Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 20 de 1.451
Filtrer
1.
PLoS One ; 19(7): e0306606, 2024.
Article de Anglais | MEDLINE | ID: mdl-39024224

RÉSUMÉ

BACKGROUND: We previously developed a prediction score for MRI-quantified abdominal visceral adipose tissue (VAT) based on concurrent measurements of height, body mass index (BMI), and nine blood biomarkers, for optimal performance in five racial/ethnic groups. Here we evaluated the VAT score for prediction of future VAT and examined if enhancement with additional biomarkers, lifestyle behavior information, and medical history improves the prediction. METHODS: We examined 500 participants from the Multiethnic Cohort (MEC) with detailed data (age 50-66) collected 10 years prior to their MRI assessment of VAT. We generated three forecasted VAT prediction models: first by applying the original VAT equation to the past data on the predictors ("original"), second by refitting the past data on anthropometry and biomarkers ("refit"), and third by building a new prediction model based on the past data enhanced with lifestyle and medical history ("enhanced"). We compared the forecasted prediction scores to future VAT using the coefficient of determination (R2). In independent nested case-control data in MEC, we applied the concurrent and forecasted VAT models to assess association of the scores with subsequent incident breast cancer (950 pairs) and colorectal cancer (831 pairs). RESULTS: Compared to the VAT prediction by the concurrent VAT score (R2 = 0.70 in men, 0.68 in women), the forecasted original VAT score (R2 = 0.54, 0.48) performed better than past anthropometry alone (R2 = 0.47, 0.40) or two published scores (VAI, METS-VF). The forecasted refit (R2 = 0.61, 0.51) and enhanced (R2 = 0.62, 0.55) VAT scores each showed slight improvements. Similar to the concurrent VAT score, the forecasted VAT scores were associated with breast cancer, but not colorectal cancer. Both the refit score (adjusted OR for tertile 3 vs. 1 = 1.27; 95% CI: 1.00-1.62) and enhanced score (1.27; 0.99-1.62) were associated with breast cancer independently of BMI. CONCLUSIONS: Predicted VAT from midlife data can be used as a surrogate to assess the effect of VAT on incident diseases associated with obesity, as illustrated for postmenopausal breast cancer.


Sujet(s)
Adiposité , Graisse intra-abdominale , Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Indice de masse corporelle , Études cas-témoins , Études de cohortes , Ethnies , Graisse intra-abdominale/imagerie diagnostique , Imagerie par résonance magnétique , Tumeurs/imagerie diagnostique ,
2.
Front Endocrinol (Lausanne) ; 15: 1434333, 2024.
Article de Anglais | MEDLINE | ID: mdl-39040678

RÉSUMÉ

Objective: Perirenal adipose tissue (PAT) has emerged as a potential therapeutic target for cardiovascular disease (CVD). However, the relationship between increased perirenal fat thickness (PrFT) and CVD risks in individuals with type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to evaluate the association between PrFT and the estimated 10-year risk of CVD and atherosclerotic cardiovascular disease (ASCVD) in T2DM. Method: The final analysis included 704 participants. PrFT was quantified using non-enhanced computed tomography scans, while the estimated 10-year CVD and ASCVD risk assessments were based on the Framingham and China-PAR equation risk scores, respectively. Multiple regression analysis was employed to analyze the correlation between PrFT and these risk scores. Results: Higher quartiles of PrFT displayed elevated Framingham and China-PAR equation risk scores (P<0.001). After adjusting for cardiometabolic risk factors and visceral fat area, PrFT remained significantly correlated with Framingham equation risk scores in men (ß=0.098, P=0.036) and women (ß=0.099, P=0.032). Similar correlations were observed between PrFT and China-PAR equation risk scores in men (ß=0.106, P=0.009) and women (ß=0.108, P=0.007). Moreover, PrFT emerged as an independent variable associated with a high estimated 10-year risk of CVD and ASCVD, with odds ratios (ORs) of 1.14 (95% CI: 1.04-1.25, P=0.016) in men and 1.20 (95% CI: 1.11-1.31, P<0.001) in women for high estimated CVD risk, and ORs of 1.22 (95% CI: 1.08-1.41, P=0.009) in men and 1.34 (95% CI: 1.12-1.60, P<0.001) in women for high estimated 10-year ASCVD risk. Furthermore, restricted cubic spline analyses confirmed a nonlinear relationship between PrFT and high estimated CVD and ASCVD risk in both genders (P for nonlinearity and overall < 0.05). Conclusions: PrFT contributed as an independent variable to the estimated 10-year risk of CVD and ASCVD in T2DM.


Sujet(s)
Athérosclérose , Maladies cardiovasculaires , Diabète de type 2 , Humains , Diabète de type 2/complications , Diabète de type 2/épidémiologie , Mâle , Femelle , Adulte d'âge moyen , Maladies cardiovasculaires/épidémiologie , Maladies cardiovasculaires/étiologie , Athérosclérose/épidémiologie , Athérosclérose/imagerie diagnostique , Facteurs de risque , Tissu adipeux/imagerie diagnostique , Tissu adipeux/anatomopathologie , Sujet âgé , Graisse intra-abdominale/imagerie diagnostique , Graisse intra-abdominale/anatomopathologie , Chine/épidémiologie , Adulte , Rein/anatomopathologie , Rein/imagerie diagnostique , Appréciation des risques , Tomodensitométrie
3.
BMJ Open ; 14(7): e082095, 2024 Jul 23.
Article de Anglais | MEDLINE | ID: mdl-39043597

RÉSUMÉ

OBJECTIVES: To assess the prevalence of metabolic syndrome (MS) and association of central obesity measures such as body mass index (BMI), visceral fat adiposity (VFA) and superficial fat adiposity (SFA) with MS, diabetes (DM) and hypertension (HTN). DESIGN: Cross-sectional study design. SETTING: Tertiary care hospital in Pakistan. PARTICIPANTS: 165 participants. There were 124 male participants and 41 female participants of Pakistani population. All participants above 18 years, who had unenhanced CT abdomen examination and relevant blood workup, were included. Patients with a known clinical history of coronary artery disease, HTN and DM as well as pregnant patients were excluded. INTERVENTIONS: VFA and SFA were estimated, at the level of the umbilicus. Data of BMI, MS, DM and HTN were extracted from patient files. Data for MS, DM and HTN were recorded as binary variables. OUTCOME MEASURES: The primary outcome measures were the prevalence of MS and the association of MS, DM and HTN with gender, VFA, SFA and BMI. P value of <0.05 was taken as significant with CI of 95%. RESULTS: The prevalence of MS was 29.7%. There was a significant association of MS, DM and HTN with VFA, SFA and BMI. In gender-based analysis 48.7% of the female participants had MS. In subset analysis, 47% of male subjects in the third tertile of VFA revealed significant association with MS (p value <0.05) while only 32.7% of subjects in the obesity category of BMI had MS. SFA revealed a significant association with DM only (p value <0.5). CONCLUSION: In conclusion, VFA shows a significant association with MS, DM and HTN. Considering these results, further studies with a larger sample size are warranted to generate gender-based cut-offs for VFA for obesity screening purposes.


Sujet(s)
Adiposité , Indice de masse corporelle , Hypertension artérielle , Syndrome métabolique X , Obésité abdominale , Centres de soins tertiaires , Humains , Femelle , Mâle , Pakistan/épidémiologie , Syndrome métabolique X/épidémiologie , Études transversales , Adulte , Prévalence , Adulte d'âge moyen , Hypertension artérielle/épidémiologie , Obésité abdominale/épidémiologie , Obésité abdominale/complications , Obésité abdominale/imagerie diagnostique , Tomodensitométrie/méthodes , Graisse intra-abdominale/imagerie diagnostique , Diabète/épidémiologie
4.
Int J Mol Sci ; 25(13)2024 Jul 08.
Article de Anglais | MEDLINE | ID: mdl-39000586

RÉSUMÉ

Visceral adipose tissue (VAT) dysfunction has been recently recognized as a potential contributor to the development of Alzheimer's disease (AD). This study aimed to explore the relationship between VAT metabolism and cerebral glucose metabolism in patients with cognitive impairment. This cross-sectional prospective study included 54 patients who underwent 18F-fluorodeoxyglucose (18F-FDG) brain and torso positron emission tomography/computed tomography (PET/CT), and neuropsychological evaluations. VAT metabolism was measured by 18F-FDG torso PET/CT, and cerebral glucose metabolism was measured using 18F-FDG brain PET/CT. A voxel-based analysis revealed that the high-VAT-metabolism group exhibited a significantly lower cerebral glucose metabolism in AD-signature regions such as the parietal and temporal cortices. In the volume-of-interest analysis, multiple linear regression analyses with adjustment for age, sex, and white matter hyperintensity volume revealed that VAT metabolism was negatively associated with cerebral glucose metabolism in AD-signature regions. In addition, higher VAT metabolism was correlated with poorer outcomes on cognitive assessments, including the Korean Boston Naming Test, Rey Complex Figure Test immediate recall, and the Controlled Oral Word Association Test. In conclusion, our study revealed significant relationships among VAT metabolism, cerebral glucose metabolism, and cognitive function. This suggests that VAT dysfunction actively contributes to the neurodegenerative processes characteristic of AD, making VAT dysfunction targeting a novel AD therapy approach.


Sujet(s)
Encéphale , Dysfonctionnement cognitif , Fluorodésoxyglucose F18 , Glucose , Graisse intra-abdominale , Tomographie par émission de positons couplée à la tomodensitométrie , Humains , Mâle , Femelle , Graisse intra-abdominale/métabolisme , Graisse intra-abdominale/imagerie diagnostique , Glucose/métabolisme , Sujet âgé , Dysfonctionnement cognitif/métabolisme , Dysfonctionnement cognitif/imagerie diagnostique , Fluorodésoxyglucose F18/métabolisme , Études transversales , Encéphale/métabolisme , Encéphale/imagerie diagnostique , Adulte d'âge moyen , Études prospectives , Maladie d'Alzheimer/métabolisme , Maladie d'Alzheimer/imagerie diagnostique , Tests neuropsychologiques
6.
Anticancer Res ; 44(8): 3515-3524, 2024 Aug.
Article de Anglais | MEDLINE | ID: mdl-39060072

RÉSUMÉ

BACKGROUND/AIM: The sex-specific effect of the visceral-to-subcutaneous fat ratio (VSR) before gastrectomy on postoperative survival in patients with gastric cancer (GC) remains unclear. This study measured the preoperative VSR in patients with GC and analyzed its relationship with 5-year overall survival (OS) and relapse-free survival (RFS) by sex. PATIENTS AND METHODS: This prospective study included 540 patients with GC undergoing gastrectomy. Preoperative visceral and subcutaneous fat volumes were measured using computed tomography, and the VSR was calculated. A cutoff value for the VSR was established using 5-year survival data, and its association with survival was analyzed using the Kaplan-Meier method, log-rank tests, and multivariate regression analysis. RESULTS: Among the 459 patients analyzed (300 males and 159 females), OS and RFS were significantly lower in the low-VSR group than in the high-VSR group in males (OS: 76.2% vs. 88.1%, p=0.01; RFS: 74.6% vs. 86.0%, p=0.02). In females, no difference in OS was observed between the groups, whereas the high-VSR group had significantly lower RFS than that of the low-VSR group (RFS: 74.7% vs. 88.9%, p=0.01). Multivariate analysis showed that a low VSR was an independent poor predictor of OS in males and a high VSR was an independent poor predictor of RFS in females. CONCLUSION: In patients with GC, the sex-dependent preoperative VSR was a potentially useful predictor of postoperative survival.


Sujet(s)
Gastrectomie , Graisse intra-abdominale , Tumeurs de l'estomac , Graisse sous-cutanée , Humains , Tumeurs de l'estomac/chirurgie , Tumeurs de l'estomac/mortalité , Tumeurs de l'estomac/anatomopathologie , Tumeurs de l'estomac/imagerie diagnostique , Mâle , Femelle , Graisse sous-cutanée/imagerie diagnostique , Graisse sous-cutanée/anatomopathologie , Graisse intra-abdominale/imagerie diagnostique , Graisse intra-abdominale/anatomopathologie , Adulte d'âge moyen , Sujet âgé , Gastrectomie/mortalité , Études prospectives , Facteurs sexuels , Pronostic , Période préopératoire , Adulte , Période postopératoire , Sujet âgé de 80 ans ou plus , Estimation de Kaplan-Meier , Tomodensitométrie
7.
Cancer Med ; 13(13): e7452, 2024 Jul.
Article de Anglais | MEDLINE | ID: mdl-38953401

RÉSUMÉ

BACKGROUND: Sarcopenic obesity (SO) in patients with gastrointestinal cancer is associated with a poor prognosis. We aimed to investigate the prognostic impact of SO in patients with gastrointestinal cancer, as well as the diagnostic cut-off value of SO in patients with gastrointestinal cancer among Chinese population. METHODS: We conducted a consecutive cohort study. Between January 2017 and January 2019, 289 patients diagnosed with gastrointestinal cancer were included in our study. Skeletal muscle area, total fat area, and subcutaneous fat area were measured by CT scan. All patients were followed up for 5 years. Receiver operating characteristic curves (ROC) were adopted to determine the cut-off values of visceral fat obesity for the prediction of sarcopenia. Based on the cut-off values, patients with sarcopenia combined with visceral fat obesity were divided into the SO group, and the others were divided into the non-sarcopenic obesity (NSO) group. Kaplan-Meier curves and univariate and multivariate Cox proportional hazard models were employed to explore the associations of body composition profiles with 5-year overall survival and disease-specific survival. RESULTS: Obtained from Youden's Index for ROC for the prediction of 5-year survival, skeletal muscle mass index (SMI) ≤40.02 cm2/m2 with VFA ≥ 126.30 cm2 in men and SMI ≤32.05 cm2/m2 with VFA ≥72.42 cm2 in women indicate a risk of poor prognosis in patients diagnosed with gastrointestinal cancer. Patients with SO had poorer 5-year overall survival (OS) than patients with NSO (6.74% vs. 82.84%, p < 0.001), and poorer 5-year DFS (6.74% vs. 81.82%, p < 0.001). In multivariate analysis, we found that the long-term mortality risk was approximately 13-fold higher among patients in the SO group compared to those with no conditions. CONCLUSIONS: Preoperative assessment of SO is useful not only for monitoring nutritional status but also for predicting 5-year OS in gastrointestinal cancer patients.


Sujet(s)
Tumeurs gastro-intestinales , Obésité , Sarcopénie , Humains , Sarcopénie/imagerie diagnostique , Mâle , Femelle , Tumeurs gastro-intestinales/mortalité , Tumeurs gastro-intestinales/complications , Tumeurs gastro-intestinales/anatomopathologie , Pronostic , Adulte d'âge moyen , Obésité/complications , Sujet âgé , Composition corporelle , Courbe ROC , Muscles squelettiques/imagerie diagnostique , Muscles squelettiques/physiopathologie , Muscles squelettiques/anatomopathologie , Estimation de Kaplan-Meier , Graisse intra-abdominale/imagerie diagnostique , Graisse intra-abdominale/physiopathologie
8.
Clin Nutr ESPEN ; 62: 192-198, 2024 Aug.
Article de Anglais | MEDLINE | ID: mdl-38901941

RÉSUMÉ

BACKGROUND & AIMS: The characterization and prognostic value of body composition parameter/phenotype based on computed tomography (CT) in patients with digestive tract cancers remain incomplete. This study aimed to investigate the relationship between parameter/phenotype and clinical outcomes in patients with digestive tract cancers. METHODS: In this prospective cohort study, 8267 patients with digestive tract cancers were assessed using CT scans to determine body composition. Body composition data, including areas of skeletal muscle (SM), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT), were collected at the third lumbar level on CT images obtained within 30 days before surgery. Body composition phenotypes (sarcopenia, cancer cachexia, sarcopenic obesity) were determined based on SM, SAT, and VAT areas. The primary endpoint was overall survival, obtained from electronic medical records and telephone follow-up surveys. Kaplan-Meier and log-rank analyses were employed to compare unadjusted survival, while multivariate survival analyses were conducted using a proportional hazards model adjusted for age, gender, and cancer-node-metastasis (TNM) stages. RESULTS: Adjusted hazard ratios (HRs) for all-cause mortality were calculated for the second (Q2), third (Q3), and fourth (Q4) quantiles relative to the first quantile (Q1) for SM areas, revealing adjusted summary HRs of 0.575 (95% CI, 0.361-0.916), 0.419 (95% CI, 0.241-0.729), and 0.384 (95% CI, 0.203-0.726), respectively. Sarcopenia-adjusted summary HRs were 1.795 (95% CI: 1.012-3.181) for male patients and 1.925 (95% CI: 1.065-3.478) for female patients. Cancer cachexia-adjusted summary HRs were 1.542 (95% CI: 1.023-2.324) for male patients and 1.569 (95% CI: 0.820-3.001) for female patients. Sarcopenic obesity-adjusted summary HRs were 1.122 (95% CI: 0.759-1.657) for male patients and 1.303 (95% CI: 0.623-2.725) for female patients. Subgroup analyses indicated varying prognostic values of body composition parameter/phenotype among different cancer types. CONCLUSIONS: Our findings suggest a large SM area is a favorable prognostic indicator, while cancer cachexia and sarcopenia signify poor prognosis in patients with digestive tract cancers. These findings have important implications for the personalized preoperative assessment of body composition in patients with digestive tract cancers.


Sujet(s)
Composition corporelle , Sarcopénie , Humains , Mâle , Femelle , Études prospectives , Adulte d'âge moyen , Pronostic , Chine , Sujet âgé , Muscles squelettiques , Cachexie , Obésité/complications , Adulte , Tomodensitométrie , Graisse intra-abdominale/imagerie diagnostique , Modèles des risques proportionnels , Estimation de Kaplan-Meier
9.
J Dtsch Dermatol Ges ; 22(6): 783-791, 2024 Jun.
Article de Anglais | MEDLINE | ID: mdl-38857075

RÉSUMÉ

BACKGROUND: The introduction of tyrosine kinase inhibitors (TKI) has greatly improved the management of metastatic melanoma. Recent studies have uncovered a relationship between the body mass index (BMI) and outcome of patients with metastatic melanoma. However, conflicting results have challenged the relevance of this finding. In the current work, we aim to dissect body composition features of melanoma patients treated with TKI to evaluate their value as biomarkers. PATIENTS AND METHODS: We analyze body composition features via CT scans in a retrospective cohort of 57 patients with non-resectable stage III/IV melanoma receiving first-line treatment with TKI in our department, focusing on the impact of body composition on treatment efficacy and occurrence of adverse events. RESULTS: In uni- and multivariate analyses, we identify an association between the visceral adipose tissue gauge index (VATGI) and survival. We furthermore profile additional body composition features including sarcopenia, which was also associated with a shorter overall survival. Finally, we detected an enrichment of cases with fatigue in patients with low VATGI. CONCLUSIONS: Our study represents the first exploratory study evaluating the suitability of body composition measurements as biomarkers for melanoma patients treated with TKI. Our data suggest a putative use of VATGI as a biomarker predicting patient outcome.


Sujet(s)
Composition corporelle , Mélanome , Inhibiteurs de protéines kinases , Tumeurs cutanées , Humains , Mélanome/traitement médicamenteux , Mélanome/anatomopathologie , Composition corporelle/effets des médicaments et des substances chimiques , Mâle , Femelle , Adulte d'âge moyen , Inhibiteurs de protéines kinases/usage thérapeutique , Inhibiteurs de protéines kinases/effets indésirables , Études rétrospectives , Tumeurs cutanées/traitement médicamenteux , Tumeurs cutanées/anatomopathologie , Sujet âgé , Indice de masse corporelle , Adulte , Résultat thérapeutique , Tomodensitométrie , Stadification tumorale , Graisse intra-abdominale/imagerie diagnostique , Graisse intra-abdominale/effets des médicaments et des substances chimiques
10.
Zhonghua Xin Xue Guan Bing Za Zhi ; 52(6): 676-683, 2024 Jun 24.
Article de Chinois | MEDLINE | ID: mdl-38880747

RÉSUMÉ

Objective: To investigate the association between body composition and coronary artery calcification in patients with chronic kidney disease (CKD). Methods: This cross-sectional study enrolled patients with CKD hospitalized from May 2019 to April 2022 at Sun Yat-sen Memorial Hospital, Guangzhou, China. Skeletal muscle mass index and visceral fat area were measured by bioelectrical impedance analysis. Coronary artery calcification was assessed by computed tomography. Patients were divided into coronary artery calcification group and non-coronary artery calcification group according to the incidence of coronary artery calcification. Patients were categorized into tertile groups according to their skeletal muscle mass index and visceral fat area levels ranging from the lowest to the highest levels (T1 to T3). We defined skeletal muscle mass index≤30.4% as low muscle mass and visceral fat area≥80.6 cm2 as high visceral fat based on the results of the restricted cubic spline graph. All individuals were divided into 4 phenotypes: normal body composition, low muscle mass, high visceral fat, and low muscle mass with high visceral fat. Spearman correlation analysis and logistic regression analysis were used to assess the association between skeletal muscle mass index, visceral fat area and coronary artery calcification. Results: A total of 107 patients with CKD were enrolled, with an age of (60.0±14.1) years, including 41 female patients (38.3%). Patients of coronary artery calcification group had lower skeletal muscle mass index ((32.0±4.8) vs. (34.3±4.8), P=0.016) and higher visceral fat area ((70.8±32.6) cm2 vs. (47.9±23.8) cm2, P<0.001) than those of non-coronary artery calcification group. Patients in the T3 group of skeletal muscle mass index had a lower prevalence of coronary artery calcification (17 (48.6%) vs. 28 (77.8%)) and a lower coronary artery calcification score (0.5 (0, 124.0) vs. 12.0 (0.3, 131.0)) than those in the T1 group (P<0.05). Similarly, patients in the T1 group of visceral fat area had a lower prevalence of coronary artery calcification (14 (40.0%) vs. 29 (80.6%)) and a lower coronary artery calcification score (0 (0, 3.0) vs. 37.0 (2.0, 131.0)) than those in the T3 group (P<0.05). Likewise, patients with both low muscle mass and low muscle mass with high visceral fat had a higher prevalence of coronary artery calcification (11(78.6%) vs. 33 (47.8%); 15 (83.3%) vs. 33 (47.8%)) and a higher coronary artery calcification score (31.1 (0.8, 175.8) vs. 0 (0, 16.4); 27.6 (6.4, 211.4) vs. 0 (0, 16.4)) than those with normal body composition (P<0.05). Spearman correlation analysis showed that skeletal muscle mass index was inversely correlated with coronary artery calcification score (r=-0.212, P=0.028), and visceral fat area was positively correlated with coronary artery calcification score (r=0.408, P<0.001). Multivariate logistic regression analysis showed that increased skeletal muscle mass index was inversely associated with coronary artery calcification prevalence (T2: OR=0.208, 95%CI: 0.056-0.770, P=0.019; T3: OR=0.195, 95%CI: 0.043-0.887, P=0.034), and reduced visceral fat area was inversely associated with coronary artery calcification prevalence (T1: OR=0.256, 95%CI: 0.071-0.923, P=0.037; T2: OR=0.263, 95%CI: 0.078-0.888, P=0.031). Consistently, both low muscle mass and low muscle mass with high visceral fat were associated with coronary artery calcification prevalence (OR=6.616, 95%CI: 1.383-31.656, P=0.018; OR=5.548, 95%CI: 1.062-28.973, P=0.042). Conclusion: Reduced skeletal muscle mass index and increased visceral fat area are significantly associated with both the prevalence and severity of coronary artery calcification in patients with CKD.


Sujet(s)
Composition corporelle , Maladie des artères coronaires , Graisse intra-abdominale , Insuffisance rénale chronique , Calcification vasculaire , Humains , Études transversales , Insuffisance rénale chronique/complications , Insuffisance rénale chronique/physiopathologie , Maladie des artères coronaires/complications , Maladie des artères coronaires/physiopathologie , Graisse intra-abdominale/imagerie diagnostique , Calcification vasculaire/imagerie diagnostique , Calcification vasculaire/complications , Calcification vasculaire/physiopathologie , Muscles squelettiques/imagerie diagnostique , Muscles squelettiques/physiopathologie , Vaisseaux coronaires/imagerie diagnostique , Vaisseaux coronaires/anatomopathologie , Mâle , Femelle , Adulte d'âge moyen
11.
Int J Colorectal Dis ; 39(1): 84, 2024 Jun 03.
Article de Anglais | MEDLINE | ID: mdl-38829434

RÉSUMÉ

OBJECTIVES: Lymph node metastasis (LNM) in colorectal cancer (CRC) patients is not only associated with the tumor's local pathological characteristics but also with systemic factors. This study aims to assess the feasibility of using body composition and pathological features to predict LNM in early stage colorectal cancer (eCRC) patients. METHODS: A total of 192 patients with T1 CRC who underwent CT scans and surgical resection were retrospectively included in the study. The cross-sectional areas of skeletal muscle, subcutaneous fat, and visceral fat at the L3 vertebral body level in CT scans were measured using Image J software. Logistic regression analysis were conducted to identify the risk factors for LNM. The predictive accuracy and discriminative ability of the indicators were evaluated using receiver operating characteristic (ROC) curves. Delong test was applied to compare area under different ROC curves. RESULTS: LNM was observed in 32 out of 192 (16.7%) patients with eCRC. Multivariate analysis revealed that the ratio of skeletal muscle area to visceral fat area (SMA/VFA) (OR = 0.021, p = 0.007) and pathological indicators of vascular invasion (OR = 4.074, p = 0.020) were independent risk factors for LNM in eCRC patients. The AUROC for SMA/VFA was determined to be 0.740 (p < 0.001), while for vascular invasion, it was 0.641 (p = 0.012). Integrating both factors into a proposed predictive model resulted in an AUROC of 0.789 (p < 0.001), indicating a substantial improvement in predictive performance compared to relying on a single pathological indicator. CONCLUSION: The combination of the SMA/VFA ratio and vascular invasion provides better prediction of LNM in eCRC.


Sujet(s)
Composition corporelle , Tumeurs colorectales , Métastase lymphatique , Invasion tumorale , Courbe ROC , Humains , Mâle , Femelle , Tumeurs colorectales/anatomopathologie , Tumeurs colorectales/imagerie diagnostique , Adulte d'âge moyen , Sujet âgé , Stadification tumorale , Tomodensitométrie , Facteurs de risque , Graisse intra-abdominale/imagerie diagnostique , Graisse intra-abdominale/anatomopathologie , Adulte , Études rétrospectives , Analyse multifactorielle , Muscles squelettiques/anatomopathologie , Muscles squelettiques/imagerie diagnostique , Vaisseaux sanguins/anatomopathologie , Vaisseaux sanguins/imagerie diagnostique
12.
Br J Radiol ; 97(1160): 1461-1466, 2024 Aug 01.
Article de Anglais | MEDLINE | ID: mdl-38848475

RÉSUMÉ

OBJECTIVES: To evaluate if ileo-psoas muscle size and visceral adipose tissue (VAT) can predict long-term survival after endovascular aneurysm repair (EVAR). METHODS: Patients who underwent EVAR between 2004 and 2012 in a single centre were included. Total psoas muscle area (TPA), abdominal VAT area, subcutaneous adipose tissue (SAT), and total adipose tissue were measured on the preoperative CT. Primary endpoint was all-cause mortality. Values are presented as median and interquartile range or absolute number and percentage. Cox regression analyses were performed to assess the associations with mortality. RESULTS: Two hundred and eighty-four patients could be included in the study. During a median follow-up of 8 (4-11) years, 223 (79.9%) patients died. Age (P ≤ .001), cardiovascular (P = .041), cerebrovascular (P = .009), renal diseases (P = .002), and chronic obstructive pulmonary disease (P ≤ .001) were independently associated with mortality. TPA was associated with mortality in a univariate (P = .040), but not in a multivariate regression model (P = .764). No significant association was found between mortality and TPA index (P = .103) or any of the adiposity measurements with the exception of SAT (P = .040). However, SAT area loss in a multivariate analysis (P = .875). CONCLUSIONS: Assessment of core muscle size and VAT did not contribute to improving the prediction of long-term survival after EVAR. ADVANCES IN KNOWLEDGE: The finding of this study contradicts the previously claimed utility of core muscle size and VAT in predicting long-term survival after EVAR.


Sujet(s)
Anévrysme de l'aorte abdominale , Procédures endovasculaires , Graisse intra-abdominale , Muscle iliopsoas , Sarcopénie , Tomodensitométrie , Humains , Mâle , Femelle , Procédures endovasculaires/méthodes , Graisse intra-abdominale/imagerie diagnostique , Sujet âgé , Sarcopénie/imagerie diagnostique , Tomodensitométrie/méthodes , Anévrysme de l'aorte abdominale/chirurgie , Anévrysme de l'aorte abdominale/imagerie diagnostique , Anévrysme de l'aorte abdominale/mortalité , Muscle iliopsoas/imagerie diagnostique , Interventions chirurgicales non urgentes , Études rétrospectives , Sujet âgé de 80 ans ou plus , Adulte d'âge moyen
13.
BMC Nephrol ; 25(1): 193, 2024 Jun 11.
Article de Anglais | MEDLINE | ID: mdl-38862924

RÉSUMÉ

BACKGROUND: Obesity is an important risk factor for kidney stones(KS). Chinese Visceral Adiposity Index (CVAI), as a specific indicator for visceral obesity in the Chinese population, can more accurately assess the visceral fat content in Chinese individuals compared to Visceral Adiposity Index (VAI). However, the association between CVAI and risk for KS has not been studied. METHODS: A total of 97,645 participants from a health screening cohort underwent ultrasound examinations for the diagnosis of kidney stones, along with measurements of their CVAI. Logistic regressions were utilized to determine the relationship between different quartiles of CVAI and the incidence of kidney stones. Simultaneously, subgroup analysis and the computation of dose-response curves were employed to pinpoint susceptible populations. RESULTS: Among the participants, 2,888 individuals (3.0%) were diagnosed with kidney stones. The mean CVAI values ± standard deviation for the four groups were: Q1 (18.42 ± 19.64), Q2 (65.24 ± 10.39), Q3 (98.20 ± 9.11), and Q4 (140.40 ± 21.73). In the fully adjusted multivariable model, CVAI was positively correlated with urolithiasis (OR = 1.001; 95% CI = 1.000, 1.002). Compared with the first quartile of CVAI, the population in the fourth quartile of CVAI had a higher prevalence of kidney stones (OR = 1.231; 95% CI = 1.066, 1.415). Through subgroup analysis, a positive correlation between CVAI and the risk of kidney stones was found in non-smokers (OR = 1.001, 95%CI:1.000, 1.002), non-drinkers (OR = 1.001, 95%CI:1.000, 1.002), non-hypertensive subgroups (OR = 1.003, 95%CI:1.002, 1.003), and non-diabetes subgroups (OR = 1.001, 95%CI:1.000, 1.002). CONCLUSION: The findings suggest that CVAI could be a reliable and effective biomarker for assessing the potential risk of kidney stone prevalence, with significant implications for the primary prevention of kidney stones and public health.


Sujet(s)
Graisse intra-abdominale , Calculs rénaux , Obésité abdominale , Échographie , Humains , Mâle , Femelle , Calculs rénaux/épidémiologie , Calculs rénaux/imagerie diagnostique , Études transversales , Adulte d'âge moyen , Chine/épidémiologie , Adulte , Obésité abdominale/épidémiologie , Obésité abdominale/complications , Obésité abdominale/imagerie diagnostique , Graisse intra-abdominale/imagerie diagnostique , Facteurs de risque , Dépistage de masse/méthodes , Adiposité , Sujet âgé , Peuples d'Asie de l'Est
14.
Nutrients ; 16(11)2024 May 27.
Article de Anglais | MEDLINE | ID: mdl-38892578

RÉSUMÉ

Many people with overweight and obesity are affected by sarcopenia, which is represented by a phenotype known as sarcopenic obesity (SO), characterized by excessive body fat (BF), combined with reduced muscle mass and strength. In this population, it is vital to identify the factors associated with SO. With this aim in mind, we investigated the association between visceral adipose tissue (VAT) mass and SO in patients with overweight or obesity in a nutritional setting. A total of 256 participants (23.8% female) with overweight or obesity were involved and completed a body composition assessment, including VAT mass, using dual-energy X-ray absorptiometry (DXA). The sample was initially categorized according to whether the individual had the SO phenotype; they were then classified according to their VAT mass into three tertiles (lowest, medium, and highest). Among the 256 participants, who had a median body mass index (BMI) of 29.3 (interquartile range (IQR): 27.0-32.4) kg/m2 and a median age of 51.0 (IQR: 47.0-54.0) years, 32.4% were identified as having SO, and they displayed a higher median VAT mass (517.0 (IQR: 384.5-677.0) vs. 790.0 (IQR: 654.0-1007.0) g; p < 0.05). The logistic regression model that accounted for age, sex and BMI revealed that a higher VAT mass increases the risk of SO (odds ratio (OR) = 1.003; 95% confidence interval (CI): 1.001-1.004; p < 0.05). In conclusion, VAT mass appears to be an independent factor associated with SO in people with overweight or obesity. However, due to the cross-sectional design, no information regarding any causality between higher VAT mass and SO can be provided. Additional longitudinal research in this direction should therefore be conducted.


Sujet(s)
Absorptiométrie photonique , Composition corporelle , Indice de masse corporelle , Graisse intra-abdominale , Obésité , Sarcopénie , Humains , Femelle , Graisse intra-abdominale/imagerie diagnostique , Mâle , Adulte d'âge moyen , Sarcopénie/imagerie diagnostique , Obésité/complications , Études transversales , Adulte , Facteurs de risque , Surpoids/complications
15.
Ups J Med Sci ; 1292024.
Article de Anglais | MEDLINE | ID: mdl-38863728

RÉSUMÉ

Background and aim: As the spleen plays a significant role in immunity, the aim was to investigate the associations of different body composition markers derived from various sources with spleen volume in a general population sample. Materials and methods: Cross-sectional data of 1095 individuals (570 women; 52%) aged between 30 and 90 years were collected in the Study of Health in Pomerania (SHIP-START-2). We measured spleen volume by magnetic resonance imaging (MRI).Body composition markers were derived from classic anthropometry, bioelectrical impedance analysis, including absolute fat mass (FM) and fat-free mass (FFM), as well as from MRI, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver fat content. Sex-stratified-adjusted linear regression models were used to analyze the associations of body composition markers with spleen volumes. Results: We observed positive associations of body mass index, body weight, waist circumference, hip circumference, waist-to-height ratio, absolute FM, absolute FFM, and VAT and SAT with spleen volume in men and women. An 8.12 kg higher absolute FFM was associated with a 38.4 mL (95% confidence interval [CI]: 26.7-50.1) higher spleen volume in men and a 5.21 kg higher absolute FFM with a 42.6 mL (95% CI: 26.2-59.0) higher spleen volume in women. Conclusion: Our findings indicate that obesity-related body composition markers and FFM are associated with a higher spleen volume. Particularly, higher absolute FFM showed a strong association with a larger spleen volume in both men and women. Further studies are warranted to understand the clinical significance of body composition markers on large spleen volume.


Sujet(s)
Composition corporelle , Indice de masse corporelle , Imagerie par résonance magnétique , Obésité abdominale , Rate , Humains , Femelle , Mâle , Rate/imagerie diagnostique , Rate/anatomie et histologie , Adulte d'âge moyen , Adulte , Sujet âgé , Études transversales , Sujet âgé de 80 ans ou plus , Taille d'organe , Graisse intra-abdominale/imagerie diagnostique , Tour de taille
16.
Clin Transl Gastroenterol ; 15(7): e00722, 2024 Jul 01.
Article de Anglais | MEDLINE | ID: mdl-38822800

RÉSUMÉ

INTRODUCTION: Anti-interleukin 12/23 agents have shown greater durability in response compared with anti-tumor necrosis factor α agents. Data on the association between body composition (BC) or body mass index (BMI) and ustekinumab's therapeutic response is limited. We aimed to evaluate the impact of BC on time to failing standard doses of ustekinumab in patients with Crohn's disease (CD). METHOD: Patients with CD aged 16 years and older from 2 tertiary centers were studied retrospectively. Included patients had abdominal imaging within 6 months of ustekinumab induction and were followed until April 30, 2022. An experienced abdominal radiologist blinded to the clinical information measured the area of visceral fat area and skeletal muscle area at the mid L3 vertebral level, with values corrected for height 2 to derive respective indices (visceral fat index [VFI], skeletal muscle index [SMI]) and the VFI:SMI ratio. RESULTS: Ninety-nine patients met inclusion criteria. The mean age at ustekinumab induction was 46.6 (±1.6) years. The median BMI (interquartile range) was 26.5 (22.6-30.8). Twenty-four patients (24.2%) did not respond or lost response to standard doses of ustekinumab over the follow-up duration. A younger age (hazard ratio 0.96, 95% confidence interval 0.94-0.99, P = 0.01) and a VFI:SMI ratio >1.6 (hazard ratio 4.65, 95% confidence interval 1.73-12.45, P = 0.002) were both associated with a shorter time to failing ustekinumab at standard doses on multivariate analysis. BMI, notably, had no association with the primary outcome. DISCUSSION: A high VFI:SMI ratio is associated with an increased risk of failing standard doses of ustekinumab. BC measurements derived from cross-sectional imaging at the start of ustekinumab therapy is a useful indicator for therapeutic durability.


Sujet(s)
Indice de masse corporelle , Maladie de Crohn , Graisse intra-abdominale , Muscles squelettiques , Échec thérapeutique , Ustékinumab , Humains , Ustékinumab/administration et posologie , Ustékinumab/usage thérapeutique , Femelle , Mâle , Adulte d'âge moyen , Études rétrospectives , Adulte , Muscles squelettiques/imagerie diagnostique , Muscles squelettiques/effets des médicaments et des substances chimiques , Muscles squelettiques/anatomopathologie , Graisse intra-abdominale/imagerie diagnostique , Graisse intra-abdominale/effets des médicaments et des substances chimiques , Maladie de Crohn/traitement médicamenteux , Maladie de Crohn/imagerie diagnostique , Composition corporelle/effets des médicaments et des substances chimiques , Tomodensitométrie
17.
BMC Public Health ; 24(1): 1364, 2024 May 21.
Article de Anglais | MEDLINE | ID: mdl-38773444

RÉSUMÉ

OBJECTIVE: Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) are considered gold standards for measuring visceral fat area (VFA). However, their relatively high prices and potential radiation exposure limit their widespread use in clinical practice and everyday life. Therefore, our study aims to develop a VFA estimated equation based on sagittal abdominal diameter (SAD) and transverse abdominal diameter (TAD) using anthropometric indexes. To the best of our knowledge, there have been limited studies investigating this aspect thus far. METHODS: This study was designed as a cross-sectional, retrospective cohort survey. A total of 288 patients (167 males and 121 females) aged 18-80 with type 2 diabetes (T2D) were consecutively collected from a multicenter hospital, and VFA was measured by CT. Subsequently, variables highly correlated with VFA were screened through general linear correlation analysis. A stepwise regression analysis was then conducted to develop a VFA estimated equation. Discrepancies between the estimated and actual VFA values were assessed using the Bland-Altman method to validate the accuracy of the equation. RESULTS: In the female T2D population, triglyceride (TG), SAD, TAD were found to be independently correlated with VFA; in the male T2D population, BMI, TG, SAD and TAD showed independent correlations with VFA. Among these variables, SAD exhibited the strongest correlation with VFA (r = 0.83 for females, r = 0.88 for males), followed by TAD (r = 0.69 for females, r = 0.79 for males). Based on these findings, a VFA estimated equation was developed for the T2D population: VFA (male) =-364.16 + 15.36*SAD + 0.77*TG + 9.41*TAD - 5.00*BMI (R2 = 0.75, adjusted R2 = 0.74); VFA(female)=-170.87 + 9.72*SAD-24.29*(TG^-1) + 3.93*TAD (R2 = 0.69, adjusted R2 = 0.68). Both models demonstrated a good fit. The Bland-Altman plot indicated a strong agreement between the actual VFA values and the estimated values, the mean differences were close to 0, and the majority of differences fell within the 95% confidence interval. CONCLUSIONS: In the T2D population, a VFA estimated equation is developed by incorporating SAD and TAD along with other measurement indices. This equation demonstrates a favorable estimated performance, suggesting to the development of novel and practical VFA estimation models in the future study.


Sujet(s)
Diabète de type 2 , Graisse intra-abdominale , Adolescent , Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Femelle , Humains , Mâle , Adulte d'âge moyen , Jeune adulte , Études transversales , Graisse intra-abdominale/imagerie diagnostique , Études rétrospectives , Diamètre abdominal sagittal , Tomodensitométrie
18.
Obesity (Silver Spring) ; 32(7): 1339-1348, 2024 Jul.
Article de Anglais | MEDLINE | ID: mdl-38783517

RÉSUMÉ

OBJECTIVE: We analyzed quantitative computed tomography (CT) and chemical shift-encoded magnetic resonance imaging (MRI) data from a Chinese cohort to investigate the effects of BMI and aging on different adipose tissue (AT) depots. METHODS: In 400 healthy, community-dwelling individuals aged 22 to 83 years, we used MRI to quantify proton density fat fraction (PDFF) of the lumbar spine (L2-L4) bone marrow AT (BMAT), the psoas major and erector spinae (ES) muscles, and the liver. Abdominal total AT, visceral AT (VAT), and subcutaneous AT (SAT) areas were measured at the L2-L3 level using quantitative CT. Partial correlation analysis was used to evaluate the relationship of each AT variable with age and BMI. Multiple linear regression analysis was performed in which each AT variable was evaluated in turn as a function of age and the other five independent AT measurements. RESULTS: Of the 168 men, 29% had normal BMI (<24.0 kg/m2), 47% had overweight (24.0-27.9 kg/m2), and 24% had obesity (≥ 28.0 kg/m2). In the 232 women, the percentages were 46%, 32%, and 22%, respectively. Strong or very strong correlations with BMI were found for total AT, VAT, and SAT in both sexes. BMAT and ES PDFF was strongly correlated with age in women and moderately correlated in men. In both sexes, BMAT PDFF correlated only with age and not with any of the other AT depots. Psoas PDFF correlated only with ES PDFF and not with age or the other AT depots. Liver PDFF correlated with BMI and VAT and weakly with SAT in men. VAT and SAT correlated with age and each other in both sexes. CONCLUSIONS: Age and BMI are both associated with adiposity, but their effects differ depending on the type of AT.


Sujet(s)
Adiposité , Indice de masse corporelle , Moelle osseuse , Graisse intra-abdominale , Foie , Imagerie par résonance magnétique , Tomodensitométrie , Humains , Mâle , Adulte d'âge moyen , Femelle , Adulte , Sujet âgé , Imagerie par résonance magnétique/méthodes , Tomodensitométrie/méthodes , Graisse intra-abdominale/imagerie diagnostique , Foie/imagerie diagnostique , Sujet âgé de 80 ans ou plus , Moelle osseuse/imagerie diagnostique , Jeune adulte , Obésité/imagerie diagnostique , Graisse sous-cutanée/imagerie diagnostique , Vieillissement/physiologie , Muscles squelettiques/imagerie diagnostique , Surpoids/imagerie diagnostique , Vertèbres lombales/imagerie diagnostique , Chine , Facteurs âges
19.
Surg Endosc ; 38(6): 3388-3394, 2024 Jun.
Article de Anglais | MEDLINE | ID: mdl-38719986

RÉSUMÉ

BACKGROUND: Pancreatic fistula (PF) is one of the most serious postoperative complications of gastrectomy. Misidentification of the boundary between the pancreas and the dissected fat is a primary concern. In this study, we focused on differences in the appearance of the pancreas and the dissected fat in actual surgical images and statistically analyzed the relationship between the pancreas and the dissected fat. METHODS: We analyzed data from 109 gastric cancer patients who underwent curative gastrectomy between November 2018 and March 2023. Intraoperative images were taken from videos of lymph node dissections of Nos.6 and 8a regions, and the mean gray value of the areas was measured using ImageJ software for analysis. The visceral fat area (VFA) was evaluated by preoperative axial CT at the umbilical level using Ziostation software. RESULTS: A significant correlation was observed between the fat/pancreas gray value ratio in the No.8a lymph node region and the drain/serum amylase ratio (P < 0.001). The fat/pancreas gray value ratio in the No.6 lymph node region correlated with VFA (P < 0.001). The VFA and drain/serum amylase ratio were significantly higher in the group with intra-abdominal complications (P = 0.004). CONCLUSIONS: We revealed significant relationships between the fat/pancreas gray value ratio with drain/serum amylase and VFA. Detecting differences in gray values between the pancreas and the dissected fat may lead to a decrease in the drain/serum amylase ratio and PF.


Sujet(s)
Gastrectomie , Laparoscopie , Fistule pancréatique , Interventions chirurgicales robotisées , Tumeurs de l'estomac , Humains , Fistule pancréatique/étiologie , Fistule pancréatique/épidémiologie , Gastrectomie/méthodes , Gastrectomie/effets indésirables , Mâle , Laparoscopie/méthodes , Laparoscopie/effets indésirables , Femelle , Interventions chirurgicales robotisées/méthodes , Interventions chirurgicales robotisées/effets indésirables , Adulte d'âge moyen , Sujet âgé , Appréciation des risques/méthodes , Tumeurs de l'estomac/chirurgie , Tumeurs de l'estomac/anatomopathologie , Lymphadénectomie/méthodes , Lymphadénectomie/effets indésirables , Complications postopératoires/épidémiologie , Complications postopératoires/imagerie diagnostique , Complications postopératoires/étiologie , Graisse intra-abdominale/imagerie diagnostique , Pancréas/imagerie diagnostique , Pancréas/chirurgie , Pancréas/anatomopathologie , Études rétrospectives , Adulte
20.
Sci Rep ; 14(1): 11982, 2024 05 25.
Article de Anglais | MEDLINE | ID: mdl-38796541

RÉSUMÉ

Epicardial adipose tissue (EAT) is the cardiac visceral fat depot proposed to play a role in the etiology of various cardiovascular disease outcomes. Little is known about EAT determinants in a general population. We examined cardiometabolic, dietary, lifestyle and socioeconomic determinants of echocardiograpghically measured EAT in early adulthood. Data on cardiometabolic, dietary, lifestyle and socioeconomic factors were collected from participants of the Cardiovascular Risk in Young Finns Study (YFS; N = 1667; age 34-49 years). EAT thickness was measured from parasternal long axis echocardiograms. Multivariable regression analysis was used to study potential EAT determinants. Possible effect modification of sex was addressed. Mean EAT thickness was 4.07 mm (95% CI 4.00-4.17). Multivariable analysis [ß indicating percentage of change in EAT(mm) per one unit increase in determinant variable] indicated female sex (ß = 11.0, P < 0.0001), type 2 diabetes (ß = 14.0, P = 0.02), waist circumference (cm) (ß = 0.38, P < 0.0001), systolic blood pressure (mmHg) (ß = 0.18, P = 0.02) and red meat intake (g/day) (ß = 0.02, P = 0.05) as EAT determinants. Sex-specific analysis revealed age (year) (ß = 0.59, P = 0.01), alcohol intake (drinks/day) (ß = 4.69, P = 0.006), heavy drinking (yes/no) (ß = 30.4, P < 0.0001) as EAT determinants in women and fruit intake (g/day) (ß = -1.0, P = 0.04) in men. In the YFS cohort, waist circumference, systolic blood pressure and red meat intake were directly associated with EAT among all participants. In women, age, alcohol intake, heavy drinking and type 2 diabetes associated directly with EAT, while an inverse association was observed between fruit intake and EAT in men.


Sujet(s)
Tissu adipeux , Maladies cardiovasculaires , Échocardiographie , Péricarde , Humains , Mâle , Femelle , Adulte , Adulte d'âge moyen , Péricarde/imagerie diagnostique , Péricarde/anatomopathologie , Tissu adipeux/imagerie diagnostique , Finlande/épidémiologie , Maladies cardiovasculaires/épidémiologie , Maladies cardiovasculaires/étiologie , Maladies cardiovasculaires/imagerie diagnostique , Mode de vie , Facteurs de risque , Facteurs de risque de maladie cardiaque , Régime alimentaire , Graisse intra-abdominale/imagerie diagnostique , Tour de taille ,
SÉLECTION CITATIONS
DÉTAIL DE RECHERCHE