RÉSUMÉ
BACKGROUND: Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis. OBJECTIVE: The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease. MATERIAL AND METHODS: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP. RESULTS: The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found. CONCLUSIONS: This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.
Sujet(s)
Tumeurs du sein/génétique , Carcinome canalaire du sein/génétique , Catechol O-methyltransferase/génétique , Cytochrome P-450 CYP1A1/génétique , Protéines tumorales/génétique , Polymorphisme de nucléotide simple , Adulte , Sujet âgé , Tumeurs du sein/enzymologie , Tumeurs du sein/épidémiologie , Carcinome canalaire du sein/enzymologie , Carcinome canalaire du sein/épidémiologie , Catechol O-methyltransferase/physiologie , Contraceptifs féminins/effets indésirables , Cytochrome P-450 CYP1A1/physiologie , Oestrogènes/métabolisme , Oestrogènes/usage thérapeutique , Femelle , Prédisposition génétique à une maladie , Génotype , Humains , Mexique/épidémiologie , Adulte d'âge moyen , Protéines tumorales/physiologie , Tumeurs hormonodépendantes/enzymologie , Tumeurs hormonodépendantes/épidémiologie , Tumeurs hormonodépendantes/génétique , Projets pilotes , Post-ménopause , Antécédents gynécologiques et obstétricaux , Risque , Fumer/épidémiologieRÉSUMÉ
The cytochrome P-450 1A1 (CYPA1A) gene plays an important role in the metabolization of estrogen and is therefore a candidate marker for fibroids. In a case-control study, we were unable to demonstrate any association between MSP I CYP1A1 polymorphism and the risk of leiomyoma in Brazilian women.