ABSTRACT
Skeletal muscle regeneration after injury is a complex process involving inflammatory signaling and myoblast activation. Pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-α) are key mediators, but their effects on gene expression in proliferating myoblasts are unclear. We performed the RNA sequencing of TNF-α treated C2C12 myoblasts to elucidate the signaling pathways and gene networks regulated by TNF-α during myoblast proliferation. The TNF-α (10 ng/mL) treatment of C2C12 cells led to 958 differentially expressed genes compared to the controls. Pathway analysis revealed significant regulation of TNF-α signaling, along with the chemokine and IL-17 pathways. Key upregulated genes included cytokines (e.g., IL-6), chemokines (e.g., CCL7), and matrix metalloproteinases (MMPs). TNF-α increased myogenic factor 5 (Myf5) but decreased MyoD protein levels and stimulated the release of MMP-9, MMP-10, and MMP-13. TNF-α also upregulates versican and myostatin mRNA. Overall, our study demonstrates the TNF-α modulation of distinct gene expression patterns and signaling pathways that likely contribute to enhanced myoblast proliferation while suppressing premature differentiation after muscle injury. Elucidating the mechanisms involved in skeletal muscle regeneration can aid in the development of regeneration-enhancing therapeutics.
Subject(s)
Cell Proliferation , Myoblasts , Signal Transduction , Tumor Necrosis Factor-alpha , Myoblasts/metabolism , Tumor Necrosis Factor-alpha/metabolism , Tumor Necrosis Factor-alpha/pharmacology , Cell Proliferation/drug effects , Animals , Mice , Cell Line , Chemokines/metabolism , Chemokines/genetics , Cytokines/metabolism , Cytokines/genetics , Gene Expression Regulation/drug effectsABSTRACT
OBJETIVO: Descrever os aplicativos voltados para a segurança do paciente idoso cirúrgico nos períodos pré e pós-operatório. MÉTODO: Prospecção tecnológica com abordagem qualitativa realizada nas lojas virtuais Apple Store, Google Play e aplicativo web. Como estratégia de busca utilizou-se os termos: 'autocuidado idoso', 'pré-operatório', 'pós-operatório', 'segurança do paciente', 'segurança do paciente idoso'. RESULTADOS: Foram identificados 12 aplicativos na loja virtual Apple Store, 17 na Google Play e um web app, os quais estavam voltados a gamificação de profissionais da saúde e da população; aplicativos educacionais aos profissionais de saúde e usuários do sistema de saúde; aplicativos relacionados como ferramenta de trabalho para os profissionais de saúde; aplicativos como ferramenta de autocuidado para usuários do sistema de saúde; e, aplicativos voltados para pós-operatório de usuários do sistema de saúde. CONCLUSÃO: Não foram encontradas tecnologias voltadas para o autocuidado e segurança do paciente idoso nos períodos pré e pós-operatório
OBJECTIVE: To describe applications focused on the safety of elderly surgical patients in the pre- and postoperative periods. METHOD: Technology prospecting with a qualitative approach in the Apple Store, Google Play virtual stores, and web application. As a search strategy, the following terms were used: 'elderly self-care', 'preoperative', 'postoperative', 'patient safety', 'elderly patient safety'. RESULTS: 12 applications were identified in the Apple Store, 17 in Google Play, and a web app, which focused on the gamification of health and population professionals; educational applications to health professionals and health system users; related applications as a work tool for health professionals; applications as a self-care tool for health system users; and, post-operative applications for health system users. CONCLUSION: Technologies aimed at self-care and the safety of elderly patients were not found in the pre- and postoperative periods.
Subject(s)
Aged , Postoperative Period , Health of the Elderly , Preoperative Period , Patient Safety , Mobile Applications , Prospective StudiesABSTRACT
Compreender as melhores práticas de enfermagem desempenhadas na Atenção Primária à Saúde em unidades de Estratégia Saúde da família em um município da região Norte do Estado de Santa Catarina. Método: pesquisa qualitativa realizada no município de JoinvilleSC por meio de entrevistas semiabertas e individuais. Resultados: Participaram da pesquisa 30 enfermeiros atuantes na atenção primária. Descrevem as melhores práticas de enfermagem voltadas à pessoa idosa, com destaque para a resolubilidade das práticas, a priorização do acesso da pessoa idosa, o cuidado ampliado para os familiares, a atuação do enfermeiro frente a situações de negligência e violência contra a pessoa idosa e, ainda, as barreiras para a efetivação das melhores práticas. Conclusão: a qualificação das ações oferecidas as pessoas idosas na atenção primária perpassa questões administrativas, sociais e resolutivas, e exigem que o enfermeiro esteja inserido no território, conhecendo potencialidades e limitações que interferem no planejamento do cuidado. Contudo, somente enfermeiros com autonomia e segurança no saber científico, aliado ao apoio institucional e ambiente adequado, desenvolvem melhores práticas.
ABSTRACT
The pursuit of better therapies for disorders creating deficiencies in skeletal muscle regeneration is in progress, and several biotoxins are used in skeletal muscle research. Since recombinant proteins derived from Lonomia obliqua bristles, recombinant Lonomia obliqua Stuart-factor activator (rLosac) and recombinant Lonomia obliqua prothrombin activator protease (rLopap) act as cytoprotective agents and promote cell survival, we hypothesize that both rLosac and rLopap favour the skeletal muscle regeneration process. In the present work, we investigate the ability of these recombinant proteins rLosac and rLopap to modulate the production of key mediators of the myogenic process. The expression of myogenic regulatory factors (MRFs), cell proliferation, the production of prostaglandin E2 (PGE2) and the protein expression of cyclooxygenases COX-1 and COX-2 were evaluated in C2C12 mouse myoblasts pre-treated with rLosac and rLopap. We found an increased proliferation of myoblasts, stimulated by both recombinant proteins. Moreover, these proteins modulated PGE2 release and MRFs activities. We also found an increased expression of the EP4 receptor in the proliferative phase of C2C12 cells, suggesting the involvement of this receptor in the effects of PGE2 in these cells. Moreover, the recombinant proteins inhibited the release of IL-6 and PGE2, which is induced by an inflammatory stimulus by IL-1ß. This work reveals rLopap and rLosac as promising proteins to modulate processes involving tissue regeneration as occurs during skeletal muscle injury.
ABSTRACT
OBJECTIVE: To reflect on the role and initiatives of the Brazilian Nursing Association (ABEn) and the Federal Nursing Council (Cofen) in the development, recognition, and regulation necessary to implement advanced practice nursing (APN) in Brazil. METHOD: This is a theoretical-reflective essay resulting from the roundtable discussion entitled "Regulation and recognition of advanced nursing practices in Brazil: how are we and what is missing" held in May 2021, at the III International Symposium on Adult Health. RESULTS: ABEn and Cofen are strategic partners to define the areas of activity of this specialization in Brazil. Nursing organizations are responsible for defining professional profiles and curricula, advanced practice nursing conditions, and adequacy of existing graduate courses aiming at technical support, political leadership, regulation, and construction of an APN foundation in Brazil. CONCLUSION: Brazil must broaden the national debate on APN, define a training model for it, and articulate efforts with all its strategic partners to build a theoretical, political, and labor framework for advanced practice nurses' full professional practice.
Subject(s)
Advanced Practice Nursing , Brazil , Curriculum , HumansABSTRACT
OBJECTIVE: to map and analyze the scientific literature on nursing care aimed at people with Parkinson's disease in Primary Health Care. METHOD: this is a scoping review using the Joanna Briggs Institute methodology, carried out between July and October 2020, and updated in November 2021 in six databases from nursing care and Parkinson's disease descriptors, and their respective acronyms and synonyms in English, Portuguese and Spanish. RESULTS: a total of 44 publications were included in this review, which identified as nursing care in Primary Care: assessment of motor and non-motor functions; management of activities of daily living and instrumental activities of daily living; disease self-management education for people with Parkinson's and their care partners; supervised group approach; and personal factor management. CONCLUSION: Nursing care for people with Parkinson's at the primary level essentially involves actions that include providing focused care at an individual and group level, encompassing clinical assessment, patient education, patient involvement in the social context of care, and developing positive relationships with family members and caregivers.
Subject(s)
Nursing Care , Parkinson Disease , Activities of Daily Living , Caregivers , Humans , Parkinson Disease/therapy , Primary Health CareABSTRACT
ABSTRACT Objective: To reflect on the role and initiatives of the Brazilian Nursing Association (ABEn) and the Federal Nursing Council (Cofen) in the development, recognition, and regulation necessary to implement advanced practice nursing (APN) in Brazil. Method: This is a theoretical-reflective essay resulting from the roundtable discussion entitled "Regulation and recognition of advanced nursing practices in Brazil: how are we and what is missing" held in May 2021, at the III International Symposium on Adult Health. Results: ABEn and Cofen are strategic partners to define the areas of activity of this specialization in Brazil. Nursing organizations are responsible for defining professional profiles and curricula, advanced practice nursing conditions, and adequacy of existing graduate courses aiming at technical support, political leadership, regulation, and construction of an APN foundation in Brazil. Conclusion: Brazil must broaden the national debate on APN, define a training model for it, and articulate efforts with all its strategic partners to build a theoretical, political, and labor framework for advanced practice nurses' full professional practice.
RESUMEN Objetivo: Reflexionar sobre el papel y las iniciativas de la Asociación Brasileña de Enfermería (ABEn) y del Consejo Federal de Enfermería (Cofen) en el desarrollo, reconocimiento y regulación necesarios a la puesta en práctica de Enfermería de Práctica Avanzada (EPA) en Brasil. Método: Ensayo teórico-reflexivo a partir de la mesa redonda titulada "Regulación y reconocimiento de la enfermería de práctica avanzada en Brasil: ¿Cómo vamos y qué nos falta?", celebrada en mayo de 2021 en el III Simposio Internacional de Salud del Adulto. Resultados: Es evidente que la ABEn y el Cofen son socios estratégicos para definir las áreas de actuación de esta especialización en el país. Las responsabilidades de las organizaciones de Enfermería consisten en definir el perfil profesional, el currículo, las condiciones para el ejercicio de las enfermeras de práctica avanzada, la adecuación de los cursos de posgrado existentes, con miras al apoyo técnico, liderazgo político, regulación y construcción de bases para la EPA en el país. Conclusión: Es necesario ampliar el debate sobre la EPA en Brasil, definir el modelo de formación y articular esfuerzos con todos los socios estratégicos, con el fin de construir un marco teórico, político y laboral para el pleno ejercicio profesional de los enfermeros de práctica avanzada.
RESUMO Objetivo: Refletir sobre o papel e as iniciativas da Associação Brasileira de Enfermagem (ABEn) e do Conselho Federal de Enfermagem (Cofen) no desenvolvimento, reconhecimento e regulamentação necessários à implantação da Enfermagem de Prática Avançada (EPA) no Brasil. Método: Ensaio teórico-reflexivo resultante da mesa-redonda intitulada "Regulamentação e reconhecimento das práticas avançadas em enfermagem no Brasil: Como estamos e o que falta?", realizada em maio de 2021, no III Simpósio Internacional de Saúde do Adulto. Resultados: Fica evidenciado que a ABEn e o Cofen são parceiros estratégicos para definição das áreas de atuação desta especialização no país. As responsabilidades das organizações da Enfermagem consistem em definir o perfil profissional, o currículo, as condições para o exercício dos enfermeiros de prática avançada, adequação dos cursos de pós-graduação existentes, com vistas ao apoio técnico, liderança política, regulação, regulamentação e construção de bases para EPA no país. Conclusão: É preciso ampliar o debate sobre a EPA no Brasil, definir o modelo de formação e articular esforços com todos os parceiros estratégicos, no intuito de construir um arcabouço teórico, político e laboral para o pleno exercício profissional do enfermeiro de prática avançada.
Subject(s)
Advanced Practice Nursing , Nursing , National Health SystemsABSTRACT
ABSTRACT Objective: to map and analyze the scientific literature on nursing care aimed at people with Parkinson's disease in Primary Health Care. Method: this is a scoping review using the Joanna Briggs Institute methodology, carried out between July and October 2020, and updated in November 2021 in six databases from nursing care and Parkinson's disease descriptors, and their respective acronyms and synonyms in English, Portuguese and Spanish. Results: a total of 44 publications were included in this review, which identified as nursing care in Primary Care: assessment of motor and non-motor functions; management of activities of daily living and instrumental activities of daily living; disease self-management education for people with Parkinson's and their care partners; supervised group approach; and personal factor management. Conclusion: Nursing care for people with Parkinson's at the primary level essentially involves actions that include providing focused care at an individual and group level, encompassing clinical assessment, patient education, patient involvement in the social context of care, and developing positive relationships with family members and caregivers.
RESUMEN Objetivo: mapear y analizar la literatura científica sobre el cuidado de enfermería dirigido a personas con enfermedad de Parkinson en la Atención Primaria de Salud. Método: una revisión del alcance utilizando la metodología del Joanna Briggs Institute, realizada entre julio y octubre de 2020, y actualizada en noviembre de 2021 en seis bases de datos, de los descriptores cuidado de enfermería y enfermedad de Parkinson, y sus respectivas siglas y sinónimos en inglés, portugués y español. Resultados: en esta revisión se incluyeron 44 publicaciones, que identificaron como cuidados de enfermería en Atención Primaria: evaluación de las funciones motoras y no motoras; gestión de Actividades de la Vida Diaria y Actividades Instrumentales de la Vida Diaria; educación para el autocontrol de enfermedades para personas con Parkinson y sus cuidadores; enfoque de grupo supervisado; y manejo de factores personales. Conclusión: la atención de enfermería a las personas con Parkinson en el nivel primario implica esencialmente acciones que incluyen brindar cuidados enfocados a nivel individual y grupal, incluyendo la evaluación clínica, educación del paciente, participación del paciente en el contexto social de la atención y desarrollo de relaciones positivas con los miembros de la familia y los cuidadores.
RESUMO Objetivo: mapear e analisar a literatura científica acerca dos cuidados de enfermagem direcionados às pessoas com doença de Parkinson na Atenção Primária à Saúde. Método: revisão de escopo utilizando a metodologia do Joanna Briggs Institute, realizada entre julho e outubro de 2020, e atualizada em novembro de 2021 em seis bases de dados, a partir dos descritores cuidados de enfermagem e doença de Parkinson, e seus respectivos acrônimos e sinônimos em inglês, português e espanhol. Resultados: foram incluídas 44 publicações nesta revisão, que identificaram como cuidados de enfermagem na Atenção Primária: avaliação das funções motoras e funções não motoras; gerenciamento das Atividades de Vida Diária e das Atividades Instrumentais de Vida Diária; educação para autogestão da doença para pessoas com Parkinson e seus parceiros de cuidado; abordagem supervisionada em grupo; e gerenciamento dos fatores pessoais. Conclusão: os cuidados de enfermagem à pessoa com Parkinson no âmbito primário envolvem, essencialmente, ações que incluem prestar cuidados centrados em nível individual e em grupo, abrangendo avaliação clínica, educação do paciente, envolvimento deste no contexto social do cuidado e desenvolvimento de relacionamentos positivos com os familiares e cuidadores.
Subject(s)
Parkinson Disease , Primary Health Care , Nursing , Review , Noncommunicable Diseases , Nursing CareABSTRACT
RESUMO Objetivo identificar os fatores associados ao risco de quedas entre as pessoas com doença de Parkinson cadastradas na Associação Parkinson Santa Catarina. Método estudo transversal exploratório descritivo e de abordagem quantitativa, realizado com 53 pessoas cadastradas na Associação Parkinson Santa Catarina, no município de Florianópolis, Brasil, no período de junho a setembro de 2019. Foram aplicados questionário sociodemográfico, Escala de Hoehn e Yahr, Mini Exame do Estado Mental e Teste de Rastreio do Risco de Queda no Idoso. Os dados foram tabulados e analisados por meio do Sistema online de Ensino-Aprendizagem de Estatística SEstatNet®. Resultados foram identificados fatores de risco, como sexo, aumento da idade, redução da força muscular, instabilidade postural e diminuição da velocidade da marcha. Em relação aos estágios da doença, foi constatado que em todos houve piora da velocidade da marcha e o medo de cair é constante, aumentando com o agravamento da doença e o tempo de diagnóstico. Conclusão e implicações para a prática ao aprofundar o estudo do tema, o enfermeiro consegue compreender os acometimentos motores que levam à fragilização e à queda em pessoas com doença de Parkinson, elaborando estratégias para preveni-las.
RESUMEN Objetivo identificar los factores asociados al riesgo de caídas en personas con enfermedad de Parkinson registradas en la Asociación de Parkinson Santa Catarina. Método estudio descriptivo exploratorio transversal, con abordaje cuantitativo realizado con 53 personas registradas en la Asociación Parkinson Santa Catarina, en la ciudad de Florianópolis, Brasil, de junio a septiembre de 2019. Se aplicaron un cuestionario sociodemográfico, la Escala de Hoehn y Yahr, el Mini Examen del Estado Mental y la Prueba de Detección del Riesgo de Caídas en Ancianos. Los datos se tabularon y analizaron utilizando el Sistema en línea de enseñanza-aprendizaje de estadísticas SEstatNet®. Resultados se identificaron factores de riesgo como sexo, mayor edad, disminución de la fuerza muscular, inestabilidad postural y disminución de la velocidad de la marcha. En cuanto a las etapas de la enfermedad, se encontró que en todas ellas se produjo un empeoramiento de la velocidad de la marcha y el miedo a caer es constante, aumentando con el empeoramiento de la enfermedad y el momento del diagnóstico. Conclusión e implicaciones para la práctica al profundizar en el estudio del tema, el enfermero es capaz de comprender las deficiencias motoras que conducen a la fragilidad y caída en personas con enfermedad de Parkinson, ideando estrategias para prevenirlas.
ABSTRACT Objective to identify the factors associated with risk of falls among people with Parkinson's disease registered at the Parkinson Santa Catarina Association. Method this is a cross-sectional exploratory descriptive study with a quantitative approach, carried out with 53 people registered at the Parkinson Santa Catarina Association, in the city of Florianópolis, Brazil, from June to September 2019. Sociodemographic questionnaire, Hoehn and Yahr scale, Mini Mental State Examination and Simple Screening Test for Risk of Falls in the Elderly were applied. The data were tabulated and analyzed using the SEstatNet® Statistics Teaching-Learning Online System. Results risk factors were identified, such as sex, increased age, reduced muscle strength, postural instability and decreased gait speed. Regarding the stages of the disease, it was found that in all of them there was a worsening of gait speed and the fear of falling is constant, increasing with the worsening of the disease and diagnosis time. Conclusion and implications for practice by deepening the study of the topic, nurses are able to understand the motor impairments that lead to frailty and fall in people with Parkinson's disease, developing strategies to prevent them.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Parkinson Disease/diagnosis , Accidental Falls/statistics & numerical data , Risk Groups , Levodopa/therapeutic use , Visual Acuity , Comorbidity , Chronic Disease , Cross-Sectional Studies , Risk Factors , Drug Interactions , Walking Speed , Pramipexole/therapeutic useABSTRACT
RESUMO Objetivo: compreender como o enfermeiro na Estratégia de Saúde da Família constrói o vínculo profissional com a pessoa idosa. Métodos: pesquisa qualitativa, com 30 enfermeiros de Estratégias de Saúde da Família de Joinville, entrevistados entre janeiro e março de 2018. Foi utilizado um instrumento de entrevista semiestruturado. Os dados foram analisados conforme a análise de conteúdo temática. Resultados: os resultados que emergiram das categorias apontam a importância de reconhecer o território de atuação, aprimorar a escuta sensível para questões do envelhecimento, valorizar a individualidade da pessoa idosa e seu contexto, a necessidade de trabalhar com parcerias intersetoriais e entre a equipe multiprofissional realizando atividades coletivas de promoção e prevenção da saúde, visando a qualidade no cuidado e, esse modo de trabalho possibilita que os enfermeiros tornem-se protagonistas, referências no cuidar, otimizando a construção e o fortalecimento de vínculo com as pessoas idosas e equipe o que pode proporcionar maior adesão a estilos de vida saudáveis e ao tratamento de saúde. Considerações finais: os enfermeiros estão imersos a um processo de construção de vínculo em suas unidades, são protagonistas, referência para sua equipe e para pessoa idosa. No entanto, há que se perfazer um longo caminho até que essas habilidades estejam de acordo ao que se postula como melhores práticas de enfermagem.
RESUMEN Objetivo: comprender cómo el enfermero en la Estrategia de Salud de la Familia construye el vínculo profesional con el adulto mayor. Métodos: investigación cualitativa, con 30 enfermeros de Estrategias de Salud de la Familia de Joinville, entrevistados entre enero y marzo de 2018. Se utilizó un instrumento de entrevista semiestructurado. Los datos fueron analizados según el análisis de contenido temático. Resultados: los resultados que surgieron de las categorías señalan la importancia de reconocer el territorio de actuación, mejorar la escucha sensible para cuestiones del envejecimiento, valorar la individualidad del adulto mayor y su contexto, la necesidad de trabajar con alianzas intersectoriales y entre el equipo multiprofesional, realizando actividades colectivas de promoción y prevención de la salud, buscando la calidad en el cuidado y, ese modo de trabajo posibilita que los enfermeros se vuelvan protagonistas, referencias en el cuidado, optimizando la construcción y el fortalecimiento de vínculo con los adultos mayores y el equipo que puede proporcionar mayor adhesión a estilos de vida saludables y al tratamiento de salud. Consideraciones finales: los enfermeros están inmersos en un proceso de construcción de vínculo en sus unidades, son protagonistas, referencia para su equipo y para la persona anciana. Sin embargo, hay que hacer un largo camino hasta que esas habilidades estén de acuerdo con lo que se postula como mejores prácticas de enfermería.
ABSTRACT Objective: tounderstand how Family Health Strategy nurses build a bond with older adults. Methods: qualitative research, with 30 nurses from the Family Health Strategies of Joinville, interviewed between January and March 2018. A semi-structured interview instrument was used. Data were analyzed according to thematic content analysis. Results: the results that emerged from the categories point to the importance of recognizing the territory of action, improving sensitive listening to aging issues, valuing the individuality of older adults and their context, the need to work with intersectoral partnerships and among the multidisciplinary team, carrying out collective health promotion and prevention activities, aiming at quality in care. This way of working allows nurses to become leaders, references in care, optimizing the building and strengthening of bonds with older adults and the team, which can provide greater adherence to healthy lifestyles and health care. Final considerations: nurses are immersed in a process of building a bond in their units, they are leaders, a reference for their team and for older adults. However, there is still a long way to go before these skills are in line with what is postulated as nursing best practices.
Subject(s)
Humans , Male , Female , Adult , Primary Health Care/organization & administration , Aged/physiology , Nursing/organization & administration , Delivery of Health Care/organization & administration , Nurses/organization & administration , Unified Health System , National Health Strategies , Aging/physiology , Disease Prevention , Health Promotion , Nursing, Team/organization & administrationABSTRACT
As a tribute to Butantan Institute in its 120th anniversary, this review describes some of the scientific research efforts carried out in the study of Lonomia envenoming in Brazil, a country where accidents with caterpillars reach over 42,000 individuals per year (especially in South and Southeast Brazil). Thus, the promising data regarding the studies with Lonomia's toxins contributed to the creation of new research centers specialized in toxinology based at Butantan Institute, as well as to the production of the antilonomic serum (ALS), actions which are in line with the Butantan Institute mission "to research, develop, manufacture, and provide products and services for the health of the population". In addition, the study of the components of the Lonomia obliqua bristle extract led to the discovery of new molecules with peculiar properties, opening a field of knowledge that could lead to the development and innovation of new drugs aimed at cell regeneration and inflammatory diseases.
Subject(s)
Arthropod Venoms/toxicity , Butterflies/physiology , Insect Bites and Stings/therapy , Animals , Brazil/epidemiology , Humans , Insect Bites and Stings/epidemiology , Larva/physiologyABSTRACT
Resumo Objetivo: Identificar na literatura os principais temas investigados sobre cuidados de enfermagem à pessoa com doença de Parkinson na atenção primária à saúde. Metodologia: Trata-se de um protocolo de revisão de escopo, realizado de acordo com a metodologia do Joanna Briggs Institute e checklist do Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR), seguindo as seguintes etapas: protocolo; critérios de elegibilidade; fontes de informação; estratégia de pesquisa; seleção de fontes de evidência; extração dos dados; análise de dados e apresentação dos resultados. Tem como pergunta de revisão: Quais os cuidados de enfermagem à pessoa com doença de Parkinson em nível de atenção primária à saúde, descritas na literatura? Para identificar documentos relevantes, as seguintes bases de dados bibliográficas serão pesquisadas: Public Medline, Cumulative Index to Nursing & Allied Health Literature, Web of Science, SciVerse Scopus, Base de Dados de Enfermagem, Literatura Latino-Americano e do Caribe em Ciências da Saúde, e Scientific Electronic Library Online. O resultado do fluxo de seleção, desta etapa metodológica, será apresentado em forma de figura, conforme o Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Resultados: Os resultados deste estudo possibilitarão o conhecimento das principais áreas de cuidados e intervenções de enfermagem voltadas a pessoas com doença de Parkinson, na atenção primária à saúde. Conclusão: Este estudo constitui o primeiro passo em uma agenda de pesquisa que visa aprofundar a análise e sistematização dos cuidados de enfermagem às pessoas que vivem com doença de Parkinson.
Resumen Objetivo: Identificar en la literatura los principales temas investigados sobre el cuidado de enfermería para personas con enfermedad de Parkinson en atención primaria de salud. Método: Es un protocolo de revisión de alcance, llevado a cabo de acuerdo con la metodología del Instituto Joanna Briggs y la lista de verificación de los elementos de informes preferidos para revisiones sistemáticas y extensión de metaanálisis para revisiones de alcance(PRISMA-ScR), siguiendo los siguientes pasos: protocolo, criterio de elegibilidad, fuentes de información, estrategia de investigación, selección de fuentes de evidencia, extracción de datos, análisis de datos y presentación de resultados. Tiene como pregunta de revisión la siguiente: ¿cuáles son los cuidados de enfermería brindados a las personas con enfermedad de Parkinson en el nivel de atención primaria de salud, descritos en la literatura? Para identificar documentos relevantes, se buscó en las siguientes bases de datos bibliográficas: Medline pública, Índice acumulativo de literatura de enfermería y salud aliada, Web of Science, SciVerse Scopus, Base de datos de enfermería, Literatura latinoamericana y caribeña en ciencias de la salud y Scientific Electronic Library en línea. El resultado del flujo de selección, de este paso metodológico, se presentará en forma de figura, de acuerdo con los elementos de informes preferidos para revisiones sistemáticas y metaanálisis. Resultados: Los resultados de este estudio permitirán conocer las principales áreas de atención e intervenciones de enfermería dirigidas a personas con enfermedad de Parkinson, en la atención primaria de salud. Conclusión: Este estudio es el primer paso de una agenda de investigación que tiene como objetivo profundizar en el análisis y sistematización de la atención de enfermería a las personas que viven con la enfermedad de Parkinson.
Abstract Aim: To identify in the literature the main topics investigated about nursing care for people with Parkinson's disease in primary health care. Method: This is a scope review protocol carried out according to the Joanna Briggs Institute methodology and the Preferred Reporting Items for Systematic reviews checklist and the Meta-Analyzes extension for Scoping Reviews(PRISMA-ScR). This investigation will follow these steps: protocol, eligibility criteria, information sources, research strategy, selection of sources, data extraction, data analysis, and presentation of results. Its review question is "What are the nursing cares provided to people with Parkinson's disease in primary health care as described in the literature?". To identify the relevant documents, the following bibliographic databases will be used: Public Medline, Cumulative Index to Nursing & Allied Health Literature, Web of Science, SciVerse Scopus, Nursing Database, Latin American and Caribbean Literature in Health Sciences, and Scientific Electronic Library Online. The results of this selections flow will be presented using figures as outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes. Results: The results of this study will shed light on the main researched areas of care and nursing interventions aimed at people with Parkinson's disease in primary healthcare. Conclusion: This study is the first step in a research agenda that aims to deepen the analysis and systematization of nursing care for people living with Parkinson's disease.
Subject(s)
Parkinson Disease/nursing , Primary Health Care/methods , Nursing AssessmentABSTRACT
OBJECTIVE: to identify scientific productions on nursing care related to fall risk prevention among hospitalized elderly people. METHODS: an integrative literature review from 2015 to 2019 in the PubMed/MEDLINE, Scopus, Web of Science, LILACS, BDENF, SciELO and CINAHL databases, in Portuguese, English and Spanish. The keywords were elderly, hospitalization, accidents due to falls, nursing care. RESULTS: thirty-three publications were analyzed. The synthesis of the studies resulted in the categories: Clinical nursing assessments to prevent falls among hospitalized elderly people; Fall risk factors for elderly people; Fall risk prevention strategies for elderly people. FINAL CONSIDERATIONS: it was found that the scientific knowledge produced on nursing care related to fall risk prevention for hospitalized elderly people evidences the clinical assessment, risk factors and strategies such as nursing care, contributing to foster self-care behavior and promotion security for elderly people.
Subject(s)
Accidental Falls , Nursing Care , Accidental Falls/prevention & control , Aged , Hospitalization , Humans , Risk FactorsABSTRACT
OBJECTIVE: To assess the contribution of gerontotechnologies in nursing care to older adults with Parkinson's disease, aiming at the prevention of falls. METHOD: Convergent Assistance Research, through the development and evaluation of gerontechnologies focused on the prevention of falls in older adults with Parkinson's Disease. Clinical evaluation, interviews and workshops with older adults were carried out, as well as analysis and judgment of the materials developed by ten judges certified in gerontology by the Brazilian Society of Geriatrics and Gerontology. RESULTS: Older adults need at least six years of study to understand the educational gerontotechnology development. The objectives related to the content, understanding of the text, illustration, presentation, motivation and cultural adaptation were achieved. CONCLUSION: The educational gerontotechnology developed has relevant content, which can be used by older adults, family members and caregivers, to generate clarification of questions on the theme of fall prevention for older adults with Parkinson's Disease.
Subject(s)
Geriatrics , Nursing Care , Parkinson Disease , Aged , Humans , MotivationABSTRACT
This is a case report of women with pregnancy morbidity (PM), some of them associated with antiphospholipid syndrome (APS), in which the glycan patterns of immunoglobulin G (IgG) were investigated based on the theory of alteration of glycosylation in autoimmunity. We used lectin blot to determine changes in terminal glycosylation of polyclonal IgG from women with antiphospholipid (aPL) antibodies and PM plus vascular thrombosis (PM/VT) and seronegative-obstetric APS (SN-OAPS). In addition, we analyzed IgG from women with PM without aPL (PM/aPL-) and healthy women, as controls. Even though the SN-OAPS and PM/VT groups share the PM, only the SN-OAPS group showed a decreased expression of galactose compared to the healthy group. We also found the presence of mannosylated oligosaccharides in IgG from all patients being significantly higher in IgG from women of the PM/aPL- group. The differences in glycans presented here could relate to pathological mechanisms of PM associated with APS.
ABSTRACT
OBJECTIVE: to analyze in available scientific literature what problems are caused to the musculoskeletal system of caregivers of older adults in the home environment. METHODS: an integrative literature review indexed in the PubMed, CINAHL, Web of Science, SCOPUS, BDENF, LILACS and SciELO databases. RESULTS: the sample totaled 17 studies that showed three thematic categories: Care overload for caregivers' health; Caregivers' physical illness; Caregiver self-neglect. CONCLUSION: the evidence identified health problems for caregivers of older adults, regarding the musculoskeletal system, demonstrating the importance of considering intervention strategies that provide guidelines for self-care guidelines, in order to prevent musculoskeletal complications resulting from older adults' care activities at home.