify because mixed substance exposure often occurs and fiberglass disease is not as well-known as asbestosis. CASE PRESENTATION: A 66-year-old man had unexplained transudative pericardial effusion requiring pleural pericardial window operation twice at another medical center where asbestosis was told because of his self-reported long-term asbestosis exposure and the histopathological finding of a ferruginous body in his lung. Constrictive pericarditis developed two years later and resulted in congestive heart failure. Radical pericardiectomy combined with lung biopsy was performed following chest computed tomography imaging and the transudative nature of pericardial effusion not compatible with asbestosis. However, the histopathologic findings of his lung and pericardium at our hospital only showed chronic fibrosis without any asbestosis body. The patient's lung was found to be extremely fragile during a lung biopsy; histopathologic specimens were reviewed, and various fragments of fiberglass were found in the lung and pericardium. The patient's occupational exposure was carefully reevaluated, and he restated that he was only exposed to asbestosis for 1-2 years but was heavily exposed to fiberglass for more than 40 years. This misleading exposure history was mainly because he was only familiar with the dangers of asbestos. Since most fiberglass lung diseases are reversible and the symptoms of heart failure resolve soon after surgery, only observation was needed. Ten months after radical pericardiectomy, his symptoms, pleural effusion, and impaired pulmonary function eventually resolved. CONCLUSION: Fiberglass could cause inflammation of the pericardium, resulting in pericardial effusion and constrictive pericarditis, which could be severe and require radical pericardiectomy. Exact exposure history and histopathological examinations are the key to diagnosis.
Sujet(s)
Verre , Exposition professionnelle , Péricardite constrictive , Humains , Mâle , Péricardite constrictive/étiologie , Péricardite constrictive/diagnostic , Péricardite constrictive/chirurgie , Sujet âgé , Exposition professionnelle/effets indésirables , Asbestose/complications , Asbestose/diagnostic , Asbestose/anatomopathologie , Tomodensitométrie , Poumon/anatomopathologie , Poumon/imagerie diagnostique , Péricardectomie , Épanchement péricardique/étiologieRÉSUMÉ
A previously healthy male patient presented with relapsing serous effusions affecting the pleural, pericardial and peritoneal membranes, along with thrombocytopaenia, following infection with COVID-19. An extensive workup was performed to rule out potential causes of polyserositis, including an infectious disease screen, autoantibody testing and imaging; however, no clear other cause was found. He exhibited a robust response to high-dose corticosteroid therapy but experienced several recurrences on tapering of treatment. His clinical course and treatment response were most suggestive of an autoimmune or autoinflammatory cause of polyserositis, though without confirmation of a specific underlying diagnosis. This report builds on existing literature on a possible link between COVID-19 and polyserositis.
Sujet(s)
COVID-19 , Récidive , Sérite , Humains , Mâle , COVID-19/complications , Sérite/étiologie , Sérite/traitement médicamenteux , SARS-CoV-2 , Adulte d'âge moyen , Épanchement pleural/étiologie , Épanchement pleural/imagerie diagnostique , Épanchement pleural/traitement médicamenteux , Glucocorticoïdes/usage thérapeutique , Épanchement péricardique/étiologie , Épanchement péricardique/imagerie diagnostique , Épanchement péricardique/traitement médicamenteux , Hormones corticosurrénaliennes/usage thérapeutiqueRÉSUMÉ
Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is a rare autosomal recessive disease caused by mutation in proteoglycan 4 (PRG4) gene on chromosome 1q25-q31. We faced a dilemma and delay in diagnosis in two sisters. The elder sister had pericardial effusion with constrictive pericarditis, underwent pericardiectomy and received empirical treatment for suspected tuberculosis. After 2 years, she developed bilateral knee swelling with restriction of movement. At the same time, her younger sister also presented with bilateral knee swelling which aroused the suspicion of genetic disease. The whole-genome sequencing revealed homozygous PRG4 mutation suggestive of CACP syndrome.
Sujet(s)
Coxa vara , Humains , Femelle , Coxa vara/diagnostic , Protéoglycanes/génétique , Anomalies morphologiques congénitales de la main/génétique , Anomalies morphologiques congénitales de la main/diagnostic , Arthropathie nerveuse/génétique , Arthropathie nerveuse/diagnostic , Épanchement péricardique/diagnostic , Anomalies morphologiques congénitales du membre supérieur/génétique , Anomalies morphologiques congénitales du membre supérieur/diagnostic , Anomalies morphologiques congénitales du membre supérieur/complications , Péricardite constrictive/diagnostic , Péricardite constrictive/complications , Péricardite constrictive/chirurgie , Anomalies morphologiques congénitales du membre inférieur/génétique , Anomalies morphologiques congénitales du membre inférieur/diagnostic , Péricardectomie , Mutation , Diagnostic différentiel , SynoviteRÉSUMÉ
Large pericardial effusions with associated cardiac tamponade are a rare manifestation of hypothyroidism. We present the case of a 63-year-old female with chronic heart failure and newly diagnosed hypothyroidism, who presented to her primary care physician complaining of progressively worsening dyspnea. Chest radiography showed cardiomegaly and transthoracic echocardiography (TTE) revealed a large pericardial effusion with tamponade physiology. An emergent pericardial window was performed, resulting in an improvement in left ventricular systolic function. Pericardial tissue biopsy was normal. Thyroid function tests were consistent with severe primary hypothyroidism. After inpatient treatment with intravenous levothyroxine and interval resolution of symptoms without recurrence of effusion, the patient was discharged home on oral levothyroxine therapy. Close follow up with surveillance echocardiography was planned. While metabolic disorders are seldom thought of as an etiology, it is imperative for clinicians to recognize hypothyroidism as a cause of the pericardial effusion. It is one of the few reversible causes and delay in treatment can result in fatal sequelae.
Sujet(s)
Hypothyroïdie , Épanchement péricardique , Thyroxine , Humains , Épanchement péricardique/étiologie , Épanchement péricardique/diagnostic , Hypothyroïdie/complications , Femelle , Adulte d'âge moyen , Thyroxine/usage thérapeutique , Thyroxine/administration et posologie , Échocardiographie , Tamponnade cardiaque/étiologie , Tamponnade cardiaque/diagnostic , Défaillance cardiaque/étiologieRÉSUMÉ
BACKGROUND: Pericardial effusion is the accumulation of fluid in the pericardial cavity. In nations with high tuberculosis (TB) load, TB is the most common cause of pericardial effusion. 1-2% of patients with pulmonary TB develop Pericardial TB worldwide. Multi-drug-resistant (MDR) TB, including extrapulmonary TB (EPTB) cases, are rising in number. Adenosine Deaminase (ADA) is an enzyme in lymphocytes and myeloid cells, which has certain immune functions in the body. ADA levels are increased in inflammatory conditions, like pleural, pericardial, or joint effusions, of bacterial etiology, granulomatous conditions, neoplasms, and autoimmune pathologies. TB is the only lymphocytosis involving disease with increased ADA levels. MDR EPTB is rare, but cases are on the rise, and tuberculous pericardial effusion is one such example. Hence, it is important to know the percentage of cases detected by a culture that can be identified by cartridge-based nucleic acid amplification test (CBNAAT), their resistance patterns, and to identify potential markers like ADA, which can help in early identification of cases. The objectives of this study were to identify the Mycobacterium tuberculosis (MTB) bacilli in culture, and correlate them with cartridge-based nucleic acid amplification test (CBNAAT) results and their drug-resistance, in the Pericardial tubercular effusion, and to find if Adenosine Deaminase (ADA) levels can be used as a predictor of the presence of MTB in pericardial fluid. METHODOLOGY: We enrolled 52 patients with moderate to large tuberculous pericardial effusion, based on pericardial fluid analysis, CBNAAT, and culture methods, between January 2021 and December 2021. RESULTS: The mean age of the patients was 41.85 + 17.88 years, with a median of 38 years. Males made up 57.7% of the total patients. MTB was detected in 16 (30.8%) patients in the CBNAAT evaluations. 14 (87.5%) of the CBNAAT-positive TB patients were sensitive to Rifampicin, whereas the remaining 2 (12.5%) were resistant to Rifampicin on CBNAAT. MTB was found to be growing in 8 (15.38%) drug sensitivity test cultures. Out of these 8, 6 were sensitive to first-line drugs, whereas 2 were resistant to both Isoniazid and Rifampicin. The presence of cough was found to have a significant difference between CBNAAT-detected MTB positive and negative patients (p = 0.020), whereas an insignificant difference was found for the presence of hypertension, diabetes mellitus, obesity, dyspnea, or fever. There was also an insignificant difference between the number of patients positive for the Tuberculin skin test, between the two groups. ADA was significantly higher in the MTB-detected CBNAAT group (85.91 + 37.60U/L vs 39.78 + 24.31U/L, p = 0.005), whereas the total leukocyte count, lymphocytes, neutrophils, random blood sugar levels, and serum protein levels had no significant difference. The area under the Receiver Operator Curve (CBNAAT positive: dependent variable; ADA: test result variable) was 0.854 (null hypothesis rejected), with a standard error of 0.078. CONCLUSIONS: Culture is the gold standard method to diagnose tuberculosis. Detection of MTB on pericardial fluid culture is very uncommon, though in our study, culture came out positive in 16% of patients, and 4% were resistant to rifampicin and isoniazid. Higher ADA levels in pericardial fluid are an indicator of tuberculous pericardial effusion.
Sujet(s)
Adenosine deaminase , Mycobacterium tuberculosis , Techniques d'amplification d'acides nucléiques , Épanchement péricardique , Tuberculose multirésistante , Humains , Adenosine deaminase/analyse , Adenosine deaminase/métabolisme , Mycobacterium tuberculosis/isolement et purification , Tuberculose multirésistante/diagnostic , Mâle , Adulte , Femelle , Épanchement péricardique/microbiologie , Adulte d'âge moyen , Liquide péricardique , Jeune adulte , Antituberculeux/pharmacologie , Antituberculeux/usage thérapeutique , Péricardite tuberculeuse/diagnosticRÉSUMÉ
BACKGROUND Despite having many benefits, frequently-used medications may still have potential risks and can cause harm. Hemopericardium is a lethal pathology with a high risk of mortality and a lower differential diagnosis consideration. When adding both mentioned elements, their consideration as a differential diagnosis would require a higher threshold. This report presents a 66-year-old man with atrial fibrillation, heart failure, and aortic stenosis status post transcatheter aortic valve replacement (TAVR) 1 year ago with hemopericardium while treated with apixaban. CASE REPORT We present the case of a 66-year-old man with multiple medical conditions, including atrial fibrillation, heart failure, and aortic stenosis post-transcatheter aortic valve replacement 1 year before admission, who presented with 2 weeks of dyspnea and lower-limb swelling. Initial assessments revealed atrial fibrillation, elevated brain natriuretic peptide, and a chest X-ray indicating possible left pleural effusion and cardiomegaly. On day 4, an echocardiogram identified a large hemopericardium and tamponade, prompting urgent surgery. A pericardial window was performed, draining 1700 cc of bloody fluid. The postoperative improvement included normalized hemodynamics and echocardiographic findings. Pathology confirmed hemopericardium. The follow-up echocardiogram showed improved cardiac function, and the patient was transferred to the general medical floor. CONCLUSIONS This case sheds light on the uncommon but critical complications associated with direct oral anticoagulant therapy. With only a handful of reported cases, the rarity of this condition underscores the need for heightened awareness among clinicians. The patient's intricate medical history accentuates the challenges in managing anticoagulation in individuals with multiple comorbidities.
Sujet(s)
Sténose aortique , Inhibiteurs du facteur Xa , Épanchement péricardique , Pyrazoles , Pyridones , Remplacement valvulaire aortique par cathéter , Humains , Pyridones/effets indésirables , Pyridones/usage thérapeutique , Mâle , Sujet âgé , Épanchement péricardique/induit chimiquement , Épanchement péricardique/étiologie , Épanchement péricardique/diagnostic , Pyrazoles/effets indésirables , Pyrazoles/usage thérapeutique , Inhibiteurs du facteur Xa/effets indésirables , Inhibiteurs du facteur Xa/usage thérapeutique , Sténose aortique/chirurgie , Remplacement valvulaire aortique par cathéter/effets indésirables , Fibrillation auriculaire/traitement médicamenteux , Complications postopératoires/diagnostic , ÉchocardiographieRÉSUMÉ
OBJECTIVES: Neonatal systemic lupus erythematosus (NLE) is an acquired autoimmune disease. The presence of effusions, such as pleural effusion and pericardial effusion, is rare. The present study helped investigate the clinical characteristics and progression of children with NLE combined with effusions. METHODS: Clinical data of patients diagnosed with NLE were retrospectively collected and analyzed from January 1, 2011, to December 31, 2023, at the Children's Hospital of Soochow University and Suzhou Municipal Hospital. Patients with NLE were divided into effusion and non-effusion groups based on the presence of effusion. Moreover, the clinical data of the newborns in both groups were compared and investigated. RESULTS: Eleven (11/45, 24.44%) NLE patients had effusions, such as pleural effusion, testicular hydrocele, peritoneal effusion, pericardial effusion, and hydrocephalus. Other organs involved in effusion patients were cutaneous, gastrointestinal, hematologic, cardiac, and neurological. Among the patients with effusion, five cases of SLE in pregnant mothers, two cases of Sjogren's syndrome, one case of photoallergic symptoms, and three of pregnant mothers with no history of antenatal autoimmune disease. Pregnant mother' autoimmune disease in remission prior to pregnancy, or stable low disease activity. Seven patients were positive for Anti-SSA, five of which were double positive for Anti-SSA and Anti-SSB. Compared with the non-effusion group, the effusion group patients had significantly higher lactate dehydrogenase, creatine kinase, and fibrinogen, significantly lower platelets, total protein, and albumin. These patients were likelier to have thrombocytopenia and coagulation abnormalities. Logistics regression analysis demonstrated that NLE patients with effusions are more likely to have decreased serum total protein levels. All NLE patients with effusion have self-resorption of the effusion. CONCLUSIONS: 24.44% of patients had effusions in our study. NLE patients with effusion are more likely to have hematologic involvement and a more inflammatory response. The effusion in NLE patients is usually self-resorption, severe cases can be treated with nonsteroidal anti-inflammatory drugs/steroids. Key Points ⢠NLE patients combined with effusions and were self-limiting, with pleural effusion being the most common. ⢠NLE patients combined with effusions have a more inflammatory response, significant abnormalities in the blood routine and biochemical-related indexes.
Sujet(s)
Lupus érythémateux disséminé , Épanchement péricardique , Épanchement pleural , Humains , Études rétrospectives , Lupus érythémateux disséminé/complications , Lupus érythémateux disséminé/congénital , Femelle , Mâle , Nouveau-né , Grossesse , Complications de la grossesse , Anticorps antinucléaires/sangRÉSUMÉ
BACKGROUND: Myxedema coma is a rare, but life-threatening endocrinological emergency. Myxedema is characterized by altered mental status, and is accompanied by hypotension, bradycardia, hypothermia, bradypnea, hyporeflexia, hyponatremia, and hypoglycemia, all stemming from reduced metabolism due to severe hypothyroidism. Additionally, patients may exhibit signs of low cardiac output, edema in the extremities, peripheral circulatory disturbances, shock, and the development of pericardial and pleural effusions, ultimately leading to confusion and coma. We present a successfully treated case of severe myxedema coma with recurrent pericardial effusion and hypotensive shock. This case is characterized by an unusual clinical presentation and required a distinct treatment strategy highlighting its exceptional rarity. CASE: A 2-year-old boy with Down syndrome presented with recurrent pericardial effusion attributed to medication non-adherence. The critically-ill patient, experiencing a severe cardiogenic shock required mechanical ventilation and inotropic infusions in the pediatric intensive care unit. Elevated thyroid stimulating hormone (TSH), and low free T4 (fT4) and free T3 (fT3) levels prompted consideration of myxedema coma. Upon reviewing the patient's medical history, it was ascertained that he had an ongoing diagnosis of primary hypothyroidism, and exhibited non-adherence to the prescribed treatment regimen and failed to attend scheduled outpatient clinic appointments for follow-up assessments. The treatment plan, devised by the pediatric endocrinology team, included the peroral administration of L-thyroxine (L-T4) at a dose of 50 micrograms per day. After beginning regular oral L-T4 treatment, a gradual improvement in the patient's condition was observed. Notably, by the 15th day of oral therapy, the patient had made a full recovery. Contrary to the recommended intravenous treatment for myxedema coma, this patient was successfully treated with oral levothyroxine, due to the unavailability of the parenteral form in Türkiye. CONCLUSIONS: This case report presents an instance of non-adherence to L-T4 therapy, which subsequently progressed to severe myxedema coma. Changes in neurologic status and hemodynamic instability in a patient with a history of hypothyroidism should raise the concern of nonadherence and, though rare, myxedema coma should be in the differential diagnosis.
Sujet(s)
Coma , Syndrome de Down , Myxoedème , Épanchement péricardique , Thyroxine , Humains , Mâle , Myxoedème/traitement médicamenteux , Myxoedème/diagnostic , Myxoedème/complications , Thyroxine/usage thérapeutique , Thyroxine/administration et posologie , Coma/étiologie , Coma/traitement médicamenteux , Enfant d'âge préscolaire , Épanchement péricardique/traitement médicamenteux , Épanchement péricardique/étiologie , Épanchement péricardique/diagnostic , Syndrome de Down/complications , Adhésion au traitement médicamenteux , Hypothyroïdie/traitement médicamenteux , Hypothyroïdie/complicationsRÉSUMÉ
Laparoscopic intraperitoneal onlay mesh repair is favoured for diaphragmatic hernias due to better outcomes. However, fixation devices pose risks, including cardiac tamponade. A man underwent laparoscopic repair for a large diaphragmatic hernia. One week later, he presented with chest discomfort which was initially attributed to postoperative pain. Subsequently, patient represented with worsening of chest pain and tachycardia. CT requested to rule out pulmonary embolism revealed a large pericardial effusion. Urgent drainage via apical approach resolved tamponade. The case highlights the challenges in managing pericardial effusions post-laparoscopy in the presence of diaphragmatic mesh and stresses multidisciplinary collaboration. Literature review highlights risks associated with fixation devices. Suggestions include limiting their use near vital structures. Key learning point of this case report is to raise awareness of cardiac tamponade following diaphragmatic hernia repair. Limited evidence necessitates cautious use of fixation devices, emphasising patient safety.
Sujet(s)
Tamponnade cardiaque , Hernie diaphragmatique , Laparoscopie , Humains , Tamponnade cardiaque/étiologie , Tamponnade cardiaque/chirurgie , Laparoscopie/effets indésirables , Mâle , Hernie diaphragmatique/chirurgie , Hernie diaphragmatique/imagerie diagnostique , Hernie diaphragmatique/étiologie , Complications postopératoires/chirurgie , Complications postopératoires/étiologie , Herniorraphie/méthodes , Herniorraphie/effets indésirables , Filet chirurgical/effets indésirables , Épanchement péricardique/étiologie , Épanchement péricardique/chirurgie , Épanchement péricardique/imagerie diagnostique , Tomodensitométrie , Douleur thoracique/étiologie , Drainage/méthodes , Adulte d'âge moyenRÉSUMÉ
BACKGROUND Effusive-constrictive pericarditis (ECP) is an uncommon clinical syndrome characterized by the coexistence of pericardial effusion and constriction involving the visceral pericardium. This differs from constrictive pericarditis, which presents with thickening of the pericardium without effusions. Specific diagnostic criteria of ECP include the failure of right atrial pressure to decrease by 50% or reach a new level below 10 mmHg after normalization of intrapericardial pressure. CASE REPORT We present the case of a 32-year-old obese man with multiple comorbidities who initially presented with flu-like symptoms and pleural effusion with development of constrictive-like symptoms. Despite undergoing numerous pericardiocentesis and appropriate medical management, the patient's condition failed to improve, leading to the likely diagnosis of effusive-constrictive pericarditis. Cultures of pericardial fluid revealed E. -faecium, which required multiple antimicrobial therapy. Despite infection, the exact etiology of ECP remained unknown and likely idiopathic. Common causes of ECP include idiopathic, tuberculosis, cardiac surgery complications, radiation, or neoplasia. Ultimately, the patient underwent a pericardiectomy involving the visceral and parietal pericardium, resulting in hemodynamic stability and resolution of symptoms. CONCLUSIONS This case highlights the challenges in diagnosing and managing ECP, emphasizing the importance of considering surgical intervention in refractory cases. ECP initially presents as a pericardial effusion, often addressed through pericardiocentesis; however, in a small subset of patients, sustained symptoms and altered hemodynamics persist following pericardiocentesis, necessitating further evaluation and management. The success of pericardiectomy in our patient highlights the potential efficacy of surgical intervention in improving outcomes for patients with ECP.
Sujet(s)
Épanchement péricardique , Péricardectomie , Péricardite constrictive , Humains , Péricardite constrictive/chirurgie , Péricardite constrictive/diagnostic , Mâle , Adulte , Épanchement péricardique/chirurgie , Épanchement péricardique/étiologie , Épanchement péricardique/diagnosticRÉSUMÉ
BACKGROUND AND AIMS: Pericardial effusion (PE) is a prevalent form of pericardial involvement in chronic kidney disease (CKD). This study aims to investigate the clinical and laboratory features associated with PE severity in patients with CKD. METHODS: In this cross-sectional study, we examined the medical records of patients admitted to tertiary hospitals with International Classification of Diseases 10th Revision (ICD-10) codes associated with CKD and PE. We included 112 CKD patients in stage 4 and 5 non-dialysis (ND) with PE for assessing the clinical and laboratory features of severity. RESULTS: Patients were divided into two categories based on the severity of PE. Seventy-two patients had mild and 40 had moderate and severe PE. Univariate analysis of demographic and laboratory features on the date of admission demonstrated that chest pain, dyspnea, serum albumin, and neutrophil-to-lymphocyte ratio (NLR) are associated with the severity of PE. The univariate analysis on the date of echocardiography showed significantly higher white blood cell count (WBC), neutrophil count (percentage and absolute count), and NLR, along with significantly lower lymphocyte percentage and serum albumin among patients with moderate and severe PE. In the multivariable analysis of laboratory features, on admission hypoalbuminemia (p-value = 0.014, OR = 4.03, CI: 1.32-12.25) and NLR greater than 5.5 (p-value = 0.015, OR = 4.22, CI: 1.32-13.50) were significantly associated with moderate and severe PE. In a parallel matter, at the time of echocardiography hypoalbuminemia (p-value = 0.004, OR = 5.38, CI: 1.74-16.65) and neutrophilia (p-value = 0.005, OR = 7.94, CI: 1.89-33.44) were significantly associated with moderate and severe PE. CONCLUSION: Despite advancements in the diagnosis and treatment of CKD, PE is still a concerning issue in these patients. This study revealed that hypoalbuminemia, neutrophilia, and NLR greater than 5.5 could be predictive factors of moderate and severe PE in CKD patients with PE. Further prospective study with larger sample size is needed to confirm these results.
Sujet(s)
Épanchement péricardique , Insuffisance rénale chronique , Humains , Femelle , Mâle , Insuffisance rénale chronique/complications , Épanchement péricardique/complications , Études transversales , Adulte d'âge moyen , Sujet âgé , Indice de gravité de la maladie , Granulocytes neutrophiles/anatomopathologie , ÉchocardiographieRÉSUMÉ
AIM: Constrictive pericarditis (CP) is characterised by scarring fibrosis and a loss of pericardial elasticity, which causes heart failure. IgG4 (immunoglobulin G4)-related disease (IgG4-RD) is a systemic fibro-inflammatory disease characterised by the infiltration of IgG4-immunopositive plasmacytes and high serum IgG4 levels that frequently shape tumorous lesions. Although pericardial involvement of IgG4-RD is rare, with indications of CP, pericardial effusion and irregular masses, the clinical and pathological features remain unclear. In this study, we examined the relationship between CP and IgG4-RD. METHODS: Among 35 thick-walled CP cases (histologically pericardial thickening ≥2 mm), eight cases were aetiology identified. Using the diagnostic criteria for IgG4-RD, 11 cases were classified as IgG4-CP, whereas the remainder were considered true idiopathic CP (16 cases) and the clinical pathological features were evaluated. RESULTS: Compared with the other groups, the IgG4-CP group was more common in men and associated with low-grade fever and massive pericardial effusion with frequent recurrence. Deaths resulting from heart failure occurred in a few cases of the IgG4-CP group, but not in other groups. An increase in C-reactive protein and a high positivity rate of anti-nuclear antibodies frequently occurred in the IgG4-CP group. Histologically, the IgG4-CP group included lymphoid follicle, eosinophil infiltration and few calcifications. CONCLUSIONS: Pericardial IgG4-RD occurs not only as nodular lesions, but also as thick-walled CP, and accounts for approximately 40% of thick-walled CP cases of unknown cause. The predominant clinical characteristic was refractory and recurrent pericardial effusion. Recognising IgG4-RD as a cause of CP is important to initiate appropriate therapy.
Sujet(s)
Maladie associée aux immunoglobulines G4 , Immunoglobuline G , Épanchement péricardique , Péricardite constrictive , Humains , Péricardite constrictive/anatomopathologie , Péricardite constrictive/immunologie , Mâle , Femelle , Adulte d'âge moyen , Maladie associée aux immunoglobulines G4/anatomopathologie , Maladie associée aux immunoglobulines G4/immunologie , Maladie associée aux immunoglobulines G4/diagnostic , Maladie associée aux immunoglobulines G4/complications , Sujet âgé , Immunoglobuline G/sang , Adulte , Épanchement péricardique/anatomopathologie , Épanchement péricardique/immunologie , Épanchement péricardique/étiologie , Sujet âgé de 80 ans ou plus , Péricarde/anatomopathologie , Péricarde/immunologie , Marqueurs biologiques/sang , Marqueurs biologiques/analyse , Récidive , Études rétrospectives , Fibrose , BiopsieRÉSUMÉ
A 64-year-old woman with a history of subarachnoid hemorrhage, breast cancer, cervical spine tumor, and syringomyelia developed recurrent pericardial effusion and cardiac tamponade after receiving the third dose of coronavirus disease 2019 mRNA vaccine, mRNA-1273 (Spikevax, Moderna). The cardiac tamponade of unknown etiology was intractable with nonsteroidal anti-inflammatory drugs, colchicine, and prednisolone. She underwent thoracoscopic pericardiectomy, and microthrombi were detected in the pericardial tissue. Although the exact causal relationship between vaccination and recurrent cardiac tamponade was unclear, the vaccine possibly caused or triggered the microthrombi formation, resulting in recurrent cardiac tamponade. Because of the potential for cardiovascular side effects such as thrombosis and myocarditis following vaccination, it was deemed necessary to accumulate and analyze such cases.
Sujet(s)
Vaccin ARNm-1273 contre la COVID-19 , COVID-19 , Tamponnade cardiaque , Récidive , SARS-CoV-2 , Humains , Femelle , Adulte d'âge moyen , Tamponnade cardiaque/étiologie , COVID-19/complications , COVID-19/prévention et contrôle , SARS-CoV-2/immunologie , Vaccin ARNm-1273 contre la COVID-19/effets indésirables , Vaccins contre la COVID-19/effets indésirables , Vaccination/effets indésirables , Épanchement péricardique/étiologie , Épanchement péricardique/immunologie , Résultat thérapeutique , Péricardectomie/effets indésirablesRÉSUMÉ
INTRODUCTION: Point of care ultrasound has long been used in the trauma setting for rapid assessment and diagnosis of critically ill patients. Its utility for diagnosis of pericardial effusion in the setting of penetrating thoracic trauma has more recently been a topic of consideration, given the rapid decompensation that these patients can experience. OBJECTIVES: This study aims to identify the diagnostic accuracy of point of care ultrasound in the diagnosis of pericardial effusion among patients with penetrating thoracic trauma. METHODS: Retrospective review of 2099 patients brought to the trauma bay between the years 2016 and 2021 were analyzed for diagnosis of pericardial effusion. Patients who were diagnosed with a pericardial effusion were investigated for point of care ultrasound findings. Descriptive statistics were performed to identify sensitivity, specificity, positive predictive value, and negative predictive value. RESULTS: Prevalence was calculated to be 26.7 cases of pericardial effusion per 1000 patients presenting with penetrating thoracic trauma. Incidence was estimated to be 3.8 cases of pericardial effusion per 1000 person-years. Calculation of diagnostic capabilities of ED POCUS revealed a sensitivity of 96.36 â%, a specificity of 100 â%, PPV of 100 â%, and NPV of 99.90 â%. CONCLUSIONS: Point of Care cardiac ultrasonography is a reliable tool for the rapid diagnosis of pericardial effusion in penetrating thoracic trauma patients. Patients with ultrasound suggestive of this condition should receive rapid surgical management to prevent decompensation.
Sujet(s)
Évaluation d'un traumatisme par échographie ciblée , Épanchement péricardique , Blessures du thorax , Centres de traumatologie , Plaies pénétrantes , Humains , Épanchement péricardique/imagerie diagnostique , Épanchement péricardique/étiologie , Études rétrospectives , Blessures du thorax/complications , Blessures du thorax/imagerie diagnostique , Plaies pénétrantes/imagerie diagnostique , Plaies pénétrantes/complications , Mâle , Femelle , Adulte , Sensibilité et spécificité , Adulte d'âge moyen , Systèmes automatisés lit malade , ÉchographieRÉSUMÉ
Point-of-care ultrasound (POCUS) has been shown to be a valuable tool in the management of acutely ill patients in the prehospital setting. POCUS not only has utility from a diagnostic perspective but also has been shown to reduce the rate of complications from otherwise traditionally "blind" procedures, such as pericardiocentesis. This case report highlights the utility of POCUS in the prehospital setting to guide emergent pericardiocentesis to treat cardiac tamponade. The applicability of various approaches to ultrasound-guided pericardiocentesis is also discussed.
Sujet(s)
Tamponnade cardiaque , Services des urgences médicales , Péricardiocentèse , Systèmes automatisés lit malade , Humains , Péricardiocentèse/méthodes , Services des urgences médicales/méthodes , Tamponnade cardiaque/imagerie diagnostique , Tamponnade cardiaque/chirurgie , Tamponnade cardiaque/thérapie , Mâle , Échographie interventionnelle/méthodes , Échographie/méthodes , Adulte d'âge moyen , Épanchement péricardique/imagerie diagnostique , Épanchement péricardique/chirurgie , Épanchement péricardique/thérapieRÉSUMÉ
Acute Myeloid Leukemia (AML) is a life-threatening illness that requires prompt diagnosis and often immediate treatment. It can present in a variety of manners but most commonly is associated with fevers, fatigue, shortness of breath, or infection. Extramedullary leukemia is a less common finding upon initial presentation, but includes dermatologic manifestations, including leukemia cutis, and rarely, large mass-like presentations known as myeloid sarcomas. While leukemic infiltration of organ systems is a well-described phenomenon, cardiac tamponade is a rare form of presentation. Herein we describe a 58-year-old man with a recent hospitalization for idiopathic cardiac tamponade who re-presented to the hospital with worsening dyspnea and fevers. He was found to have a recurrent pericardial effusion with features concerning for tamponade, as well as worsening thrombocytopenia and macrocytic anemia. Bone marrow biopsy revealed 24% myeloblasts, confirming the diagnosis of AML. Notably, his cardiac symptoms improved with treatment of his leukemia. To our knowledge, this is one of only a few cases of AML with cardiac tamponade as the initial presentation.