Clinical evaluation of neovascular and non-neovascular chronic central serous chorioretinopathy (CSC) diagnosed by swept source optical coherence tomography angiography (SS OCTA).

PURPOSE: To evaluate the clinical characteristics of eyes with chronic central serous chorioretinopathy based on swept source optical coherence tomography angiography (SS OCTA). METHODS: Twenty-nine eyes presenting with chronic central serous chorioretinopathy (CSC) were examined with the Topcon SS OCTA, using the DRI optical coherence tomography (OCT) Triton machine, and were classified as neovascular or non-neovascular CSC depending on whether a vascular pattern was detected in the outer retina on OCT angiogram. The two groups were compared based on the following clinical findings: best corrected distance and reading visual acuity (BCDVA, best corrected reading acuity (BCRA)), rate of subretinal fluid, intraretinal fluid, hyperreflective flat pigment epithelial detachment (PED), and serous PED. RESULTS: Of 29 eyes with chronic CSC, 10 (34.5%) showed a neovascular pattern, suggesting neovascular CSC, in the outer retina of SS OCTA. Eyes with neovascular CSC showed a significantly worse initial and final BCDVA, with a mean value of 0.39 ± 0.20 logMAR (Snellen equivalent 20/49) and 0.33 ± 0.36 logMAR (Snellen equivalent 20/43), compared to eyes with non-neovascular CSC with a mean value of 0.16 ± 0.15 logMAR (Snellen equivalent 20/29) and 0.04 ± 0.11 logMAR (Snellen equivalent 20/22) (p < 0.05), respectively. Final mean BCRA was 0.14 ± 0.20 logRAD for non-neovascular CSC compared to 0.34 ± 0.28 logRAD (p = 0.031) for neovascular CSC. The mean time between the first and final visits was 3 years for both groups. The mean anti-VEGF injection rate was 6.4 for neovascular CSC and 2.9 for non-neovascular CSC, whereas 26.3% of non-neovascular CSC eyes had an additional half fluence photodynamic therapy (PDT). CONCLUSION: SS OCTA provides a promising CNV detection rate, secondary to chronic CSC, in a clinical setting. Neovascular CSC is associated with a worse outcome in terms of visual and reading acuity compared to non-neovascular CSC.

Assessment of long-term intraocular lens (IOL) decentration and tilt in eyes with pseudoexfoliation syndrome (PES) following cataract surgery.

BACKGROUND: To evaluate long-term intraocular lens (IOL) decentration and tilt in eyes with pseudoexfoliation syndrome (PES) following cataract surgery using Visante anterior segment OCT and iTrace Visual Function Analyzer. METHODS: Sixty-four eyes following cataract surgery from 2009 to 2012 were included, 34 eyes had PES and 30 eyes did not show PES. A standard phacoemulsification procedure followed by IOL implantation was performed and patients were followed 4-6 years after surgery (mean = 69 months). Best-corrected visual acuity (BCVA), capsulorhexis size, and intraocular pressure (IOP) were measured. IOL decentration and IOL tilt were evaluated using Visante Omni anterior segment OCT (Carl Zeiss Jena GmBH, Germany). The iTrace VFA (Visual Function Analyzer, Hoya surgical optics) was used to measure corneal, internal, and total optical aberrations. RESULTS: Measurements with iTrace showed that horizontal coma was significantly different between PES and control eyes (p = 0.037). Horizontal as well as vertical tilt showed a significant difference between PES and control eyes (p = 0.035 and p = 0.039). Tilt correlated with capsulorhexis size in PES patients (p = 0.011). This indicates a forward tilt of the superior edge of the IOL in eyes with PES. CONCLUSIONS: Patients affected by PES seem to have a higher risk for long-term complications and changes in visual perception due to IOL tilt and decentration after cataract surgery.

Comparison of Two Toric IOLs with Different Haptic Design: Optical Quality after 1 Year.

BACKGROUND: The purpose of this prospective, randomised study was to interocularly compare the visual performance after implantation of two different toric IOLs with different haptic design. METHODS: 59 subjects with corneal astigmatism greater than 1.25 diopter (D) were implanted with an AT TORBI 709M IOL (Carl Zeiss Meditec AG) in one eye and with a Tecnis toric aspheric IOL (Abbot Medical Optics) in the other eye. Observation procedure was performed 12 months postoperatively. Main outcome measures included uncorrected distance visual acuity (UDVA), manifest refraction, IOL rotation, and IOL position. RESULTS: Mean UCDVA was 0.04 ± 0.14 logMAR for AT TORBI eyes and 0.06 ± 0.15 logMAR for Tecnis eyes (p = 0.3). The postoperative spherical equivalent values were significantly lower in the AT TORBI group. Mean toric IOL axis rotation was 3.0 ± 2.26 degrees for AT TORBI eyes and 3.27 ± 2.37 for Tecnis eyes (p = 0.5). The mean vertical IOL tilt and vertical decentration values measured with the Visante OCT were significantly larger in the AT TORBI group (p < 0.05). CONCLUSIONS: Both the Tecnis and the AT TORBI toric IOLs successfully reduced ocular astigmatism. Emmetropia could be better achieved with the AT TORBI IOL, whereas the Tecnis showed better positional stability. This trial is registered with ICMJE NCT03371576.

Patient knowledge concerning age-related macular degeneration: an AMD questionnaire.

BACKGROUND: Age-related macular degeneration (AMD) is a disease with rising prevalence. This study evaluates patients' knowledge and the need for more patient information. METHODS: 271 patients with AMD were asked to complete a questionnaire concerning their knowledge about AMD. 150 patients were interviewed by a physician and 121 patients completed the questionnaire on their own. RESULTS: 79.4 % of patients had previous knowledge about AMD. Most patients, 97.3 %, got their information from physicians. 58 % of patients find their knowledge concerning AMD adequate. Only 23.9 % knew about aid organizations for patients with visual impairments. DISCUSSION: Though the majority of patients had good knowledge concerning AMD, there was a large percentage of patients who seemed to lack information. Physicians should actively ask their patients if they have any questions related to their disease. Medial focus on AMD and information about aid organizations could help patients to cope with their disease. CONCLUSION: A large number of patients seemed to need additional information. We suggest that ophthalmologists provide general information concerning AMD to their patients every 3 to 5 years. Information about aid organizations specializing in visual impairment could also be provided. Well-informed patients would be better able to follow their physician's instructions and would have a better understanding of their disease, particularly for the sake of therapy.

Reproducibility of a new colour test.

PURPOSE: To evaluate the reproducibility of a new colour test, using the Chromatometer CM3. METHODS: Twenty healthy subjects were recruited at the Department of Ophthalmology, at the Medical University of Vienna. A total of 40 eyes were tested. Both eyes were tested separately with the Chromatometer CM3. The colour test was repeated after several days. Each time, best-corrected visual acuity was tested using Snellen charts, and colour perception was tested using the Chromatometer CM3. RESULTS: The Chromatometer CM3 showed reproducible results between the two tests at almost every luminosity level. All 4 green-red measurements and 2 blue-yellow brightness measurements showed reproducible results between the first and second tests. CONCLUSION: The Chromatometer CM3 seems to be an appropriate method to detect changes in colour perception, although the red-green comparison appeared to be more precise than the blue-yellow comparison.