Subject(s)
Hemophilia A , Hemophilia B , Humans , Hemophilia A/epidemiology , Prevalence , Hemophilia B/epidemiologySubject(s)
Alleles , Blood Coagulation Factor Inhibitors/immunology , Hemophilia A/genetics , Hemophilia A/immunology , Isoantibodies/immunology , Lactase/genetics , Polymorphism, Single Nucleotide , Brazil/epidemiology , Gene Frequency , Genotype , Hemophilia A/drug therapy , Hemophilia A/epidemiology , Humans , Severity of Illness IndexABSTRACT
The corneomandibular reflex was first described in 1902 by German doctor Von Sölder, who reported the presence of the reflex in patients and in the general population. For him, the corneomandibular reflex represented an exaggeration of the normal response. This was one of the more than 250 reflexes described in the beginning of the 20th century, during the so called "race of the reflexes".
O reflexo córneo-mandibular foi descrito pela primeira vez em 1902 pelo alemão Von Sölder, que relatou a presença de reflexos em pacientes e indivíduos normais. Segundo ele, o reflexo córneo-mandibular representa um exagero da resposta convencional. Este é um dos mais de 250 reflexos descritos no início do século XX, durante a chamada "corrida dos reflexos".
Subject(s)
Humans , Reflex , Cornea , Mandible , HistoryABSTRACT
Fanconi anaemia (FA) is a rare genetic chromosomal instability syndrome caused by impairment of DNA repair and reactive oxygen species (ROS) imbalance. This disease is also related to bone marrow failure and cancer. Treatment of these complications with radiation and alkylating agents may enhance chromosomal breakage. We have evaluated the effect of amifostine (AMF) on basal and mitomycin C (MMC)-induced chromosomal breakage in FA blood cells using the micronucleus assay. The basal micronuclei count was higher among FA patients than healthy subjects. Pre-treatment with AMF significantly inhibited micronucleation induced by MMC in healthy subjects (23.4 +/- 4.0 - MMC vs 12.3 2.9 - AMF --> MMC) MN/1000CB, p < 0.01, one way ANOVA) as well as in FA patients (80.0 +/- 5.8 - MMC vs 40.1 +/- 5.8 - AMF --> MMC) MN/1000CB, p < 0.01, ANOVA). Release of ROS by peripheral blood mononuclear cells treated with AMF -> MMC and measured by chemoluminometry showed that AMF-protection was statistically higher among FA patients than in healthy individuals. Based on these results we suggest that AMF prevents chromosomal breakage induced by MMC, probably by its antioxidant effect.
Subject(s)
Amifostine/pharmacology , Chromosome Breakage/drug effects , Fanconi Anemia/drug therapy , Lymphocytes/drug effects , Mitomycin/adverse effects , Adolescent , Adult , Blood Cells , Case-Control Studies , Child , Fanconi Anemia/genetics , Female , Humans , Male , Micronuclei, Chromosome-Defective/drug effects , Reactive Oxygen Species/metabolismABSTRACT
Os ambientes frigoríficos expõem os trabalhadores a esforços repetitivos, posturas etereotipadas e desconforto térmico. Esses riscos estão associados a problemas musculoesqueléticos devido às respostas dos tecidos moles ao excesso de solicitação das estruturas dos membros superiores, e ainda, aos acidentes de trabalho causados pelas diminuição da destreza, que tem como origem, provavelmente, a isquemia provocada pela queda da temperatura do tecido musculoesquelético. O resfriamento de todo corpo ou de parte dele resulta em desconforto, distúrbio da sensibilidade e da função neuromuscular, por último, injúria por frio. A prevenção do resfriamento através de uso de roupas protetoras, sapatos, luvas e capacetes ou gorros interfere na mobilidade e na destreza do trabalhador. Há um" custo de proteção", de modo que os movimentos se tornam restritos e exaustivos. Deve-se enfatizar a tríade: proteção, formação e ergonomia