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2.
Neonatology ; 121(2): 266-270, 2024.
Article de Anglais | MEDLINE | ID: mdl-38043518

RÉSUMÉ

INTRODUCTION: Here we present the case of a newborn baby boy with severe plasminogen deficiency causing occlusive hydrocephalus and ligneous conjunctivitis. CASE PRESENTATION: Shortly after birth, the hydrocephalus was treated with a ventriculoperitoneal shunt implantation. However, the child had to be readmitted soon afterward because of shunt obstruction. Subglottic microtrauma caused by the necessary intubations then led to another life-threatening complication - subglottic stenosis with pseudomembrane formation. Microsurgical removal had to be performed to secure the airway. Initially, regular plasma transfusions achieved slightly elevated plasminogen activity levels and short-term improvement of the respiratory situation. However, shunt dysfunction reoccurred, and alternative treatment options were needed. Since therapy with plasminogen concentrate is already available in the USA with encouraging results, this treatment option was organized in hopes of equally good results for this patient. Fortunately, under short-term substitution with plasminogen concentrates, the implantation of a new ventriculoperitoneal shunt was successful, and respiratory problems resolved. CONCLUSION: Plasminogen concentrates are critically needed in Europe and other parts of the world to improve the care of and prevent complications among patients with plasminogen deficiency.


Sujet(s)
Conjonctivite , Hydrocéphalie , Mâle , Nourrisson , Nouveau-né , Enfant , Humains , Sténose pathologique/complications , , Hydrocéphalie/chirurgie , Hydrocéphalie/complications , Plasminogène , Conjonctivite/complications
3.
West Afr J Med ; 40(11): 1216-1222, 2023 Nov 30.
Article de Anglais | MEDLINE | ID: mdl-38096550

RÉSUMÉ

BACKGROUND: The barrier dysfunction of atopic dermatitis (AD) promotes epicutaneous sensitization to aeroallergens. This study aimed to evaluate the prevalence of food and aeroallergen sensitization in AD and to explore the relationship between allergen sensitization and the personal or family history of allergic rhinitis, conjunctivitis, asthma, eosinophil count, and AD severity of Nigerian patients. METHODS: Children and adults with AD who visited the dermatology clinic were included in this study. AD diagnosis was made using the modified Hanifin and Rajka criteria, and severity was rated and graded using the Scoring Atopic Dermatitis (SCORAD) index. Skin-prick test for 14 allergens (5 food and 9 aeroallergens) was used to assess IgE sensitization. To look for significant relationships, chi-square and odds ratio were used. RESULTS: Sensitization to at least one allergen was observed in 65.8% of the patients, sensitization to aeroallergen was 85% and to foods was 15%. More patients had concomitant allergic conjunctivitis (n=29) and only three had asthma. The mean age of onset of AD was 10.6±12.9 years, ranging from 2 months to 51 years, and a family history of atopy was observed in 49.4%. Majority had moderate AD and normal eosinophil count. Allergen sensitization in AD patients was significantly associated with the age of patients but not with personal or family history of allergic rhinitis, conjunctivitis, asthma, eosinophil count or AD severity. CONCLUSION: Analysis of our result showed a high prevalence of food and aeroallergen sensitization in AD. Sensitization was not influenced by the presence of other allergic diseases, eosinophils and the severity of AD.


CONTEXTE: La dysfonction de la barrière cutanée de la dermatite atopique (DA) favorise la sensibilisation épicutanée aux aéroallergènes. Cette étude visait à évaluer la prévalence de la sensibilisation alimentaire et aéroallergénique dans la DA et à explorer la relation entre la sensibilisation aux allergènes et les antécédents personnels ou familiaux de rhinite allergique, conjonctivite, asthme, le taux d'éosinophiles et la sévérité de la DA chez les patients nigérians. MÉTHODES: Les enfants et les adultes atteints de DA qui ont visité la clinique dermatologique ont été inclus dans cette étude. Le diagnostic de la DA a été établi en utilisant les critères modifiés de Hanifin et Rajka, et la gravité a été évaluée et classée à l'aide de l'indice de ScoringAtopic Dermatitis (SCORAD). Le test cutané aux 14 allergènes (5 alimentaires et 9 aéroallergènes) a été utilisé pour évaluer la sensibilisation IgE. Pour rechercher des relations significatives, le chi carré et le rapport de cotes ont été utilisés. RÉSULTATS: Une sensibilisation à au moins un allergène a été observée chez 65,8% des patients, la sensibilisation aux aéroallergènes était de 85% et aux aliments de 15%. Plus de patients présentaient une conjonctivite allergique concomitante (n=29) et seulement trois avaient de l'asthme. L'âge moyen de début de la DA était de 10,6 ± 12,9 ans, allant de 2 mois à 51 ans, et des antécédents familiaux d'atopie ont été observés chez 49,4%. La majorité avait une DAmodérée et un taux d'éosinophiles normal. La sensibilisation aux allergènes chez les patients atteints de DA était significativement associée à l'âge des patients, mais pas aux antécédents personnels ou familiaux de rhinite allergique, conjonctivite, asthme, au taux d'éosinophiles ou à la gravité de la DA. CONCLUSION: L'analyse de nos résultats a montré une prévalence élevée de la sensibilisation alimentaire et aéroallergénique dans la DA. La sensibilisation n'était pas influencée par la présence d'autres maladies allergiques, d'éosinophiles et de la sévérité de la DA. Mots-clés: Dermatite atopique, sensibilisation alimentaire et aéroallergénique, maladies atopiques, éosinophiles, sévérité de la dermatite atopique. Severity of atopic dermatitis Short title:Allergen sensitization in atopic dermatitis.


Sujet(s)
Asthme , Conjonctivite , Eczéma atopique , Rhinite allergique , Enfant , Adulte , Humains , Adolescent , Jeune adulte , Eczéma atopique/épidémiologie , Granulocytes éosinophiles , Allergènes , Asthme/complications , Rhinite allergique/complications , Conjonctivite/complications
4.
Medicina (Kaunas) ; 59(12)2023 Dec 10.
Article de Anglais | MEDLINE | ID: mdl-38138248

RÉSUMÉ

Background and Objectives: Atopic dermatitis (AD), also known as eczema, is a common chronic inflammatory skin condition affecting 16.5 million adults in the United States. AD is characterized by an impaired epidermal barrier that can predispose individuals to infection. End-stage renal disease (ESRD) is also commonly complicated by infections due to chronic vascular access and immune-system dysfunction, possibly related to uremia. Multiple studies have reported that renal disease is a common comorbidity in adults with atopic dermatitis. The aim of this study was to determine whether AD is a risk factor for certain infections in patients with ESRD. Materials and Methods: Using the United States Renal Data System, a retrospective cohort analysis was conducted on adult ESRD patients initiating dialysis between 2004 and 2019 to investigate associations between infections and AD in this population. Results: Of 1,526,266 patients, 2290 were identified with AD (0.2%). Infectious outcomes of interest were bacteremia, septicemia, cellulitis, herpes zoster, and conjunctivitis. In all infectious outcomes except for conjunctivitis, patients with the infectious outcomes were more likely to carry a diagnosis of AD. After controlling for demographic and clinical covariates, AD was associated with an increased risk of cellulitis (adjusted relative risk (aRR) = 1.39, 95% confidence interval (CI) = 1.31-1.47) and herpes zoster (aRR = 1.67, CI = 1.44-1.94), but not with bacteremia (aRR = 0.96, CI = 0.89-1.05), septicemia (aRR = 1.02, CI = 0.98-1.08), or conjunctivitis (aRR = 0.97, CI = 0.740-1.34). Conclusions: Overall, after controlling for demographic and clinical covariates and adjusting for person-years-at-risk, AD was associated with an increased risk for some, but not all, infections within the population of patients with ESRD.


Sujet(s)
Bactériémie , Conjonctivite , Eczéma atopique , Zona , Défaillance rénale chronique , Sepsie , Adulte , Humains , Eczéma atopique/complications , Eczéma atopique/épidémiologie , Études rétrospectives , Cellulite sous-cutanée/complications , Dialyse rénale/effets indésirables , Facteurs de risque , Défaillance rénale chronique/complications , Défaillance rénale chronique/épidémiologie , Conjonctivite/complications , Sepsie/complications
5.
Curr Opin Allergy Clin Immunol ; 23(5): 383-389, 2023 10 01.
Article de Anglais | MEDLINE | ID: mdl-37527055

RÉSUMÉ

PURPOSE OF REVIEW: Atopic dermatitis (AD) and ocular allergy aka allergic eye disease (AED) are two common conditions that often coexist in patients. However, molecular connections between these two conditions are incompletely understood. While common etiologic components including Th2 immune signaling have been suggested for AD and AED, the mechanism how current Th2-targetd therapies (dupilumab, tralokinumab) for AD can augment conjunctivitis is not well understood. RECENT FINDINGS: Differentially regulated genes and pathways relevant for AD disease manifestation are known. In contrast, similar information is not yet available for AED, which could be largely addressed by emerging noninvasive ocular sampling techniques. Emerging evidence indicated a reduction in goblet cell number and mucin production in a subpopulation of AD patients with AD leading to adverse ocular outcomes, while other potential mechanisms could also be involved. Involvement of particular barrier function protein(s) in AED needs further investigation. SUMMARY: Modern cytokine-targeted therapies for AD showed elevated risk for developing conjunctivitis. Recently developed noninvasive sampling techniques should be leveraged to identify AD endotypes associated with AED and with dupilumab-associated ocular outcomes.


Sujet(s)
Conjonctivite , Eczéma atopique , Humains , Eczéma atopique/complications , Conjonctivite/complications
6.
J Fr Ophtalmol ; 46(7): 769-775, 2023 Sep.
Article de Anglais | MEDLINE | ID: mdl-37541801

RÉSUMÉ

PURPOSE: To evaluate the ophthalmological findings in patients diagnosed with acute, subacute or chronic brucellosis and to determine the effects of this disease on ocular structures. METHODS: Eighty-seven patients diagnosed with brucellosis and 71 healthy cases (as a control group) were enrolled in this prospective study. All participants underwent a complete ophthalmic evaluation, including slit lamp biomicroscopic examination, Goldman applanation tonometry, specular microscopy, optical coherence tomography and fundoscopy with pupil dilation. RESULTS: Overall, ocular involvement was present in 47 eyes of 27 (31.03%) patients diagnosed with brucellosis and was most common in the chronic brucellosis group. In the acute brucellosis group, papillary conjunctivitis in 8 eyes of 4 patients and anterior uveitis in 10 eyes of 6 patients were noted. In the subacute brucellosis group, papillary conjunctivitis in 4 eyes of 2 patients and sequelae of anterior uveitis in 6 eyes of 3 patients were observed. In the chronic brucellosis group, panuveitis in 4 eyes of 2 patients, choroiditis in 4 eyes of 2 patients, and signs of previous anterior uveitis in 11 eyes of 6 patients were noted. Visual acuity was significantly worse in patients with acute anterior uveitis (AAU) or previous anterior uveitis (PAU) compared with the control cases. CONCLUSION: Ocular involvement should be kept in mind in patients with brucellosis, especially acute, and brucellosis should be included in the differential diagnosis of patients with anterior uveitis living in endemic areas, since the clinical presentation of the disease may not be overt.


Sujet(s)
Brucellose , Conjonctivite , Uvéite antérieure , Uvéite , Humains , Uvéite/diagnostic , Études prospectives , Uvéite antérieure/diagnostic , Conjonctivite/complications , Brucellose/complications , Brucellose/diagnostic , Études rétrospectives
7.
Ocul Immunol Inflamm ; 31(8): 1677-1686, 2023 Oct.
Article de Anglais | MEDLINE | ID: mdl-36638336

RÉSUMÉ

AIM: Brucellosis may affect the eye to varying degrees. The aim of this study was to investigate the ocular involvement of brucellosis and highlight key points. MATERIAL AND METHODS: Published literature in English language on the ocular involvement of brucellosis within last 30 years was evaluated. The PubMed international database was screened using certain keywords. RESULTS: The study included 27 publications evaluating a total of 159 cases. The most common types of ocular involvement were uveitis (52.2%) and conjunctivitis (17.6%). Most cases had concomitant systemic brucellosis (27.7%), and the most commonly used diagnostic method was a serological test (92.4%). Of all the patients, 37.1% recovered with sequelae. CONCLUSION: Brucellosis may cause a wide range of ophthalmic manifestations, and an overlooked or late diagnosis may also lead to the development of sequelae or loss of vision. A routine ophthalmologic examination should be performed in all patients with systemic brucellosis.


Sujet(s)
Brucellose , Conjonctivite , Infections bactériennes de l'oeil , Uvéite , Humains , Brucellose/complications , Brucellose/diagnostic , Brucellose/épidémiologie , Uvéite/diagnostic , Uvéite/épidémiologie , Uvéite/étiologie , Oeil , Conjonctivite/complications , Infections bactériennes de l'oeil/diagnostic , Infections bactériennes de l'oeil/épidémiologie , Infections bactériennes de l'oeil/étiologie
8.
J Med Life ; 15(8): 1000-1004, 2022 Aug.
Article de Anglais | MEDLINE | ID: mdl-36188652

RÉSUMÉ

Eye care is one of the most critical tasks of intensive care unit (ICU) nurses. Patients in this unit are exposed to potential ocular problems due to critical conditions. This study aimed to establish a new eye care protocol for preventing ocular surface disorders in patients admitted to ICU. This was a clinical trial study performed on patients admitted to ICU in 2019. The data gathering tools included the demographic questionnaire, the Schirmer test for dry eye, fluorescein staining and slit lamp manual for examining corneal ulcers, and slit lamp manual to check keratitis and conjunctivitis. A type of eye care protocol was performed on the patient's eyes. After five consecutive days of executing the protocol, the data were analyzed using SPSS software version 18. The use of eye care protocol reduced the risk of keratitis (P=0.027), conjunctivitis (P=0.012), eye dryness (P=0.001), and corneal ulcer (P=0.003) in patients admitted to ICU in the intervention group compared to the control group. Ophthalmology protocols reduced the incidence of keratitis, conjunctivitis, dry eye, and corneal ulcers in ICU patients. Therefore, using this method in ICU patients can improve nursing care.


Sujet(s)
Conjonctivite , Syndromes de l'oeil sec , Kératite , Conjonctivite/complications , Conjonctivite/prévention et contrôle , Syndromes de l'oeil sec/épidémiologie , Syndromes de l'oeil sec/étiologie , Syndromes de l'oeil sec/prévention et contrôle , Fluorescéine/usage thérapeutique , Humains , Unités de soins intensifs , Kératite/complications , Kératite/traitement médicamenteux , Kératite/prévention et contrôle , Ulcère/complications
9.
Drug Discov Ther ; 16(4): 164-168, 2022 Sep 17.
Article de Anglais | MEDLINE | ID: mdl-35989284

RÉSUMÉ

This study aims to clarify the clinical significance of dupilumab-induced elevation of blood eosinophil in Japanese patients with atopic dermatitis (AD). Eosinophil elevation was defined as ≥ 5% increase of eosinophil percentage within one year after dupilumab initiation. Seven patients (15.7%) were shown to have eosinophil elevation, six of whom developed dupilumab-associated conjunctivitis (DAC) and were accompanied with DAC more frequently than those without eosinophil elevation, with statistically significant difference. Eosinophil percentage resolved spontaneously in all seven patients, including the one without DAC, despite the continuation of dupilumab treatment. None of the patients with eosinophil elevation had cardiac or pulmonary complications attributable to the hypereosinophilia. The patients with eosinophil elevation were all male. Furthermore, none of four patients in whom efficacy of dupilumab was < 25% showed eosinophil elevation. Childhood onset tended to be more common in patients with the elevation of eosinophil. This study suggests that most eosinophil elevation is associated with DAC, and that the eosinophil ratio is a biomarker for DAC.


Sujet(s)
Conjonctivite , Eczéma atopique , Anticorps monoclonaux humanisés , Marqueurs biologiques , Enfant , Conjonctivite/induit chimiquement , Conjonctivite/complications , Eczéma atopique/traitement médicamenteux , Granulocytes éosinophiles , Humains , Japon , Mâle , Indice de gravité de la maladie , Résultat thérapeutique
10.
Pediatr Cardiol ; 43(4): 816-820, 2022 Apr.
Article de Anglais | MEDLINE | ID: mdl-34854940

RÉSUMÉ

Kawasaki disease is an acute systemic vasculitis which can cause cardiac involvement among other symptoms. In this study we aimed to assess the relationship between the echocardiographic findings of Kawasaki disease with the clinical and paraclinical findings of the patients. In this cross-sectional study, the symptoms of 307 Kawasaki patients were registered and the association of the symptoms with paraclinical findings and echocardiographic studies was assessed. 190 (61.9%) of the patients were male and 117 (38.1%) were female. 193 patients (62.9%) did not have any abnormalities in their echocardiography, while others showed coronary artery aneurysms, perivascular brightness, coronary artery dilatation, and trivial Mitral Regurgitation in their echocardiography. A significant inverse relationship was seen with echocardiographic findings and age. Thrombocytosis, conjunctivitis, and oral and/or pharyngeal erythema and/or strawberry tongue were associated with higher rates of echocardiographic abnormalities. Echocardiographic abnormalities are associated with younger age, higher platelets, and the existence of conjunctivitis and oral and/or pharyngeal erythema and/or strawberry tongue.


Sujet(s)
Conjonctivite , Anévrysme coronarien , Maladie de Kawasaki , Conjonctivite/complications , Anévrysme coronarien/étiologie , Études transversales , Échocardiographie , Érythème/complications , Femelle , Humains , Nourrisson , Mâle , Maladie de Kawasaki/complications , Maladie de Kawasaki/imagerie diagnostique
11.
Optom Vis Sci ; 98(5): 429-436, 2021 05 01.
Article de Anglais | MEDLINE | ID: mdl-33973912

RÉSUMÉ

SIGNIFICANCE: This analysis and review demonstrate that, although emerging data indicate that the prevalence of severe acute respiratory coronavirus 2 (SARS-CoV-2) on the ocular surface and coronavirus disease 2019 (COVID-19) conjunctivitis is rare, the ocular surface remains of interest as a potential inoculation and transmission site for SARS-CoV-2. Continued safety precautions should be taken as more data become available.COVID-19, caused by SARS-CoV-2, is a novel, global pandemic that has infected millions and, up to this point, caused more than two million fatalities worldwide. The ocular surface has become of interest as a possible vector for transmission by acting as a direct inoculation site, being a conduit for the virus into the respiratory system or as a method of transmission from potentially infected conjunctiva or tears. The components necessary for SARS-CoV-2 to theoretically infect ocular tissues are present: binding receptors (angiotensin-converting enzyme 2 and cluster of differentiation 147) and mechanisms for cell entry (transmembrane protease serine 2 and cathepsin L). This meta-analysis of COVID-19 prevalence data indicates that SARS-CoV-2 RNA has been infrequently found in conjunctival samples when tested with reverse transcriptase-polymerase chain reaction. This review estimates the prevalence of SARS-CoV-2 on the ocular surface and prevalence of conjunctivitis in patients with laboratory-confirmed COVID-19. There is much to be learned regarding ocular tropism of SARS-CoV-2.


Sujet(s)
COVID-19/épidémiologie , Conjonctivite/épidémiologie , RT-PCR/méthodes , Angiotensin-converting enzyme 2/métabolisme , COVID-19/complications , Détection de l'acide nucléique du virus de la COVID-19 , Conjonctive/virologie , Conjonctivite/complications , Conjonctivite/virologie , Humains , Pandémies , Réaction de polymérisation en chaîne , Prévalence , ARN viral/analyse , Larmes/composition chimique , Larmes/virologie
15.
Arch. Soc. Esp. Oftalmol ; 96(1): 41-44, ene. 2021. ilus
Article de Espagnol | IBECS | ID: ibc-200183

RÉSUMÉ

El «anquilobléfaron filiforme adnatum» es una anomalía congénita caracterizada por la adhesión parcial de los párpados superiores e inferiores. Los márgenes del párpado permanecen fusionados hasta el final del quinto mes de edad gestacional. La separación suele completarse alrededor del séptimo mes fetal. El anquilobléfaron puede ser una manifestación aislada o puede estar asociado con anomalías en otros órganos y/o sistemas. Presentamos un varón recién nacido con antecedentes familiares de displasia ectodérmica hipohidrótica (madre y abuelo materno). Se revelaron bandas extensibles de piel en el ojo derecho y en el izquierdo. Aparte de esto, presentó labio leporino, ausencia total de paladar, displasia de uñas y ungueal y pezones supernumerarios


"Ankyloblepharon filiforme adnatum" is a congenital anomaly characterized by partial or complete adhesion of upper and lower eyelids. The lid margins remain fused until the end of the fifth month of gestational age. Complete separation usually is completed about the seventh fetal month. Ankyloblepharon may be an isolated manifestation or may be associated with abnormalities in other organs and / or systems. The case is presented on a newborn male with family history of hypohydrotic ectodermal dysplasia (mother and maternal grandfather). It revealed extensible bands of skin in right and in left eye. Apart from this, he presented cleft lip, complete absence of palate, nail and ungueal dysplasia and supernumerary nipples


Sujet(s)
Humains , Infections à coronavirus/complications , Maladies de l'oeil/étiologie , Pneumopathie virale/complications , Syndrome respiratoire aigu sévère/complications , Conjonctivite/complications , Betacoronavirus , Infections à coronavirus/thérapie , Infections à coronavirus/transmission , Maladies de l'oeil/prévention et contrôle , Pneumopathie virale/traitement médicamenteux , Pneumopathie virale/transmission , Rétinopathies/complications , Paralysie
17.
J Am Acad Dermatol ; 85(2): 453-461, 2021 08.
Article de Anglais | MEDLINE | ID: mdl-33253849

RÉSUMÉ

BACKGROUND: Conjunctivitis and several other ocular surface diseases (OSDs) have been linked to atopic dermatitis (AD) and its treatment. OBJECTIVES: To examine the association between AD, conjunctivitis, and other OSDs. METHODS: A systematic review and meta-analysis was performed. Two authors independently searched EMBASE, PubMed, SCOPUS, and Web of Science and performed title/abstract and full-text review and data abstraction. Pooled random-effects prevalence and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. RESULTS: The search yielded 5719 nonduplicate articles; 134 were included in the quantitative analysis. AD was associated with conjunctivitis compared to reference individuals (OR, 2.78; 95% CI, 2.33-3.32); the prevalences of conjunctivitis in patients with AD and reference individuals were 31.7% (95% CI, 27.7-35.9) and 13.3% (95% CI, 11.0-15.7), respectively. Keratoconus (OR, 3.71; 95% CI, 1.99-6.94) and ocular herpes simplex (OR, 3.65; 95% CI 2.04-6.51) were also associated with AD. LIMITATIONS: Disease definitions differed and often relied on self-reports. Few studies provided data concerning AD phenotype or OSDs other than conjunctivitis. CONCLUSIONS: Conjunctivitis is the most common ocular comorbidity in AD. Signs and symptoms of conjunctivitis and other OSDs in AD may be underreported, making proactive inquiry and examination by physicians treating patients with AD important.


Sujet(s)
Conjonctivite/complications , Eczéma atopique/complications , Maladies de l'oeil/complications , Humains
18.
Sci Rep ; 10(1): 17419, 2020 10 15.
Article de Anglais | MEDLINE | ID: mdl-33060700

RÉSUMÉ

Changes in immune and coagulation systems and possible viral spread through the blood-brain barrier have been described in SARS-CoV-2 infection. In this study, we evaluated the possible retinal involvement and ocular findings in severe COVID-19 pneumonia patients. A cross-sectional study was conducted on 46 patients affected by severe COVID-19 who were hospitalized in one intensive care unit (ICU) and in two infectious disease wards, including bedside eye screening, corneal sensitivity assessment and retinography. A total of 43 SARS-CoV-2-positive pneumonia patients affected with COVID-19 pneumonia were included, including 25 males and 18 females, with a median age of 70 years [IQR 59-78]. Except for one patient with unilateral posterior chorioretinitis of opportunistic origin, of whom aqueous tap was negative for SARS-CoV-2, no further retinal manifestation related to COVID-19 infection was found in our cohort. We found 3 patients (7%) with bilateral conjunctivitis in whom PCR analysis on conjunctival swabs provided negative results for SARS-CoV-2. No alterations in corneal sensitivity were found. We demonstrated the absence of retinal involvement in SARS-CoV-2 pneumonia patients. Ophthalmologic evaluation in COVID-19, particularly in patients hospitalized in an ICU setting, may be useful to reveal systemic co-infections by opportunistic pathogens.


Sujet(s)
Infections à coronavirus/anatomopathologie , Pneumopathie virale/anatomopathologie , Rétine/anatomopathologie , Sujet âgé , Sujet âgé de 80 ans ou plus , Betacoronavirus/isolement et purification , COVID-19 , Conjonctivite/complications , Conjonctivite/anatomopathologie , Conjonctivite/virologie , Infections à coronavirus/complications , Infections à coronavirus/virologie , Études transversales , Femelle , Humains , Rétinopathie hypertensive/complications , Rétinopathie hypertensive/diagnostic , Unités de soins intensifs , Mâle , Adulte d'âge moyen , Pandémies , Pneumopathie virale/complications , Pneumopathie virale/virologie , ARN viral/métabolisme , Réaction de polymérisation en chaine en temps réel , Rétine/virologie , SARS-CoV-2 , Indice de gravité de la maladie
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