Evaluation of Carotid Stiffness in Metabolic Syndrome by Real-Time Shear Wave Elasticity Imaging and Ultrafast Pulse Wave Velocity.

OBJECTIVE: This study utilized real-time shear wave elasticity imaging (SWE) and ultrafast pulse wave velocity (ufPWV) to assess carotid arterial stiffness, aiming to predict atherosclerosis risk in patients with metabolic syndrome (MS). METHODS: In this study, 181 patients with metabolic syndrome (MS group) were compared with 73 healthy adults. The MS group was divided into three groups: MS I group: CIMT was normal (CIMT < 1.0 mm, no plaque, n = 61); MS II group: CIMT thickening (1.0 mm ≤ CIMT<1.5 mm, no plaque, n = 39); MS III group: plaque group (CIMT ≥ 1.5 mm, plaque, n = 81). Concurrently, the group of 73 healthy individuals was designated as the control set (NC). Parameters assessed include carotid intima-media thickness (CIMT), elastic modulus values of the carotid artery's anterior and posterior walls (Mean, Max, Min), pulse wave velocity at systole's commencement (PWV-BS), and pulse wave velocity at systole's termination (PWV-ES). Differences, distribution characteristics, and correlations across these groups were analyzed. RESULTS: A significant association was found between PWV-BS, PWV-ES, and arteriosclerosis severity, with these factors gaining importance as arteriosclerosis progressed. Notably, PWV-ES differences were significant across the four groups (p < 0.05). Both MS III and MS II groups exhibited higher PWV-ES values compared to the MS I group and controls. Statistically significant differences were observed between MS III, MS II, and MS I groups relative to the control group (p < 0.05). Additionally, the Mean, Max, and Min values of the anterior and posterior carotid walls in the MS III group surpassed those of the other groups. CONCLUSION: Real-time shear wave elasticity imaging and ultrafast pulse wave velocity are valuable tools for assessing atherosclerosis risk in MS patients. These non-invasive, safe, and reproducible imaging techniques can quantitatively evaluate the stiffness of the common carotid artery's wall, offering important insights into cardiovascular risk assessment.

Real-time imaging of decompression gas bubble growth in the spinal cord of live rats.

PURPOSE: To observe the growth and resolution of decompression gas bubbles in the spinal cord of live rats in real time using MRI. METHODS: We constructed an MRI-compatible pressure chamber system to visualize gas bubble dynamics in deep tissues in real time. The system pressurizes and depressurizes rodents inside an MRI scanner and monitors their respiratory rate, heart rate, and body temperature while providing gaseous anesthesia under pressure during the experiments. RESULTS: We observed the formation of decompression gas bubbles in the spinal cord of rats after compression to 7.1 bar absolute and rapid decompression inside the MRI scanner while maintaining continuous gaseous anesthesia and vital monitoring. CONCLUSION: We have shown the direct observation of decompression gas bubble formation in real time by MRI in live, anesthetized rats.

A new paradigm for smart packaging: A dual-channel freshness monitoring platform based on aerogels of sodium alginate-anthocyanin complex with high colorimetric sensitivity and stability.

Global seafood consumption is estimated at 156 million tons annually, with an economic loss of >25 billion euros annually due to marine fish spoilage. In contrast to traditional smart packaging which can only roughly estimate food freshness, an intelligent platform integrating machine learning and smart aerogel can accurately predict remaining shelf life in food products, reducing economic losses and food waste. In this study, we prepared aerogels based on anthocyanin complexes that exhibited excellent environmental responsiveness, high porosity, high color-rendering properties, high biocompatibility, high stability, and irreversibility. The aerogel showed excellent indication properties for rainbow trout and proved suitable for fish storage environments. Among the four machine learning models, the radial basis function neural network and backpropagation network optimized by genetic algorithm demonstrated excellent monitoring performance. Also, the two-channel dataset provided more comprehensive information and superior descriptive capability. The three-layer structure of the monitoring platform provided a new paradigm for intelligent and sophisticated food packaging. The results of the study might be of great significance to the food industry and sustainable development.

A method for nonlinear electric-thermal coupling calculations of bushings based on unbiased gradient-free smooth domains.

High-voltage dry-type bushings, serving as the crucial junctions in DC power transmission, represent equipment with the highest failure rate on the DC primary side, underscoring the critical importance of monitoring their condition. Presently, numerical simulation methods are commonly employed to assess the internal state of bushings. However, due to limitations in the efficiency of multi-physics field computations, the guidance provided by numerical simulation results in the field of power equipment condition assessment is relatively weak. This paper focuses on solving the electrical-thermal coupling in high-voltage dry-type bushings. Addressing the most widely used tetrahedral mesh in numerical computations, we propose an efficient solution method based on the concept of "smooth domains." This method involves partitioning the volume centroids of the elements into multiple smooth domains within the computational domain. Electric and thermal conduction matrix calculations occur within these smooth domains, rather than within the grid or element interiors. This approach eliminates the need for traditional element mapping and complex volume integration. To demonstrate the effectiveness of this method, we use high-voltage dry-type bushings as a case study, comparing the performance of our approach with traditional finite element algorithms. We verify the algorithm's computational efficiency and apply it to the analysis of typical temperature anomalies in bushings, further illustrating its suitability for electrical equipment condition assessment.

Real-time soft body dissection simulation with parallelized graph-based shape matching on GPU.

BACKGROUND AND OBJECTIVE: Interactive soft tissue dissection has been a fundamental procedure in virtual surgery systems. Existing cutting algorithms involve complex topology changes of simulation meshes, which can increase simulation overhead and produce visual artifacts. In this paper, we proposed a novel graph-based shape-matching method that allows for real-time, flexible, progressive, and discontinuous cuts on soft tissue. METHODS: We employed shape-matching constraints within the position-based dynamics (PBD) framework, a widely adopted approach for real-time simulation applications. The soft tissue was effectively modeled using overlapping clusters, each governed by shape-matching constraints. The dissection process was bifurcated into two distinct stages. In the first stage, the surgical scalpel presses the surface of the soft tissue. The soft tissue is cut apart when the surface pressure exceeds a threshold, entering the second stage. To address the discrepancy between the visual mesh and the simulation model during cluster separation, we developed an Aggregate Finding Connected Components (AFCC) algorithm, optimized for GPU computation and integrated with a background grid. This approach also avoids ghost forces and fragmentation artifacts. To control the increase in the number of clusters, we also propose a merging strategy that can run in parallel. RESULTS: Our simulation outcomes demonstrated that the AFCC dissection algorithm effectively manages cluster separation and expansion with robustness. There were no ghost forces between the cutting surface and unrealistic fragments. Our simulation capability extended to supporting intricate and discontinuous cutting routes. Our dissection simulation maintained real-time performance even with over 100,000 particles constituting the soft tissue. CONCLUSIONS: Our real-time and robust surgical dissection simulation technique enables the performance of complex cuts in various surgical scenarios, demonstrating its potential in virtual surgery applications.

Enhancing the control of doubly fed induction generators using artificial neural networks in the presence of real wind profiles.

This study tackles the complex task of integrating wind energy systems into the electric grid, facing challenges such as power oscillations and unreliable energy generation due to fluctuating wind speeds. Focused on wind energy conversion systems, particularly those utilizing double-fed induction generators (DFIGs), the research introduces a novel approach to enhance Direct Power Control (DPC) effectiveness. Traditional DPC, while simple, encounters issues like torque ripples and reduced power quality due to a hysteresis controller. In response, the study proposes an innovative DPC method for DFIGs using artificial neural networks (ANNs). Experimental verification shows ANNs effectively addressing issues with the hysteresis controller and switching table. Additionally, the study addresses wind speed variability by employing an artificial neural network to directly control reactive and active power of DFIG, aiming to minimize challenges with varying wind speeds. Results highlight the effectiveness and reliability of the developed intelligent strategy, outperforming traditional methods by reducing current harmonics and improving dynamic response. This research contributes valuable insights into enhancing the performance and reliability of renewable energy systems, advancing solutions for wind energy integration complexities.

Resilience analysis and improvement strategy of microgrid system considering new energy connection.

With the increasing demand for electricity, microgrid systems are facing issues such as insufficient backup capacity, frequent load switching, and frequent malfunctions, making research on microgrid resilience crucial, especially to improve system power supply reliability. This paper proposes a method for analyzing the resilience metric of new energy grid-connected microgrid system, and proposes optimization strategies to improve resilience. Firstly, a measurement method for the resilience of the microgrid system is established based on the operating characteristics of the system components. Secondly, the sensitivity relationship between system resilience and parameters is established, and an optimization model for resilience improvement strategies of microgrid systems based on parameter sensitivity is constructed. Finally, simulation verification is conducted based on the IEEE 37-node microgrid system. The results show that the proposed measurement method can scientifically and reasonably measure the resilience of the microgrid system, and the resilience improvement strategy significantly improves the operational resilience, verifying the effectiveness and robustness of the proposed analysis method.

Real-Time Precise Targeting of the Subthalamic Nucleus via Transfer Learning in a Rat Model of Parkinson's Disease Based on Microelectrode Arrays.

In neurodegenerative disorders, neuronal firing patterns and oscillatory activity are remarkably altered in specific brain regions, which can serve as valuable biomarkers for the identification of deep brain regions. The subthalamic nucleus (STN) has been the primary target for DBS in patients with Parkinson's disease (PD). In this study, changes in the spike firing patterns and spectral power of local field potentials (LFPs) in the pre-STN (zona incerta, ZI) and post-STN (cerebral peduncle, cp) regions were investigated in PD rats, providing crucial evidence for the functional localization of the STN. Sixteen-channel microelectrode arrays (MEAs) with sites distributed at different depths and widths were utilized to record neuronal activities. The spikes in the STN exhibited higher firing rates than those in the ZI and cp. Furthermore, the LFP power in the delta band in the STN was the greatest, followed by that in the ZI, and was greater than that in the cp. Additionally, increased LFP power was observed in the beta bands in the STN. To identify the best performing classification model, we applied various convolutional neural networks (CNNs) based on transfer learning to analyze the recorded raw data, which were processed using the Gram matrix of the spikes and the fast Fourier transform of the LFPs. The best transfer learning model achieved an accuracy of 95.16%. After fusing the spike and LFP classification results, the time precision for processing the raw data reached 500 ms. The pretrained model, utilizing raw data, demonstrated the feasibility of employing transfer learning for training models on neural activity. This approach highlights the potential for functional localization within deep brain regions.

Predictive models for short-term load forecasting in the UK's electrical grid.

There are global efforts to deploy Electric Vehicles (EVs) because of the role they promise to play in energy transition. These efforts underscore the e-mobility paradigm, representing an interplay between renewable energy resources, smart technologies, and networked transportation. However, there are concerns that these initiatives could burden the electricity grid due to increased demand. Hence, the need for accurate short-term load forecasting is pivotal for the efficient planning, operation, and control of the grid and associated power systems. This study presents robust models for forecasting half-hourly and hourly loads in the UK's power system. The work leverages machine learning techniques such as Support Vector Regression (SVR), Artificial Neural Networks (ANN), and Gaussian Process Regression (GPR) to develop robust prediction models using the net imports dataset from 2010 to 2020. The models were evaluated based on metrics like Root Mean Square Error (RMSE), Mean Absolute Prediction Error (MAPE), Mean Absolute Deviation (MAD), and the Correlation of Determination (R2). For half-hourly forecasts, SVR performed best with an R-value of 99.85%, followed closely by GPR and ANN. But, for hourly forecasts, ANN led with an R-value of 99.71%. The findings affirm the reliability and precision of machine learning methods in short-term load forecasting, particularly highlighting the superior accuracy of the SVR model for half-hourly forecasts and the ANN model for hourly forecasts.

Factors That Influence Successful Adoption of Real-Time Location Systems for Use in a Dementia Care Setting: Mixed Methods Study.

BACKGROUND: Technology has been identified as a potential solution to alleviate resource gaps and augment care delivery in dementia care settings such as hospitals, long-term care, and retirement homes. There has been an increasing interest in using real-time location systems (RTLS) across health care settings for older adults with dementia, specifically related to the ability to track a person's movement and location. OBJECTIVE: In this study, we aimed to explore the factors that influence the adoption or nonadoption of an RTLS during its implementation in a specialized inpatient dementia unit in a tertiary care rehabilitation hospital. METHODS: The study included data from a brief quantitative survey and interviews from a convenience sample of frontline participants. Our deductive analysis of the interview used the 3 categories of the Fit Between Individuals, Task, and Technology framework as follows: individual and task, individual and technology, and task and technology. The purpose of using this framework was to assess the quality of the fit between technology attributes and an individual's self-reported intentions to adopt RTLS technology. RESULTS: A total of 20 health care providers (HCPs) completed the survey, of which 16 (80%) participated in interviews. Coding and subsequent analysis identified 2 conceptual subthemes in the individual-task fit category, including the identification of the task and the perception that participants were missing at-risk patient events. The task-technology fit category consisted of 3 subthemes, including reorganization of the task, personal control in relation to the task, and efficiency or resource allocation. A total of 4 subthemes were identified in the individual-technology fit category, including privacy and personal agency, trust in the technology, user interfaces, and perceptions of increased safety. CONCLUSIONS: By the end of the study, most of the unit's HCPs were using the tablet app based on their perception of its usefulness, its alignment with their comfort level with technology, and its ability to help them perform job responsibilities. HCPs perceived that they were able to reduce patient search time dramatically, yet any improvements in care were noted to be implied, as this was not measured. There was limited anecdotal evidence of reduced patient risk or adverse events, but greater reported peace of mind for HCPs overseeing patients' activity levels.

Demand side management using optimization strategies for efficient electric vehicle load management in modern power grids.

The Electric Vehicle (EV) landscape has witnessed unprecedented growth in recent years. The integration of EVs into the grid has increased the demand for power while maintaining the grid's balance and efficiency. Demand Side Management (DSM) plays a pivotal role in this system, ensuring that the grid can accommodate the additional load demand without compromising stability or necessitating costly infrastructure upgrades. In this work, a DSM algorithm has been developed with appropriate objective functions and necessary constraints, including the EV load, distributed generation from Solar Photo Voltaic (PV), and Battery Energy Storage Systems. The objective functions are constructed using various optimization strategies, such as the Bat Optimization Algorithm (BOA), African Vulture Optimization (AVOA), Cuckoo Search Algorithm, Chaotic Harris Hawk Optimization (CHHO), Chaotic-based Interactive Autodidact School (CIAS) algorithm, and Slime Mould Algorithm (SMA). This algorithm-based DSM method is simulated using MATLAB/Simulink in different cases and loads, such as residential and Information Technology (IT) sector loads. The results show that the peak load has been reduced from 4.5 MW to 2.6 MW, and the minimum load has been raised from 0.5 MW to 1.2 MW, successfully reducing the gap between peak and low points. Additionally, the performance of each algorithm was compared in terms of the difference between peak and valley points, computation time, and convergence rate to achieve the best fitness value.

Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics.

Large-scale imaging of neuronal activities is crucial for understanding brain functions. However, it is challenging to analyze large-scale imaging data in real time, preventing closed-loop investigation of neural circuitry. Here we develop a real-time analysis system with a field programmable gate array-graphics processing unit design for an up to 500-megabyte-per-second image stream. Adapted to whole-brain imaging of awake larval zebrafish, the system timely extracts activity from up to 100,000 neurons and enables closed-loop perturbations of neural dynamics.

Identifying childhood malaria hotspots and risk factors in a Nigerian city using geostatistical modelling approach.

Malaria ranks high among prevalent and ravaging infectious diseases in sub-Saharan Africa (SSA). The negative impacts, disease burden, and risk are higher among children and pregnant women as part of the most vulnerable groups to malaria in Nigeria. However, the burden of malaria is not even in space and time. This study explores the spatial variability of malaria prevalence among children under five years (U5) in medium-sized rapidly growing city of Akure, Nigeria using model-based geostatistical modeling (MBG) technique to predict U5 malaria burden at a 100 × 100 m grid, while the parameter estimation was done using Monte Carlo maximum likelihood method. The non-spatial logistic regression model shows that U5 malaria prevalence is significantly influenced by the usage of insecticide-treated nets-ITNs, window protection, and water source. Furthermore, the MBG model shows predicted U5 malaria prevalence in Akure is greater than 35% at certain locations while we were able to ascertain places with U5 prevalence > 10% (i.e. hotspots) using exceedance probability modelling which is a vital tool for policy development. The map provides place-based evidence on the spatial variation of U5 malaria in Akure, and direction on where intensified interventions are crucial for the reduction of U5 malaria burden and improvement of urban health in Akure, Nigeria.

Assessment and validation of glottic motion using cone-beam CT and real-time cine MRI.

PURPOSE: This study aimed to assess the margin for the planning target volume (PTV) using the Van Herk formula. We then validated the proposed margin by real-time magnetic resonance imaging (MRI). METHODS: An analysis of cone-beam computed tomography (CBCT) data from early glottic cancer patients was performed to evaluate organ motion. Deformed clinical target volumes (CTV) after rigid registration were acquired using the Velocity program (Varian Medical Systems, Palo Alto, CA, USA). Systematic (Σ) and random errors (σ) were evaluated. The margin for the PTV was defined as 2.5 Σ + 0.7 σ according to the Van Herk formula. To validate this margin, we accrued healthy volunteers. Sagittal real-time cine MRI was conducted using the ViewRay system (ViewRay Inc., Oakwood Village, OH, USA). Within the obtained sagittal images, the vocal cord was delineated. The movement of the vocal cord was summed up and considered as the internal target volume (ITV). We then assessed the degree of overlap between the ITV and the PTV (vocal cord plus margins) by calculating the volume overlap ratio, represented as (ITV∩PTV)/ITV. RESULTS: CBCTs of 17 early glottic patients were analyzed. Σ and σ were 0.55 and 0.57 for left-right (LR), 0.70 and 0.60 for anterior-posterior (AP), and 1.84 and 1.04 for superior-inferior (SI), respectively. The calculated margin was 1.8 mm (LR), 2.2 mm (AP), and 5.3 mm (SI). Four healthy volunteers participated for validation. A margin of 3 mm (AP) and 5 mm (SI) was applied to the vocal cord as the PTV. The average volume overlap ratio between ITV and PTV was 0.92 (range 0.85-0.99) without swallowing and 0.77 (range 0.70-0.88) with swallowing. CONCLUSION: By evaluating organ motion by using CBCT, the margin was 1.8 (LR), 2.2 (AP), and 5.3 mm (SI). The margin acquired using CBCT fitted well in real-time cine MRI. Given that swallowing during radiotherapy can result in a substantial displacement, it is crucial to consider strategies aimed at minimizing swallowing and related motion.

Modeling failures in smart grids by a bilinear logistic regression approach.

Modeling and recognizing events in complex systems through machine learning techniques is a challenging task. Especially if the model is constrained to be explainable and interpretable, while ensuring high levels of accuracy. In this paper, we adopt a bilinear logistic regression model in which the parameters are trained in a data-driven fashion on a real-world dataset of power grid failure data. The bilinear white-box model - grounded on a specific neural architecture - has been proven effective in classifying faulty states with a performance comparable to several classifiers in technical literature. Additionally, the low computational complexity of the bilinear model, in terms of the number of free parameters, allows gaining insights into the fault phenomenon correlating the events that impact the power grid (exogenous causes) with its constitutive characteristics, thence eliciting the relational information hidden in the data. The proposed model is also able to estimate a vulnerability vector that can be associated, as a suitable characteristic "label", to power grid components, opening the way, as will be deeply demonstrated in the following, not only to predictive maintenance programs or condition monitoring tasks but also to risk assessment and scenario analyses in line with the explainable AI paradigm.

Enhancing intersection safety in autonomous traffic: A grid-based approach with risk quantification.

Existing studies on autonomous intersection management (AIM) primarily focus on traffic efficiency, often overlooking the overall intersection safety, where conflict separation is simplified and traffic conflicts are inadequately assessed. In this paper, we introduce a calculation method for the grid-based Post Encroachment Time (PET) and the total kinetic energy change before and after collisions. The improved grid-based PET metric provides a more accurate estimation of collision probability, and the total kinetic energy change serves as a precise measure of collision severity. Consequently, we establish the Grid-Based Conflict Index (GBCI) to systematically quantify collision risks between vehicles at an autonomous intersection. Then, we propose a traffic-safety-based AIM model aimed at minimizing the weighted sum of total delay and conflict risk at the intersection. This entails the optimization of entry time and trajectory for each vehicle within the intersection, achieving traffic control that prioritizes overall intersection safety. Our results demonstrate that GBCI effectively assesses conflict risks within the intersection, and the proposed AIM model significantly reduces conflict risks between vehicles and enhances traffic safety while ensuring intersection efficiency.

Finite difference-embedded UNet for solving transcranial ultrasound frequency-domain wavefield.

Transcranial ultrasound imaging assumes a growing significance in the detection and monitoring of intracranial lesions and cerebral blood flow. Accurate solution of partial differential equation (PDE) is one of the prerequisites for obtaining transcranial ultrasound wavefields. Grid-based numerical solvers such as finite difference (FD) and finite element methods have limitations including high computational costs and discretization errors. Purely data-driven methods have relatively high demands on training datasets. The fact that physics-informed neural network can only target the same model limits its application. In addition, compared to time-domain approaches, frequency-domain solutions offer advantages of reducing computational complexity and enabling stable and accurate inversions. Therefore, we introduce a framework called FD-embedded UNet (FEUNet) for solving frequency-domain transcranial ultrasound wavefields. The PDE error is calculated using the optimal 9-point FD operator, and it is integrated with the data-driven error to jointly guide the network iterations. We showcase the effectiveness of this approach through experiments involving idealized skull and brain models. FEUNet demonstrates versatility in handling various input scenarios and excels in enhancing prediction accuracy, especially with limited datasets and noisy information. Finally, we provide an overview of the advantages, limitations, and potential avenues for future research in this study.

Smart distribution network voltage estimation using PMU technology considering zero injection constraints.

To properly control the network of the power system and ensure its protection, Phasor measurement units (PMUs) must be used to monitor the network's operation. PMUs can provide synchronized real-time measurements. These measurements can be used for state estimation, fault detection and diagnosis, and other grid control applications. Conventional state estimation methods use weighting factors to balance the different types of measurements, and zero injection measurements can lead to large weighting factors that can introduce computational errors. The offered methods are designed to ensure that these zero injection criteria can be strictly satisfied while calculating the voltage profile and observability of the various distribution networks without sacrificing computing efficiency. The proposed method's viability is assessed using standard IEEE distribution networks. MATLAB coding is used to simulate the case analyses. Overall, the study provides a valuable contribution to the field of power distribution system monitoring and control by simplifying the process of determining the optimal locations for PMUs in a distribution network and assessing the impact of ZI buses on the voltage profile of the system.

Ultra short term power load forecasting based on the fusion of Seq2Seq BiLSTM and multi head attention mechanism.

Ultra-short-term power load forecasting is beneficial to improve the economic efficiency of power systems and ensure the safe and stable operation of power grids. As the volatility and randomness of loads in power systems, make it difficult to achieve accurate and reliable power load forecasting, a sequence-to-sequence based learning framework is proposed to learn feature information in different dimensions synchronously. Convolutional Neural Networks(CNN) Combined with Bidirectional Long Short Term Memory(BiLSTM) Networks is constructed in the encoder to extract the correlated timing features embedded in external factors affecting power loads. The parallel BiLSTM network is constructed in the decoder to mine the power load timing information in different regions separately. The multi-headed attention mechanism is introduced to fuse the BiLSTM hidden layer state information in different components to further highlight the key information representation. The load forecastion results in different regions are output through the fully connected layer. The model proposed in this paper has the advantage of high forecastion accuracy through the example analysis of real power load data.

Optimizing Visual Stimulation Paradigms for User-Friendly SSVEP-Based BCIs.

In steady-state visual evoked potential (SSVEP)-based brain-computer interface (BCI) systems, traditional flickering stimulation patterns face challenges in achieving a trade-off in both BCI performance and visual comfort across various frequency bands. To investigate the optimal stimulation paradigms with high performance and high comfort for each frequency band, this study systematically compared the characteristics of SSVEP and user experience of different stimulation paradigms with a wide stimulation frequency range of 1-60 Hz. The findings suggest that, for a better balance between system performance and user experience, ON and OFF grid stimuli with a Weber contrast of 50% can be utilized as alternatives to traditional flickering stimulation paradigms in the frequency band of 1-25 Hz. In the 25-35 Hz range, uniform flicker stimuli with the same 50% contrast are more suitable. In the higher frequency band, traditional uniform flicker stimuli with a high 300% contrast are preferred. These results are significant for developing high performance and user-friendly SSVEP-based BCI systems.