1.
J Pediatr
; 221: 235-239, 2020 06.
Article
in English
| MEDLINE
| ID: mdl-32111377
ABSTRACT
Methotrexate is used to treat autoimmune and oncologic diseases in children with Down syndrome. However, increased methotrexate-related toxicity is reported in this population. We evaluated differences in the concentrations and distribution of erythrocyte folates in children with Down syndrome as a potential basis for this enhanced toxicity.
Subject(s)
Down Syndrome/blood , Folic Acid/blood , Homeostasis , Child, Preschool , Erythrocytes/metabolism , Folic Acid/administration & dosage , Humans , Methotrexate/pharmacology , Methotrexate/toxicity , Pilot Projects , Sampling Studies , Vitamin B Complex/administration & dosage
2.
J Pediatr
; 164(2): 231-6, 2014 Feb.
Article
in English
| MEDLINE
| ID: mdl-24286573