Immunopathology of oral mucosal ulcerative, desquamative, and bullous diseases: selective review of the literature

Cell/cell and cell/matrix adhesion proteins are responsible for maitaining the integrity of the mucosal lining of the oral cavity. Disease processes that destroy keratinocytes or adversely affect their adhesion to one another or to the subjacent basement membrane will result in erosions, ulcerations, and desquamations. Immunologic processes that have a deleterious effect on the integrity of the epithelial/basement membrane/submucosa complex are reviewed, and current research findings with respect to pathogenesis are discussed. In particular, T-cell-mediated hypersensitivity is involved in recurrent aphthous stomatitis and lichen planus; humoral-mediated immunity to cadherin intercellular adhesion molecules in important in the process of acantholysis in pemphigus vulgaris, and genetic defects and antibody-mediated processes give rise to junctional separation epidemolysis bullosa and mucous membrane pemphigoid, respectively. An immune complex mechanism appears to underline the pathogenesis of eryhtema multiforme

Epidermolise bolhosa adquirida (Penfigoide dermolitico) / Acquired epidermolysis bullosa (dermolytic pemphigoid)

E estudado um caso de epidermolise bolhosa adquirida (Penfigoide bolhoso) em um homem adulto com insucesso terapeutico. E feita uma revisao da entidade e estudadas as relacoes com o penfigoide bolhoso o e penfigoide cicatricial. Discute-se a autonomia da entidade e destaca-se, sobretudo, como de valor diagnostico o nivel da clivagem-sublamina densa

Epidermolise bolhosa adquirida (Penfigoide dermolitico) / Acquired epidermolysis bullosa (dermolytic pemphigoid)

E estudado um caso de epidermolise bolhosa adquirida (Penfigoide bolhoso) em um homem adulto com insucesso terapeutico. E feita uma revisao da entidade e estudadas as relacoes com o penfigoide bolhoso o e penfigoide cicatricial. Discute-se a autonomia da entidade e destaca-se, sobretudo, como de valor diagnostico o nivel da clivagem-sublamina densa

When and how to use sulfones in bullous diseases

The treatment with sulfones, although of great value in several skin disorders, is still empirical, and the mechanism of action is poorly understood. Thus, the only guidelines for their use is clinical experience. Some new data on the mechanism of action of sulfones in skin diseases and their adverse effects have been extensively reviewed recently by Lang Jr.