Real-World Study of Definisse Threads for Facial Reshaping in Indian Patients: REDEFINE FACE Study.

INTRODUCTION: In recent years, thread lifting has gained popularity as a less invasive cosmetic surgery. It helps raise and realign sagging tissue. The newest thread type for thread lifting procedure is poly-lactic acid-polycaprolactone (PLCL) Definisse threads (RELIFE S.r.l., Florence, Italy). These are fourth-generation absorbable suspended barbed threads. Their double action involves an immediate elevating impact through mechanical action and, over time, the promotion of histological rejuvenating activity through inducing fibroblasts and the synthesis of elastin, hyaluronic acid, and collagen. OBJECTIVES: The REDEFINE FACE study assessed the effectiveness and tolerance of Definisse threads in a real-world setting for facial reshaping in patients in India. METHODS: This multicenter, retrospective observational research included patients treated with Definisse threads for face contouring. RESULTS: Three hundred seventeen patients with a mean follow-up of 4.9 months and an average age of 48.6 years participated in the study. All patients underwent thread lifts using either a single or a combination of Definisse thread reshaping techniques. The Global Aesthetic Improvement Scale for Physicians and Subjects (PGAIS and SGAIS) reported improvement instantly following the treatment (mean score- 3.23 and 3.18, respectively). Improvements continued to enhance during the follow-up visits (mean score- 4.09 and 4.03, respectively). Following the procedure, 96% of patients on the PGAIS and SGAIS exhibited enhancement. Most procedure-related side effects were minor and went away on their own in a few days without the need for proactive care. CONCLUSION: The results of this real-world analysis showed that the latest Definisse threads effectively achieve facial reshaping on patients in India and have both immediate and long-term effects. Treatment was generally well tolerated, and no patient experienced serious adverse events.

Retrospective real-world study of Definisse threads for jaw line reshaping in Indian patients (REDEFINE JAW study).

BACKGROUND: Thread lifting is a minimally invasive aesthetic procedure that lifts and realigns sagging tissue. Definisse double-needle threads are the latest fourth generation absorbable, monofilament, suspension barbed threads of synthetic origin with convergent bidirectional barbs. Definisse thread produces dual action; mechanical action gives a lifting effect and over a period, it promotes histological revitalizing action. OBJECTIVES: To evaluate the real-world efficacy and safety of Definisse double-needle threads for lower facial lifting for jaw line reshaping in Indian patients. METHODS: This is an observational, retrospective study involving patients who underwent treatment for lower-face reshaping using Definisse double-needle 12 cm threads. RESULTS: Fifty patients with a mean age of 47.44 years were included in the study with an average follow-up of 5.14 months. All the patients have undergone Jawline Reshaping (JR) procedure, while 70% of patients also underwent Malar Reshaping (MR) technique simultaneously. Mean of Physician and Subject Global Aesthetic Improvement Scale (PGAIS and SGAIS) showed improvement immediately after the procedure (mean scores 2.82 and 2.7, respectively) and showed further improvement at the follow-up (3.72 and 3.58, respectively). Moreover, most of the patients immediately after the procedure rated the improvement in PGAIS and SGAIS as "much improved" compared to pre-procedure appearance (78% and 66%, respectively), while, at follow-up, 76% and 66% of the patients, respectively, rated "improved very much" compared to pre-procedure appearance. CONCLUSION: Current study has demonstrated the effectiveness of the latest Definisse threads in Indian patients in performing tissue repositioning to provide a noticeable lifting effect. Procedure was also well tolerated and none of the patients developed serious complications.

Newer injection points for facial contouring with hyaluronic acid filler-Case Report.

BACKGROUND: Hyaluronic fillers have been used for filling in folds and contour the face according to global aesthetic standards to achieve a smooth ogee curve on the face. But sometimes these result in a bulkier look to the face thus preventing more people from opting for these procedures. Although M.D codes have now been given to guide the injecting physicians for various points of injections on the face, they need to be used judiciously and tailored to individuals, using the lateral points of the face first. AIMS: Patients still come to physicians to get the midface and nasolabial folds corrected but a proper aesthetic evaluation is essential and it was observed that targeting the peripheral points of the face leads to better tightening of the face and a slimmer look for the patient. A case was injected on peripheral points including some newer points not mentioned in the M.D codes. These points are on the forehead along the hairline and the mastoid process. Safety and efficacy of injecting on these particular points were evaluated. METHODS: 2-ml hyaluronic acid syringes (20 mg conc) were used to give bolus injections on the peripheral points of the face, including a new point on mastoid process and peripheral points on forehead. RESULTS: A good aesthetic outcome was achieved resulting in slimming of face with patient satisfaction and without any complications. CONCLUSION: A good nonsurgical contouring of a young face can be achieved with 2 ml hyaluronic acid injection when the correct points are injected.