Sujet(s)
Bromures/intoxication , Colique/traitement médicamenteux , Agents gastro-intestinaux/intoxication , Syndromes neurotoxiques/étiologie , Composés du potassium/intoxication , Bromures/histoire , Sécurité des produits de consommation , République dominicaine/ethnologie , Emballage de médicament , Bourses d'études et bourses universitaires , Femelle , Agents gastro-intestinaux/histoire , Histoire du 19ème siècle , Histoire du 20ème siècle , Histoire du 21ème siècle , Humains , Nouveau-né , Léthargie/induit chimiquement , Hypotonie musculaire/induit chimiquement , Syndromes neurotoxiques/diagnostic , Syndromes neurotoxiques/physiopathologie , Syndromes neurotoxiques/thérapie , New York (ville) , Médicaments sans ordonnance , Centres antipoison , Composés du potassium/histoire , Réflexes anormaux , Toxicologie , Résultat thérapeutiqueRÉSUMÉ
We studied prospectively 15 male middle age workers before and after a fumigation period with methyl bromide, that lasted 2 to 4 weeks. According to the initial assessment, 5 of these subjects had a chronic exposure to the chemical. As controls, 10 non exposed workers matched for age, sex and working conditions were studied in 2 occasions. The evaluation included the Who Neuro Behavior Core Test Battery, dynamometric and vibrator assessment of peripheral nerve function, the Nothingham test for psychological functioning and Titmus test for visual acuity. Methyl bromide levels were measured in blood and irine. Blood methyl bromide levels increased from 13.3 to 30 mg/dl after headache, paresthesiae, mood changes and loss of memory and concentration. In these subjects, the threshold for the Vibration test increased from 2.4 to 2.85 sec, dynamometry the score fro negative auto-perception in the Nothingham test from 11.2 to 13.6. No deterioration in these tests were observed in unexposed workers. Acute and chronic methyl bromide exposure causes important psychological and neurological derangement