Physical activity and sitting time in adults after positive diagnosis for COVID-19: a cross-sectional study / Atividade física e tempo sentado em adultos após diagnóstico positivo para COVID-19: um estudo transversal

This study aimed to: a) investigate the most common signs and symptoms reported by people infect-ed by the COVID-19, b) compare total time and weekly level of physical activity of people between pre- and post-infection period, and c) examine the association between physical activity levels and signs and symptoms reported during the disease cycle. Twenty-two adult people (14 males and 8 females, mean age 37.9 ± 16.8 years) living in Ribeirão Preto, Brazil participated in this study. Par-ticipants received a positive diagnosis for COVID-19 by PCR. Physical activity and sitting time was assessed using the International Physical Activity Questionnaire. Variables such as body mass index and the clinical condition of the disease (signs and symptoms) were collected. The most frequent signs and symptoms reported by active and inactive individuals, respectively, were loss of taste (77.8% and 25%), headache (66.7% and 25%), coughing (66.7% and 25%), difficulty breathing (61.1% and 25%), and sore throat (61.1% and 75%). A 120-minute reduction (p = 0.010) in the total time of weekly physical activity and a 155-minute reduction (p = 0.003) of weekly moderate physical activity was observed in the pre- and post-diagnostic COVID-19 infection comparison. There was further an association between difficulty breathing and being physically inactive (odds ratio = 0.222; 95%CI: 0.094 ­ 0.527). Our findings suggest that COVID-19 had a negative impact on physical activity and that being physically active may reduce the likelihood of presenting with difficulty breathing if infected with the SARS-CoV-2 and associated disease COVID-19

Este estudo teve como objetivo: a) investigar os sinais e sintomas mais comuns relatados por pessoas infectadas por COVID-19, b) comparar o tempo total e o nível semanal de atividade física das pessoas no período pré e pós-infecção, c) examinar a associação entre os níveis de atividade física e os sinais e sintomas relatados du-rante o ciclo da doença. Participaram deste estudo 22 pessoas (14 do sexo masculino e oito do feminino, idade média 37,9 ± 16,8 anos) residentes na cidade de Ribeirão Preto, Brasil. Todos receberam diagnóstico positivo para COVID-19 via PCR. A atividade física e o tempo sentado foram avaliados por meio do Questionário Internacional de Atividade Física. Variáveis como índice de massa corporal e o quadro clínico da doença (sinais e sintomas), foram coletadas. Os sinais e sintomas mais frequentes foram perda do paladar (77,8% e 25%), dor de cabeça (66,7% e 25%), tosse (66,7% e 25%), dificuldade para respirar (61,1% e 25%) e dor gar-ganta (61,1% e 75%), para indivíduos ativos e inativos, respectivamente. Uma redução de 120 minutos (p = 0,010) no tempo total de atividade física semanal e de 155 minutos (p = 0,003) de atividade física moderada semanal foi observada na comparação pré e pós-diagnóstico por COVID-19. Houve associação entre dificul-dade para respirar e ser fisicamente inativo (odds ratio = 0,222; IC95%: 0,094 ­ 0,527). Nossos resultados sugerem que a COVID-19 teve impacto negativo na atividade física e que pessoas fisicamente ativas podem reduzir a probabilidade de apresentar dificuldade para respirar quando diagnosticadas por COVID-19

Classification of nutritional status by fat mass index: does the measurement tool matter? / Classificação do estado nutricional pelo índice de massa gorda: o instrumento de medição importa?

Abstract Assessment of the Nutritional Status (NS) allows screening for malnutrition and obesity, conditions associated with chronic non-communicable diseases. The fat mass index (FMI) stands out concerning traditional NS indicators. However, proposals that define thresholds for FMI are not sensitive to discriminate extreme cases (degrees of obesity or thinness). Only one proposal (NHANES), determined by total body densitometry (DXA), established eight categories of NS classification (FMI). However, DXA is expensive and not always clinically available. Our study aims to test the validity of the NHANES method using electrical bioimpedance (BIA) and skinfold thickness (ST) to classify NS. The FMI of 135 (69 women) university students aged 18 to 30 years old was determined using DXA, BIA, and ST. The agreement between the instruments (Bland-Altman) and the agreement coefficient in the NS classifications (Chi-square and Kappa index) were tested. The agreement test against DXA indicated that ST underestimated the FMI (-1.9 kg/m2) for both sexes and BIA in women (-2.0 kg/m2). However, BIA overestimated FMI (1.4 kg/m2) in men, although with less bias. There was no agreement between the NS classifications (NHANES) by FMI between DXA and BIA, or DXA and ST. The exception occurred between DXA and BIA in men who showed a slightly better consensus, considered "fair" (k = 0.214; p = 0.001). In conclusion, ST and BIA did not show enough agreement to replace DXA for NS classification, within NHANES thresholds. The FMI measurement tools for the NHANES classification of the categories of NS matters.

Resumo Avaliar o Estado Nutricional (EN) permite rastrear desnutrição e obesidade, condições associadas a doenças crônicas não transmissíveis. O índice de massa gorda (IMG) destaca-se em relação aos indicadores tradicionais de EN. No entanto, propostas que definem limiares para IMG não são sensíveis para discriminar casos extremos (graus de obesidade ou magreza). Apenas uma proposta (NHANES) estabeleceu oito categorias de classificação EN (IMG), mas foi determinada por densitometria corporal total (DXA). Porém, DXA é caro e nem sempre disponível. O objetivo foi testar a validade do método NHANES usando bioimpedância elétrica (BIA) e dobras cutâneas (DOCs) para classificar o EN. O IMG de 135 (69 mulheres) universitários com idade entre 18 e 30 anos foi obtido por DXA, BIA e DOCs. A concordância foi testada entre os instrumentos (Bland-Altman) e classificações de EN (Qui quadrado e índice Kappa). O teste de concordância com a DXA indicou as DOCs subestimarem o IMG (-1,9 kg/m2) para ambos os sexos e a BIA em mulheres (-2,0 kg/m2). No entanto, as BIA superestimaram o IMG (1,4 kg/m2) nos homens, embora com menos viés. Não houve concordância entre as classificações de EN (NHANES) pelo IMG entre DXA e BIA/DOCs. A exceção ocorreu entre DXA e BIA em homens que apresentaram concordância "razoável" (k = 0,214; p = 0,001). Em conclusão, DOCs e BIA não mostraram concordância suficiente para substituir DXA pela classificação de EN, dentro dos limites NHANES. As ferramentas diferem para medir IMG e classificar categorias de EN (NHANES).

Normalizing calf circumference to identify low skeletal muscle mass in older women: a cross-sectional study / Normalización de la circunferencia de la pantorrilla para identificar la masa muscular esquelética baja en las mujeres mayores: un estudio transversal

Introduction: functional limitation is a result of sarcopenia and is associated with loss of skeletal muscle mass (SMM). Cost-effective methods are important for the identification of sarcopenia. Objective: to propose cutoff points for normalized calf circumference (CC) in order to identify low SMM in older women based on their functional limitation.Methods: in this descriptive, cross-sectional study the CC values of a young female sample (n = 78) were used to establish cutoff points (-2 SD) for low SMM in older women (n = 67). Functional limitation was identified by the six-minute walk test (≤ 400 m). CC was normalized by body mass, height, and BMI. The diagnostic accuracy of CC was calculated with a ROC curve, using functional limitation as standard. Results: cutoff points and area under the curve (AUC) were: CC (≤ 28.5; 0.62); CC·body mass-1 (≤ 0.40; 0.63); CC·height-2 (≤ 8.52; 0.55) and CC·BMI-1 (≤ 1.10; 0.73). Only CC·BMI-1 achieved a desirable accuracy (AUC > 0.7) to distinguish functional limitation. Conclusion: the accuracy attained supports the use of CC·BMI-1 to identify low SMM in older women. In the clinical context it is possible to predict the risk of sarcopenia when sophisticated methods for determining SMM are not available. (AU)

Introducción: la limitación funcional es consecuencia de la sarcopenia y se asocia con la pérdida de masa muscular esquelética (MME). Los métodos rentables son importantes para la identificación de la sarcopenia. Objetivo: proponer puntos de corte para la circunferencia de la pantorrilla (CP), normalizada para identificar un MME bajo en mujeres mayores en función de su limitación funcional. Métodos: en este estudio descriptivo de carácter transversal se utilizaron los valores de CP de una muestra de mujeres jóvenes (n = 78) para establecer los puntos de corte (-2 DS) de la MME baja en las mujeres mayores (n = 67). La limitación funcional se identificó mediante la prueba de la marcha de seis minutos (≤ 400 m). La CP se normalizó por la masa corporal, la altura y el IMC. La precisión diagnóstica de la CP se calculó con la curva ROC, utilizando como estándar la limitación funcional. Resultados: los puntos de corte y el área bajo la curva (AUC) fueron: CP (≤ 28,5; 0,62); CP·masa corporal-1 (≤ 0,40; 0,63); CP·altura-2 (≤ 8,52; 0,55) y CP·IMC-1 (≤ 1,10; 0,73). Solo el CP·IMC-1 logró la precisión deseable (AUC > 0,7) para distinguir la limitación funcional. Conclusión: la precisión alcanzada respalda el uso de CP·IMC-1 para identificar la MME baja en las mujeres mayores. En el contexto clínico es posible predecir el riesgo de sarcopenia cuando no se dispone de métodos sofisticados para determinar la MME. (AU)

Population specificity affects prediction of appendicular lean tissues for diagnosed sarcopenia: a cross-sectional study / La especificidad de la población impacta en la predicción de los tejidos magros apendiculares para la sarcopenia diagnosticada: un estudio transversal

INTRODUCTION: sarcopenia is a disease characterized by reduced musculoskeletal tissue and muscle strength. The estimation of appendicular lean soft tissue by DXA (ALSTDXA) is one of the criteria for the diagnosis of sarcopenia. However, this method is expensive and not readily avaiable in clinical practice. Anthropometric equations are low-cost and able to accurate predict ALST, but such equations have not been validated for male Brazilian older adults between the ages of 60 to 79 years. To this end, this study sought to validate the existing predictive anthropometric equations for ALST, and to verify its accuracy for the diagnosis of sarcopenia in male Brazilian older adults. METHODS: this cross-sectional study recruited and enrolled 25 male older adults (69.3 ± 5.60 years). ALSTDXA and anthropometric measures were determined. ALST estimations with 13 equations were compared to ALSTDXA. The validity of the equations was established when: p > 0.05 (paired t-test); standard error of the estimate (SEE) < 3.5 kg; and coefficient of determination r² > 0.70. RESULTS: two Indian equations met the criteria (Kulkarini 1: 22.19 ± 3.41 kg; p = 0.134; r² = 0.78; EPE = 1.3 kg. Kulkarini 3: 22.14 ± 3.52 kg; p = 0.135; r² = 0.82; SEE = 1.2 kg). However, these equations presented an average bias (Bland-Altman: 0.54 and 0.48 kg) and 'false negative' classification for the ALST index. Thus, three explanatory equations were developed. The most accurate equation demonstrated a high level of agreement (r2 adj = 0.87) and validity (r²PRESS = 0.83), a low predictive error (SEEPRESS = 1.53 kg), and an adequate ALST classification. CONCLUSION: anthropometric models for predicting ALST are valid alternatives for the diagnosis and monitoring of sarcopenia in older adults; however, population specificity affects predictive validity, with risks of false positive/negative misclassification

INTRODUCCIÓN: la sarcopenia es una enfermedad caracterizada por una reducción del tejido musculoesquelético y la fuerza muscular. Uno de los criterios utilizados para su diagnóstico es la determinación de tejido blando magro apendicular por DXA (TBMADXA), método costoso que no siempre está disponible en la práctica clínica. Las ecuaciones antropométricas suponen un bajo coste y predicen bien el TBMA, pero con una validez desconocida para los varones brasileños de 60 a 79 años. Por lo tanto, nuestro objetivo fue validar las ecuaciones antropométricas existentes predictivas del TBMA y verificar su precisión para el diagnóstico de sarcopenia en varones brasileños de edad avanzada. MÉTODOS: participaron en este estudio transversal 25 hombres de edad avanzada (69,3 ± 5,60 años). Se determinaron el TBMADXA y las medidas antropométricas. Las ecuaciones predictivas del TBMA se compararon con el TBMADXA. La validez de las ecuaciones en las comparaciones se confirmó cuando: p > 0,05 (prueba de la "t" pareada); error estándar estimado (EEE) < 3,5 kg; coeficiente de determinación r² > 0,70. RESULTADOS: dos ecuaciones indias cumplieron los criterios (Kulkarini 1: 22,19 ± 3,41 kg; p = 0,134; r² = 0,78; EEE = 1,3 kg. Kulkarini 3: 22,14 ± 3,52 kg; p = 0,135; r² = 0,82; EEE = 1,2 kg). Sin embargo, presentaron sesgo promedio (Bland-Altman: 0,54 y 0,48 kg) y clasificación de 'falso negativo' para el índice de TBMA. Por lo tanto, se crearon tres ecuaciones explicativas. La ecuación más precisa mostró un alto acuerdo (r2 adj = 0,87), uma alta validez (r²PRESS = 0,83), um bajo error predictivo (EEEPRESS = 1,53 kg) y uma clasificación del TBMA adecuada. CONCLUSIÓN: los modelos antropométricos para predecir el TBMA son alternativas válidas para el diagnóstico y el seguimiento de la sarcopenia en los ancianos. Pero la especificidad de la población afecta a su validez predictiva, con riesgos de incorrección por clasificación falsa positiva/negativa

Anthropometric cutoff points to identify lipodystrophy characteristics in people living with HIV/AIDS: an observational study / Puntos de corte antropométricos para identificar las características de la lipodistrofia en personas que viven con VIH/SIDA: un estudio observacional

Introduction: currently, there is no consensus regarding accurate and low-cost methods for diagnosing lipodystrophy in people living with HIV/ AIDS (PLWHA). The aim of this study was to propose anthropometric cutoff points for the diagnosis of lipodystrophy among PLWHA. Methods: we included 106 PLWHA (men = 65, women = 41) who are under antiretroviral therapy and have been clinically classified into either a "lipodystrophy" or "non-lipodystrophy" group. Anthropometric measurements included 19 regions of body perimeters and 6 skinfold thickness measures. The Youden index was used to establish anthropometric cutoff points for the diagnosis of lipodystrophy, using the mean values of the anthropometric data (referred to as "original") along with the "Z index" (ZI) values, which were adjusted by the "Phantom Strategy." The cutoff points were proposed when "original" anthropometric measurements and ZI values had a statistical significance of p < 0.01 and an area under the curve (AUC) higher than 70%. The size effect was assessed to verify the influence of lipodystrophy on each anthropometric measure. Results: our data analysis proposes sex-specific cutoff points for the diagnosis of lipodystrophy in PLWHA - 17 points using the "original" anthropometric measurements, and 20 using the ZI values (average effect size between 1.0 and 1.1, and AUC = 76.7% and 78%). Conclusions: our study proposes accurate cutoff points for the diagnosis of lipodystrophy using "original" anthropometric measurements and ZI values adjusted by the "Phantom Strategy." Our findings support the use of anthropometric measurements as a simplified method for diagnosing lipodystrophy and monitoring body composition alterations in people living with HIV/AIDS

Introducción: no existe consenso con respecto a métodos precisos y de bajo coste para diagnosticar la lipodistrofia en personas que viven con VIH/SIDA (PVVS). El objetivo de este estudio es proponer puntos de corte antropométricos para el diagnóstico de lipodistrofia entre las PVVS. Métodos: se incluyeron 106 PVVS (hombres = 65, mujeres = 41) en tratamiento antirretroviral que se clasificaron clínicamente en dos grupos de "lipodistrofia" o "no lipodistrofia". Las mediciones antropométricas incluyeron 19 regiones de parámetros corporales y 6 medidas de pliegues cutáneos. El índice de Youden se utilizó para establecer puntos de corte antropométricos para el diagnóstico de lipodistrofia utilizando la media de los datos antropométricos (denominados "originales") junto con los valores del "índice Z" (IZ), que fueron ajustados por la "estrategia Phantom". Los puntos de corte se propusieron cuando las mediciones antropométricas "originales" y los valores de IZ fueron estadísticamente significativos con un valor p < 0,01 y un área bajo la curva (AUC) superior al 70%. Se evaluó el tamaño del efecto para verificar la influencia de la lipodistrofia en cada medida antropométrica. Resultados: se propusieron puntos de corte específicos según el sexo para el diagnóstico de lipodistrofia en PVVS: 17 puntos usando las medidas antropométricas "originales" y 20 usando los valores de IZ (tamaño del efecto promedio entre 1.0 y 1.1, y AUC = 76.7% y 78%). Conclusiones: se propusieron puntos de corte antropométricos para el diagnóstico de lipodistrofia. Las mediciones antropométricas son un método simplificado para diagnosticar y monitorear los cambios de composición corporal en las PVVS

Validation of anthropometric models in the estimation of appendicular lean soft tissue in young athletes / Validação de modelos antropométricos na estimação da massa isenta de gordura e osso apendicular em jovens atletas

Abstract Magnetic resonance imaging and Computer tomography are gold standards in the measurement of muscle tissue (MT), but are expensive. Dual Energy X-Ray Absorptiometry (DXA) is also costly but safer and allows for the measurement of Appendicular Lean Soft Tissue (ALST), a strong predictor of MT. Alternatively, there are anthropometric models that predict the ALST of Portuguese athletes with low cost/risk that have not been validated in other populations. The aim of this study was to validate anthropometric Portuguese models that predict ALST in young athletes or, if the validation fails, to propose new models. The ALSTDXA of 174 young athletes was determined by DXA. Two anthropometric models (ALSTmod1 and ALSTmod2) measuring ALST among Portuguese athletes were tested. To validate the coefficient of determination, the difference (bias) and concordance correlation coefficient between predicted and actual values were computed. Finally, association between mean and difference of methods was verified. Validation failed and, for this reason, new multiple regression models were proposed and validated using PRESS statistics. The Portuguese models explained ~96% of the ALSTDXA variability. The difference between ALST (-0.7kg) was less than that found for the ALSTmod2 and ALSTDXA limits of agreement from 3.6 to -2.1 and from 6.1 to -1.5kg, respectively. The new models included three predictive equations for ALST. Only ASLTmod1was valid; however, it was prone to bias, depending on the magnitude of ALST values. The newly proposed models present validity with greater concordance (r2PRESS=0.98), lower standard error of estimate (SEEPRESS [kg]=0.91) and more homogeneous predicted extreme values.

Resumo Ressonância magnética e tomografia computadorizada são referências para medir o tecido muscular (TM), porém apresentam custo elevado. A Absorciometria Radiológica de Dupla Energia (DXA) é segura, embora ainda dispendiosa, permite medir a Massa Isenta de Gordura e Osso apendicular (MIGOap), forte preditor do TM. Alternativamente, existem modelos antropométricos preditivos da MIGOap de atletas portugueses com baixo custo/risco, porém sem validação para outras populações. Objetivou-se validar modelos antropométricos portugueses preditivos da MIGOap em jovens atletas ou propor novos modelos, caso a validação falhe. A determinação da MIGOapDXA de 174 jovens atletas foi realizada por DXA. Dois modelos antropométricos (MIGOapmdJ1 e MIGOapmd2) de atletas portugueses foram testados para predizer MIGOap. Para validação o coeficiente de determinação, a diferença (viés) e a concordância entre valores medidos e preditos foram calculados. Finalmente, a associação entre média-e-diferença dos métodos foi calculada. A validação falhou, assim foram propostos novos modelos de regressão múltipla validados por estatística PRESS. Os modelos portugueses explicaram ~96% da variabilidade da MIGOapDJAf A diferença entre MIGOapmod1 e MIGOapDXA (-0,7kg) foi menor do que MI-GOapmod2 (-2,3kg), com limites de concordância de3,6 a -2,1 e de 6,1 a -1,5kg, respectivamente. Os novos modelos incluíram três equaçõespreditivaspara MIGOap. Somente MIGOapmd1foi válido, todavia mostrou grande tendência a vieses, conforme magnitude dos valores de MIGOap. Os novos modelos propostos mostraram validade com maior concordância (r2PRESS=0,98), menores erros de estimativa (EPEPRESS =0,91) e valores preditos mais homogêneos para casos extremos.

Estimate of Resting Energy Expenditure by DXA in Boys of Different Nutritional Statuses

Abstract Aim: to estimate the resting energy expenditure (REE) of organ tissue components using Dual Energy x-ray Absorptiometry (DXA) in pubertal boys. The mass of components and REE were compared among groups of different nutritional statuses. Methods: a sample of 278 boys (13.7 ± 2.4 years old) was grouped according to BMI nutritional status for Brazilian children and adolescents1 such as Underweight (UW), Normal weight (NW), Overweight (OW), and Obese (OB). The REE of organ tissue components given by DXA was calculated using specific models for skeletal muscle tissue (SMT), adipose tissue (AT), bone tissue (BT) and residual tissue (RT) based on previous reports. The absolute and relative REE (REEDXA) of each component were statistically compared among groups. Results: No differences of total REEDXA were found among nutritional groups (F(3, 274)=0.071, p=0.976). When, however, specific REE was considered per component, differences were found for BT and REEBT between NW-OW (p=0.003) and NW-OB (p=0.048); in AT and REEAT for all the groups (p<0.001), except between UW-NW (p=1.000); in RT and REERT between NW-OB (p=0,022) and SMT and REESMT (p=0,039). Greater proportions of organ tissue of RT and high metabolic rates, were observed in the UW group (78.3%) in comparison to the OB group (60.7%). Conclusion: This approach provides a new opportunity to examine energy metabolism for individual differences of pediatric populations. It is an applicable strategy both to prescribe exercises and to administer diets to this population, as it reveals the magnitude of heat-producing body components.