BACKGROUND: COVID-19 acute respiratory distress syndrome (ARDS) is often managed with mechanical ventilation (MV), requiring sedation and paralysis, with associated risk of complications. There is limited evidence on the use of high flow nasal cannula (HFNC). We hypothesized that management of COVID-19 ARDS without MV is feasible. METHODS: Included were all adult patients diagnosed with COVID-19 ARDS, with PaO
COVID-19 , Noninvasive Ventilation , Respiratory Distress Syndrome , Respiratory Insufficiency , Adult , Humans , Respiration, Artificial/adverse effects , Feasibility Studies , COVID-19/complications , COVID-19/therapy , Respiratory Distress Syndrome/therapy , Respiratory Distress Syndrome/etiology , Respiratory Insufficiency/therapy , Oxygen Inhalation Therapy
BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related disease (COVID-19) is an infectious disease characterized by systemic inflammation, which might enhance baseline thrombotic risk, especially in hospitalized patients. Little is, however, known about predictors of thrombotic complications in patients with COVID-19. METHODS: We prospectively followed up 180 hospitalized COVID-19 patients. Demographics, clinical and laboratory features at presentation and past medical history were tested as predictors of the first thrombotic complication through multivariate Cox regression analysis and a categorical score generated based on the results. RESULTS: Sixty-four thromboses were recorded in 54 patients, of whom seven with thrombosis on admission and 47 with thrombosis during hospitalization. Patients with thrombosis were mainly Caucasian and diabetic, had marked baseline signs of inflammation and organ damage, lower PaO
COVID-19 , Thromboembolism , Thrombosis , Algorithms , COVID-19/complications , COVID-19/epidemiology , Hemorrhage , Humans , Inflammation , Preliminary Data , SARS-CoV-2 , Thromboembolism/epidemiology , Thromboembolism/etiology , Thrombosis/epidemiology , Thrombosis/etiology