RÉSUMÉ
Diffuse toxic goiter (DTG) is an autoimmune disease caused by antibodies against thyroid-stimulating hormone (TSH) receptors. Combinations of DTG with other autoimmune diseases such as endocrine ophthalmopathy, pretibial myxedema and acropathy are often observed in clinical practice. Along with this pathology, the patient has hypodynamia and, as a result, the development of functional disorders of the musculoskeletal system. Aim - to analyze the comprehensive clinical observation of the diagnosis and treatment of DTZ with EOP of a child aged 15 years. Material and methods. Analysis of medical history data, comprehensive examination, including fixation of the physiological and dental status, supervision of patient K., 15 years old, who was on inpatient treatment in the children's department of the State Medical Institution "OKB No. 1" in Tyumen. Conclusion. This case report demonstrates symptoms of diffuse toxic goiter with ophthalmopathy that may manifest on only one side. It shows a decrease in functional parameters, manifestations in the dental system, due to a decrease in habitual motor activity, which corresponds to the clinical picture of manifestations of periodontal disease. In addition, it shows the possibility of relapse of the disease after clinical and laboratory remission during medication intake, what may be an indication for surgical treatment. Practitioners need to remember about this pathology and the need for its timely diagnosis, including specialists in related fields.
Sujet(s)
Ophtalmopathie basedowienne , Humains , Adolescent , Ophtalmopathie basedowienne/diagnostic , Femelle , Mâle , Goitre/traitement médicamenteux , Goitre/anatomopathologie , Goitre/diagnosticRÉSUMÉ
A gentleman in his 90s presented with a slowly enlarging goitre over 18 months, causing manifestations of superior vena cava obstruction, dysphagia and hoarseness of voice. Investigations were suggestive of a fibrosing thyroid pathology. Surgical management was avoided due to high surgical risk. Treatment included prednisolone and tamoxifen with palliative management in the event of further medical deterioration. This article illustrates the difficulties in diagnosing and managing fibrosing thyroid diseases.
Sujet(s)
Fibrose , Maladie de Hashimoto , Thyroïdite , Humains , Mâle , Maladie de Hashimoto/complications , Maladie de Hashimoto/diagnostic , Maladie de Hashimoto/traitement médicamenteux , Thyroïdite/complications , Thyroïdite/traitement médicamenteux , Thyroïdite/diagnostic , Sujet âgé de 80 ans ou plus , Prednisolone/usage thérapeutique , Tamoxifène/usage thérapeutique , Diagnostic différentiel , Goitre/complications , Goitre/diagnostic , Glande thyroide/anatomopathologieRÉSUMÉ
Acute airway obstruction is a life-threatening complication of benign goitre mostly occurring in cases of known progressing goitres. The index presentation of goitre with decompensated type two respiratory failure is an exceedingly rare and a diagnostically challenging presentation. We discuss the case of a woman in her 50 s, who had been diagnosed with asthma by her general practitioner, but during admission was found to have a large goitre with retrosternal extension causing critical tracheal compression. She presented with acute decompensated type two respiratory failure. We explore the diagnostic confounding posed by the patient's background of asthma and describe the initial management of the patient with non-invasive ventilation by the emergency department. The diagnosis of upper airway obstruction was not apparent which is an interesting anomaly in this case. She underwent an emergency hemithyroidectomy and recovered with a resolution of her respiratory symptoms. Histology confirmed benign multinodular hyperplasia.
Sujet(s)
Obstruction des voies aériennes , Asthme , Goitre , , Insuffisance respiratoire , Femelle , Humains , Obstruction des voies aériennes/chirurgie , Obstruction des voies aériennes/complications , Asthme/complications , Goitre/complications , Goitre/diagnostic , Goitre/chirurgie , /complications , Insuffisance respiratoire/complications , Thyroïdectomie/effets indésirables , Adulte d'âge moyenRÉSUMÉ
OBJECTIVES: Resistance to thyroid hormone (RTH) is a genetic condition, caused by mutations in the thyroid hormone receptor gene and characterized by impaired end organ responsiveness to thyroid hormone. Here we describe a novel case of THR associated with large goiter mimicking infiltrative c. CASE PRESENTATION: A 13-year-old male with a hyperthyroid phenotype of RTH diagnosed as a toddler, on methimazole and nadolol therapies presented with an increase in goiter size and possible nodule. Thyroid ultrasound was concerning for a diffuse infiltrative process or malignancy. Methimazole was discontinued and he underwent further imaging, fine needle aspiration and core biopsies. Biopsy results were reassuring and imaging findings were subsequently attributed to RTH rather than malignancy. He started every other day liothyronine therapy, which led to a decrease in goiter size, thyroglobulin level, and improvement of hyperthyroid symptoms. CONCLUSIONS: This is the first case to our knowledge describing the above thyroid imaging findings in association with RTH. It also adds important information to the pediatric literature regarding management of the hyperthyroid phenotype of RTH, including the role of liothyronine therapy.
Sujet(s)
Carcinomes , Goitre , Hyperthyroïdie , Syndrome de résistance aux hormones thyroïdiennes , Mâle , Humains , Enfant , Adolescent , Syndrome de résistance aux hormones thyroïdiennes/complications , Syndrome de résistance aux hormones thyroïdiennes/diagnostic , Syndrome de résistance aux hormones thyroïdiennes/génétique , Tri-iodothyronine , Thiamazol , Hormones thyroïdiennes , Goitre/diagnostic , Hyperthyroïdie/complications , Carcinomes/complicationsRÉSUMÉ
Congenital goitre is a deadly thyroid metabolic disorder characterised by low thyroid hormone levels, subsequent secretion of excess Thyroid-Stimulating Hormone (TSH) from the pituitary gland, and compensatory thyroid gland hyperplasia. This study aimed to summarise the clinical and pathological features of congenital goitre in a goat kid. In April 2019, a dead female goat kid with a history of dystocia was referred to Ferdowsi University of Mashhad Veterinary Teaching Hospital, Mashhad, Iran, to examine the carcass and find the reason for death. The necropsy were performed, along with histopathology examination, and clinical signs were recorded. Examination of the foetus revealed the presence of an enlarged thyroid gland, and the skin was thick with myxedema, pale, and without hair. After cutting the skin, the swelling showed a significantly enlarged thyroid gland with two asymmetrical lobes, with the right lobe 3.9×7.1 cm and the left 3.7×7.5 cm in size. In the histopathological examination, a severe proliferation of follicular cells was observed, which caused the thyroid gland to be microscopically dense. In conclusion, this study highlights the importance of recognising and addressing congenital goitre in goat kids. To prevent such tragic outcomes, it is crucial to focus on early detection and intervention. Furthermore, the agents of goitre need to find out and be clear.
Sujet(s)
Maladies des chèvres , Goitre , Femelle , Animaux , Capra , Hôpitaux vétérinaires , Hôpitaux d'enseignement , Goitre/diagnostic , Goitre/médecine vétérinaire , Goitre/étiologie , Maladies des chèvres/diagnosticRÉSUMÉ
Thyroid gland is an endocrine gland playing a major role in energy and phosphocalcic metabolism, among others. It commonly occurs in the anterior cervical and pretracheal region. Ectopic thyroid is quite rare. It is dominated by ectopic basilingual thyroid. We here report the case of a patient with goiter in normal cervical position (eutopic) and ectopic thyroid tissue in basicervical position. Cervicotomy revealed the ectopic nodule and the diagnosis was confirmed by histology. This clinical case illustrates a differential diagnosis of cervical masses.
Sujet(s)
Goitre , Dysgénésie thyroïdienne , Humains , Cou , Goitre/diagnostic , Goitre/chirurgie , Dysgénésie thyroïdienne/diagnostic , Dysgénésie thyroïdienne/chirurgie , Diagnostic différentielRÉSUMÉ
OBJECTIVE: The goal of this study was to look at the patterns of thyroid tumors and how thyroid cancer markers showed up in immunohistochemistry in Northern Saudi Arabia. PATIENTS AND METHODS: This study investigated retrospectively 190 patients who attended with thyroid complaints. About 140 thyroid biopsies were diagnosed in the Department of Pathology at King Salman Hospital, Ha'il, from November 2019 to November 2020. RESULTS: Out of the 190 patients who attended with thyroid complaints, 140/190 (73.7%) were detected with thyroid lesions (58 malignant and 82 benign). Benign lesions included goiter 49/82 (60%), follicular adenoma 17/82 (21%), Hashimoto's thyroiditis 13/82 (16%), and toxic goiter 3/82 (3%). 5/6 (83.3%) of males with benign lesions had goiters. CK19 was positive in 68.5% of the cases; 71.8% were papillary, 66.7% were follicular, and 100% were undifferentiated carcinomas. Out of the 26/54 (48%) CD56-positive cases, 18/39 (46%) were papillary, 7/12 (58.3%) were follicular, and 3/3 (100%) were undifferentiated carcinomas. Out of the 35/54 (64.8%) Galectin-3-positive cases, 69.2% were papillary, 7/12 (58.3%) were follicular, and 3/3 (100%) were undifferentiated carcinomas. CONCLUSIONS: Thyroid cancer is prevalent in northern Saudi Arabia, with the predominant type being papillary thyroid carcinoma. Most patients are female and younger. The combined use of CK19, CD56, and Galectin-3 tumor markers assists in the accurate differential diagnosis of thyroid neoplasms.
Sujet(s)
Carcinome papillaire , Carcinomes , Goitre , Tumeurs de la thyroïde , Mâle , Humains , Femelle , Galectine -3 , Marqueurs biologiques tumoraux , Études rétrospectives , Arabie saoudite/épidémiologie , Carcinome papillaire/anatomopathologie , Kératine-19 , Tumeurs de la thyroïde/diagnostic , Tumeurs de la thyroïde/épidémiologie , Tumeurs de la thyroïde/anatomopathologie , Goitre/diagnostic , Diagnostic différentielRÉSUMÉ
Introduction: literature on Hashimoto´s thyroiditis, the common thyroid illness in the young populations, in Sudan and Africa is scarce. We aimed to study its clinical profile and outcome among Sudanese children and adolescents. Methods: records of 73 patients were reviewed. Data related to demographics, presenting features, family history and coexistence of autoimmune diseases, physical examination findings, and biochemical progression over time were obtained. Results: patients´ mean age at the diagnosis was 10.6 ± 2.9 years, 80.8% (n = 59) of them were female and 83.6% (n = 61) were residing in iodine-sufficient areas. The commonest presenting features were thyromegaly and fatigability (79.5%, n = 58 and 43.8%, n = 32, respectively) after an illness duration of 0.5-48 months. Autoimmune comorbidities were documented in 8.2% (n = 6) of our series and more than half (53.4%, n = 39) of them were pre-pubertal at the diagnosis. Sixty point three percent (60.3%) (n = 44), 20.5% (n = 15), 13.7% (n = 10) and 5.5% (n = 4) of patients presented with overt hypothyroidism, sub-clinical hypothyroidism, euthyroidism and hyperthyroidism respectively, and there were no significant differences in the clinical profile between them. In patients' continued follow-up, 94.1% (n = 32/34) of those presented with overt hypothyroidism required levothyroxine therapy to maintain euthyroidism for 0.5-13 years, while 85.7% (n = 6/7) of those with euthyroidism remained so for 0.5-6 years. Remission was reported in all hyperthyroid patients and in only 5.9% (n = 2/34) of those with overt hypothyroidism at diagnosis. The majority of our patients with subclinical hypothyroidism were treated with levothyroxine and continued to be euthyroid for 10 months to 13 years. Conclusion: goiter was the commonest presenting feature of Hashimoto´s thyroiditis. The majority of patients had overt or subclinical hypothyroidism and almost all of them required long-term levothyroxine therapy.
Sujet(s)
Goitre , Maladie de Hashimoto , Hyperthyroïdie , Hypothyroïdie , Adolescent , Humains , Enfant , Femelle , Mâle , Études transversales , Thyroxine , Maladie de Hashimoto/diagnostic , Maladie de Hashimoto/traitement médicamenteux , Maladie de Hashimoto/épidémiologie , Hypothyroïdie/diagnostic , Hypothyroïdie/traitement médicamenteux , Hypothyroïdie/épidémiologie , Goitre/diagnostic , Soudan/épidémiologieRÉSUMÉ
Patients with insulin resistance (IR) have a higher thyroid volume therefore the aim of our study is to examine the correlation between IR and thyroid volume in the residents of Georgia. METHODS: 413 patients with a mean age of 37.3 ± and 11.4 years were included in this study. Out of those, 120 were males, and 293 were females who were studied retrospectively. They had hyperinsulinemia and were referred to the clinic from 2017 to 2019. The factors studied were age, sex, body mass index (BMI), clinical signs, thyroid ultrasound, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipids, fasting insulin, fasting glucose, thyroid stimulating hormone (TSH), Free thyroxine (FT4), and Zinc (Zn). RESULTS: IR was detected in 252 individuals. The frequency of men with insulin resistance was significantly higher than in the control group - 72.50%, and 56.31%, respectively (F = 9.55, p= 0.0021). Mean thyroid volume in the patients with IR was significantly higher compared to the controls 20.52 + 6.39 cm3 and 15.25 + 6.55 cm3, respectively (p < 0.001). Hyperinsulinemia had a significant positive correlation with Goiter r = 0.445, p < 0.0001. The associated factors for hyperinsulinemia are: Goiter (1) - OR = 5.12 (95% CI:3.02-8.69); Cholesterol - OR = OR = 3.31 (95% CI: 1.54-7.14); Triglycerides - OR = 3.23 (95% CI:1.02-10.28); Obesity (1)- OR = 3.94 (95% CI: 2.23-6.98); Thyroid structural changes (1) - OR = 2.01 (95% CI: 1.12-3.60); ALT/AST-OR = 4.53 (95% CI: 2.33-8.80); Zn decreased Odds Ratio hyperinsulinemia - OR = 0.95 (95% CI: 0.94-0.97). CONCLUSION: Hyperinsulinemia is the most common cause of diffuse goiter and the heterogeneous structure of the thyroid. The volume of the thyroid gland shows a significant positive association with the characteristics of metabolic syndrome and increased thyroid volume predictors of metabolic syndrome.
Sujet(s)
Goitre , Hyperinsulinisme , Insulinorésistance , Syndrome métabolique X , Mâle , Femelle , Humains , Adulte , Adulte d'âge moyen , Syndrome métabolique X/étiologie , Études rétrospectives , Géorgie , Hyperinsulinisme/diagnostic , Hyperinsulinisme/épidémiologie , Goitre/diagnostic , Goitre/épidémiologieRÉSUMÉ
Systemic amyloidosis is a rare but potentially lethal disease characterized by amyloid accumulation in all organs. Amyloid goiter is an extremely rare pathological lesion characterized by thyroid gland enlargement with fat deposition due to local or systemic amyloidosis. A 60 s woman with rheumatoid arthritis was found unconscious on her bed and declared dead after failed cardiopulmonary resuscitation. Postmortem computed tomography showed severe enlargement of the heart and thyroid glands, suggestive of cardiac hypertrophy and thyroidism. Histological examination revealed amorphous eosinophilic deposits with parenchymal cell destruction in all organs, including the heart and thyroid gland. Abnormal amorphous deposits in the tissues were positive for amyloid A as noted upon Congo red immunohistochemical staining and birefringence microscopy, confirming systemic amyloidosis with amyloid goiter. Serum biochemical analysis revealed increased levels of C-reactive protein; anti-cyclic citrullinated peptide antibody; creatinine kinase-myoglobin binding and N-terminal pro-brain natriuretic peptide; and thyroglobulin, free triiodothyronine, and free thyroxine, indicating systemic inflammation, active rheumatoid arthritis, heart failure, and destructive hyperthyroidism, respectively. These findings suggested that the cause of death was undiagnosed heart failure due to secondary systemic amyloid A (AA) amyloidosis related to rheumatoid arthritis. In addition, destructive hyperthyroidism caused by systemic AA amyloidosis may have also been one of the causes of death as indicated by cardiac overload. To the best of our knowledge, this is the first forensic autopsy report of cardiac amyloidosis with amyloid goiter. In conclusion, this autopsy report highlights the importance of increased awareness and early intervention for severe but treatable complications of systemic amyloidosis.
Sujet(s)
Amyloïdose , Goitre , Défaillance cardiaque , Hyperthyroïdie , Humains , Femelle , Autopsie , Amyloïdose/diagnostic , Goitre/complications , Goitre/diagnostic , Goitre/anatomopathologie , Amyloïde/métabolisme , Hyperthyroïdie/complicationsRÉSUMÉ
BACKGROUND Amyloid deposition in the thyroid gland can be primary or secondary and can result in goiter. There have been previous reports of amyloid goiter and thyroid lipomatosis or fatty infiltration. Papillary thyroid carcinoma is the most common thyroid malignancy. We report a rare case of a 54-year-old woman with papillary thyroid carcinoma associated with secondary amyloid goiter and thyroid lipomatosis. CASE REPORT A 54-year-old woman with chronic pyelonephritis and bronchiectasis presented with compressive symptoms due to an enlarged thyroid gland. Thyroid function test results were in the normal range and serum thyroid autoantibodies and serum calcitonin levels were undetectable. Cervical ultrasound showed a diffusely swollen thyroid and a well-defined nodule in the right lobe, of which fine-needle aspiration cytology was suspicious for follicular neoplasm. Computed tomography showed an enlarged thyroid with low attenuation, suggestive of diffuse lipomatosis of the gland. Total thyroidectomy was performed, and a histopathology study indicated the presence of papillary carcinoma and diffuse lipomatosis of the thyroid gland with amyloid deposition. The patient was later diagnosed with secondary amyloidosis. CONCLUSIONS The presentation of secondary amyloidosis as a diffuse goiter with extensive fatty infiltration must be considered in the differential diagnosis of thyroid enlargement, especially those with rapid onset, and particularly in patients with a history of chronic inflammatory disorders or chronic infections predisposing to amyloid deposition. Rarely, differentiated thyroid carcinoma is found within an amyloid goiter and it must be excluded in the differential diagnosis.
Sujet(s)
Amyloïdose , Goitre , Lipomatose , Tumeurs de la thyroïde , Femelle , Humains , Adulte d'âge moyen , Cancer papillaire de la thyroïde/complications , Goitre/complications , Goitre/diagnostic , Amyloïdose/complications , Amyloïdose/diagnostic , Lipomatose/complications , Lipomatose/diagnostic , Thyroïdectomie/effets indésirables , Tumeurs de la thyroïde/complications , Tumeurs de la thyroïde/diagnostic , Tumeurs de la thyroïde/anatomopathologieRÉSUMÉ
Amyloid goitre is an infrequent benign entity characterized by a rapid increase in the size of the thyroid gland due to amyloid deposit in the parenchyma. Such an increase in size, which takes place over only a few months, can cause symptoms such as dyspnea, dysphagia and dysphonia. We present three cases diagnosed in the same centre and estimated its incidence. All cases showed similar morphology, with varying proportions of thyroid follicles, mature adipose tissue and amyloid. AA Amyloid accumulation was verified and associated to previous pathologies (Crohn's disease, juvenile rheumatoid arthritis and chronic renal disease). One case showed a papillary microcarcinoma. Amyloid goitre is an infrequent entity which should be considered in the differential diagnosis of all patients with goitre, especially those with chronic underlying diseases.
Sujet(s)
Amyloïdose , Carcinome papillaire , Goitre , Tumeurs de la thyroïde , Amyloïdose/complications , Amyloïdose/diagnostic , Amyloïdose/anatomopathologie , Goitre/complications , Goitre/diagnostic , Humains , Tumeurs de la thyroïde/diagnosticRÉSUMÉ
Introducción: Las enfermedades tiroideas son relativamente frecuentes que puede tener carácter benigno o maligno. El algoritmo para el diagnóstico de los nódulos tiroideos se dirige principalmente a definir la presencia o no de un carcinoma de la glándula. El tratamiento quirúrgico puede incluir técnicas convencionales, parciales y totales, y mínimamente invasivas. Objetivo: Describir los resultados del tratamiento quirúrgico de las enfermedades tiroideas en el Hospital General Docente "Enrique Cabrera" entre enero 2013 y diciembre de 2020. Métodos: Se realizó un estudio descriptivo ambispectivo, en el mencionado centro, entre el 1ro de enero de 2013 hasta el 31 de diciembre de 2020. El universo se conformó por todos los pacientes con enfermedades de tiroides que fueron tratados quirúrgicamente. La muestra quedó constituida por 96 pacientes. Resultados: La edad media fue 48,1 años. Predominó el sexo femenino (83,3 por ciento). El diagnóstico más frecuente fue el bocio con síntomas compresivos (39,6 por ciento), seguido del carcinoma tiroideo (25 por ciento), en este último el más observado fue el carcinoma papilar (66,6 por ciento). Se realizó tiroidectomía total en 40,6 por ciento, con pocas complicaciones posoperatorias (7,3 por ciento), siendo la parálisis recurrencial la más frecuente de ellas. Conclusiones: El tratamiento quirúrgico de las enfermedades tiroideas en el Hospital General Docente "Dr. Enrique Cabrera" tuvo buenos resultados, tanto en enfermedades benignas como en el cáncer tiroideo(AU)
Introduction: Thyroid diseases are relatively frequent and can be benign or malignant. The algorithm for the diagnosis of thyroid nodules is mainly aimed at defining the presence or absence of a carcinoma in the gland. Surgical treatment can include conventional, partial or total, as well as minimally invasive, techniques. Objective: To describe the outcomes of surgical treatment for thyroid diseases at Enrique Cabrera General Teaching Hospital between 2013 and 2020. Methods: An ambispective and descriptive study was carried out, between January 1, 2013 and December 31, 2020, in the aforementioned center. The universe was made up of all patients with thyroid diseases treated surgically. The sample consisted of 96 patients. Results: The mean age was 48.1 years. The female sex predominated (83.3 percent). The most frequent diagnosis was goiter with compressive symptoms (39.6 percent), followed by thyroid carcinoma (25 percent); among the latter, the most observed was papillary carcinoma (66.6 percent). Total thyroidectomy was performed in 40.6 percent, with few postoperative complications (7.3 percent), recurrent paralysis being the most frequent of them. Conclusions: The surgical treatment for thyroid diseases at Dr. Enrique Cabrera General Teaching Hospital had good outcomes, both in benign diseases and in thyroid cancer(AU)
Sujet(s)
Humains , Femelle , Adulte d'âge moyen , Maladies de la thyroïde/chirurgie , Thyroïdectomie/méthodes , Tumeurs de la thyroïde/diagnostic , Épidémiologie Descriptive , Goitre/diagnosticRÉSUMÉ
The prevalence of asthma is high, but 'all that wheezes is not asthma'. We present the case of a 38-year-old pregnant woman who had acute severe ventilatory failure initially thought to be an exacerbation of asthma. This delayed the actual diagnosis of haemorrhagic enlargement of a goitre complicated by pre-eclampsia. We also perform a literature review of previous publications. This case highlights the goitrogenic effects of pregnancy and the associated risks of respiratory compromise.
Sujet(s)
Asphyxie/complications , Asthme/diagnostic , Goitre/complications , Complications de la grossesse/diagnostic , Adulte , Asphyxie/étiologie , Asthme/complications , Diagnostic différentiel , Femelle , Goitre/diagnostic , Humains , GrossesseRÉSUMÉ
Dyshormonogenetic goiter is a rare cause for congenital hypothyroidism because of the lack of enzymes needed for the synthesis of thyroid hormones. They are usually treated with hormonal treatment. Cytomorphological features can lead to misdiagnosis of malignancy. Elaboration on the cytomorphological features of dyshormonogenetic goiter is scarce, with only four case reports in the literature. We present a case of a child with dyshormonogenetic goiter, highlighting its cytological features, and common differential diagnosis. We also compared cytomorphologic features with other cases reported in the literature.
Sujet(s)
Carcinome papillaire/anatomopathologie , Hypothyroïdie congénitale/anatomopathologie , Goitre/anatomopathologie , Tumeurs de la thyroïde/anatomopathologie , Enfant , Hypothyroïdie congénitale/diagnostic , Hypothyroïdie congénitale/chirurgie , Diagnostic différentiel , Goitre/diagnostic , Goitre/chirurgie , Humains , Glande thyroide/anatomopathologie , Tumeurs de la thyroïde/diagnostic , Thyroïdectomie/méthodesSujet(s)
Goitre nodulaire/complications , Goitre nodulaire/diagnostic , Surdité neurosensorielle/complications , Surdité neurosensorielle/diagnostic , Glande thyroide/anatomopathologie , Diabète de type 1/complications , Diabète de type 1/diagnostic , Diabète de type 1/génétique , Femelle , Goitre/diagnostic , Goitre/génétique , Goitre/anatomopathologie , Goitre nodulaire/génétique , Goitre nodulaire/anatomopathologie , Surdité neurosensorielle/génétique , Surdité neurosensorielle/anatomopathologie , Humains , Hyperplasie/complications , Hyperplasie/diagnostic , Hyperplasie/génétique , Mutation faux-sens , Transporteurs de sulfate/génétique , Jeune adulteRÉSUMÉ
INTRODUCTION: the aim of this retrospective study is to review patients with malignant goiter, as regards their nature, demographic characterization, clinical presentation and preoperative histopathological data. METHODS: the study focused on a period of 4 years from December 2015 to January 2019. Patients´ demographic data, clinical presentation, Intra-operative findings, Pre and postoperative histopathological staging and grading were all recorded. Postoperative follow up whether early or late were also included. RESULTS: a total of 100% (n = 65) patients underwent surgery. The female to male ratio was found to be 5:1 (48 females and 17 males). Solitary nodule was the main clinical presentation in 80% (n = 52) of cases while 20% (n = 13) were multinodular swellings. Papillary carcinoma was recorded in 80% (n = 52) of patients while in 15.4% (n =10) of patients were having follicular carcinoma. The remaining 4.6% (n = 3) suffered of lymphoma; no medullary or anaplastic tumors were reported. CONCLUSION: thyroid cancer is the most commonly encountered endocrinal malignancy at our institute. Fine Needle Aspiration Cytology (FNAC) showed a high percentage of reliability in diagnosing thyroid cancer among our series. It is recommended to adapt this technique in initial screening of goiter patients in our local setting.