ABSTRACT
Pegylated liposomal doxorubicin (PLD) is a nano-doxorubicin anticancer agent. It was used as early as 2014 to treat ovarian and breast cancer, multiple myeloma and Kaposi's sarcoma. The 2018 National Comprehensive Cancer Network guidelines listed PLD as first-line chemotherapy for ovarian cancer. PLD has significant anticancer efficacy and good tolerance. Although PLD significantly reduces the cardiotoxicity of conventional doxorubicin, its cumulative-dose cardiotoxicity remains a clinical concern. This study summarizes the high-risk factors for PLD-induced cardiotoxicity, clinical dose thresholds, and cardiac function testing modalities. For patients with advanced, refractory, and recurrent malignant tumors, the use of PLD is still one of the most effective strategies in the absence of evidence of high risk such as cardiac dysfunction, and the lifetime treatment dose should be unlimited. Of course, they should also be comprehensively evaluated in combination with the high-risk factors of the patients themselves and indicators of cardiac function. This review can help guide better clinical use of PLD.
Subject(s)
Antibiotics, Antineoplastic , Ovarian Neoplasms , Antibiotics, Antineoplastic/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Ovarian Epithelial/drug therapy , Cardiotoxicity/drug therapy , Cardiotoxicity/etiology , Doxorubicin/analogs & derivatives , Female , Humans , Neoplasm Recurrence, Local/drug therapy , Ovarian Neoplasms/complications , Polyethylene GlycolsABSTRACT
<p><b>OBJECTIVE</b>To study the incidence of injuries among residents living in the communities in Zhejiang.</p><p><b>METHODS</b>A household questionnaire survey was conducted to 16 899 residents in four communities.</p><p><b>RESULTS</b>The incidence of injuries was 16.11% in total, higher in urban area than in rural area and higher in men than in women. The leading causes of injuries were falls (4.80%), knife-cutting or by sharp articles (3.86%), traffic accident (2.07%), collision (1.99%), scalds (1.13%) and animal bites (1.06%). Peak incidence of age group was different in different injuries, such as traffic accident was high in 45 - 60 age group and falls was high in 5 and 60 age group. Direct economic loss for each case with injury would cost 324.21 RMB yuan.</p><p><b>CONCLUSION</b>Injury was common and frequently occurred among residents at the community level which seriously on danger their health and families.</p>