Efecto de la restricción motriz temprana sobre el desarrollo dendrítico de las neuronas de Purkinje / Effect of early motor restriction over dendritic development of Purkinje cells

El objetivo principal del presente estudio fue evaluar si la experiencia somatomotriz temprana modifica el desarrollo dendrítico de las células de Purkinje en ratas expuestas a entornos restrictivos durante el período de postlactancia. Ratas albinas de la cepa Sprague-Dawley (machos y hembras) fueron expuestas a restricción de movimiento mediante su ubicación permanente en cajas metálicas de pequeño tamaño (10x10x10 cm) entre los días postnatales 18 y 31. El día 31 se evaluó la conducta exploratoria, y al día siguiente fueron anestesiadas, sacrificadas por decapitación y sus cerebelos procesados con el método de Golgi-Cox-Sholl. Un total de 1.106 células de Purkinje localizadas en la región vermiana fueron dibujadas bajo cámara lúcida (400x), evaluando su desarrollo dendrítico. Los resultados conductuales y morfométricos revelaron que la restricción de movimiento produjo un significativo retraso de la ramificación dendrítica de las células de Purkinje, asociado a una pobre conducta exploratoria

Normas para atendimento aos hemofílicos e portadores de coagulopatias congênitas / Rules for attending patients with hemophilia and congenital blood coagulation disorders

O objetivo primordial do trabalho foi dar as linhas gerais de diagnóstico e conduta frente às diversas intercorrências médicas, odontológicas, psico-sociais e fisioterápicas...

Deficiencia congénita en factor X de la coagulación sanguínea: resultado exitoso del empleo de concentrados de complejo protrombínico en el control de la tendencia hemorrágica en operación cesárea en 2 embarazos / Congenital deficiency of blood coagulation factor X: successful result of prothrombin complex concentrates use in hemorrhagic diathesis in cesarean section in 2 pregnancies

There is little experience in the prevention of the severe hemorrhagic diathesis of factor X coagulation factor deficiency, before surgical procedures. A female with congenital deficiency of factor X that received prothrombin complex concentrates that contained 1000 IU of factor X (16.7 U/I Kg BW) inmediately prior to a cesarean section in two occasions, is reported. Factor X concentration rose from 1 to 25 percent in the first ocassion and from 10 to 63 percent in the second. In both episodes, factor X decreased in the first 24 h of the postoperative period and required new infusions of prothrombin complex concentrates. No episodes of abnormal bleeding were observed. It is concluded that the infusion of prothrombin complex concentrates prevents the hemorrhagic diathesis of factor X deficiency, despite its modest increase in plasma. A initial infusion of 1.000 UI of factor X (16-20 IU/Kg BW), followed by 500 IU (8-10 IU/Kg) every 24 hours is suggested for an adequate management of this condition

[Hepatitis B and C virus infections in children with congenital coagulation disorders]. / Infección con los virus de la hepatitis B y C en niños con trastornos congénitos de la coagulación.

The prevalence of hepatitis B and C virus infections, transmitted by blood transfusions, was studied in 79 children with congenital coagulation disorders. Twenty nine percent had evidences of hepatitis B virus infection and 52% evidences of hepatitis C virus infection. Older children and those with the higher number of transfusions had the highest rates of infections. It is concluded that children with congenital coagulation disorders constitute a high risk group for hepatitis B and C virus infections.