Prognostic Significance of Synchronous Colorectal Adenocarcinoma: A Matched-Pair Analysis.

OBJECTIVE: To determine the prognostic significance of the synchronous colorectal cancer (S-CRC) on survival and recurrence rate. METHODS: Authors conducted an analysis of 90 colorectal adenocarcinoma patients who received a curative (R0) resection with a full course of standard adjuvant treatment. A total of 45 patients diagnosed with S-CRC at the time of initial presentation were individually matched to a group of 45 solitary CRC patients in pair at a ratio of 1:1. The case-matched criteria included age (± 5 years), gender, tumor location, and tumor stage. For S-CRC, the most advanced pathologic lesion was defined as the index lesion, and the matching cancer stage was categorized according to the index lesion. The N-stage was determined based on all lymph nodes. RESULT: There were a higher number of retrieved nodes in patients with S-CRC than those with solitary CRC. The median (min, max) of the total number of retrieved nodes for S-CRC was 18 (3, 53) nodes, compared to 14 (4, 45) nodes for solitary CRC (p < 0.01). All patients were without distant metastasis (stage I to III). The total accumulative number of patients experiencing tumor recurrence was 9 (20%) amongst the solitary CRC patients and 18 (40%) amongst the S-CRC patients at the 15-year surveillance period (p<0.05). The disease-free survival (DFS) (mean + SD) was 147.6 + 9.3 months in the solitary CRC group, compared to 110.5 + 11.7 months in the S-CRC group (p<0.05). Amongst S-CRC patients, those having primary and synchronous tumors located across anatomical segments had poorer DFS (70.5 months) and higher 15-year tumor recurrence rate (17.8%) than those with all tumors in the same or contiguous anatomical segments. In addition, the S-CRC patients with all tumors located in contiguous segment had a longer DFS (123.7 months) than the other types of anatomical correlation. CONCLUSION: Patients with S-CRC had worse prognosis than those with solitary CRC. For S-CRC, the anatomical correlation between the primary and the synchronous tumors may influence DFS and recurrence rate.

Sudden-Onset Disaster Mass-Casualty Incident Response: A Modified Delphi Study on Triage, Prehospital Life Support, and Processes.

The application and provision of prehospital care in disasters and mass-casualty incident response in Europe is currently being explored for opportunities to improve practice. The objective of this translational science study was to align common principles of approach and action and to identify how technology can assist and enhance response. To achieve this objective, the application of a modified Delphi methodology study based on statements derived from key findings of a scoping review was undertaken. This resulted in 18 triage, eight life support and damage control interventions, and 23 process consensus statements. These findings will be utilized in the development of evidence-based prehospital mass-casualty incident response tools and guidelines.

Synchronous Advanced Colorectal Neoplasia: Clinicopathologic Features and Prognostic Significance.

OBJECTIVE: This study aimed to compare the clinico-pathologic features, recurrence rate and disease-free survival between colorectal cancers (CRCs) with synchronous advanced colorectal neoplasia (SCN) and solitary CRCs to determine the prognostic significance of SCN. METHODS: A retrospective review of prospectively collected data of patients with CRCs was conducted in Phramongkutklao Hospital from January 2009 to December 2014. Patients were categorized in 3 groups: 1) solitary CRCs, 2) CRCs with advanced colorectal adenomas (ACAs) but having no another cancer and 3) synchronous colorectal cancers (S-CRCs) with or without ACAs. Patients undergoing curative resection and complete standard adjuvant treatment were recruited to evaluate the prognostic significance of SCN.  Clinicopathologic features, recurrence rate and disease-free survival were analyzed to compare among different groups.  Result: Among 328 recruited patients, 282 were classified as solitary CRCs (86%), 23 as CRCs with ACAs (7%) and 23 as S-CRCs (7%). Patients with CRCs with SCN (groups 2 and 3) were significantly older than patients with solitary CRCs (p <0.01), and SCN was found more commonly among males (15.2%) than females (12.3%) (p=0.045). In all, 288 patients achieved a curative resection and accomplished complete standard postoperative adjuvant treatment. Of these, the accumulative number of patients experiencing tumor recurrence was 11.8, 21.2, 24.6, 26.4 and 26.7% at the 1-, 3-, 5-, 7- and 10-year surveillance period, respectively. The disease-free survival of the groups with SCN was marginally higher than that of solitary CRCs groups (p=0.72) (solitary CRCs, 120.7±4.4 months; CRCs/ACAs, 127.4±13.9 months and S-CRCs: 126.2±13.6 months). CONCLUSION: CRCs with SCN were found at a more advanced age than those with solitary CRCs. SCN was found more often among males than females. After achieving curative resection and complete adjuvant treatment, the recurrence rate and disease-free survival of CRCs with SCN did not significantly differ from those of solitary CRCs.

Measures for emergency medical technicians in helping victims at scenes guided by the pattern of injuries and bombing attacks in the three most southern provinces of Thailand.

Bombing attacks by terrorists in the three most southern provinces of Thailand increased both in frequency and intensity from the year 2004 until now. Patterns of bombing were not only destroying buildings or killing targets victims by dropping bombs under roads and in public places but also harming scene investigators by dropping second bombs nearby. Emergency medical personnel working there also had some risks from these second bombs while helping victims at the scene. The purposes of the present study aimed to describe patterns and risks of bombing attacks, analyze locations of wounds of bombing casualties and propose a standing operation procedure for emergency medical technicians (EMTs) in helping victims at scenes to reduce harm from second bombs. The authors gathered some information about patterns of bombing from the Forward 4th Army Area Explosive Ordnance Disposal (EOD) team and reviewed insurgency related casualty reports from Yala, Pattani and Narathivasrajanakarin Hospital from January 2004 to December 2006. From these reports, data of deep wounds or wounds that caused serious injuries or deaths of 144 improvised explosive devices (IED) victims was collected and separated into fatal (45 casualties) and nonfatal groups (99 casualties). In each group, casualties' demographic data and number of casualties separated by locations of wounds and occupations are shown and compared by percentage of the total number of each group and was found that most of fatal casualties had wounds on head (42.22%), chest (33.33%) and abdomen (33.33%) that should be protected by wearing helmets and body armors. But there was a higher proportion of extremity injuries in non-fatal casualties (63.64%). Thus, the authors proposed measures for EMTs in helping victims at scenes to reduce their risks by wearing helmets and body armors and quickly removal of the injured with minimal medical intervention.

The impact of providing medical assistance to local people of medical unit of the Royal Thai Army task force in East Timor.

The Royal Thai Army deployed a large troop overseas to join the United Nation Peace Operation in East Timor in October 1999. The operations included recovering peace, providing security and humanitarian assistance in the area of operations in Baucau and Viqueque. Our level 2 medical unit provided medical assistance to the Timoreses by opening consultation at our medical unit and sending mobile clinics into remote areas. This mission made Thailand uphold its good reputation and good relationship with the Timoreses. To reduce any conflicts and to ensure a high success of UN peacekeeping missions, enhancing a collaborative work and relationship with the NGO who previously pursued health service activities in that area are needed. Additionally, concerning negative impacts to the local people should be considered after implementation of the health service system. They had to adapt themselves to the limitation of their own local health service after the humanitarian assistance was over. There is a need to improve the training of military personnel with internationally accepted guidelines and they understand their potential roles within armed forces and improve the coverage of humanitarian needs for the next mission.

Local perianal nerve block versus spinal block for closed hemorrhoidectomy: a ramdomized controlled trial.

OBJECTIVE: To compare analgesic effectiveness, postoperative pain, complications, and patients' satisfaction between two randomly allocated groups--one group that had local perianal nerve block and another group that had spinal block following closed hemorrhoidectomy. MATERIAL AND METHOD: Sixty-seven patients underwent elective hemorrhoidectomy. Of these, 33 were randomly allocated to receive spinal anesthesia (SA) while 34 received perianal local analgesia (LA) with bupivacaine. Pain measurement at 6 and 24 hours following hemorrhoidectomy, the quantity of postoperative analgesic medication administered, patient's satisfaction and complications were recorded. RESULTS: Among the patients who had SA, there were 5 patients (15.2%) who developed hypotension during surgery. There was no reported case of hypotension among those who had LA. There was no significant difference in degree of median postoperative pain at 6 hours (LA: 38 vs. SA: 50 with VAS; p = 0.09) and at 24 hours (LA: 31 vs. SA: 35 with VAS; p = 0.35) between the two groups. Patients had a high satisfaction on both anesthetic methods. Patients in the SA group required more parenteral analgesics (p = 0.03) and had a higher incidence of urinary retention than those in the LA group (SA: 30.3% vs. LA: 8.8%, p = 0.03). CONCLUSION: Local perianal nerve block for hemorrhoidectomy is feasible and safe and superior to spinal block due to a lower incidence of post-op urinary retention and less requirement of parenteral analgesics post-op.