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1.

Dual-acting GLP-1 conjugate enhances weight loss.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 2024 May 29.

Article En | MEDLINE | ID: mdl-38811796

2.

Assessing accuracy of AlphaFold2.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 2024 May 31.

Article En | MEDLINE | ID: mdl-38822115

3.

Predicting ligand-protein interactions.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 2024 May 31.

Article En | MEDLINE | ID: mdl-38822117

4.

Designing reversible anticoagulants.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 2024 May 31.

Article En | MEDLINE | ID: mdl-38822114

5.

Mapping cysteine ligandability.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(6): 420, 2024 Jun.

Article En | MEDLINE | ID: mdl-38710826

Cysteine , Ligands , Cysteine/metabolism , Humans

6.

Designing novel macrocyclic drugs.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(6): 420, 2024 Jun.

Article En | MEDLINE | ID: mdl-38714845

Drug Design , Macrocyclic Compounds , Macrocyclic Compounds/chemistry , Macrocyclic Compounds/pharmacology , Macrocyclic Compounds/therapeutic use , Humans

7.

ASO to treat Timothy syndrome.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(6): 420, 2024 Jun.

Article En | MEDLINE | ID: mdl-38714847

Syndactyly , Humans , Syndactyly/drug therapy , Autistic Disorder/drug therapy , Long QT Syndrome/chemically induced , Primary Immunodeficiency Diseases/drug therapy

8.

Targeting ephrin signalling in sepsis.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(6): 420, 2024 Jun.

Article En | MEDLINE | ID: mdl-38714846

Sepsis , Signal Transduction , Humans , Sepsis/drug therapy , Sepsis/metabolism , Signal Transduction/drug effects , Animals , Ephrins/metabolism

9.

Reducing seizures with senolytic drugs.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 2024 May 31.

Article En | MEDLINE | ID: mdl-38822116

10.

Sterol analogue suppresses hedgehog signalling.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(5): 340, 2024 May.

Article En | MEDLINE | ID: mdl-38575782

Hedgehog Proteins , Signal Transduction , Sterols , Hedgehog Proteins/metabolism , Hedgehog Proteins/antagonists & inhibitors , Signal Transduction/drug effects , Humans , Sterols/pharmacology , Sterols/metabolism , Animals

11.

PROTAC induces HIV-1 Nef degradation.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(5): 340, 2024 May.

Article En | MEDLINE | ID: mdl-38575781

HIV-1 , nef Gene Products, Human Immunodeficiency Virus , Humans , HIV-1/drug effects , nef Gene Products, Human Immunodeficiency Virus/metabolism , HIV Infections/drug therapy , Anti-HIV Agents/pharmacology , Anti-HIV Agents/therapeutic use , Proteolysis/drug effects

12.

Restoring a youthful immune system.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(5): 340, 2024 May.

Article En | MEDLINE | ID: mdl-38575783

Immune System , Humans , Immune System/drug effects , Immune System/immunology

13.

Antibody drug conjugate combats inflammation.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(5): 340, 2024 May.

Article En | MEDLINE | ID: mdl-38575784

Immunoconjugates , Inflammation , Humans , Inflammation/drug therapy , Inflammation/immunology , Immunoconjugates/therapeutic use , Immunoconjugates/pharmacology , Animals , Anti-Inflammatory Agents/therapeutic use , Anti-Inflammatory Agents/pharmacology , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal/pharmacology

14.

mRNA therapy shows promise for metabolic disorder.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(6): 416, 2024 Jun.

Article En | MEDLINE | ID: mdl-38654137

Metabolic Diseases , RNA, Messenger , Humans , Metabolic Diseases/therapy , RNA, Messenger/genetics , Animals , Genetic Therapy/methods

15.

MYC inhibitor achieves phase I success.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(4): 253, 2024 Apr.

Article En | MEDLINE | ID: mdl-38448668

16.

Making macrophages with anti-tumour activity.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(4): 253, 2024 Apr.

Article En | MEDLINE | ID: mdl-38448670

Neoplasms , Humans , Neoplasms/drug therapy , Neoplasms/pathology , Macrophages

17.

Monkeypox mRNA vaccine protects mice and macaques.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(4): 251, 2024 Apr.

Article En | MEDLINE | ID: mdl-38467772

Mpox (monkeypox) , Animals , Mice , Macaca , mRNA Vaccines

18.

Kinase inhibitor rescues the liver.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(5): 336, 2024 May.

Article En | MEDLINE | ID: mdl-38548888

Protein Kinase Inhibitors , Humans , Animals , Protein Kinase Inhibitors/pharmacology , Protein Kinase Inhibitors/therapeutic use , Liver/drug effects , Liver/enzymology , Liver/metabolism

19.

Targeting proteins with bivalent glues.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(4): 253, 2024 Apr.

Article En | MEDLINE | ID: mdl-38448669

20.

Increasing the potency of T cell therapies.

Crunkhorn, Sarah.

Nat Rev Drug Discov ; 23(4): 253, 2024 Apr.

Article En | MEDLINE | ID: mdl-38448667