RÉSUMÉ
OBJECTIVE: Menopause symptoms result from the interaction of estrogen deprivation, psychosocial influences, and genetic factors. We examined the influence of stress and of estrogen receptor-α (ER-α; PvuII and XbaI) and serotonin transporter (5-HTT) polymorphisms on symptoms at postmenopause. METHODS: We studied 290 urban women from three cities in Mexico. General characteristics, menopause symptoms, and scores of perceived stress, effort-reward imbalance, dominance, and submission were collected. A fasting blood sample was obtained for hormone measurements and genotypification. RESULTS: Women had a mean ± SD age of 54.4 ± 4.5 years and BMI of 29.5 ± 4.9 kg/m. The frequency of hot flashes was 75.5%; vaginal dryness, 57.8%; and diminished sexual interest, 78.7%. Follicle-stimulating hormone and estradiol levels were 59 ± 27 mIU/mL and 22 ± 29 pg/mL, respectively. Women from Torreón had higher schooling and less parity but higher scores for depression and lower submission. Hot flashes were more frequent in women from León. Genotype distribution was similar among cities. Lower scores for dominance were found in women with the pp and xx ER-α genotypes. Increased smoking habit was found for the SS genotype of 5-HTT. Factors significantly associated with symptoms were years since menopause, with hot flashes (negative), and with diminished sexual interest (positive); dominance was negatively associated with depression, perceived stress, and vaginal dryness; submission was positively associated with depression, perceived stress, anxiety, and hot flashes; and effort-reward imbalance was positively associated with anxiety, hot flashes, and perceived stress. CONCLUSIONS: Symptoms at postmenopause were associated mainly with dominance, submission, and effort-reward imbalance. The pp genotype of ER-α showed lower scores of dominance.
Sujet(s)
Récepteur alpha des oestrogènes/génétique , Post-ménopause/génétique , Transporteurs de la sérotonine/génétique , Stress psychologique/complications , Études transversales , Amorces ADN/composition chimique , Dépression/génétique , Oestradiol/sang , Femelle , Hormone folliculostimulante/sang , Génotype , Bouffées de chaleur/génétique , Humains , Mexique , Adulte d'âge moyen , Polymorphisme génétique , Post-ménopause/sang , Post-ménopause/psychologie , Psychologie , Comportement sexuel , Maladies du vagin/génétiqueRÉSUMÉ
O autor apresenta três casos de septo transverso de vagina cujo diagnóstico foi estabelecido pela histerossalpingografia. Näo havia suspeita anterior da anomalia, e as hipóteses clínicas eram de agenesia do colo uterino e da vagina. Em dois casos as pacientes eram irmäs, com dois parentes tendo a mesma malformaçäo. O autor ressalta a importância da herança autossômica recessiva simples como causa da afecçäo encontrada