Angiolymphoid Hyperplasia of the External Auditory Canal; Reconstruction of a Complex Defect.

Angiolymphoid hyperplasia (AH) was first described by Wells and Whimster in 1969 as a benign vasoproliferative pathology with a varied infiltrate of eosinophils, lymphocytes, and plasmatic cells. Clinical presentation has been described in the literature as small red-bluish nodules, less than 3 cm in diameter that can bleed in 25% of the cases and be pruritic and painful in 37% and 20% of the cases, respectively. Particularly, AH can appear in the ear; nevertheless, other regions have been affected, including the scalp, lips, tongue, orbit, muscle, and bone. Most of these cases have occurred in adults with an unknown etiology; however, an inflammatory process has been associated in approximately 20% with eosinophilia. No malignancy has been reported.

[Kimura's disease mimicking primary neoplasm of the parotid gland: A case report]. / Enfermedad de Kimura simulando neoplasia primaria de glándula parótida: Reporte de caso.

Background: Kimura's disease is an infrequent inflammatory disorder, of unknown etiology, with few reports outside of Asia. It presents as a nodule or tumor predominantly in the postauricular region, neck and parotid gland. It is histologically characterized by follicular hyperplasia with wellformed mantle zones, preservation of nodal architecture, prominent eosinophilic infiltrate in the germinal centers and interfollicular areas; and associated with elevated levels of IgE and peripheral eosinophilia. Clinical case: We present a case of a 23-year-old man from Mexico, he presented with a recurrent tumor in the right parotid gland, previously treated with surgical resection. Imaging studies were performed and a primary neoplasm of the salivary gland was suspected, he was treated with surgical resection. The histological diagnosis was Kimura's disease. Conclusions: Communication and divulgation of this rare inflammatory disorder expans the knowledge for the differential diagnosis of tumors of the head and neck, and salivary glands, mainly in men with peripheral eosinophilia and elevated IgE; it can sometimes simulate malignant neoplasms, leads to inadequate diagnostic and therapeutic approaches.

Introducción: la enfermedad de Kimura es un desorden inflamatorio poco frecuente, de etiología desconocida y raramente reportado fuera del continente asiático. Se presenta como un nódulo o tumor predominantemente en la región retroauricular, cervical o glándula parótida. Se caracteriza histológicamente por hiperplasia folicular con zonas del manto bien formadas, preservación de la arquitectura ganglionar, infiltrado eosinofílico prominente en los centros germinales y áreas interfoliculares; generalmente asociada a niveles elevados de IgE y eosinofilia periférica. Caso clínico: presentamos el caso de un hombre de 23 años, de origen mexicano que se presentó con un tumor recidivante a dos años de resección quirúrgica previa en glándula parótida derecha, se realizaron estudios de imagen y se sospechó de neoplasia primaria de glándula salival, fue tratado con resección quirúrgica. El diagnóstico histológico fue de enfermedad de Kimura. Conclusiones: la comunicación y difusión de este raro desorden inflamatorio amplía la base del conocimiento para el diagnóstico diferencial de tumores de cabeza y cuello, y glándulas salivales, predominantemente en hombres con eosinofilia periférica y elevación de IgE; que en ocasiones puede simular neoplasias malignas, llevando a abordajes diagnósticos y terapéuticos inadecuados.

Hemangioma epitelioide vulvar (hiperplasia angiolinfoide com eosinofilia): relato de caso / Vulvar epithelioid haemangioma (angiolymphoid hyperplasia with eosinophilia): a case report

Relata-se um caso clássico de hemangioma epitelioide encontrado em localização incomum - região vulvar - em uma paciente de 62 anos. Abordam-se aspectos histopatológicos, além do comportamento biológico e prognóstico da lesão.

This is a report of a 62 years old patient with haemangioma epithelioid in a very uncommon site. We study histopathological aspects, biological behaviour and prognosis.

Epithelioid hemangioma of the colon: a case report.

CONTEXT: Epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia is an uncommon benign vascular neoplasm that is usually located on the face or neck. Exceptionally, it has been described affecting the colon, with only two such cases described in the worldwide literature. The aim here was to present a case of primary epithelioid hemangioma of the sigmoid colon with confirmation by immunohistochemical examination. CASE REPORT: A 37-year-old woman had had a complaint of intermittent abdominal pain for six months. Two months after the condition started, she began to present changes in her intestinal habit, with evacuations containing blood and mucus and a weight loss of 4 kg over this period. At physical examination, a palpable mass was noted in the lower left quadrant of the abdomen. Neoplasia of the colon was clinically suspected and she underwent colonoscopy. This demonstrated the presence of a vegetating sessile lesion of approximately 5 cm in diameter, at a distance of 36 cm from the anal margin. It occupied 80% of the intestinal lumen. A biopsy collected during the examination suggested a diagnosis of neoplasia of vascular origin. After surgical resection, histopathological examination of the resected specimen confirmed the diagnosis of epithelioid hemangioma of the colon, which was backed up by the immunohistochemical panel (factor VIII, Ki-67, CD-34). At present, three years after the surgery, the patient is asymptomatic, she has recovered her normal weight and she has normal findings from control colonoscopy. Despite the rarity of neoplasia of vascular origin, this possibility should be considered in the differential diagnosis for colorectal tumors.

Epithelioid hemangioma of the colon: a case report / Hemangioma epitelióide do cólon: relato de caso

CONTEXT: Epithelioid hemangioma or angiolymphoid hyperplasia with eosinophilia is an uncommon benign vascular neoplasm that is usually located on the face or neck. Exceptionally, it has been described affecting the colon, with only two such cases described in the worldwide literature. The aim here was to present a case of primary epithelioid hemangioma of the sigmoid colon with confirmation by immunohistochemical examination. CASE REPORT: A 37-year-old woman had had a complaint of intermittent abdominal pain for six months. Two months after the condition started, she began to present changes in her intestinal habit, with evacuations containing blood and mucus and a weight loss of 4 kg over this period. At physical examination, a palpable mass was noted in the lower left quadrant of the abdomen. Neoplasia of the colon was clinically suspected and she underwent colonoscopy. This demonstrated the presence of a vegetating sessile lesion of approximately 5 cm in diameter, at a distance of 36 cm from the anal margin. It occupied 80 percent of the intestinal lumen. A biopsy collected during the examination suggested a diagnosis of neoplasia of vascular origin. After surgical resection, histopathological examination of the resected specimen confirmed the diagnosis of epithelioid hemangioma of the colon, which was backed up by the immunohistochemical panel (factor VIII, Ki-67, CD-34). At present, three years after the surgery, the patient is asymptomatic, she has recovered her normal weight and she has normal findings from control colonoscopy. Despite the rarity of neoplasia of vascular origin, this possibility should be considered in the differential diagnosis for colorectal tumors.

CONTEXTO: Hemangioma epitelióide ou hiperplasia angiolinfóide com eosinofilia são neoplasias vasculares benignas raras, habitualmente localizadas na face e pescoço. O acometimento do intestino grosso é excepcionalmente descrito, existindo apenas dois casos descritos na literatura mundial. O objetivo deste artigo é apresentar um caso de hemangioma epitelióide primário do sigmóide com diagnóstico histopatológico confirmado por meio de estudo imunoistoquímico. RELATO DE CASO: Mulher de 37 anos apresentou queixa de dor abdominal de forte intensidade, intermitente, localizada no hipogástrio. Dois meses após o início do quadro, notou alteração do hábito intestinal, evacuações com sangue, muco e perda ponderal de 4 quilos no período. Ao exame físico abdominal, identificou-se massa palpável no quadrante inferior esquerdo. Com suspeita clínica de neoplasia de cólon foi submetida a colonoscopia, que demonstrou presença de lesão vegetante de aproximadamente cinco centímetros de diâmetro, ocupando cerca de 80 por cento da luz colônica. A biópsia mostrou a presença de neoplasia de origem vascular. Após a ressecção cirúrgica, o exame histopatológico do espécime extirpado estabeleceu o diagnóstico de hemangioma epitelióide do cólon, confirmado por meio de painel imunoistoquímico (fator VIII, Ki-67, CD-34). No momento, a paciente encontra-se bem, tendo recuperado o peso inicial três anos após a cirurgia e apresenta resultado de colonoscopia de controle normal. Não obstante a raridade, deve-se considerar a possibilidade das neoplasias de origem vascular no diagnóstico diferencial dos tumores colorretais.

Angiolymphoid hyperplasia with eosinophilia of the lacrimal gland: a case report.

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare clinicopathologic entity that has been the subject of considerable confusion and debate. ALHE shares both clinical and histopathologic features with Kimura disease (KD). Because of this overlap, ALHE and KD have been used synonymously in the Western medical literature, as they were thought to represent variations of the same disease. Some pathologic reports have called for distinguishing ALHE and KD as two separate nosological entities, based on their clinical, laboratory, and especially histopathologic findings. ALHE commonly affects women in the third and fourth decades, with head and neck involvement. ALHE has been described rarely in the orbit, eyelids, and lacrimal gland. We report a case of ALHE involving the left lacrimal gland in a 40-year-old Mexican woman. Because ALHE can cause proptosis, lid swelling, ocular dysmotility, or a palpable mass, it should be considered in the differential diagnosis of orbital lesions occurring in adults.

[Angiolymphoid hyperplasia of the lip with eosinophilia. Report of one case]. / Hiperplasia angiolinfoidea con eosinofilia. Presentación de un caso en cavidad oral y revisión de la literatura.

We report a 33 year-old female presenting with a 2 cm tumor of the upper lip lasting one year. The tumor was excised and the pathological examination showed multiple blood vessels with thickened walls, prominent endothelial cells, lymphoid follicles and an increased number of eosinophils. The final diagnosis was an angiolymphoid hyperplasia with eosinophilia. Six months after surgery, the patient was free of disease. This is a rare condition that must be distinguished from Kimura disease.

Hiperplasia angiolinfoidea con eosinofilia: Presentación de un caso en cavidad oral y revisión de la literatura / Angiolymphoid hyperplasia of the lip with eosinophilia: Report of one case

We report a 33 year-old female presenting with a 2 cm tumor of the upper lip lasting one year. The tumor was excised and the pathological examination showed multiple blood vessels with thickened walls, prominent endothelial cells, lymphoid follicles and an increased number of eosinophils. The final diagnosis was an angiolymphoid hyperplasia with eosinophilia. Six months after surgery, the patient was free of disease. This is a rare condition that must be distinguished from Kimura disease.

Angiolymphoid hyperplasia with eosinophilia associated to a squamous cell carcinoma of the ear.

BACKGROUND: Angiolymphoid hyperplasia with eosinophilia is a benign vascular proliferation that usually affects the head and neck region. METHOD: An 89-year-old man who had a squamous cell carcinoma on the posterior aspect of one ear developed lesions of angiolymphoid hyperplasia with eosinophilia on the anterior aspect of the same ear. RESULTS: After surgical treatment of the malignant neoplasm, the lesions of angiolymphoid hyperplasia with eosinophilia disappeared spontaneously. CONCLUSIONS: Damage to the vasculature of the ear by the malignant neoplasm or the release of angiogenic factors by the same neoplasm is a plausible explanation for the development and eventual resolution of the vascular proliferation.

Hiperplasia angiolinfoide con eosinofilia: sobre 4 observaciones / Angiolymphoid hyperplasia with eosinophilia

La hiperplasia angiolinfoide con eosinofilia es una patología infrecuente de origen desconocido, que se caracteriza clínicamente por presentar nódulos ubicados en cabeza o cuero cabelludo de adultos jóvenes. Presentamos cuatro casos clínicos, tres de ellos con lesiones múltiples y uno solitario

Hiperplasia angiolinfoide con eosinofilia: sobre 4 observaciones / Angiolymphoid hyperplasia with eosinophilia

La hiperplasia angiolinfoide con eosinofilia es una patología infrecuente de origen desconocido, que se caracteriza clínicamente por presentar nódulos ubicados en cabeza o cuero cabelludo de adultos jóvenes. Presentamos cuatro casos clínicos, tres de ellos con lesiones múltiples y uno solitario (AU)

Hiperplasia angiolinfoide con eosinofilia / Angiolymphoid hyperplasia with eosinophia

Se presenta un caso de Hiperplasia Angiolinfoide con Eosinofilia en una paciente de 37 años de edad con caracteres clínicos e histopatológicos típicos. Se describe el tratamiento realizado y se destacan los ragos más importantes de esta entidad nosológica

Hiperplasia angiolinfoide con eosinofilia / Angiolymphoid hyperplasia with eosinophia

Se presenta un caso de Hiperplasia Angiolinfoide con Eosinofilia en una paciente de 37 años de edad con caracteres clínicos e histopatológicos típicos. Se describe el tratamiento realizado y se destacan los ragos más importantes de esta entidad nosológica (AU)