Treatment of Villous Adenoma With Underlying Adenocarcinoma of the Prostatic Urethra Using Combined Chemoradiation: A Case Report.

The presence of villous adenoma in the urinary tract is an exceedingly rare finding. On a histological and cytological level, this tissue is essentially identical to that typically found in the colon. These lesions do have malignancy potential and, when present with coexistent adenocarcinoma, have a risk of recurrence and metastasis even after surgical resection. Although villous adenomas of the urinary tract have been almost exclusively treated with surgical intervention in the literature, we present a case of villous adenoma with underlying adenocarcinoma of the prostatic urethra that was successfully treated with combined chemoradiation therapy. While surgical excision has been shown to be curative in diseases with isolated villous adenoma, more aggressive treatment with radiation and/or chemotherapy can be considered in patients with concurrent adenocarcinoma. However, more research into this subject is required to properly determine the best choice of therapy for this niche patient population.

Transient gas-induced differential refractive index effects in as-drawn hollow core optical fibers.

When a hollow core fiber is drawn, the core and cladding holes within the internal cane geometry are pressurized with an inert gas to enable precise control over the internal microstructure of the fiber and counteract surface tension forces. Primarily by considering the temperature drop as the fiber passes through the furnace and the geometrical transformation of the internal microstructure from preform-to-fiber, we recently established that the gas pressure within the final 'as-drawn' fiber is substantially below atmospheric pressure. We have also established that slight changes in the gas refractive index within the core and surrounding cladding holes induced by changes in gas pressure are sufficient to significantly affect both the modality and loss of the fiber. Here we demonstrate, through both simulations and experimental measurements, that the combination of these effects leads to transient changes in the fiber's attenuation when the fibers are opened to atmosphere post-fabrication. It is important to account for this phenomenon for accurate fiber characterization, particularly when long lengths of fiber are drawn where it could take many weeks for every part of the internal microstructure to reach atmospheric pressure.

Three stage HCF fabrication technique for high yield, broadband UV-visible fibers.

Hollow-core optical fibers can offer broadband, single mode guidance in the UV-visible-NIR wavelength range, with the potential for low-loss, solarization-free operation, making them desirable and potentially disruptive for a wide range of applications. To achieve this requires the fabrication of fibers with <300nm anti-resonant membranes, which is technically challenging. Here we investigate the underlying fluid dynamics of the fiber fabrication process and demonstrate a new three-stage fabrication approach, capable of delivering long (∼350m) lengths of fiber with the desired thin-membranes.

Effect of different enamel conditionings on the bond strength of glass ionomer cement and ceramic brackets

Aim: To evaluate the effect of different enamel conditionings on the shear bond strength (SBS) and bond failure patterns of a resin modified glass ionomer cement (RMGIC) used to bond ceramic brackets. Methods: 105 human premolars extracted for orthodontic reasons were divided into 7 groups according to the enamel surface treatments: conditioners (35% phosphoric acid and 10% polyacrylic acid), type of adhesive (Transbond(r) and Fuji Ortho LC Capsule(r)), washing time and drying of the surface. Results: A significant p<0.05 was observed among the shear bond strength values obtained with seven different types of enamel preparation prior to bonding. The group that had the tooth surface conditioned with polyacrylic acid and enamel surface slightly dried before bracket placement showed no significant difference (p>0.05) to the group that had brackets bonded with composite resin. The two groups that had enamel prepared with polyacrylic acid and brackets bonded with GIC on a wet surface showed significantly lower shear bond strength than the control group (p<0.05). Conclusions: Moisture contamination decreased SBS, but not enough to preclude the use of RMGIC as an alternative to composite resin (CR) for direct bonding of ceramic brackets.