Background and objectives The exact etiology of migraine is unknown; however, it is likely a mixture of genetic and non-genetic factors including lifestyle variables like smoking and diet. This study aims to assess the causal effect of modifiable risk factors on the risk of migraine using two-sample Mendelian randomization. Materials and methods The study used publicly available genome-wide significant single nucleotide polymorphisms (SNPs). The study evaluated a diverse smoking exposure, encompassing age at smoking initiation, smoking intensity, and maternal smoking, alongside other pertinent risk factors, namely key dietary aspects, coffee consumption, BMI, and physical activity. Self-reported migraine was the outcome of the study. The genetic data for migraine were obtained from the FinnGen (Finland) and the UK Biobank (United Kingdom) cohorts. Results With sample sizes ranging from 64,949 to 632,802 for each risk factor collected from several consorts, the study included a total of 282 SNPs for all risk factors. The findings demonstrated that in the FinnGen consortium, genetically estimated dietary factors as well as BMI, were significantly associated with the risk of migraine (OR 0.765 per single unit of BMI, p = 0.011; OR 0.468 per one SD higher cheese intake, p = 0.012; OR 0.286 per one SD higher salad intake, p = 0.004, and 0.625 per one SD higher coffee consumption, p = 0.003, respectively). The results also showed that in the UK Biobank specifically, a genetically estimated history of maternal smoking was significantly associated with an elevated risk of migraine (OR=1.02, p=0.004). Conclusions The latest study implies a connection between maternal smoking and a heightened risk of migraines, whereas cheese intake, salad intake, coffee consumption, BMI, and physical activity are associated with a lower risk of migraine development.
BACKGROUND AND OBJECTIVE: Antibiotics (Abs) are a class of medication generally prescribed for bacterial infections. Abs misuse, caused by either medication non-compliance or self-medication, may lead to Abs resistance, a problem that is trending around the globe. In 2018, dispensing Abs without a prescription became prohibited in Saudi Arabia. This study aimed to evaluate knowledge and attitude toward Abs use and resistance in Jazan Province. MATERIALS AND METHODS: A cross-sectional study was conducted in the population of Jazan, using a self-administered electronic questionnaire to assess the knowledge and attitude toward Abs use and resistance and its related factors. RESULTS: According to our findings, 543 participants responded and most of the participants use Abs with a prescription (n = 280; 75%). About 40% identified correctly that Abs can treat only bacteria, not viruses, and 44% denied that Abs can treat all coughs and common cases. Then, regarding the knowledge about resistance, we found that those who had heard about Abs resistance represented more than half of the participants (56%), and had better knowledge about Abs use. Further, more than half of those who have heard about Abs resistance correctly defined the antibiotic susceptibility test, and about two-thirds were able to answer the related questions about Abs resistance. CONCLUSION: To conclude, a positive correlation was found between knowledge about Abs resistance and Abs use. Thus, national Abs regulations and policies with continuous education and awareness must be continued to ensure a better understanding of Abs use.
