ABSTRACT
Hereditary factor VII deficiency is a rare autosomal recessive condition. Factor VII's level elevates during pregnancy in normal patients, as well in deficient individuals for some authors. Various treatments (fresh frozen plasma, prothrombin complex or factor VII concentrate) have been used to lessen the peri-partum hemorrhage in those factor VII-deficient pregnant women. We report the case of a pregnant woman presenting a factor VII deficiency (level 4%), without variation of level during her pregnancy. The single infusion of factor VII concentrate, prior to delivery, has elevated factor VII's level at 17% and has likely permitted minimal post-partum bleeding. The peripartum management of factor VII deficiency is discussed.
Subject(s)
Factor VII Deficiency/therapy , Pregnancy Complications, Hematologic , Adult , Factor VII/administration & dosage , Factor VII/therapeutic use , Female , Humans , Postpartum Hemorrhage/prevention & control , PregnancyABSTRACT
A ten-year retrospective study was conducted in 4 women in labor and 23 surgical patients with congenital clotting factor deficiency. Appropriate use of replacement therapy and good cooperation between biologists, anesthesiologists, and surgeons are essential to ensure a favorable outcome.
Subject(s)
Blood Coagulation Disorders/congenital , Surgical Procedures, Operative , Adolescent , Adult , Child , Child, Preschool , Evaluation Studies as Topic , Female , Hospitals, General , Humans , Infant , Male , Middle Aged , Retrospective StudiesABSTRACT
During the summer 1994, six cases of airport malaria occurred in France, near the Roissy-Charles-de-Gaulle airport. Due to Plasmodium falciparum, all cases underwent rapid and severe deterioration, and in one case, the patient died. The role of laboratory tests is essential to establish the diagnosis of persons who have never resided in the endemic malaria areas and follow up with the patients already under treatment to detect possible complications.
